MA34010B1 - Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou - Google Patents

Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou

Info

Publication number
MA34010B1
MA34010B1 MA35156A MA35156A MA34010B1 MA 34010 B1 MA34010 B1 MA 34010B1 MA 35156 A MA35156 A MA 35156A MA 35156 A MA35156 A MA 35156A MA 34010 B1 MA34010 B1 MA 34010B1
Authority
MA
Morocco
Prior art keywords
neck
head
cell carcinoma
squamous cell
antibiotics
Prior art date
Application number
MA35156A
Other languages
Arabic (ar)
English (en)
Inventor
Cruz Luis A G Da
Elizabeth Jane Franzmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43858306&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34010(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA34010B1 publication Critical patent/MA34010B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne un anticorps monoclonal anti-cd44, ou un fragment se liant à l'antigène de celui-ci, destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou (hnscc) chez un mammifère, ledit hnscc étant caractérisé par l'expression de cd44. Ledit anticorps monoclonal peut être produit par l'hybridome déposé auprès de l'atcc sous le numéro d'accès pta-4621, et peut être sous une forme chimérique ou humanisée.
MA35156A 2010-02-04 2011-02-02 Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou MA34010B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30144910P 2010-02-04 2010-02-04
PCT/EP2011/051436 WO2011095498A1 (fr) 2010-02-04 2011-02-02 Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou

Publications (1)

Publication Number Publication Date
MA34010B1 true MA34010B1 (fr) 2013-02-01

Family

ID=43858306

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35156A MA34010B1 (fr) 2010-02-04 2011-02-02 Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou

Country Status (30)

Country Link
US (2) US20130224108A1 (fr)
EP (1) EP2531527B1 (fr)
JP (2) JP5763105B2 (fr)
KR (1) KR20130042466A (fr)
CN (1) CN102741292B (fr)
AU (1) AU2011212485B2 (fr)
BR (1) BR112012019475A8 (fr)
CA (1) CA2786337A1 (fr)
CL (1) CL2012001980A1 (fr)
CR (1) CR20120429A (fr)
DK (1) DK2531527T3 (fr)
EC (1) ECSP12012138A (fr)
ES (1) ES2460945T3 (fr)
HR (1) HRP20140513T1 (fr)
IL (1) IL220092A (fr)
MA (1) MA34010B1 (fr)
MX (1) MX2012008699A (fr)
MY (1) MY157532A (fr)
NZ (1) NZ600079A (fr)
PE (1) PE20130380A1 (fr)
PH (1) PH12012501525A1 (fr)
PL (1) PL2531527T3 (fr)
PT (1) PT2531527E (fr)
RS (1) RS53327B (fr)
RU (1) RU2599447C2 (fr)
SG (2) SG10201505118PA (fr)
SI (1) SI2531527T1 (fr)
TW (1) TW201130512A (fr)
WO (1) WO2011095498A1 (fr)
ZA (1) ZA201205649B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA34010B1 (fr) * 2010-02-04 2013-02-01 Hoffmann La Roche Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou
US20140308301A1 (en) * 2011-10-26 2014-10-16 The Regents Of The University Of California Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies
WO2013083497A1 (fr) * 2011-12-06 2013-06-13 F. Hoffmann-La Roche Ag Formulation d'anticorps
US20150044232A1 (en) * 2013-06-12 2015-02-12 Hoffmann-La Roche Inc. Markers for the responsiveness to anti-cd44 antibodies
WO2015017692A1 (fr) * 2013-07-31 2015-02-05 University Of Miami Compositions et procédés d'identification d'un risque de développement d'un cancer chez un patient
WO2015076425A1 (fr) * 2013-11-25 2015-05-28 リンク・ジェノミクス株式会社 Nouvel anticorps monoclonal
KR102215384B1 (ko) * 2014-06-11 2021-02-15 (재) 스크립스코리아항체연구원 CD44v3 도메인 3 및 도메인 6 특이적 단일클론 항체 및 그 용도
TWI535452B (zh) 2015-01-23 2016-06-01 長庚醫療財團法人 使用抗－ｃｄ４４中和抗體來治療和／或預防心房顫動
EP3823987A4 (fr) 2018-07-20 2022-03-02 Eucure (Beijing) Biopharma Co., Ltd Anticorps anti-cd40 et leurs utilisations
JP2023516080A (ja) * 2020-03-06 2023-04-17 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｃｄ４４抗体およびその使用
EP4153192B8 (fr) 2020-05-19 2024-09-04 Institut Curie Antagoniste de la voie cd44/acide hyaluronique pour utilisation dans une méthode de traitement du syndrome de libération de cytokines
EP4301782A1 (fr) * 2021-03-05 2024-01-10 Go Therapeutics, Inc. Anticorps anti-glyco-cd44 et leurs utilisations
WO2026032937A1 (fr) * 2024-08-06 2026-02-12 Institut National de la Santé et de la Recherche Médicale Inhibiteur de cd44 destiné à être utilisé dans le traitement d'une maladie hépatique liée à l'alcool

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
UY24389A1 (es) * 1995-12-06 2001-10-25 Karlsruhe Forschzent Composición farmacéutica para el tratamiento de carcinoma de epitelio plano
DE19545472A1 (de) * 1995-12-06 1997-06-12 Boehringer Ingelheim Int Verfahren zur Diagnose und Therapie von Plattenepithelkarzinomen
US20050100542A1 (en) 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) * 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7252821B2 (en) 1999-10-08 2007-08-07 Arius Research Inc. Cancerous disease modifying antibodies
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US6180357B1 (en) 1999-10-08 2001-01-30 Arius Research, Inc. Individualized patient-specific anti-cancer antibodies
US8071072B2 (en) * 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20030103985A1 (en) * 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
AR036154A1 (es) 2001-05-18 2004-08-18 Boehringer Ingelheim Pharma Anticuerpos especificos de cd44v6.
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
EP1532984A1 (fr) * 2003-11-19 2005-05-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation d'anticorps anti-CD44 pour l'éradication des cellules souches de la leucémie myéloide aigue
MA34010B1 (fr) * 2010-02-04 2013-02-01 Hoffmann La Roche Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou

Also Published As

Publication number Publication date
BR112012019475A2 (pt) 2017-01-10
DK2531527T3 (da) 2014-05-05
JP6037149B2 (ja) 2016-11-30
AU2011212485A1 (en) 2012-07-19
US20130224108A1 (en) 2013-08-29
BR112012019475A8 (pt) 2017-12-26
RU2012137380A (ru) 2014-03-10
SG10201505118PA (en) 2015-07-30
PH12012501525A1 (en) 2017-07-26
RS53327B (sr) 2014-10-31
HRP20140513T1 (hr) 2014-07-18
PT2531527E (pt) 2014-05-16
US20150374848A1 (en) 2015-12-31
NZ600079A (en) 2013-07-26
EP2531527A1 (fr) 2012-12-12
PE20130380A1 (es) 2013-03-30
IL220092A0 (en) 2012-09-24
JP2015155409A (ja) 2015-08-27
MY157532A (en) 2016-06-15
RU2599447C2 (ru) 2016-10-10
WO2011095498A1 (fr) 2011-08-11
CL2012001980A1 (es) 2012-11-23
EP2531527B1 (fr) 2014-03-19
CA2786337A1 (fr) 2011-08-11
CR20120429A (es) 2012-12-06
KR20130042466A (ko) 2013-04-26
SG182704A1 (en) 2012-08-30
JP2013518848A (ja) 2013-05-23
JP5763105B2 (ja) 2015-08-12
IL220092A (en) 2016-02-29
PL2531527T3 (pl) 2014-08-29
ES2460945T3 (es) 2014-05-16
TW201130512A (en) 2011-09-16
ECSP12012138A (es) 2012-09-28
ZA201205649B (en) 2015-01-28
CN102741292A (zh) 2012-10-17
MX2012008699A (es) 2012-09-12
SI2531527T1 (sl) 2014-07-31
CN102741292B (zh) 2015-10-21
AU2011212485B2 (en) 2014-04-17

Similar Documents

Publication Publication Date Title
MA34010B1 (fr) Anticorps monoclonal anti-cd44 destiné à être utilisé pour traiter le carcinome à cellules squameuses de la tête et du cou
WO2016164731A8 (fr) Thérapies anti-cd20, thérapies anti-cd22, et polythérapies comprenant une cellule exprimant le récepteur antigénique chimérique (car) dirigé contre le cd19
AU2018260863A1 (en) Human IgG1 Fc region variants and uses thereof
CL2017001580A1 (es) Anticuerpo o fragmento de anticuerpo contra cd38 anticuerpo humanizado, conjugado del anticuerpo con un compuesto citotoxico composición farmacéutica con dichos anticuerpos uso de los anticuerpos para tratar cáncer o enfermedad autoinmune método para diagnosticar cáncer polinucleotido vector y célula huésped.
WO2020016662A3 (fr) Anticorps spécifiques de l'antigène trophoblaste 2 (trop2)
PE20141188A1 (es) Polipeptidos anticuerpos que antagonizan cd40
EA201991577A1 (ru) Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер
EP3991748A3 (fr) Anticorps anti-sortiline et leurs procédés d'utilisation
NZ591541A (en) Pcsk9 antagonists
PE20120815A1 (es) Anticuerpos anti il-17f y metodos de uso de los mismos
AU2010243942A8 (en) Anti-mesothelin immunoconjugates and uses therefor
PE20120902A1 (es) Anticuerpos anti-egfl7 humanizados
WO2016201389A3 (fr) Anticorps anti-cd33 et leurs procédés d'utilisation
WO2016201388A3 (fr) Anticorps anti-cd33 et leurs procédés d'utilisation
EA200870411A1 (ru) Полипептиды с усиленным противовоспалительным и пониженным цитотоксическим свойствами и связанные с ними способы
ME03819B (fr) Anticorps anti-icos
MY202133A (en) Anti-sortilin antibodies and methods of use thereof
MX394165B (es) Anticuerpos anti-receptor ccr7 humanizados.
MX341958B (es) Anticuerpos contra el il33r humano y usos de los mismos.
SG10201803473WA (en) Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide
NZ586357A (en) Antibodies to the pcrv antigen of pseudomonas aeruginosa
WO2017083451A8 (fr) Molécules de liaison spécifiques d'asct2 et leurs utilisations
PE20120475A1 (es) Anticuerpos especificos para dkk-1
EP4219556A3 (fr) Anticorps humain specifiques pour flt3 et leur modes d'utilisation
AU2013232386A8 (en) Treatment of multiple sclerosis with anti-CD19 antibody