MA34207B1 - Inhibiteurs de la pi3 kinase et/ou du mtor - Google Patents

Inhibiteurs de la pi3 kinase et/ou du mtor

Info

Publication number
MA34207B1
MA34207B1 MA34389A MA34389A MA34207B1 MA 34207 B1 MA34207 B1 MA 34207B1 MA 34389 A MA34389 A MA 34389A MA 34389 A MA34389 A MA 34389A MA 34207 B1 MA34207 B1 MA 34207B1
Authority
MA
Morocco
Prior art keywords
mtor
kinase
inhibitors
compounds
variables
Prior art date
Application number
MA34389A
Other languages
English (en)
Inventor
Kristin Andrews
Yunxin Y Bo
Shon Booker
Victor J Cee
Kevin Yang
Mark H Norman
Anthony B Reed
Adrian L Smith
Seifu Tadesse
Nuria A Tamayo
Bin Wu
Ryan Wurz
Nobuko Nishimura
Angelo Noel D
Bradley J Herberich
Fang-Tsao Hong
Claire L M Jackson
Brian A Lanman
Hongyu Liao
Longbin Liu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA34207B1 publication Critical patent/MA34207B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention porte sur des composés de formule I ou sur un sel pharmaceutiquement acceptable de ces derniers ; sur des procédés pour traiter des maladies ou des conditions telles que le cancer, par utilisation des composés ; et sur des compositions pharmaceutiques contenant les composés, les variables étant telles que définies dans l'invention.
MA34389A 2009-04-28 2011-11-25 Inhibiteurs de la pi3 kinase et/ou du mtor MA34207B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17352009P 2009-04-28 2009-04-28
US25853209P 2009-11-05 2009-11-05
PCT/US2010/032593 WO2010126895A1 (fr) 2009-04-28 2010-04-27 Inhibiteurs de la pi3 kinase et/ou du mtor

Publications (1)

Publication Number Publication Date
MA34207B1 true MA34207B1 (fr) 2013-05-02

Family

ID=42315845

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34389A MA34207B1 (fr) 2009-04-28 2011-11-25 Inhibiteurs de la pi3 kinase et/ou du mtor

Country Status (23)

Country Link
US (2) US8362241B2 (fr)
EP (1) EP2424859B1 (fr)
JP (1) JP5697662B2 (fr)
KR (1) KR20120007540A (fr)
CN (1) CN102548984B (fr)
AR (1) AR076486A1 (fr)
AU (1) AU2010241723B2 (fr)
BR (1) BRPI1015262A2 (fr)
CA (1) CA2758986C (fr)
CL (1) CL2011002691A1 (fr)
CO (1) CO6440596A2 (fr)
CR (1) CR20110634A (fr)
EA (1) EA019700B1 (fr)
IL (1) IL215731A0 (fr)
MA (1) MA34207B1 (fr)
MX (1) MX2011011335A (fr)
NZ (1) NZ595572A (fr)
PE (1) PE20121159A1 (fr)
SG (1) SG175364A1 (fr)
TW (1) TW201103902A (fr)
UY (1) UY32582A (fr)
WO (1) WO2010126895A1 (fr)
ZA (1) ZA201108101B (fr)

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US20130079303A1 (en) 2013-03-28
US8362241B2 (en) 2013-01-29
CO6440596A2 (es) 2012-05-15
AR076486A1 (es) 2011-06-15
US8772480B2 (en) 2014-07-08
EP2424859B1 (fr) 2015-04-08
MX2011011335A (es) 2011-11-18
CA2758986C (fr) 2014-05-27
SG175364A1 (en) 2011-11-28
US20100273764A1 (en) 2010-10-28
CA2758986A1 (fr) 2010-11-04
ZA201108101B (en) 2012-07-25
HK1167862A1 (en) 2012-12-14
JP5697662B2 (ja) 2015-04-08
EP2424859A1 (fr) 2012-03-07
UY32582A (es) 2010-11-30
CR20110634A (es) 2012-01-06
CL2011002691A1 (es) 2012-03-16
TW201103902A (en) 2011-02-01
AU2010241723B2 (en) 2012-12-13
BRPI1015262A2 (pt) 2016-05-03
EA201101583A1 (ru) 2012-05-30
WO2010126895A1 (fr) 2010-11-04
KR20120007540A (ko) 2012-01-20
CN102548984A (zh) 2012-07-04
EA019700B1 (ru) 2014-05-30
AU2010241723A1 (en) 2011-11-17
PE20121159A1 (es) 2012-09-19
CN102548984B (zh) 2015-11-25
JP2012525395A (ja) 2012-10-22
IL215731A0 (en) 2012-01-31
NZ595572A (en) 2013-07-26

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