MA34671B1 - Sel de sodium de 1h-pyrazol-5-olate substitué - Google Patents

Sel de sodium de 1h-pyrazol-5-olate substitué

Info

Publication number
MA34671B1
MA34671B1 MA35911A MA35911A MA34671B1 MA 34671 B1 MA34671 B1 MA 34671B1 MA 35911 A MA35911 A MA 35911A MA 35911 A MA35911 A MA 35911A MA 34671 B1 MA34671 B1 MA 34671B1
Authority
MA
Morocco
Prior art keywords
pyrazol
sodium salt
substituted
diseases
olate
Prior art date
Application number
MA35911A
Other languages
English (en)
Inventor
Hans-Christian Militzer
Joerg Gries
Stefan Koep
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34671(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA34671B1 publication Critical patent/MA34671B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)

Abstract

L'INVENTION CONCERNE LE SEL DE SODIUM DE 1-[6-{MORPHOLINE-4-YL)PYRIMIDINE-4-YL]-4-(1H-1,2,3- TRIAZOL-1-YL)-1H-PYRAZOL-5-OLATE, UN PROCÉDÉ POUR SA PRODUCTION, SON UTILISATION POUR LE TRAITEMENT ET/OU LA PROPHYLAXIE DE MALADIES, AINSI QUE SON UTILISATION POUR LA PRODUCTION DE MÉDICAMENTS DESTINÉS AU TRAITEMENT ET/OU À LA PROPHYLAXIE DE MALADIES, EN PARTICULIER DE MALADIES CARDIOVASCULAIRES ET HÉMATOLOGIQUES, D'AFFECTIONS RÉNALES, ET POUR ACCÉLÉRER LA GUÉRISON DES PLAIES.
MA35911A 2010-11-18 2011-11-15 Sel de sodium de 1h-pyrazol-5-olate substitué MA34671B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010044131A DE102010044131A1 (de) 2010-11-18 2010-11-18 Substituiertes Natrium-1H-pyrazol-5-olat
PCT/EP2011/070099 WO2012065967A1 (fr) 2010-11-18 2011-11-15 Sel de sodium de 1h-pyrazol-5-olate substitué

Publications (1)

Publication Number Publication Date
MA34671B1 true MA34671B1 (fr) 2013-11-02

Family

ID=44999768

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35911A MA34671B1 (fr) 2010-11-18 2011-11-15 Sel de sodium de 1h-pyrazol-5-olate substitué

Country Status (49)

Country Link
US (2) US8653074B2 (fr)
EP (1) EP2640718B8 (fr)
JP (1) JP5918779B2 (fr)
KR (2) KR20180023043A (fr)
CN (2) CN103270031B (fr)
AP (1) AP3429A (fr)
AR (1) AR083887A1 (fr)
AU (1) AU2011331305B2 (fr)
BR (1) BR112013012223B1 (fr)
CA (1) CA2818002C (fr)
CL (1) CL2013001390A1 (fr)
CO (1) CO6741155A2 (fr)
CR (1) CR20130196A (fr)
CU (1) CU20130072A7 (fr)
CY (1) CY1120375T1 (fr)
DE (1) DE102010044131A1 (fr)
DK (1) DK2640718T3 (fr)
DO (1) DOP2013000096A (fr)
EA (1) EA023103B1 (fr)
EC (1) ECSP13012627A (fr)
ES (1) ES2675580T3 (fr)
FI (1) FIC20260012I1 (fr)
FR (1) FR26C1021I1 (fr)
GT (1) GT201300125A (fr)
HK (1) HK1210776A1 (fr)
HR (1) HRP20180993T1 (fr)
HU (1) HUE038024T2 (fr)
IL (1) IL226192A (fr)
JO (1) JOP20110347B1 (fr)
LT (2) LT2640718T (fr)
MA (1) MA34671B1 (fr)
MX (1) MX347670B (fr)
MY (1) MY167219A (fr)
NO (1) NO2026022I1 (fr)
NZ (1) NZ610614A (fr)
PE (2) PE20140391A1 (fr)
PH (1) PH12013500997A1 (fr)
PL (1) PL2640718T3 (fr)
PT (1) PT2640718T (fr)
RS (1) RS57599B1 (fr)
SG (1) SG189975A1 (fr)
SI (1) SI2640718T1 (fr)
TN (1) TN2013000215A1 (fr)
TR (1) TR201806652T4 (fr)
TW (1) TWI516485B (fr)
UA (1) UA112422C2 (fr)
UY (1) UY33736A (fr)
WO (1) WO2012065967A1 (fr)
ZA (1) ZA201304430B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006050516A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat
UA116349C2 (uk) * 2012-05-08 2018-03-12 Байєр Фарма Акцієнгезелльшафт Спосіб одержання морфолінпіримідинових похідних піразолу
MY190202A (en) * 2013-10-17 2022-04-04 Bayer Pharma AG Pharmaceutical dosage forms containing sodium-1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1h-1,2,3-triazol-1-yl)-1h-pyrazol-5-olate
WO2016049541A2 (fr) 2014-09-26 2016-03-31 The Cleveland Clinic Foundation Traitement et prévention d'une maladie avec des agents de réduction de la tma et du tmao
CL2015003047A1 (es) * 2015-10-15 2016-06-17 Univ Chile Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina
WO2018149929A1 (fr) * 2017-02-16 2018-08-23 Bayer Pharma Aktiengesellschaft Dosages de gènes rapporteurs et analyse transcriptionnelle combinés
EP3888684A1 (fr) * 2020-03-31 2021-10-06 Bayer Animal Health GmbH Composition ayant une acceptation volontaire améliorée

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1519069A (fr) 1966-04-13 1968-03-29 Geigy Ag J R Dérivés du sulfanilamide et leur préparation
US4075003A (en) 1975-12-11 1978-02-21 Eli Lilly And Company Novel herbicidal method utilizing 1,4-diphenyl-3-pyrazolin-5-ones
GR63123B (en) 1975-12-11 1979-09-11 Lilly Co Eli Preparation process of novel 1,4-diphenyl-3-pyrazolin-5-ones
PL103509B1 (pl) 1976-09-20 1979-06-30 Lilly Co Eli Srodek chwastobojczy
US4663327A (en) 1984-05-23 1987-05-05 Bayer Aktiengesellschaft 1-heteroaryl-4-aryl-pyrazolin-5-ones
DE3443308A1 (de) 1984-11-28 1986-05-28 Bayer Ag, 5090 Leverkusen 1-heteroaryl-4-aryl-pyrazolin-5-one zur verwendung als arzneimittel
DE3527157A1 (de) 1985-07-30 1987-02-12 Bayer Ag 1-heteroaryl-4-aryl-pyrazol-derivate
DE4204919A1 (de) 1992-02-19 1993-08-26 Bayer Ag Verfahren zur herstellung von 2-chlor-5-alkylaminomethyl-pyridinen
JPH0735361B2 (ja) * 1993-09-09 1995-04-19 日産化学工業株式会社 ヒドラゾン誘導体およびその製造方法
FR2725988B1 (fr) 1994-10-24 1997-01-24 Roussel Uclaf Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
JPH10306077A (ja) 1997-05-07 1998-11-17 Daiichi Rajio Isotope Kenkyusho:Kk ビピラゾール誘導体並びにこれを有効成分とする医薬および試薬
DE19909237A1 (de) 1999-03-03 2000-09-07 Merck Patent Gmbh Pyrazol-3-on-derivate
US6878729B2 (en) 2001-05-04 2005-04-12 The Procter & Gamble Company Medicinal uses of dihydropyrazoles
ATE438710T1 (de) 2001-05-15 2009-08-15 Ortho Mcneil Janssen Pharm Ex-vivo-priming zur erzeugung cd40-ligand spezifischer zytotoxischer t-lymphozyten zur behandlung von autoimmun- und allergischen erkrankungen
JP4316893B2 (ja) 2001-05-16 2009-08-19 バーテックス ファーマシューティカルズ インコーポレイテッド Ｓｒｃおよび他のプロテインキナーゼのインヒビター
CN101659639A (zh) 2001-09-21 2010-03-03 索尔瓦药物有限公司 具有cb1-拮抗活性的新的4,5-二氢-1h-吡唑衍生物
JP4286146B2 (ja) 2001-12-18 2009-06-24 メルク エンド カムパニー インコーポレーテッド メタボトロピックグルタミン酸受容体−５のヘテロアリール置換ピラゾール系調節剤
AU2003213673A1 (en) 2002-03-01 2003-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7652033B2 (en) 2003-03-27 2010-01-26 Emory University HIF-1 inhibitors
EP1613614A2 (fr) 2003-04-03 2006-01-11 Merck & Co., Inc. Modulateurs au pyrazole a substitution diaryle du recepteur-5 de glutamate metabotropique
JP2007527854A (ja) 2003-05-01 2007-10-04 パナシア ファーマシューティカルズ インコーポレーテッド 虚血関連状態の治療方法
JP4499721B2 (ja) 2003-06-30 2010-07-07 ヒフ バイオ，インク． 化合物、組成物および方法
CN1842332A (zh) * 2003-06-30 2006-10-04 Hif生物公司 化合物、组合物及方法
WO2006088491A2 (fr) 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Procedes et compositions concernant la modulation de jonctions intercellulaires
DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
CA2601098C (fr) 2005-03-16 2011-07-05 Aventis Pharmaceuticals Inc. Dipyrazoles utiles comme agents du systeme nerveux central
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
WO2007008541A2 (fr) 2005-07-08 2007-01-18 Kalypsys, Inc. Modificateurs d'absorption de cholesterol cellulaire
WO2007121687A1 (fr) 2006-04-26 2007-11-01 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China Dérivés du 4-méthyl-1h-diaryl pyrazole et leur utilisation comme médicaments
DE102006050516A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050515A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung
DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung
DE102010044131A1 (de) * 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Also Published As

Publication number Publication date
TR201806652T4 (tr) 2018-06-21
KR20130131335A (ko) 2013-12-03
KR101984317B1 (ko) 2019-05-30
CA2818002C (fr) 2019-01-15
IL226192A (en) 2016-06-30
JP5918779B2 (ja) 2016-05-18
CN103270031A (zh) 2013-08-28
SG189975A1 (en) 2013-06-28
PH12013500997A1 (en) 2015-03-06
IL226192A0 (en) 2013-07-31
TW201307328A (zh) 2013-02-16
EA201390703A1 (ru) 2013-12-30
EP2640718A1 (fr) 2013-09-25
JOP20110347B1 (ar) 2021-08-17
UY33736A (es) 2012-06-29
FR26C1021I1 (fr) 2026-06-12
MY167219A (en) 2018-08-14
BR112013012223A2 (pt) 2020-03-10
AP2013006922A0 (en) 2013-06-30
GT201300125A (es) 2017-07-26
DE102010044131A1 (de) 2012-05-24
HK1210776A1 (en) 2016-05-06
EP2640718B1 (fr) 2018-03-28
CR20130196A (es) 2013-08-06
ECSP13012627A (es) 2013-07-31
LT2640718T (lt) 2018-07-10
HK1188782A1 (en) 2014-05-16
LTPA2026515I1 (fr) 2026-05-11
US9533972B2 (en) 2017-01-03
AR083887A1 (es) 2013-03-27
EA023103B1 (ru) 2016-04-29
KR20180023043A (ko) 2018-03-06
CY1120375T1 (el) 2019-07-10
WO2012065967A1 (fr) 2012-05-24
PT2640718T (pt) 2018-07-04
JP2014500877A (ja) 2014-01-16
CA2818002A1 (fr) 2012-05-24
US20120129857A1 (en) 2012-05-24
NZ610614A (en) 2015-05-29
US8653074B2 (en) 2014-02-18
HRP20180993T1 (hr) 2018-08-10
CN104650047A (zh) 2015-05-27
AP3429A (en) 2015-09-30
TWI516485B (zh) 2016-01-11
CL2013001390A1 (es) 2014-04-04
ES2675580T3 (es) 2018-07-11
PE20180324A1 (es) 2018-02-13
PE20140391A1 (es) 2014-03-29
AU2011331305A1 (en) 2013-06-06
SI2640718T1 (en) 2018-08-31
UA112422C2 (uk) 2016-09-12
MX347670B (es) 2017-05-03
CN103270031B (zh) 2015-06-17
TN2013000215A1 (en) 2014-11-10
MX2013004797A (es) 2013-06-28
NO2026022I1 (no) 2026-04-22
BR112013012223B1 (pt) 2021-06-29
DK2640718T3 (da) 2018-07-16
ZA201304430B (en) 2014-12-23
FIC20260012I1 (fi) 2026-04-15
CU20130072A7 (es) 2013-09-27
AU2011331305B2 (en) 2016-06-02
US20130310381A1 (en) 2013-11-21
DOP2013000096A (es) 2013-06-15
HUE038024T2 (hu) 2018-09-28
CO6741155A2 (es) 2013-08-30
EP2640718B8 (fr) 2018-06-27
PL2640718T3 (pl) 2018-08-31
RS57599B1 (sr) 2018-11-30

Similar Documents

Publication Publication Date Title
MA35365B1 (fr) Pyrimidines annelées substituées et leur utilisation
MA34248B1 (fr) 5-fluoro-1h-pyrazolopyridines substituées et leur utilisation
MA35844B1 (fr) Pyrimidines et triazines annelées substituées et leur utilisation
MA38365A1 (fr) Pyrimidines annelées à subsitution trifluorométhyle et utilisation correspondante
MA42376A (fr) Dérivés d'oxopyridine substitués
MA40893A (fr) Dérivés de phényltriazole à substitution hydroxyalkyle et utilisations associées
MA30914B1 (fr) Dihydropyrazolones substituees utilisees dans le traitement de maladies cardiovasculaires et hematologiques.
UA112422C2 (uk) Заміщений натрій-1h-піразол-5-олат
MX351463B (es) Formas cristalinas de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trif luorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-is obenzofuran]-1-il)-2-(metilsulfonil)etanona.
MA32251B1 (fr) Dihydropyrazolones substituées utilisées comme inhibiteurs de la hif-prolyl-4-hydroxylase
MA38071B1 (fr) Formes cristallines d'un inhibiteur de facteur xia
MY191956A (en) 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
MA33123B1 (fr) 2-acetamido-5-aryl-1,2,4-triazolones substitues et leur utilisation
MY151191A (en) Novel antibodies
MA39170A1 (fr) Composes inhibiteurs de sérine/thréonine kinase pour leurs utilisations dans le traitement du cancer
MA37709B1 (fr) Pansement a liberation prolongee d'actifs
MA30039B1 (fr) Nouveaux derives de furopyrimidines a substitution acyclique et leur utilisation pour traiter des maladies cardiovasculaires
EP2579863A4 (fr) Composés pour le traitement de la mastite bovine
MA33290B1 (fr) Pipéridines substituées
FR2938777B1 (fr) Catalyseur en coquille, procede de preparation et utilisation de ce catalyseur.
MA33291B1 (fr) Pipéridines substituées
MA38974A1 (fr) Formes galéniques pharmaceutiques contenant du sodium 1-[6-{morpholine-4-yl)pyrimidine-4-yl]-4-(1h-1,2,3- triazol-1-yl)-1h-pyrazol-5-olate
MA34480B1 (fr) Docosahexanoate de panthényle et son utilisation pour traiter et prévenir les maladies cardiovasculaires
MX2011011177A (es) Proceso para la preparacion de 4-(3-cloro-2-fluoro-anilino)-7-meto xi-6-[1-(n-metilcarbamoilmetil) piperidin-4-il] quinazolina.