MA34889B1 - Dérivés de 6 - cyclobutyl - 1, 5 - dihydro - pyrazolo [3, 4-d] pyrimidin- 4 - one et leur utilisation en tant qu'inhibiteurs de pde9a - Google Patents

Dérivés de 6 - cyclobutyl - 1, 5 - dihydro - pyrazolo [3, 4-d] pyrimidin- 4 - one et leur utilisation en tant qu'inhibiteurs de pde9a

Info

Publication number
MA34889B1
MA34889B1 MA36160A MA36160A MA34889B1 MA 34889 B1 MA34889 B1 MA 34889B1 MA 36160 A MA36160 A MA 36160A MA 36160 A MA36160 A MA 36160A MA 34889 B1 MA34889 B1 MA 34889B1
Authority
MA
Morocco
Prior art keywords
medicines
pyrazolo
pyrimidin
cyclobutyl
dihydro
Prior art date
Application number
MA36160A
Other languages
English (en)
Inventor
Niklas Heine
Riccardo Giovannini
Marco Ferrara
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46671960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34889(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2011/063705 external-priority patent/WO2012020022A1/fr
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA34889B1 publication Critical patent/MA34889B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX PYRAZOLOPYRIMIDINONES DE FORMULE (I) DANS LAQUELLE R1 EST UN GROUPE PYRIDYLE OU PYRIMIDINYLE ET D EST CYCLOPENTYLE, CYCLOHEXYLE, TÉTRAHYDROFURANYLE, TÉTRAHYDROPYRANYLE OU 2-, 3-OU 4-PYRIDYLE ÉVENTUELLEMENT SUBSTITUÉ. LES NOUVEAUX COMPOSÉS SONT DESTINÉS À ÊTRE UTILISÉS EN TANT QUE PRINCIPE ACTIF DE MÉDICAMENTS OU POUR LA FABRICATION DE MÉDICAMENTS RESPECTIVEMENT, EN PARTICULIER DES MÉDICAMENTS POUR LE TRAITEMENT DE CONDITIONS CONCERNANT DES DÉFICIENCES DE PERCEPTION, DE CONCENTRATION, D'APPRENTISSAGE OU DE MÉMOIRE. DE TELLES CONDITIONS PEUVENT PAR EXEMPLE ÊTRE ASSOCIÉES À LA MALADIE D'ALZHEIMER, LA SCHIZOPHRÉNIE ET D'AUTRES MALADIES. LES NOUVEAUX COMPOSÉS SONT ÉGALEMENT UTILISÉS PAR EXEMPLE POUR LA FABRICATION DE MÉDICAMENTS ET/OU POUR LE TRAITEMENT DE CES MALADIES, EN PARTICULIER LA DÉTÉRIORATION COGNITIVE ASSOCIÉE À UNE TELLE MALADIE. LES COMPOSÉS SELON L'INVENTION PRÉSENTENT DES PROPRIÉTÉS INHIBITRICES DE PDE9.
MA36160A 2011-02-14 2012-02-13 Dérivés de 6 - cyclobutyl - 1, 5 - dihydro - pyrazolo [3, 4-d] pyrimidin- 4 - one et leur utilisation en tant qu'inhibiteurs de pde9a MA34889B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11154397 2011-02-14
PCT/EP2011/063705 WO2012020022A1 (fr) 2010-08-12 2011-08-09 Dérivés de 6-cycloalkyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one et leurs utilisations en tant qu'inhibiteurs de pde9a
PCT/EP2012/052378 WO2012110440A1 (fr) 2011-02-14 2012-02-13 Dérivés de 6 - cyclobutyl - 1, 5 - dihydro - pyrazolo [3, 4-d] pyrimidin- 4 - one et leur utilisation en tant qu'inhibiteurs de pde9a

Publications (1)

Publication Number Publication Date
MA34889B1 true MA34889B1 (fr) 2014-02-01

Family

ID=46671960

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36160A MA34889B1 (fr) 2011-02-14 2012-02-13 Dérivés de 6 - cyclobutyl - 1, 5 - dihydro - pyrazolo [3, 4-d] pyrimidin- 4 - one et leur utilisation en tant qu'inhibiteurs de pde9a

Country Status (23)

Country Link
US (1) US20130040971A1 (fr)
EP (1) EP2675807B1 (fr)
JP (1) JP2014505091A (fr)
KR (1) KR20140010036A (fr)
CN (1) CN103459397A (fr)
AP (1) AP2013007045A0 (fr)
AR (1) AR085219A1 (fr)
AU (1) AU2012217208A1 (fr)
BR (1) BR112013020605A2 (fr)
CA (1) CA2827261A1 (fr)
CL (1) CL2013002341A1 (fr)
CO (1) CO6791616A2 (fr)
EA (1) EA023574B1 (fr)
EC (1) ECSP13012852A (fr)
IL (1) IL227526A0 (fr)
MA (1) MA34889B1 (fr)
MX (1) MX2013009343A (fr)
PE (1) PE20140970A1 (fr)
PH (1) PH12013501677A1 (fr)
SG (1) SG192756A1 (fr)
TN (1) TN2013000324A1 (fr)
TW (1) TW201245199A (fr)
WO (1) WO2012110440A1 (fr)

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KR20200010220A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제
RU2019135834A (ru) 2017-06-01 2021-07-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Терапевтическое средство для лечения деменции, представляющее собой комбинацию производного пиразолохинолина и донепезила
KR20200010211A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 Pde9 저해제를 포함하는 약제학적 조성물
SG10202113199RA (en) 2017-06-01 2021-12-30 Eisai R&D Man Co Ltd Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
AU2018281131B2 (en) * 2017-06-08 2022-01-20 Merck Sharp & Dohme Corp. Pyrazolopyrimidine PDE9 inhibitors
WO2020123271A1 (fr) * 2018-12-12 2020-06-18 Merck Sharp & Dohme Corp. Inhibiteurs de pde9 au pyrazolopyrimidine cyclobutyle
CN110339197A (zh) * 2019-06-24 2019-10-18 中山大学 一种防治血管性痴呆的磷酸二酯酶9a抑制剂的用途

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PH12013501677A1 (en) 2018-04-11
ECSP13012852A (es) 2014-09-30
US20130040971A1 (en) 2013-02-14
EP2675807A1 (fr) 2013-12-25
AP2013007045A0 (en) 2013-08-31
WO2012110440A1 (fr) 2012-08-23
CA2827261A1 (fr) 2012-08-23
WO2012110440A9 (fr) 2013-03-14
EP2675807B1 (fr) 2015-04-22
AR085219A1 (es) 2013-09-18
EA201300908A1 (ru) 2014-01-30
MX2013009343A (es) 2013-10-01
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JP2014505091A (ja) 2014-02-27
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CN103459397A (zh) 2013-12-18
AU2012217208A1 (en) 2013-08-01
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BR112013020605A2 (pt) 2016-10-18
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