TW201326169A - 用於治療細胞增生性病症之pak抑制劑 - Google Patents

用於治療細胞增生性病症之pak抑制劑 Download PDF

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Publication number
TW201326169A
TW201326169A TW101141080A TW101141080A TW201326169A TW 201326169 A TW201326169 A TW 201326169A TW 101141080 A TW101141080 A TW 101141080A TW 101141080 A TW101141080 A TW 101141080A TW 201326169 A TW201326169 A TW 201326169A
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Taiwan
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substituted
group
unsubstituted
cancer
compound
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TW101141080A
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English (en)
Chinese (zh)
Inventor
David Campbell
Sergio G Duron
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Afraxis Inc
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Application filed by Afraxis Inc filed Critical Afraxis Inc
Publication of TW201326169A publication Critical patent/TW201326169A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW101141080A 2011-11-04 2012-11-05 用於治療細胞增生性病症之pak抑制劑 TW201326169A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161555902P 2011-11-04 2011-11-04

Publications (1)

Publication Number Publication Date
TW201326169A true TW201326169A (zh) 2013-07-01

Family

ID=48192852

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101141080A TW201326169A (zh) 2011-11-04 2012-11-05 用於治療細胞增生性病症之pak抑制劑

Country Status (20)

Country Link
US (2) US20150031693A1 (fr)
EP (2) EP2773643A4 (fr)
JP (2) JP2015501786A (fr)
KR (2) KR20140105451A (fr)
CN (2) CN104093717A (fr)
AR (1) AR089175A1 (fr)
AU (2) AU2012327183A1 (fr)
BR (2) BR112014010631A2 (fr)
CA (2) CA2854471A1 (fr)
CL (2) CL2014001131A1 (fr)
CO (1) CO7030960A2 (fr)
CR (2) CR20140250A (fr)
EA (2) EA201490927A1 (fr)
IL (2) IL232154A0 (fr)
MA (2) MA35660B1 (fr)
MX (2) MX2014005292A (fr)
PH (2) PH12014500956A1 (fr)
SG (2) SG11201401996TA (fr)
TW (1) TW201326169A (fr)
WO (2) WO2013067423A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
CN103906735B (zh) 2011-11-04 2016-12-07 霍夫曼-拉罗奇有限公司 新芳基-喹啉衍生物
CN105307657B (zh) 2013-03-15 2020-07-10 西建卡尔有限责任公司 杂芳基化合物和其用途
EP3943087A1 (fr) 2013-03-15 2022-01-26 Celgene CAR LLC Composés hétéroaryle et utilisations associées
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2015011252A1 (fr) * 2013-07-26 2015-01-29 F. Hoffmann-La Roche Ag Inhibiteurs pyrimidine-pyridinone de sérine/thréonine kinase
PT3102577T (pt) * 2014-02-07 2018-10-23 Principia Biopharma Inc Derivados de quinolona como inibidores do recetor do fator de crescimento de fibroblastos
CN105294682B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10694988B2 (en) * 2016-02-17 2020-06-30 Nuralogix Corporation System and method for detecting physiological state
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
WO2017220516A1 (fr) * 2016-06-23 2017-12-28 F. Hoffmann-La Roche Ag Dérivés de triazolo[4,5-d]pyrimidine
WO2018013466A2 (fr) * 2016-07-15 2018-01-18 Dana-Farber Cancer Institute, Inc. Biomarqueurs prédictifs de la résistance endocrinienne dans le cancer du sein
CN106818805A (zh) * 2016-12-27 2017-06-13 东莞市联洲知识产权运营管理有限公司 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用
CN107083428B (zh) * 2017-04-10 2020-09-25 徐州医科大学 Pak5在癌症诊断预后治疗及药物筛选中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
WO2020086882A1 (fr) * 2018-10-24 2020-04-30 Northwestern University Inhibiteurs d'agrégation de cellules tumorales pour le traitement du cancer
WO2020142612A1 (fr) 2019-01-03 2020-07-09 Genentech, Inc. Composés de pyrido-pyrimidinone et de ptéridinone utilisés en tant qu'inhibiteurs de l'enzyme nécessitant l'inositol i (ire i alpha) à activité endoribonucléase pour le traitement de maladies cancéreuses
CN112213400B (zh) * 2019-07-09 2022-06-07 四川弘合生物科技有限公司 一种β-榄香烯及其有关物质的检测方法
CN110496128B (zh) * 2019-09-23 2022-09-30 吉林大学 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用
IL302807A (en) 2020-11-18 2023-07-01 Deciphera Pharmaceuticals Llc Gcn2 and perk kinase inhibitors and methods of use thereof
CN117858879A (zh) * 2021-01-15 2024-04-09 南京再明医药有限公司 Cdk2/4/6抑制剂及其制备方法和应用
CN113046323A (zh) * 2021-04-02 2021-06-29 四川农业大学 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法
PE20250609A1 (es) 2021-12-03 2025-02-26 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos
WO2025257301A1 (fr) * 2024-06-13 2025-12-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Traitement de la neurofibromatose de type 2 par des inhibiteurs de g6pd, acsl3 et/ou oxsm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
WO2008055842A1 (fr) * 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Dérivés de 6-phényl-pyrido [2,3-d] pyrimidine-7-one substitués utilisés comme inhibiteurs de la kinase et méthodes d'utilisation de ceux-ci
EP2112150B1 (fr) * 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
WO2010071846A2 (fr) * 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
US8372970B2 (en) * 2009-10-09 2013-02-12 Afraxis, Inc. 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders
EP2580214A4 (fr) * 2010-06-09 2013-12-04 Afraxis Holdings Inc 8-(sulfonylaryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc
US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders

Also Published As

Publication number Publication date
WO2013067434A1 (fr) 2013-05-10
CR20140250A (es) 2014-08-20
EA201490925A1 (ru) 2014-09-30
PH12014500956A1 (en) 2014-06-30
MA35661B1 (fr) 2014-11-01
PH12014500995A1 (en) 2014-08-04
BR112014010631A2 (pt) 2017-04-25
EA201490927A1 (ru) 2014-10-30
AU2012327187A1 (en) 2013-05-23
AR089175A1 (es) 2014-08-06
CL2014001132A1 (es) 2014-08-22
AU2012327183A1 (en) 2013-05-30
CL2014001131A1 (es) 2014-08-22
MX2014005296A (es) 2014-08-27
US20130116263A1 (en) 2013-05-09
SG11201401996TA (en) 2014-05-29
WO2013067423A1 (fr) 2013-05-10
EP2773643A4 (fr) 2015-07-29
IL232215A0 (en) 2014-06-30
EP2773642A1 (fr) 2014-09-10
AU2012327183A8 (en) 2013-07-18
CA2854462A1 (fr) 2013-05-10
MA35660B1 (fr) 2014-11-01
CA2854471A1 (fr) 2013-05-10
MX2014005292A (es) 2014-09-11
BR112014010420A2 (pt) 2017-04-25
AU2012327187A8 (en) 2013-07-25
CR20140251A (es) 2014-08-20
IL232154A0 (en) 2014-05-28
JP2014532724A (ja) 2014-12-08
CN104093717A (zh) 2014-10-08
US20150031693A1 (en) 2015-01-29
EP2773643A1 (fr) 2014-09-10
KR20140096098A (ko) 2014-08-04
SG11201401914WA (en) 2014-05-29
JP2015501786A (ja) 2015-01-19
KR20140105451A (ko) 2014-09-01
CO7030960A2 (es) 2014-08-21
CN104039786A (zh) 2014-09-10

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