TW201326169A - 用於治療細胞增生性病症之pak抑制劑 - Google Patents
用於治療細胞增生性病症之pak抑制劑 Download PDFInfo
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| TW101141080A TW201326169A (zh) | 2011-11-04 | 2012-11-05 | 用於治療細胞增生性病症之pak抑制劑 |
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| EP (2) | EP2773643A4 (fr) |
| JP (2) | JP2015501786A (fr) |
| KR (2) | KR20140096098A (fr) |
| CN (2) | CN104093717A (fr) |
| AR (1) | AR089175A1 (fr) |
| AU (2) | AU2012327183A1 (fr) |
| BR (2) | BR112014010631A2 (fr) |
| CA (2) | CA2854471A1 (fr) |
| CL (2) | CL2014001131A1 (fr) |
| CO (1) | CO7030960A2 (fr) |
| CR (2) | CR20140251A (fr) |
| EA (2) | EA201490927A1 (fr) |
| IL (2) | IL232154A0 (fr) |
| MA (2) | MA35660B1 (fr) |
| MX (2) | MX2014005296A (fr) |
| PH (2) | PH12014500956A1 (fr) |
| SG (2) | SG11201401996TA (fr) |
| TW (1) | TW201326169A (fr) |
| WO (2) | WO2013067434A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2580216A4 (fr) * | 2010-06-10 | 2014-07-23 | Afraxis Holdings Inc | 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc |
| MX343893B (es) | 2011-11-04 | 2016-11-28 | Hoffmann La Roche | Nuevos derivados de aril-quinolina. |
| WO2014144737A1 (fr) | 2013-03-15 | 2014-09-18 | Celgene Avilomics Research, Inc. | Composés hétéroaryle et utilisations associées |
| CA2907243C (fr) | 2013-03-15 | 2021-12-28 | Celgene Avilomics Research, Inc. | Composes de dihydropyrimidopyrimidinones substitues et leurs compositions pharmaceutiques utilisees en tant qu'inhibiteur du gene fgfr4 |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| TW201516045A (zh) * | 2013-07-26 | 2015-05-01 | Hoffmann La Roche | 絲胺酸/蘇胺酸激酶抑制劑 |
| RU2721723C2 (ru) * | 2014-02-07 | 2020-05-21 | Принсипиа Биофарма, Инк. | Производные хинолона как ингибиторы рецептора фактора роста фибробластов |
| US9828373B2 (en) | 2014-07-26 | 2017-11-28 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof |
| WO2016174664A1 (fr) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Compositions à désintégration par voie orale |
| CA3013959C (fr) * | 2016-02-17 | 2024-05-28 | Nuralogix Corporation | Systeme et procede de detection d'etat physiologique |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CN109415366B (zh) * | 2016-06-23 | 2022-02-22 | 豪夫迈·罗氏有限公司 | [1,2,3]三唑并[4,5-d]嘧啶衍生物 |
| WO2018013466A2 (fr) * | 2016-07-15 | 2018-01-18 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs prédictifs de la résistance endocrinienne dans le cancer du sein |
| CN106818805A (zh) * | 2016-12-27 | 2017-06-13 | 东莞市联洲知识产权运营管理有限公司 | 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用 |
| CN107083428B (zh) * | 2017-04-10 | 2020-09-25 | 徐州医科大学 | Pak5在癌症诊断预后治疗及药物筛选中的应用 |
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| US20220002429A1 (en) * | 2018-10-24 | 2022-01-06 | Northwestern University | Tumor cell aggregation inhibitors' for treating cancer |
| WO2020142612A1 (fr) * | 2019-01-03 | 2020-07-09 | Genentech, Inc. | Composés de pyrido-pyrimidinone et de ptéridinone utilisés en tant qu'inhibiteurs de l'enzyme nécessitant l'inositol i (ire i alpha) à activité endoribonucléase pour le traitement de maladies cancéreuses |
| CN112213400B (zh) * | 2019-07-09 | 2022-06-07 | 四川弘合生物科技有限公司 | 一种β-榄香烯及其有关物质的检测方法 |
| CN110496128B (zh) * | 2019-09-23 | 2022-09-30 | 吉林大学 | 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用 |
| KR20230121758A (ko) | 2020-11-18 | 2023-08-21 | 데시페라 파마슈티칼스, 엘엘씨. | Gcn2 및 perk 키나제 억제제 및 그의 사용 방법 |
| CN117858879A (zh) * | 2021-01-15 | 2024-04-09 | 南京再明医药有限公司 | Cdk2/4/6抑制剂及其制备方法和应用 |
| CN113046323A (zh) * | 2021-04-02 | 2021-06-29 | 四川农业大学 | 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法 |
| JP2024544632A (ja) | 2021-12-03 | 2024-12-03 | デシフェラ・ファーマシューティカルズ,エルエルシー | Gcn2及びperkキナーゼ阻害剤としての複素環式化合物 |
| WO2025257301A1 (fr) * | 2024-06-13 | 2025-12-18 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Traitement de la neurofibromatose de type 2 par des inhibiteurs de g6pd, acsl3 et/ou oxsm |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1201765A3 (fr) * | 2000-10-16 | 2003-08-27 | Axxima Pharmaceuticals Aktiengesellschaft | Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition |
| CA2668731A1 (fr) * | 2006-11-09 | 2008-05-15 | Tobias Gabriel | Derives de 6-phenyl-pyrido [2,3-d] pyrimidine-7-one substitues utilises comme inhibiteurs de la kinase et methodes d'utilisation de ceux-ci |
| EP2112150B1 (fr) * | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Inhibiteurs Raf améliorés |
| WO2010071846A2 (fr) * | 2008-12-19 | 2010-06-24 | Afraxis, Inc. | Composés pour traiter des états neuropsychiatriques |
| PH12012500692A1 (en) * | 2009-10-09 | 2012-11-12 | Afraxis Inc | 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
| US8912203B2 (en) * | 2010-06-09 | 2014-12-16 | Afraxis Holdings, Inc. | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders |
| EP2580216A4 (fr) * | 2010-06-10 | 2014-07-23 | Afraxis Holdings Inc | 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc |
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2012
- 2012-11-02 CA CA2854471A patent/CA2854471A1/fr not_active Abandoned
- 2012-11-02 EP EP12845870.0A patent/EP2773643A4/fr not_active Withdrawn
- 2012-11-02 MX MX2014005296A patent/MX2014005296A/es not_active Application Discontinuation
- 2012-11-02 EA EA201490927A patent/EA201490927A1/ru unknown
- 2012-11-02 PH PH1/2014/500956A patent/PH12014500956A1/en unknown
- 2012-11-02 CN CN201280066127.2A patent/CN104093717A/zh active Pending
- 2012-11-02 CN CN201280066130.4A patent/CN104039786A/zh active Pending
- 2012-11-02 AU AU2012327183A patent/AU2012327183A1/en not_active Abandoned
- 2012-11-02 JP JP2014540157A patent/JP2015501786A/ja active Pending
- 2012-11-02 AU AU2012327187A patent/AU2012327187A1/en not_active Abandoned
- 2012-11-02 KR KR1020147014683A patent/KR20140096098A/ko not_active Withdrawn
- 2012-11-02 JP JP2014540152A patent/JP2014532724A/ja active Pending
- 2012-11-02 CA CA2854462A patent/CA2854462A1/fr not_active Abandoned
- 2012-11-02 US US13/668,079 patent/US20130116263A1/en not_active Abandoned
- 2012-11-02 SG SG11201401996TA patent/SG11201401996TA/en unknown
- 2012-11-02 US US14/356,118 patent/US20150031693A1/en not_active Abandoned
- 2012-11-02 WO PCT/US2012/063426 patent/WO2013067434A1/fr not_active Ceased
- 2012-11-02 SG SG11201401914WA patent/SG11201401914WA/en unknown
- 2012-11-02 BR BR112014010631A patent/BR112014010631A2/pt not_active Application Discontinuation
- 2012-11-02 MX MX2014005292A patent/MX2014005292A/es not_active Application Discontinuation
- 2012-11-02 EP EP12844804.0A patent/EP2773642A1/fr not_active Ceased
- 2012-11-02 EA EA201490925A patent/EA201490925A1/ru unknown
- 2012-11-02 KR KR1020147014685A patent/KR20140105451A/ko not_active Withdrawn
- 2012-11-02 BR BR112014010420A patent/BR112014010420A2/pt not_active Application Discontinuation
- 2012-11-02 WO PCT/US2012/063413 patent/WO2013067423A1/fr not_active Ceased
- 2012-11-05 TW TW101141080A patent/TW201326169A/zh unknown
- 2012-11-05 AR ARP120104155A patent/AR089175A1/es unknown
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2014
- 2014-04-22 IL IL232154A patent/IL232154A0/en unknown
- 2014-04-24 IL IL232215A patent/IL232215A0/en unknown
- 2014-04-30 CL CL2014001131A patent/CL2014001131A1/es unknown
- 2014-04-30 CL CL2014001132A patent/CL2014001132A1/es unknown
- 2014-05-02 PH PH12014500995A patent/PH12014500995A1/en unknown
- 2014-05-26 MA MA37064A patent/MA35660B1/fr unknown
- 2014-05-26 MA MA37065A patent/MA35661B1/fr unknown
- 2014-05-26 CR CR20140251A patent/CR20140251A/es unknown
- 2014-05-26 CR CR20140250A patent/CR20140250A/es unknown
- 2014-06-04 CO CO14119704A patent/CO7030960A2/es unknown
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