TW201326169A - 用於治療細胞增生性病症之pak抑制劑 - Google Patents

用於治療細胞增生性病症之pak抑制劑 Download PDF

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Publication number
TW201326169A
TW201326169A TW101141080A TW101141080A TW201326169A TW 201326169 A TW201326169 A TW 201326169A TW 101141080 A TW101141080 A TW 101141080A TW 101141080 A TW101141080 A TW 101141080A TW 201326169 A TW201326169 A TW 201326169A
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TW
Taiwan
Prior art keywords
substituted
group
unsubstituted
cancer
compound
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TW101141080A
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English (en)
Chinese (zh)
Inventor
David Campbell
Sergio G Duron
Original Assignee
Afraxis Inc
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Filing date
Publication date
Application filed by Afraxis Inc filed Critical Afraxis Inc
Publication of TW201326169A publication Critical patent/TW201326169A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW101141080A 2011-11-04 2012-11-05 用於治療細胞增生性病症之pak抑制劑 TW201326169A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161555902P 2011-11-04 2011-11-04

Publications (1)

Publication Number Publication Date
TW201326169A true TW201326169A (zh) 2013-07-01

Family

ID=48192852

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101141080A TW201326169A (zh) 2011-11-04 2012-11-05 用於治療細胞增生性病症之pak抑制劑

Country Status (20)

Country Link
US (2) US20130116263A1 (fr)
EP (2) EP2773642A1 (fr)
JP (2) JP2015501786A (fr)
KR (2) KR20140096098A (fr)
CN (2) CN104039786A (fr)
AR (1) AR089175A1 (fr)
AU (2) AU2012327183A1 (fr)
BR (2) BR112014010420A2 (fr)
CA (2) CA2854462A1 (fr)
CL (2) CL2014001131A1 (fr)
CO (1) CO7030960A2 (fr)
CR (2) CR20140251A (fr)
EA (2) EA201490927A1 (fr)
IL (2) IL232154A0 (fr)
MA (2) MA35660B1 (fr)
MX (2) MX2014005296A (fr)
PH (2) PH12014500956A1 (fr)
SG (2) SG11201401914WA (fr)
TW (1) TW201326169A (fr)
WO (2) WO2013067434A1 (fr)

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* Cited by examiner, † Cited by third party
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US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
JP6170060B2 (ja) 2011-11-04 2017-07-26 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 新規アリール−キノリン誘導体
CA2907243C (fr) 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Composes de dihydropyrimidopyrimidinones substitues et leurs compositions pharmaceutiques utilisees en tant qu'inhibiteur du gene fgfr4
JP6576325B2 (ja) 2013-03-15 2019-09-18 セルジーン シーエーアール エルエルシー ヘテロアリール化合物およびそれらの使用
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
TW201516045A (zh) * 2013-07-26 2015-05-01 Hoffmann La Roche 絲胺酸/蘇胺酸激酶抑制劑
EP3102577B1 (fr) * 2014-02-07 2018-07-18 Principia Biopharma Inc. Dérivés de quinolone utilisés en tant qu'inhibiteurs du récepteur du facteur de croissance des fibroblastes
CA2954189A1 (fr) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido [2,3-d] pyrimidin -7 (8h)-one utilises en tant qu'inhibiteurs de cdk et utilisations de ceux-ci
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
EP3416555A1 (fr) * 2016-02-17 2018-12-26 Nuralogix Corporation Système et procédé de détection d'état physiologique
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3475280B1 (fr) * 2016-06-23 2020-04-08 H. Hoffnabb-La Roche Ag Nouvelles dérivés de [1,2,3]triazolo[4,5-d]pyrimidine
US11685954B2 (en) * 2016-07-15 2023-06-27 Dana-Farber Cancer Institute, Inc. Biomarkers predictive of endocrine resistance in breast cancer
CN106818805A (zh) * 2016-12-27 2017-06-13 东莞市联洲知识产权运营管理有限公司 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用
CN107083428B (zh) * 2017-04-10 2020-09-25 徐州医科大学 Pak5在癌症诊断预后治疗及药物筛选中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
WO2020086882A1 (fr) * 2018-10-24 2020-04-30 Northwestern University Inhibiteurs d'agrégation de cellules tumorales pour le traitement du cancer
JP7539892B2 (ja) * 2019-01-03 2024-08-26 ジェネンテック, インコーポレイテッド 癌疾患の処置のためのエンドリボヌクレアーゼのイノシトール要求酵素i(ireiアルファ)の阻害剤としてのピリド-ピリミジノン化合物及びプテリジノン化合物
CN112213400B (zh) * 2019-07-09 2022-06-07 四川弘合生物科技有限公司 一种β-榄香烯及其有关物质的检测方法
CN110496128B (zh) * 2019-09-23 2022-09-30 吉林大学 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用
JP2023549540A (ja) 2020-11-18 2023-11-27 デシフェラ・ファーマシューティカルズ,エルエルシー Gcn2およびperkキナーゼ阻害剤およびその使用方法
CN117858879A (zh) * 2021-01-15 2024-04-09 南京再明医药有限公司 Cdk2/4/6抑制剂及其制备方法和应用
CN113046323A (zh) * 2021-04-02 2021-06-29 四川农业大学 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法
PE20250609A1 (es) 2021-12-03 2025-02-26 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos
WO2025257301A1 (fr) * 2024-06-13 2025-12-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Traitement de la neurofibromatose de type 2 par des inhibiteurs de g6pd, acsl3 et/ou oxsm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
WO2008055842A1 (fr) * 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Dérivés de 6-phényl-pyrido [2,3-d] pyrimidine-7-one substitués utilisés comme inhibiteurs de la kinase et méthodes d'utilisation de ceux-ci
EP2112150B1 (fr) * 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
WO2010071846A2 (fr) * 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
EP2486037A4 (fr) * 2009-10-09 2013-01-16 Afraxis Inc 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles de snc
EP2580214A4 (fr) * 2010-06-09 2013-12-04 Afraxis Holdings Inc 8-(sulfonylaryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc
US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders

Also Published As

Publication number Publication date
JP2014532724A (ja) 2014-12-08
MX2014005296A (es) 2014-08-27
SG11201401914WA (en) 2014-05-29
EP2773643A1 (fr) 2014-09-10
EP2773643A4 (fr) 2015-07-29
MA35660B1 (fr) 2014-11-01
CR20140251A (es) 2014-08-20
AR089175A1 (es) 2014-08-06
MA35661B1 (fr) 2014-11-01
EA201490925A1 (ru) 2014-09-30
SG11201401996TA (en) 2014-05-29
EP2773642A1 (fr) 2014-09-10
KR20140096098A (ko) 2014-08-04
AU2012327183A8 (en) 2013-07-18
CN104039786A (zh) 2014-09-10
JP2015501786A (ja) 2015-01-19
AU2012327187A8 (en) 2013-07-25
CN104093717A (zh) 2014-10-08
CR20140250A (es) 2014-08-20
BR112014010420A2 (pt) 2017-04-25
CA2854471A1 (fr) 2013-05-10
AU2012327187A1 (en) 2013-05-23
PH12014500956A1 (en) 2014-06-30
CO7030960A2 (es) 2014-08-21
CL2014001132A1 (es) 2014-08-22
US20150031693A1 (en) 2015-01-29
WO2013067423A1 (fr) 2013-05-10
BR112014010631A2 (pt) 2017-04-25
EA201490927A1 (ru) 2014-10-30
MX2014005292A (es) 2014-09-11
US20130116263A1 (en) 2013-05-09
PH12014500995A1 (en) 2014-08-04
IL232154A0 (en) 2014-05-28
CA2854462A1 (fr) 2013-05-10
WO2013067434A1 (fr) 2013-05-10
KR20140105451A (ko) 2014-09-01
IL232215A0 (en) 2014-06-30
AU2012327183A1 (en) 2013-05-30
CL2014001131A1 (es) 2014-08-22

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