MA37764A1 - Composés n-alkyltriazole utilisés comme antagonistes de lpar - Google Patents

Composés n-alkyltriazole utilisés comme antagonistes de lpar

Info

Publication number
MA37764A1
MA37764A1 MA37764A MA37764A MA37764A1 MA 37764 A1 MA37764 A1 MA 37764A1 MA 37764 A MA37764 A MA 37764A MA 37764 A MA37764 A MA 37764A MA 37764 A1 MA37764 A1 MA 37764A1
Authority
MA
Morocco
Prior art keywords
alkyltriazole
lpar
antagonists
compounds used
compounds
Prior art date
Application number
MA37764A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Matthew C Lucas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37764(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA37764A1 publication Critical patent/MA37764A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne des composés de formule (i) ainsi que des sels pharmaceutiquement acceptables de ceux-ci, les substituants étant ceux qui sont indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies et de troubles inflammatoires tels que le fibrose pulmonaire par exemple.
MA37764A 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar MA37764A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (fr) 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar

Publications (1)

Publication Number Publication Date
MA37764A1 true MA37764A1 (fr) 2016-01-29

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37764A MA37764A1 (fr) 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar

Country Status (22)

Country Link
US (1) US9321738B2 (fr)
EP (1) EP2864300A1 (fr)
JP (1) JP2015520202A (fr)
KR (1) KR20150021057A (fr)
CN (1) CN104411692A (fr)
AU (1) AU2013279512A1 (fr)
BR (1) BR112014030685A2 (fr)
CA (1) CA2869541A1 (fr)
CL (1) CL2014003243A1 (fr)
CO (1) CO7131358A2 (fr)
CR (1) CR20140525A (fr)
EA (1) EA201492285A1 (fr)
HK (1) HK1206342A1 (fr)
IL (1) IL236088A0 (fr)
IN (1) IN2014DN09348A (fr)
MA (1) MA37764A1 (fr)
MX (1) MX2014014710A (fr)
PE (1) PE20142448A1 (fr)
PH (1) PH12014502789A1 (fr)
SG (1) SG11201407220YA (fr)
UA (1) UA109868C2 (fr)
WO (1) WO2013189864A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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CA2844982A1 (fr) 2011-08-15 2013-02-21 Intermune, Inc. Antagonistes des recepteurs d'acide lysophosphatidique
JP2015520203A (ja) * 2012-06-20 2015-07-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｌｐａｒ拮抗薬としてのｎ−アリールトリアゾール化合物
SG11201507459YA (en) 2013-03-15 2015-10-29 Epigen Biosciences Inc Heterocyclic compounds useful in the treatment of disease
CN106458964B (zh) 2014-06-27 2019-11-22 宇部兴产株式会社 卤素取代杂环化合物的盐
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
AR113964A1 (es) 2017-12-19 2020-07-01 Bristol Myers Squibb Co Carbamoíl ciclohexil ácidos ligados a n de triazol como antagonistas de lpa
CN112041029B (zh) 2017-12-19 2025-01-24 百时美施贵宝公司 作为lpa拮抗剂的环己基酸吡唑唑类
SG11202005701VA (en) 2017-12-19 2020-07-29 Bristol Myers Squibb Co Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
WO2019126087A1 (fr) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Acide cyclohexyle isoxazole azoles en tant qu'antagonistes de lpa
ES2925626T3 (es) 2017-12-19 2022-10-19 Bristol Myers Squibb Co Acidos isoxazol-O-carbamoilciclohexílicos como antagonistas de LPA
KR20200100713A (ko) * 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 트리아졸 아졸
US11319309B2 (en) 2017-12-19 2022-05-03 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as LPA antagonists
WO2019126099A1 (fr) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Acides carbamoyle cyclohexyliques à liaison n isoxazole utilisés en tant qu'antagonistes de lpa
KR102725744B1 (ko) * 2017-12-19 2024-11-01 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 피라졸 아진
WO2019126093A1 (fr) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Azines triazoles d'acide cyclohexyle utilisées en tant qu'antagonistes de lpa
ES2943661T3 (es) 2017-12-19 2023-06-15 Bristol Myers Squibb Co Acidos carbamoil ciclohexílicos pirazol-O-ligados como antagonistas de LPA
AR114070A1 (es) * 2017-12-29 2020-07-15 Biomarin Pharm Inc Inhibidores de glicolato oxidasa para el tratamiento de una enfermedad
KR102950123B1 (ko) 2018-09-18 2026-04-08 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로펜틸 산
US20220041572A1 (en) * 2018-09-18 2022-02-10 Bristol-Myers Squibb Company Cycloheptyl acids as lpa antagonists
KR102788997B1 (ko) * 2018-09-18 2025-03-28 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 옥사비시클로 산
AU2020257890B2 (en) * 2019-04-16 2025-10-23 Bristol-Myers Squibb Company Process for preparing carbamoyloxymethyl triazole cyclohexyl acid compounds
AU2020384883B2 (en) * 2019-11-15 2023-11-16 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
JP7591066B2 (ja) 2020-06-03 2024-11-27 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
WO2022240879A1 (fr) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
KR20240007233A (ko) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
JP7709612B2 (ja) 2021-12-08 2025-07-16 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
AR128613A1 (es) 2022-02-25 2024-05-29 Lhotse Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (fr) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Antagoniste du récepteur de l'acide lysophosphatidique et ses utilisations
WO2011159633A1 (fr) * 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Formulations inhalables d'antagonistes de récepteur d'acide lysophosphatidique
CN103347510B (zh) 2010-12-07 2015-11-25 艾米拉医药股份有限公司 溶血磷脂酸受体拮抗剂及其在治疗纤维化中的用途
WO2012138648A1 (fr) 2011-04-06 2012-10-11 Irm Llc Compositions et procédés pour la modulation de récepteurs au lpa
CA2844982A1 (fr) * 2011-08-15 2013-02-21 Intermune, Inc. Antagonistes des recepteurs d'acide lysophosphatidique

Also Published As

Publication number Publication date
US20150133511A1 (en) 2015-05-14
IL236088A0 (en) 2015-02-01
UA109868C2 (ru) 2015-10-12
BR112014030685A2 (pt) 2017-06-27
HK1206342A1 (en) 2016-01-08
SG11201407220YA (en) 2014-12-30
PE20142448A1 (es) 2015-01-28
CA2869541A1 (fr) 2013-12-27
US9321738B2 (en) 2016-04-26
CL2014003243A1 (es) 2015-03-20
CO7131358A2 (es) 2014-12-01
JP2015520202A (ja) 2015-07-16
EA201492285A1 (ru) 2015-04-30
IN2014DN09348A (fr) 2015-07-17
AU2013279512A1 (en) 2014-10-16
CN104411692A (zh) 2015-03-11
EP2864300A1 (fr) 2015-04-29
WO2013189864A1 (fr) 2013-12-27
PH12014502789A1 (en) 2015-02-09
MX2014014710A (es) 2015-03-04
KR20150021057A (ko) 2015-02-27
CR20140525A (es) 2015-01-12

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