MA37764A1 - Composés n-alkyltriazole utilisés comme antagonistes de lpar - Google Patents

Composés n-alkyltriazole utilisés comme antagonistes de lpar

Info

Publication number
MA37764A1
MA37764A1 MA37764A MA37764A MA37764A1 MA 37764 A1 MA37764 A1 MA 37764A1 MA 37764 A MA37764 A MA 37764A MA 37764 A MA37764 A MA 37764A MA 37764 A1 MA37764 A1 MA 37764A1
Authority
MA
Morocco
Prior art keywords
alkyltriazole
lpar
antagonists
compounds used
compounds
Prior art date
Application number
MA37764A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Matthew C Lucas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37764(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA37764A1 publication Critical patent/MA37764A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne des composés de formule (i) ainsi que des sels pharmaceutiquement acceptables de ceux-ci, les substituants étant ceux qui sont indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies et de troubles inflammatoires tels que le fibrose pulmonaire par exemple.
MA37764A 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar MA37764A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (fr) 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar

Publications (1)

Publication Number Publication Date
MA37764A1 true MA37764A1 (fr) 2016-01-29

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37764A MA37764A1 (fr) 2012-06-20 2013-06-17 Composés n-alkyltriazole utilisés comme antagonistes de lpar

Country Status (22)

Country Link
US (1) US9321738B2 (fr)
EP (1) EP2864300A1 (fr)
JP (1) JP2015520202A (fr)
KR (1) KR20150021057A (fr)
CN (1) CN104411692A (fr)
AU (1) AU2013279512A1 (fr)
BR (1) BR112014030685A2 (fr)
CA (1) CA2869541A1 (fr)
CL (1) CL2014003243A1 (fr)
CO (1) CO7131358A2 (fr)
CR (1) CR20140525A (fr)
EA (1) EA201492285A1 (fr)
HK (1) HK1206342A1 (fr)
IL (1) IL236088A0 (fr)
IN (1) IN2014DN09348A (fr)
MA (1) MA37764A1 (fr)
MX (1) MX2014014710A (fr)
PE (1) PE20142448A1 (fr)
PH (1) PH12014502789A1 (fr)
SG (1) SG11201407220YA (fr)
UA (1) UA109868C2 (fr)
WO (1) WO2013189864A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014525932A (ja) 2011-08-15 2014-10-02 インターミューン， インコーポレイテッド リゾホスファチド酸レセプターアンタゴニスト
IN2014DN09352A (fr) * 2012-06-20 2015-07-17 Hoffmann La Roche
WO2014145873A2 (fr) 2013-03-15 2014-09-18 Epigen Biosciences, Inc. Composés hétérocycliques utilisés pour le traitement de maladies
RU2689315C2 (ru) 2014-06-27 2019-05-27 Убе Индастриз, Лтд. Соль гетероциклического соединения, замещенного галогеном
AR108838A1 (es) * 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
JP7299892B2 (ja) * 2017-12-19 2023-06-28 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアジン
JP7208240B2 (ja) * 2017-12-19 2023-01-18 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸トリアゾールアジン
US11261180B2 (en) 2017-12-19 2022-03-01 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azoles as LPA antagonists
US11447475B2 (en) 2017-12-19 2022-09-20 Bristol-Myers Squibb Company Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
CN112041302B (zh) 2017-12-19 2024-11-19 百时美施贵宝公司 作为lpa拮抗剂的吡唑o-连接的氨基甲酰基环己基酸
ES2898364T3 (es) * 2017-12-19 2022-03-07 Bristol Myers Squibb Co Acidos carbamoilciclohexílicos ligados a N triazol como antagonistas de LPA
WO2019126084A1 (fr) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Acides carbamoyle cyclohexyliques à liaison o isoxazole utilisés en tant qu'antagonistes de lpa
JP7212047B2 (ja) 2017-12-19 2023-01-24 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール
EP3728209B1 (fr) 2017-12-19 2025-12-24 Bristol-Myers Squibb Company Azines isoxazole d'acide de cyclohexyle en tant qu'antagonistes de lpa
CN111712492B (zh) 2017-12-19 2024-05-31 百时美施贵宝公司 作为lpa拮抗剂的环己基酸三唑唑类
EP3728216B1 (fr) 2017-12-19 2023-09-06 Bristol-Myers Squibb Company Acides carbamoyle cyclohexyliques à liaison n pyrazole utilisés en tant qu'antagonistes de lpa
BR112020013073A2 (pt) * 2017-12-29 2020-12-01 Biomarin Pharmaceutical Inc. composto, composto, estereoisômero único ou mistura de estereoisômeros ou sal farmaceuticamente aceitável, composição farmacêutica, método de tratamento de uma doença ou distúrbio e composto ou sal farmaceuticamente aceitável do mesmo
ES2946657T3 (es) 2018-09-18 2023-07-24 Bristol Myers Squibb Co Acidos ciclopentílicos como antagonistas de LPA
ES2948793T3 (es) * 2018-09-18 2023-09-19 Bristol Myers Squibb Co Acidos cicloheptílicos como antagonistas de LPA
EP3853232B1 (fr) 2018-09-18 2023-03-01 Bristol-Myers Squibb Company Oxabicyclo-acides en tant qu'antagonistes de lpa
SG11202111366WA (en) * 2019-04-16 2021-11-29 Bristol Myers Squibb Co Process for preparing carbamoyloxymethyl triazole cyclohexyl acid compounds
EP4058144A1 (fr) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Pyridylsulfonamides de carbamate de triazole utilisées en tant qu'antagonistes du récepteur de lpa et leurs utilisations
EP4161936A1 (fr) 2020-06-03 2023-04-12 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
WO2022240879A1 (fr) 2021-05-11 2022-11-17 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
KR20240007233A (ko) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
WO2023107938A1 (fr) 2021-12-08 2023-06-15 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (fr) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Antagoniste du récepteur de l'acide lysophosphatidique et ses utilisations
WO2011159633A1 (fr) * 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Formulations inhalables d'antagonistes de récepteur d'acide lysophosphatidique
KR20130126659A (ko) 2010-12-07 2013-11-20 아미라 파마슈티칼스 인코포레이티드 리소포스파티드산 수용체 길항제 및 섬유증 치료에서의 그의 용도
WO2012138648A1 (fr) 2011-04-06 2012-10-11 Irm Llc Compositions et procédés pour la modulation de récepteurs au lpa
JP2014525932A (ja) * 2011-08-15 2014-10-02 インターミューン， インコーポレイテッド リゾホスファチド酸レセプターアンタゴニスト

Also Published As

Publication number Publication date
IL236088A0 (en) 2015-02-01
KR20150021057A (ko) 2015-02-27
EA201492285A1 (ru) 2015-04-30
PE20142448A1 (es) 2015-01-28
WO2013189864A1 (fr) 2013-12-27
EP2864300A1 (fr) 2015-04-29
UA109868C2 (ru) 2015-10-12
CO7131358A2 (es) 2014-12-01
JP2015520202A (ja) 2015-07-16
BR112014030685A2 (pt) 2017-06-27
CR20140525A (es) 2015-01-12
CL2014003243A1 (es) 2015-03-20
AU2013279512A1 (en) 2014-10-16
IN2014DN09348A (fr) 2015-07-17
HK1206342A1 (en) 2016-01-08
PH12014502789A1 (en) 2015-02-09
CA2869541A1 (fr) 2013-12-27
MX2014014710A (es) 2015-03-04
US9321738B2 (en) 2016-04-26
SG11201407220YA (en) 2014-12-30
US20150133511A1 (en) 2015-05-14
CN104411692A (zh) 2015-03-11

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