MA38009A1 - Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancer - Google Patents
Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancerInfo
- Publication number
- MA38009A1 MA38009A1 MA38009A MA38009A MA38009A1 MA 38009 A1 MA38009 A1 MA 38009A1 MA 38009 A MA38009 A MA 38009A MA 38009 A MA38009 A MA 38009A MA 38009 A1 MA38009 A1 MA 38009A1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- cancer
- treatment
- prophylaxis
- inhibitory activity
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- QDKGOMZIPXGDDJ-UHFFFAOYSA-N 2,3-dihydro-1h-indazole Chemical class C1=CC=C2CNNC2=C1 QDKGOMZIPXGDDJ-UHFFFAOYSA-N 0.000 title 1
- 230000006907 apoptotic process Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Inorganic Chemistry (AREA)
Abstract
L'invention concerne des composés de formule (i), ou leurs sels pharmaceutiquement acceptables, dans laquelle w, y, z, r1, r2, r3 et r4 sont tels que décrits dans la présente demande, et des procédés d'utilisation des composés dans le traitement du cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712305P | 2012-10-11 | 2012-10-11 | |
| PCT/EP2013/070881 WO2014056871A1 (fr) | 2012-10-11 | 2013-10-08 | Azaindolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38009A1 true MA38009A1 (fr) | 2018-02-28 |
| MA38009B1 MA38009B1 (fr) | 2018-09-28 |
Family
ID=49304982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38009A MA38009B1 (fr) | 2012-10-11 | 2013-10-08 | Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9309248B2 (fr) |
| EP (1) | EP2906559B1 (fr) |
| JP (1) | JP6333826B2 (fr) |
| KR (1) | KR20150067182A (fr) |
| CN (1) | CN104540825B (fr) |
| AU (1) | AU2013328870A1 (fr) |
| CA (1) | CA2880324A1 (fr) |
| CL (1) | CL2015000886A1 (fr) |
| CR (1) | CR20150148A (fr) |
| EA (1) | EA201590656A1 (fr) |
| ES (1) | ES2623304T3 (fr) |
| IL (1) | IL237115A (fr) |
| MA (1) | MA38009B1 (fr) |
| MX (1) | MX2015004525A (fr) |
| PE (1) | PE20150965A1 (fr) |
| PH (1) | PH12015500399A1 (fr) |
| SG (1) | SG11201501314TA (fr) |
| WO (1) | WO2014056871A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016079527A1 (fr) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Polythérapie |
| WO2016097773A1 (fr) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Antagonistes des iap thérapeutiques pour traiter des troubles prolifératifs |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| KR102662373B1 (ko) * | 2017-07-06 | 2024-04-29 | 얀센 파마슈티카 엔브이 | Nik 억제제로서의 신규 치환 아자인돌린 유도체 |
| WO2021026349A1 (fr) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Polythérapie pour le traitement du cancer |
| WO2023056069A1 (fr) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118985A1 (fr) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
| WO2002094263A2 (fr) * | 2001-05-23 | 2002-11-28 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de caspase et leurs utilisations |
| CA2573644A1 (fr) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Analogues de tetrapeptide |
| WO2007009883A1 (fr) | 2005-07-15 | 2007-01-25 | F. Hoffmann-La Roche Ag | Nouvelles amines cycliques fusionnés avec hétéroaryle |
| WO2009136290A1 (fr) * | 2008-05-05 | 2009-11-12 | Aegera Therapeutics, Inc. | Pyrrolidines fonctionnalisées et leur utilisation comme inhibiteurs d’iap |
| JP2011529962A (ja) * | 2008-08-02 | 2011-12-15 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
| WO2010080503A1 (fr) * | 2008-12-19 | 2010-07-15 | Genentech, Inc. | Composés hétérocycliques et leurs procédés d'utilisation |
| US8551955B2 (en) | 2009-10-28 | 2013-10-08 | Joyant Pharmaceuticals, Inc. | Dimeric Smac mimetics |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| WO2014056867A1 (fr) * | 2012-10-11 | 2014-04-17 | F. Hoffmann-La Roche Ag | Azaindolines |
-
2013
- 2013-10-08 AU AU2013328870A patent/AU2013328870A1/en not_active Abandoned
- 2013-10-08 KR KR1020157008986A patent/KR20150067182A/ko not_active Withdrawn
- 2013-10-08 EA EA201590656A patent/EA201590656A1/ru unknown
- 2013-10-08 CN CN201380042809.4A patent/CN104540825B/zh not_active Expired - Fee Related
- 2013-10-08 MA MA38009A patent/MA38009B1/fr unknown
- 2013-10-08 US US14/433,216 patent/US9309248B2/en not_active Expired - Fee Related
- 2013-10-08 CA CA2880324A patent/CA2880324A1/fr not_active Abandoned
- 2013-10-08 JP JP2015536090A patent/JP6333826B2/ja not_active Expired - Fee Related
- 2013-10-08 PE PE2015000475A patent/PE20150965A1/es not_active Application Discontinuation
- 2013-10-08 EP EP13773766.4A patent/EP2906559B1/fr not_active Not-in-force
- 2013-10-08 MX MX2015004525A patent/MX2015004525A/es unknown
- 2013-10-08 ES ES13773766.4T patent/ES2623304T3/es active Active
- 2013-10-08 WO PCT/EP2013/070881 patent/WO2014056871A1/fr not_active Ceased
- 2013-10-08 SG SG11201501314TA patent/SG11201501314TA/en unknown
-
2015
- 2015-02-05 IL IL237115A patent/IL237115A/en not_active IP Right Cessation
- 2015-02-24 PH PH12015500399A patent/PH12015500399A1/en unknown
- 2015-03-19 CR CR20150148A patent/CR20150148A/es unknown
- 2015-04-08 CL CL2015000886A patent/CL2015000886A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013328870A1 (en) | 2015-02-26 |
| CR20150148A (es) | 2015-04-30 |
| JP6333826B2 (ja) | 2018-05-30 |
| EP2906559B1 (fr) | 2017-02-08 |
| CN104540825A (zh) | 2015-04-22 |
| MA38009B1 (fr) | 2018-09-28 |
| PE20150965A1 (es) | 2015-06-20 |
| HK1206738A1 (en) | 2016-01-15 |
| EP2906559A1 (fr) | 2015-08-19 |
| KR20150067182A (ko) | 2015-06-17 |
| EA201590656A1 (ru) | 2015-07-30 |
| PH12015500399A1 (en) | 2015-04-27 |
| CA2880324A1 (fr) | 2014-04-17 |
| US9309248B2 (en) | 2016-04-12 |
| SG11201501314TA (en) | 2015-03-30 |
| MX2015004525A (es) | 2015-07-06 |
| CN104540825B (zh) | 2017-10-24 |
| ES2623304T3 (es) | 2017-07-10 |
| WO2014056871A1 (fr) | 2014-04-17 |
| JP2015534570A (ja) | 2015-12-03 |
| CL2015000886A1 (es) | 2015-07-17 |
| US20150266879A1 (en) | 2015-09-24 |
| IL237115A (en) | 2016-12-29 |
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