MA32135B1 - Inhibiteurs de pim kinase et leurs procedes d'utilisation - Google Patents
Inhibiteurs de pim kinase et leurs procedes d'utilisationInfo
- Publication number
- MA32135B1 MA32135B1 MA33140A MA33140A MA32135B1 MA 32135 B1 MA32135 B1 MA 32135B1 MA 33140 A MA33140 A MA 33140A MA 33140 A MA33140 A MA 33140A MA 32135 B1 MA32135 B1 MA 32135B1
- Authority
- MA
- Morocco
- Prior art keywords
- pim kinase
- novel compounds
- methods
- kinase inhibitors
- pharmaceutically acceptable
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention porte sur de nouveaux composés représentés par les formules (i) et (ii), sur leurs tautomères, stéréoisomères et polymorphes et sur leurs sels pharmaceutiquement acceptables, esters, métabolites ou promédicaments, sur des compositions des nouveaux composés conjointement avec des véhicules pharmaceutiquement acceptables et sur des utilisations des nouveaux composés, soit seuls soit en association avec au moins un agent thérapeutique supplémentaire, dans l'inhibition de l'activité de la pim kinase et/ou la prophylaxie ou le traitement d'un cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3335908P | 2008-03-03 | 2008-03-03 | |
| PCT/EP2009/052506 WO2009109576A1 (fr) | 2008-03-03 | 2009-03-03 | Inhibiteurs de pim kinase et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32135B1 true MA32135B1 (fr) | 2011-03-01 |
Family
ID=41055566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33140A MA32135B1 (fr) | 2008-03-03 | 2010-09-02 | Inhibiteurs de pim kinase et leurs procedes d'utilisation |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP2596790B1 (fr) |
| JP (1) | JP5412448B2 (fr) |
| KR (1) | KR20100120709A (fr) |
| CN (2) | CN104098559A (fr) |
| AR (1) | AR070531A1 (fr) |
| AU (1) | AU2009221134B2 (fr) |
| BR (1) | BRPI0909102A2 (fr) |
| CA (1) | CA2717388A1 (fr) |
| CL (1) | CL2009000483A1 (fr) |
| CO (1) | CO6290687A2 (fr) |
| EA (1) | EA201001412A1 (fr) |
| EC (1) | ECSP10010447A (fr) |
| ES (2) | ES2443496T3 (fr) |
| IL (1) | IL207865A0 (fr) |
| MA (1) | MA32135B1 (fr) |
| MX (1) | MX2010009739A (fr) |
| PE (1) | PE20091577A1 (fr) |
| TW (1) | TW200942536A (fr) |
| UY (1) | UY31679A1 (fr) |
| WO (1) | WO2009109576A1 (fr) |
| ZA (1) | ZA201006128B (fr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI630207B (zh) | 2005-12-13 | 2018-07-21 | 英塞特控股公司 | 作為傑納斯激酶(JANUS KINASE)抑制劑之經雜芳基取代之吡咯并〔2,3-b〕吡啶及吡咯并〔2,3-b〕嘧啶 |
| EP3070090B1 (fr) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Utilisation des sels de l'inhibiteur de janus kinase (r)-3-(4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl)-1h-pyrazol-1-yl) -3-cyclopentylpropanenitrile |
| CN104311480A (zh) * | 2008-09-02 | 2015-01-28 | 诺华股份有限公司 | 作为激酶抑制剂的吡啶甲酰胺衍生物 |
| EP3643312A1 (fr) | 2009-05-22 | 2020-04-29 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidine-4-yl)-1h-pyrazol-1-yl]octane- ou heptane-nitrile en tant qu'inhibiteurs de jak |
| AR076794A1 (es) | 2009-05-22 | 2011-07-06 | Incyte Corp | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen |
| AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
| US8435976B2 (en) | 2009-09-08 | 2013-05-07 | F. Hoffmann-La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
| SG10201405568UA (en) * | 2009-09-08 | 2014-11-27 | Hoffmann La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
| EP3050882B1 (fr) | 2010-03-10 | 2018-01-31 | Incyte Holdings Corporation | Dérivés de pipéridin -4-yl azétidine utilisés en tant qu'inhibiteurs de jak1 |
| SG184475A1 (en) * | 2010-04-07 | 2012-11-29 | Hoffmann La Roche | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| US9156827B2 (en) | 2010-04-30 | 2015-10-13 | The University Of Tokyo | Anticancer agent |
| SG10201503983QA (en) | 2010-05-21 | 2015-06-29 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
| JP2013530199A (ja) * | 2010-07-06 | 2013-07-25 | ノバルティス アーゲー | キナーゼ阻害剤として有用な環状エーテル化合物 |
| US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
| CN103415515B (zh) | 2010-11-19 | 2015-08-26 | 因塞特公司 | 作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物 |
| UY33929A (es) * | 2011-03-04 | 2012-10-31 | Novartis Ag | Compuestos de ciclohexilo tetrasustituido como inhibidores de quinasas |
| UY33930A (es) * | 2011-03-04 | 2012-10-31 | Novartis Ag | Inhibidores novedosos de quinasas |
| CA2834166A1 (fr) | 2011-04-29 | 2012-11-01 | Amgen Inc. | Composes pyridazines bicycliques en tant qu'inhibiteurs de pim |
| PE20140832A1 (es) | 2011-06-20 | 2014-07-14 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
| PL3409278T3 (pl) | 2011-07-21 | 2021-02-22 | Sumitomo Pharma Oncology, Inc. | Heterocykliczne inhibitory kinazy białkowej |
| CN102924444B (zh) * | 2011-08-11 | 2015-07-08 | 上海吉铠医药科技有限公司 | Pim激酶抑制剂及其制备方法与在制药中的应用 |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US8614206B2 (en) | 2011-09-27 | 2013-12-24 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| CA2873672A1 (fr) | 2012-05-21 | 2013-11-28 | Novartis Ag | Nouveaux n-pyridinylamides substitues par un cycle a titre d'inhibiteurs de kinase |
| WO2014033630A1 (fr) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Nouveaux carboxamides d'aminothiazole en tant qu'inhibiteurs de kinase |
| WO2014033631A1 (fr) * | 2012-08-31 | 2014-03-06 | Novartis Ag | N- (3-pyridyl)-biarylamides en tant qu'inhibiteurs de kinase |
| JP6666147B2 (ja) * | 2012-09-26 | 2020-03-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 環状エーテルピラゾール−4−イル−ヘテロシクリル−カルボキサミド化合物と使用方法 |
| PL2919766T3 (pl) | 2012-11-15 | 2021-10-04 | Incyte Holdings Corporation | Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu |
| CA2897200C (fr) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Composes de carboxamide aromatique bicyclique utiles comme inhibiteurs de pim kinase |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| CN105189509B (zh) | 2013-03-06 | 2017-12-19 | 因赛特公司 | 用于制备jak抑制剂的方法及中间体 |
| SG10201912203XA (en) | 2013-08-07 | 2020-02-27 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| WO2015184305A1 (fr) | 2014-05-30 | 2015-12-03 | Incyte Corporation | Traitement de la leucémie neutrophile chronique (cnl) et de la leucémie myéloïde chronique atypique (acml) par des inhibiteurs de jak1 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016196244A1 (fr) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (fr) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Composés hétérocycliques utiles en tant qu'inhibiteurs de la kinase pim |
| CN111386261B (zh) * | 2017-09-20 | 2024-03-22 | 利德发现中心有限责任公司 | 香豆素衍生物、其制备方法及其在癌症治疗中的用途 |
| WO2019113487A1 (fr) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs |
| WO2019111218A1 (fr) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs d'irak4 |
| EP3746429B1 (fr) | 2018-01-30 | 2022-03-09 | Incyte Corporation | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) |
| PT3773593T (pt) | 2018-03-30 | 2024-06-25 | Incyte Corp | Tratamento da hidradenite supurativa com inibidores de jak |
| CN117959303A (zh) | 2018-04-13 | 2024-05-03 | 住友制药肿瘤公司 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| NZ778055A (en) | 2019-02-12 | 2025-11-28 | Sumitomo Pharma America Inc | Formulations comprising heterocyclic protein kinase inhibitors |
| CN110452164B (zh) * | 2019-09-10 | 2022-07-22 | 上海皓鸿生物医药科技有限公司 | Pim447关键中间体的制备方法 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| EP4611753A1 (fr) | 2022-10-31 | 2025-09-10 | Sumitomo Pharma America, Inc. | Inhibiteur de pim-1 pour le traitement de néoplasmes myéloprolifératifs |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028467A1 (fr) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Composes heteroaromatiques et aromatiques a substitution 3,5-diaminopiperidine antibacteriens |
| TW200523252A (en) * | 2003-10-31 | 2005-07-16 | Takeda Pharmaceutical | Pyridine compounds |
| US20090209522A1 (en) * | 2005-06-28 | 2009-08-20 | Graham Andrew Showell | Heterocyclic Non-Peptide GNRH Antagonists |
| WO2007058942A2 (fr) * | 2005-11-10 | 2007-05-24 | Schering Corporation | Imidazopyrazines inhibant la proteine kinase |
| TW200808788A (en) * | 2006-04-19 | 2008-02-16 | Astellas Pharma Inc | Azolecarboxamide derivative |
| JP5103604B2 (ja) * | 2006-10-31 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としての2−アミノチアゾール−4−カルボン酸アミド |
| PE20080928A1 (es) * | 2006-10-31 | 2008-08-15 | Schering Corp | Derivados de anilinopiperazina como inhibidores de proteina quinasa |
| EP2078003B1 (fr) * | 2006-10-31 | 2017-03-08 | Merck Sharp & Dohme Corp. | Dérivés d'anilinopipérazine et leurs méthodes d'utilisation |
| ES2431163T3 (es) * | 2007-03-01 | 2013-11-25 | Novartis Ag | Inhibidores de PIM quinasa y métodos para su uso |
-
2009
- 2009-02-27 UY UY031679A patent/UY31679A1/es not_active Application Discontinuation
- 2009-02-27 AR ARP090100684A patent/AR070531A1/es not_active Application Discontinuation
- 2009-02-27 PE PE2009000308A patent/PE20091577A1/es not_active Application Discontinuation
- 2009-03-02 TW TW098106739A patent/TW200942536A/zh unknown
- 2009-03-02 CL CL2009000483A patent/CL2009000483A1/es unknown
- 2009-03-03 CA CA2717388A patent/CA2717388A1/fr not_active Abandoned
- 2009-03-03 KR KR1020107022008A patent/KR20100120709A/ko not_active Withdrawn
- 2009-03-03 BR BRPI0909102A patent/BRPI0909102A2/pt not_active IP Right Cessation
- 2009-03-03 WO PCT/EP2009/052506 patent/WO2009109576A1/fr not_active Ceased
- 2009-03-03 JP JP2010549127A patent/JP5412448B2/ja active Active
- 2009-03-03 CN CN201410286911.5A patent/CN104098559A/zh active Pending
- 2009-03-03 EP EP13154157.5A patent/EP2596790B1/fr active Active
- 2009-03-03 EA EA201001412A patent/EA201001412A1/ru unknown
- 2009-03-03 ES ES09717066.6T patent/ES2443496T3/es active Active
- 2009-03-03 CN CN200980115821.7A patent/CN102015701B/zh active Active
- 2009-03-03 MX MX2010009739A patent/MX2010009739A/es not_active Application Discontinuation
- 2009-03-03 ES ES13154157.5T patent/ES2562306T3/es active Active
- 2009-03-03 AU AU2009221134A patent/AU2009221134B2/en not_active Expired - Fee Related
- 2009-03-03 EP EP09717066.6A patent/EP2262802B1/fr active Active
-
2010
- 2010-08-27 ZA ZA2010/06128A patent/ZA201006128B/en unknown
- 2010-08-30 IL IL207865A patent/IL207865A0/en unknown
- 2010-09-02 MA MA33140A patent/MA32135B1/fr unknown
- 2010-09-03 EC EC2010010447A patent/ECSP10010447A/es unknown
- 2010-09-07 CO CO10110544A patent/CO6290687A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091577A1 (es) | 2009-11-05 |
| CN102015701B (zh) | 2014-07-23 |
| CN102015701A (zh) | 2011-04-13 |
| TW200942536A (en) | 2009-10-16 |
| EP2262802B1 (fr) | 2013-10-23 |
| WO2009109576A1 (fr) | 2009-09-11 |
| AU2009221134A1 (en) | 2009-09-11 |
| ECSP10010447A (es) | 2010-10-30 |
| AU2009221134B2 (en) | 2012-02-23 |
| UY31679A1 (es) | 2009-09-30 |
| CO6290687A2 (es) | 2011-06-20 |
| IL207865A0 (en) | 2010-12-30 |
| CN104098559A (zh) | 2014-10-15 |
| EP2596790B1 (fr) | 2015-12-09 |
| JP5412448B2 (ja) | 2014-02-12 |
| EA201001412A1 (ru) | 2011-06-30 |
| JP2011513363A (ja) | 2011-04-28 |
| AR070531A1 (es) | 2010-04-14 |
| ZA201006128B (en) | 2011-10-26 |
| ES2562306T3 (es) | 2016-03-03 |
| CA2717388A1 (fr) | 2009-09-11 |
| ES2443496T3 (es) | 2014-02-19 |
| EP2596790A1 (fr) | 2013-05-29 |
| KR20100120709A (ko) | 2010-11-16 |
| EP2262802A1 (fr) | 2010-12-22 |
| MX2010009739A (es) | 2010-09-28 |
| CL2009000483A1 (es) | 2010-02-19 |
| BRPI0909102A2 (pt) | 2019-01-15 |
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