MA32135B1 - Inhibiteurs de pim kinase et leurs procedes d'utilisation - Google Patents

Inhibiteurs de pim kinase et leurs procedes d'utilisation

Info

Publication number
MA32135B1
MA32135B1 MA33140A MA33140A MA32135B1 MA 32135 B1 MA32135 B1 MA 32135B1 MA 33140 A MA33140 A MA 33140A MA 33140 A MA33140 A MA 33140A MA 32135 B1 MA32135 B1 MA 32135B1
Authority
MA
Morocco
Prior art keywords
pim kinase
novel compounds
methods
kinase inhibitors
pharmaceutically acceptable
Prior art date
Application number
MA33140A
Other languages
Arabic (ar)
English (en)
Inventor
Matthew Burger
Jiong Lan
Mika Lindvall
Gisele Nishiguchi
Michelle Tetalman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41055566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32135(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32135B1 publication Critical patent/MA32135B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention porte sur de nouveaux composés représentés par les formules (i) et (ii), sur leurs tautomères, stéréoisomères et polymorphes et sur leurs sels pharmaceutiquement acceptables, esters, métabolites ou promédicaments, sur des compositions des nouveaux composés conjointement avec des véhicules pharmaceutiquement acceptables et sur des utilisations des nouveaux composés, soit seuls soit en association avec au moins un agent thérapeutique supplémentaire, dans l'inhibition de l'activité de la pim kinase et/ou la prophylaxie ou le traitement d'un cancer.
MA33140A 2008-03-03 2010-09-02 Inhibiteurs de pim kinase et leurs procedes d'utilisation MA32135B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3335908P 2008-03-03 2008-03-03
PCT/EP2009/052506 WO2009109576A1 (fr) 2008-03-03 2009-03-03 Inhibiteurs de pim kinase et leurs procédés d'utilisation

Publications (1)

Publication Number Publication Date
MA32135B1 true MA32135B1 (fr) 2011-03-01

Family

ID=41055566

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33140A MA32135B1 (fr) 2008-03-03 2010-09-02 Inhibiteurs de pim kinase et leurs procedes d'utilisation

Country Status (21)

Country Link
EP (2) EP2262802B1 (fr)
JP (1) JP5412448B2 (fr)
KR (1) KR20100120709A (fr)
CN (2) CN104098559A (fr)
AR (1) AR070531A1 (fr)
AU (1) AU2009221134B2 (fr)
BR (1) BRPI0909102A2 (fr)
CA (1) CA2717388A1 (fr)
CL (1) CL2009000483A1 (fr)
CO (1) CO6290687A2 (fr)
EA (1) EA201001412A1 (fr)
EC (1) ECSP10010447A (fr)
ES (2) ES2443496T3 (fr)
IL (1) IL207865A0 (fr)
MA (1) MA32135B1 (fr)
MX (1) MX2010009739A (fr)
PE (1) PE20091577A1 (fr)
TW (1) TW200942536A (fr)
UY (1) UY31679A1 (fr)
WO (1) WO2009109576A1 (fr)
ZA (1) ZA201006128B (fr)

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TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
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WO2011136319A1 (fr) * 2010-04-30 2011-11-03 国立大学法人 東京大学 Agent anticancéreux
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EP3812387A1 (fr) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology, Inc. Inhibiteurs de protéine kinase hétérocycliques
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TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
EP2760857A1 (fr) 2011-09-27 2014-08-06 F.Hoffmann-La Roche Ag Composés de type pyrazol-4-yl-hétérocyclyl-carboxamide et leurs méthodes d'utilisation
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
US9173883B2 (en) * 2012-05-21 2015-11-03 Novartis Ag Ring-substituted N-pyridinyl amides as kinase inhibitors
WO2014033631A1 (fr) * 2012-08-31 2014-03-06 Novartis Ag N- (3-pyridyl)-biarylamides en tant qu'inhibiteurs de kinase
WO2014033630A1 (fr) * 2012-08-31 2014-03-06 Novartis Ag Nouveaux carboxamides d'aminothiazole en tant qu'inhibiteurs de kinase
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US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (fr) 2015-05-29 2016-12-08 Incyte Corporation Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim
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US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2019057821A1 (fr) * 2017-09-20 2019-03-28 Lead Discovery Center Gmbh Dérivés de coumarine, leurs procédés de préparation et leurs utilisations dans le traitement du cancer
WO2019113487A1 (fr) 2017-12-08 2019-06-13 Incyte Corporation Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs
WO2019111218A1 (fr) 2017-12-08 2019-06-13 Cadila Healthcare Limited Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs d'irak4
SG11202007164UA (en) 2018-01-30 2020-08-28 Incyte Corp Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
SMT202400306T1 (it) 2018-03-30 2024-09-16 Incyte Corp Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
JP2021521170A (ja) 2018-04-13 2021-08-26 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤
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Also Published As

Publication number Publication date
TW200942536A (en) 2009-10-16
AU2009221134B2 (en) 2012-02-23
CN104098559A (zh) 2014-10-15
CN102015701B (zh) 2014-07-23
IL207865A0 (en) 2010-12-30
ES2443496T3 (es) 2014-02-19
AU2009221134A1 (en) 2009-09-11
EA201001412A1 (ru) 2011-06-30
EP2262802B1 (fr) 2013-10-23
ZA201006128B (en) 2011-10-26
KR20100120709A (ko) 2010-11-16
PE20091577A1 (es) 2009-11-05
ES2562306T3 (es) 2016-03-03
CA2717388A1 (fr) 2009-09-11
UY31679A1 (es) 2009-09-30
EP2596790A1 (fr) 2013-05-29
ECSP10010447A (es) 2010-10-30
EP2262802A1 (fr) 2010-12-22
MX2010009739A (es) 2010-09-28
BRPI0909102A2 (pt) 2019-01-15
CN102015701A (zh) 2011-04-13
CO6290687A2 (es) 2011-06-20
CL2009000483A1 (es) 2010-02-19
JP5412448B2 (ja) 2014-02-12
JP2011513363A (ja) 2011-04-28
EP2596790B1 (fr) 2015-12-09
WO2009109576A1 (fr) 2009-09-11
AR070531A1 (es) 2010-04-14

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