MA38588A1 - Dérivés bi-aromatiques antibactériens - Google Patents

Dérivés bi-aromatiques antibactériens

Info

Publication number
MA38588A1
MA38588A1 MA38588A MA38588A MA38588A1 MA 38588 A1 MA38588 A1 MA 38588A1 MA 38588 A MA38588 A MA 38588A MA 38588 A MA38588 A MA 38588A MA 38588 A1 MA38588 A1 MA 38588A1
Authority
MA
Morocco
Prior art keywords
hydroxy
alkoxy
cyano
dashed line
oxoethoxy
Prior art date
Application number
MA38588A
Other languages
English (en)
Other versions
MA38588B1 (fr
Inventor
Christian Hubschwerlen
Georg Rueedi
Sylvaine Cren
Astrid Friedli
Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA38588A1 publication Critical patent/MA38588A1/fr
Publication of MA38588B1 publication Critical patent/MA38588B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention porte sur des composés antibactériens de formule i i dans laquelle r est h, un groupe cyano, alcoxy, cyanométhoxy, cycloalkylméthoxy, hydroxyalcoxy, alcoxyalcoxy, alcoxycarbonyle, 2-éthoxy-2-oxoéthoxy, 2-(méthylamino)-2-oxoéthoxy, (1-cyanocyclobutyl)méthoxy, 3-hydroxy-pyrrolidin-1-yle ou 3,4-dihydroxycyclopentyl)méthoxy; u1 est n ou cr1, u2 est n ou cr2, u3 est n ou cr3 et u4 est n ou cr4, étant entendu qu'au plus trois de u1, u2, u3 et u4 peuvent être n en même temps; v1 est n ou cr5, v2 est n ou cr6, v3 est n ou cr7 et v4 est n ou ch, étant entendu qu'au plus deux de v1, v2, v3 et v4 peuvent être n en même temps; r1 est h, un groupe cyano, hydroxy ou alcoxy; r2 est h, un groupe hydroxy ou alcoxy; r3 est h, un groupe cyano, hydroxy, alcoxy ou carboxamido; r4 est h ou un groupe alcoxy; r5 est h ou un groupe hydroxy ou halogéno; r6 est h ou un groupe hydroxy ou halogéno; r7 est h; la ligne en tirets " " représente une liaison ou est absente; w représente ch ou n quand la ligne en tirets " " est une liaison, ou w représente ch2 quand la ligne en tirets " " est absente; x représente ch ou n; et q représente o ou s; et leurs sels.
MA38588A 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens MA38588B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013053021 2013-04-16
PCT/IB2014/060724 WO2014170821A1 (fr) 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens

Publications (2)

Publication Number Publication Date
MA38588A1 true MA38588A1 (fr) 2017-05-31
MA38588B1 MA38588B1 (fr) 2018-04-30

Family

ID=50639826

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38588A MA38588B1 (fr) 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens

Country Status (21)

Country Link
US (1) US9527867B2 (fr)
EP (1) EP2986607B1 (fr)
JP (1) JP6375365B2 (fr)
KR (1) KR20150143720A (fr)
CN (1) CN105143216B (fr)
AR (1) AR095884A1 (fr)
AU (1) AU2014255326B2 (fr)
BR (1) BR112015026261A8 (fr)
CA (1) CA2907832A1 (fr)
CL (1) CL2015003019A1 (fr)
EA (1) EA029361B1 (fr)
ES (1) ES2640482T3 (fr)
HK (1) HK1221459A1 (fr)
MA (1) MA38588B1 (fr)
MX (1) MX362338B (fr)
PH (1) PH12015502411A1 (fr)
PL (1) PL2986607T3 (fr)
SA (1) SA515361261B1 (fr)
SG (1) SG11201508479RA (fr)
TW (1) TWI631119B (fr)
WO (1) WO2014170821A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4833385B1 (ja) 2008-10-07 2011-12-07 アクテリオン ファーマシューティカルズ リミテッド 三環式オキサゾリジノン抗生物質化合物
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
TW201808906A (zh) 2016-03-16 2018-03-16 拜耳作物科學股份有限公司 作為殺蟲劑之經取代吡啶化合物
AR108108A1 (es) 2016-04-14 2018-07-18 Idorsia Pharmaceuticals Ltd Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
TW201833120A (zh) * 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
EP3284739A1 (fr) 2017-07-19 2018-02-21 Bayer CropScience Aktiengesellschaft Composés (hét)aryl substitués comme produit de lutte contre les parasites
CN111527093B (zh) * 2017-11-29 2023-06-09 巴格沃克斯研究有限公司 抗菌杂环化合物及其合成
MY210507A (en) 2018-08-13 2025-09-28 Hoffmann La Roche New heterocyclic compounds as monoacylglycerol lipase inhibitors
WO2020104494A1 (fr) 2018-11-22 2020-05-28 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques
PH12022550339A1 (en) 2019-09-12 2023-03-13 Hoffmann La Roche 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
EP4126855B1 (fr) * 2020-03-24 2024-04-24 F. Hoffmann-La Roche AG Composés et leur utilisation dans le traitement des infections bactériennes
CN115785718B (zh) * 2022-11-25 2023-08-22 四川大学 一种多基底表面的金属配位抗菌涂层及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0297042A1 (fr) 1987-06-23 1988-12-28 Ciba-Geigy Ag Dérivés de pénème substitués
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
AU1026901A (en) 1999-10-29 2001-05-08 Syngenta Participations Ag Novel herbicides
AU2002347985A1 (en) 2001-11-15 2003-06-10 Eli Lilly And Company Peroxisome proliferator activated receptor alpha agonists
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
US20090186834A1 (en) 2005-03-24 2009-07-23 Microbia, Inc. Diphenylheterocycle cholesterol absorption inhibitors
TW200734311A (en) 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
EP2141154A4 (fr) 2007-03-30 2011-06-01 Inst Med Molecular Design Inc Dérivé d'oxazolidinone ayant une activité inhibitrice sur la 11 -hydroxystéroïde déshydrogénase de type i
CL2008001003A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
HRP20140015T1 (hr) 2007-12-20 2014-02-14 Pharma Mar, S.A. Antitumorski spojevi
BRPI0907892A2 (pt) 2008-02-20 2015-07-28 Actelion Pharmaceuticals Ltd Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo
CA2713187C (fr) 2008-02-22 2016-06-07 Actelion Pharmaceuticals Ltd Derives d'oxazolidinone
WO2010015985A1 (fr) * 2008-08-04 2010-02-11 Actelion Pharmaceuticals Ltd Dérivés d'alkylaminométhyloxazolidinone tricycliques
JP4833385B1 (ja) 2008-10-07 2011-12-07 アクテリオン ファーマシューティカルズ リミテッド 三環式オキサゾリジノン抗生物質化合物
ES2395491T3 (es) 2008-10-10 2013-02-13 Actelion Pharmaceuticals Ltd. 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos
IN2014CN04126A (fr) 2011-11-08 2015-07-10 Actelion Pharmaceuticals Ltd

Also Published As

Publication number Publication date
MA38588B1 (fr) 2018-04-30
KR20150143720A (ko) 2015-12-23
EP2986607B1 (fr) 2017-06-14
BR112015026261A2 (pt) 2017-07-25
WO2014170821A1 (fr) 2014-10-23
PL2986607T3 (pl) 2017-11-30
US20160075722A1 (en) 2016-03-17
TWI631119B (zh) 2018-08-01
AR095884A1 (es) 2015-11-18
TW201516043A (zh) 2015-05-01
EA029361B1 (ru) 2018-03-30
EP2986607A1 (fr) 2016-02-24
AU2014255326B2 (en) 2018-09-13
EA201501025A1 (ru) 2016-08-31
SA515361261B1 (ar) 2016-06-15
ES2640482T3 (es) 2017-11-03
MX2015014576A (es) 2016-03-04
JP6375365B2 (ja) 2018-08-15
BR112015026261A8 (pt) 2017-12-26
PH12015502411A1 (en) 2016-02-22
MX362338B (es) 2019-01-11
JP2016516805A (ja) 2016-06-09
US9527867B2 (en) 2016-12-27
SG11201508479RA (en) 2015-11-27
AU2014255326A1 (en) 2015-11-26
CN105143216B (zh) 2018-04-13
CN105143216A (zh) 2015-12-09
CA2907832A1 (fr) 2014-10-23
HK1221459A1 (zh) 2017-06-02
CL2015003019A1 (es) 2016-09-30

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