MA38698B1 - Système d'administration transdermique - Google Patents

Système d'administration transdermique

Info

Publication number
MA38698B1
MA38698B1 MA38698A MA38698A MA38698B1 MA 38698 B1 MA38698 B1 MA 38698B1 MA 38698 A MA38698 A MA 38698A MA 38698 A MA38698 A MA 38698A MA 38698 B1 MA38698 B1 MA 38698B1
Authority
MA
Morocco
Prior art keywords
buprenorphine
sensitive adhesive
adhesive layer
acid
pressure
Prior art date
Application number
MA38698A
Other languages
English (en)
Other versions
MA38698A1 (fr
Inventor
Thomas Hille
Gabriel Wauer
Frank Seibertz
Shu-Lun Weinheimer
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51022809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38698(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of MA38698A1 publication Critical patent/MA38698A1/fr
Publication of MA38698B1 publication Critical patent/MA38698B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0256—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the parametric properties of the adhesive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un système thérapeutique transdermique pour l'administration transdermique de buprénorphine, comprenant une structure de couche auto-adhésive contenant de la buprénorphine comprenant a) une couche de support imperméable à la buprénorphine et b) une couche adhésive sensible à la pression contenant de la buprénorphine sur ladite couche de support imperméable à la buprénorphine, la couche adhésive comprenant a) au moins un adhésif sensible à la pression à base de polymère, b) une quantité efficace de façon analgésique de base de buprénorphine ou d'un sel pharmaceutiquement acceptable de celle-ci, c) une substance augmentant la viscosité dans une quantité d'environ 0,1 % à environ 8 % de ladite couche adhésive sensible à la pression contenant de la buprénorphine et d) un acide carboxylique choisi dans le groupe consistant en acide oléique, acide linoléique, acide linolénique, acide lévulinique et leurs mélanges, dans une quantité suffisante de telle sorte que ladite quantité efficace de façon analgésique de buprénorphine y est solubilisée pour former un mélange comprenant ladite substance augmentant la viscosité, et le mélange contenant l'acide carboxylique, la buprénorphine et la substance augmentant la viscosité formant des dépôts dispersés dans ledit adhésif sensible à la pression, et ladite couche adhésive sensible à la pression contenant de la buprénorphine étant la couche de contact avec la peau.
MA38698A 2013-06-04 2014-06-04 Système d'administration transdermique MA38698B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361830975P 2013-06-04 2013-06-04
PCT/EP2014/061567 WO2014195352A1 (fr) 2013-06-04 2014-06-04 Système d'administration transdermique

Publications (2)

Publication Number Publication Date
MA38698A1 MA38698A1 (fr) 2017-02-28
MA38698B1 true MA38698B1 (fr) 2017-10-31

Family

ID=51022809

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38698A MA38698B1 (fr) 2013-06-04 2014-06-04 Système d'administration transdermique

Country Status (34)

Country Link
US (6) US20160008294A1 (fr)
EP (2) EP2810646B1 (fr)
JP (1) JP6559121B2 (fr)
KR (1) KR102302505B1 (fr)
CN (1) CN105377245B (fr)
AP (1) AP2015008920A0 (fr)
AR (1) AR096521A1 (fr)
AU (1) AU2014276910B2 (fr)
BR (1) BR112015029920A2 (fr)
CA (1) CA2914425C (fr)
CL (1) CL2015003377A1 (fr)
CR (1) CR20150647A (fr)
CY (1) CY1118054T1 (fr)
DE (1) DE112014002664T5 (fr)
DK (1) DK2810646T3 (fr)
EA (1) EA201592246A1 (fr)
ES (1) ES2599802T3 (fr)
GB (1) GB2529789A (fr)
HK (1) HK1222135A1 (fr)
HU (1) HUE031662T2 (fr)
LT (1) LT2810646T (fr)
MA (1) MA38698B1 (fr)
MX (1) MX362614B (fr)
NI (1) NI201500170A (fr)
PE (1) PE20160002A1 (fr)
PH (1) PH12015502550A1 (fr)
PL (1) PL2810646T3 (fr)
PT (1) PT2810646T (fr)
SG (1) SG11201509218SA (fr)
SI (1) SI2810646T1 (fr)
TN (1) TN2015000493A1 (fr)
TW (1) TW201509416A (fr)
WO (1) WO2014195352A1 (fr)
ZA (1) ZA201509309B (fr)

Families Citing this family (27)

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DE102006054731B4 (de) 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie
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EP3145502B1 (fr) 2014-05-20 2022-07-06 LTS Lohmann Therapie-Systeme AG Système d'administration transdermique contenant de la rotigotine
US11426359B2 (en) 2014-05-20 2022-08-30 Lts Lohmann Therapie-Systeme Ag Method for adjusting the release of active agent in a transdermal delivery system
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Also Published As

Publication number Publication date
CY1118054T1 (el) 2017-06-28
CA2914425A1 (fr) 2014-12-11
GB201522307D0 (en) 2016-02-03
MA38698A1 (fr) 2017-02-28
KR20160014064A (ko) 2016-02-05
MX2015016123A (es) 2016-07-21
US11529345B2 (en) 2022-12-20
ZA201509309B (en) 2017-11-29
US20160101100A1 (en) 2016-04-14
TN2015000493A1 (en) 2017-04-06
TW201509416A (zh) 2015-03-16
EP2810646A1 (fr) 2014-12-10
AR096521A1 (es) 2016-01-13
US20170128384A1 (en) 2017-05-11
KR102302505B1 (ko) 2021-09-15
CN105377245A (zh) 2016-03-02
AU2014276910A1 (en) 2016-01-28
CL2015003377A1 (es) 2016-06-17
US20200316055A1 (en) 2020-10-08
ES2599802T3 (es) 2017-02-03
EA201592246A1 (ru) 2016-05-31
AU2014276910B2 (en) 2017-03-09
DE112014002664T5 (de) 2016-04-07
DK2810646T3 (en) 2016-10-31
PE20160002A1 (es) 2016-01-23
BR112015029920A2 (pt) 2017-07-25
CR20150647A (es) 2016-02-19
EP3106153A1 (fr) 2016-12-21
HK1204766A1 (en) 2015-12-04
SI2810646T1 (sl) 2016-11-30
PH12015502550A1 (en) 2016-02-22
HUE031662T2 (en) 2017-07-28
PL2810646T3 (pl) 2017-02-28
MX362614B (es) 2019-01-28
US20180092905A1 (en) 2018-04-05
CA2914425C (fr) 2019-09-17
JP2016520638A (ja) 2016-07-14
HK1222135A1 (zh) 2017-06-23
WO2014195352A1 (fr) 2014-12-11
JP6559121B2 (ja) 2019-08-14
PT2810646T (pt) 2016-10-05
SG11201509218SA (en) 2015-12-30
EP2810646B1 (fr) 2016-07-27
CN105377245B (zh) 2018-07-17
NI201500170A (es) 2016-08-05
AP2015008920A0 (en) 2015-12-31
LT2810646T (lt) 2016-10-25
US20160008294A1 (en) 2016-01-14
US20200237748A1 (en) 2020-07-30
GB2529789A (en) 2016-03-02

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