MA38816A - Sulfamidase modifiée et sa production - Google Patents
Sulfamidase modifiée et sa productionInfo
- Publication number
- MA38816A MA38816A MA038816A MA38816A MA38816A MA 38816 A MA38816 A MA 38816A MA 038816 A MA038816 A MA 038816A MA 38816 A MA38816 A MA 38816A MA 38816 A MA38816 A MA 38816A
- Authority
- MA
- Morocco
- Prior art keywords
- sulfamidase
- modified
- modified sulfamidase
- production
- mammal
- Prior art date
Links
- 108010006140 N-sulfoglucosamine sulfohydrolase Proteins 0.000 title abstract 8
- 102100027661 N-sulphoglucosamine sulphohydrolase Human genes 0.000 title abstract 8
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
- C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
- C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne une sulfamidase modifiée, une composition comprenant une sulfamidase modifiée, ainsi que des procédés de préparation d'une sulfamidase modifiée et l'utilisation thérapeutique d'une telle sulfamidase. En particulier, la présente invention concerne une sulfamidase modifiée ne comprenant pratiquement pas d'épitopes pour des récepteurs de reconnaissance de glycane, permettant ainsi le transport de ladite sulfamidase à travers la barrière hémato-encéphalique d'un mammifère, ladite sulfamidase ayant une activité catalytique dans le cerveau dudit mammifère.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14162996 | 2014-04-01 | ||
| EP15713502.1A EP2970413B1 (fr) | 2014-04-01 | 2015-04-01 | Sulfamidase modifiée et sa production |
| PCT/EP2015/057256 WO2015150490A1 (fr) | 2014-04-01 | 2015-04-01 | Sulfamidase modifiée et son procédé de production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38816A true MA38816A (fr) | 2016-01-20 |
| MA38816B1 MA38816B1 (fr) | 2018-10-31 |
Family
ID=50389999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38816A MA38816B1 (fr) | 2014-04-01 | 2015-04-01 | Sulfamidase modifiée et sa production |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US9982243B2 (fr) |
| EP (2) | EP3401325A1 (fr) |
| JP (1) | JP6594896B2 (fr) |
| KR (1) | KR20160138282A (fr) |
| CN (1) | CN106414727A (fr) |
| AU (1) | AU2015239126B2 (fr) |
| BR (1) | BR112016022333A2 (fr) |
| CA (1) | CA2943140A1 (fr) |
| CL (1) | CL2016002469A1 (fr) |
| CY (1) | CY1120697T1 (fr) |
| DK (1) | DK2970413T3 (fr) |
| ES (1) | ES2687262T3 (fr) |
| HK (1) | HK1231510A1 (fr) |
| HR (1) | HRP20181507T1 (fr) |
| HU (1) | HUE039691T2 (fr) |
| IL (1) | IL247978A0 (fr) |
| LT (1) | LT2970413T (fr) |
| MA (1) | MA38816B1 (fr) |
| MX (1) | MX368947B (fr) |
| PH (1) | PH12016501812A1 (fr) |
| PL (1) | PL2970413T3 (fr) |
| PT (1) | PT2970413T (fr) |
| RS (1) | RS57842B1 (fr) |
| RU (1) | RU2708026C2 (fr) |
| SA (1) | SA516371859B1 (fr) |
| SG (1) | SG11201608025QA (fr) |
| SI (1) | SI2970413T1 (fr) |
| SM (1) | SMT201800511T1 (fr) |
| UA (1) | UA120432C2 (fr) |
| WO (1) | WO2015150490A1 (fr) |
| ZA (1) | ZA201606492B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2970413T1 (sl) | 2014-04-01 | 2018-10-30 | Swedish Orphan Biovitrum Ab (Publ) | Modificirana sulfamidaza in proizvodja le-te |
| BR112018006278A2 (pt) * | 2015-10-01 | 2018-10-16 | Swedish Orphan Biovitrum Ab Publ | proteína lisossômica modificada e produção da mesma |
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| WO2019145500A1 (fr) | 2018-01-26 | 2019-08-01 | Swedish Orphan Biovitrum Ab (Publ) | Méthode de traitement |
| US11708569B2 (en) | 2018-08-29 | 2023-07-25 | University Of Copenhagen | Modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase having low mannose-6-phosphate and high sialic acid |
| EP3741867A1 (fr) | 2019-05-24 | 2020-11-25 | Swedish Orphan Biovitrum AB (Publ) | Dosage d'activité de sulfatase |
| EP4229192A1 (fr) | 2020-10-14 | 2023-08-23 | Denali Therapeutics Inc. | Protéines de fusion comprenant des enzymes sulfoglucosamine sulfohydrolase et méthodes associées |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| CA2257357C (fr) | 1996-06-07 | 2010-04-13 | Neorx Corporation | Anticorps humanises a glycosylation modifiee |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| AU2002347910A1 (en) | 2001-10-16 | 2003-04-28 | Symbiontics Inc. | Methods and compositions for targeting proteins across the blood brain barrier |
| EP1552298A4 (fr) | 2002-07-01 | 2006-11-08 | Kenneth S Warren Inst Inc | Cytokines protectrices des tissus recombinees et acides nucleiques codants associes pour la protection, la restauration et l'amelioration de cellules, de tissus et d'organes sensibles |
| CA2680189A1 (fr) * | 2007-03-06 | 2008-09-12 | Saint Louis University | Enzyme modifiee et procede de traitement |
| CA2711590C (fr) * | 2008-01-18 | 2021-03-23 | Biomarin Pharmaceutical Inc. | Fabrication d'enzymes de sulfatase lysosomales humaines hautement phosphorylees actives et leurs utilisations |
| EP2394667A1 (fr) * | 2010-06-10 | 2011-12-14 | Laboratorios Del Dr. Esteve, S.A. | Vecteurs et séquences pour le traitement de maladies |
| AU2010366066B2 (en) | 2010-12-22 | 2016-01-14 | Fondazione Telethon | Therapeutic strategies to treat CNS pathology in mucopolysaccharidoses |
| US9155784B2 (en) * | 2011-06-20 | 2015-10-13 | Icahn School Of Medicine At Mount Sinai | Anti-TNF-α therapy for the mucopolysaccharidoses and other lysosomal disorders |
| WO2014194427A1 (fr) | 2013-06-06 | 2014-12-11 | Angiochem Inc. | Protéines de fusion iduronate-2-sulfatase ciblées |
| US20140377246A1 (en) | 2013-06-19 | 2014-12-25 | Carol Ann Foundation and International Morquio Organization | Enzyme replacement therapy for treating mps vii related bone lesions using a chemically modified enzyme |
| SI2970413T1 (sl) | 2014-04-01 | 2018-10-30 | Swedish Orphan Biovitrum Ab (Publ) | Modificirana sulfamidaza in proizvodja le-te |
-
2015
- 2015-04-01 SI SI201530397T patent/SI2970413T1/sl unknown
- 2015-04-01 MX MX2016012910A patent/MX368947B/es active IP Right Grant
- 2015-04-01 HU HUE15713502A patent/HUE039691T2/hu unknown
- 2015-04-01 PL PL15713502T patent/PL2970413T3/pl unknown
- 2015-04-01 WO PCT/EP2015/057256 patent/WO2015150490A1/fr not_active Ceased
- 2015-04-01 BR BR112016022333A patent/BR112016022333A2/pt not_active Application Discontinuation
- 2015-04-01 KR KR1020167030393A patent/KR20160138282A/ko not_active Withdrawn
- 2015-04-01 HR HRP20181507TT patent/HRP20181507T1/hr unknown
- 2015-04-01 HK HK17105213.1A patent/HK1231510A1/zh unknown
- 2015-04-01 CN CN201580026957.6A patent/CN106414727A/zh active Pending
- 2015-04-01 JP JP2016560417A patent/JP6594896B2/ja not_active Expired - Fee Related
- 2015-04-01 RS RS20181119A patent/RS57842B1/sr unknown
- 2015-04-01 MA MA38816A patent/MA38816B1/fr unknown
- 2015-04-01 LT LTEP15713502.1T patent/LT2970413T/lt unknown
- 2015-04-01 RU RU2016140844A patent/RU2708026C2/ru not_active IP Right Cessation
- 2015-04-01 PT PT15713502T patent/PT2970413T/pt unknown
- 2015-04-01 SG SG11201608025QA patent/SG11201608025QA/en unknown
- 2015-04-01 UA UAA201610956A patent/UA120432C2/uk unknown
- 2015-04-01 DK DK15713502.1T patent/DK2970413T3/en active
- 2015-04-01 ES ES15713502.1T patent/ES2687262T3/es active Active
- 2015-04-01 CA CA2943140A patent/CA2943140A1/fr not_active Abandoned
- 2015-04-01 AU AU2015239126A patent/AU2015239126B2/en not_active Ceased
- 2015-04-01 EP EP18180516.9A patent/EP3401325A1/fr not_active Withdrawn
- 2015-04-01 EP EP15713502.1A patent/EP2970413B1/fr active Active
- 2015-04-01 SM SM20180511T patent/SMT201800511T1/it unknown
- 2015-07-22 US US14/806,504 patent/US9982243B2/en active Active
-
2016
- 2016-09-16 PH PH12016501812A patent/PH12016501812A1/en unknown
- 2016-09-19 SA SA516371859A patent/SA516371859B1/ar unknown
- 2016-09-20 ZA ZA2016/06492A patent/ZA201606492B/en unknown
- 2016-09-22 IL IL247978A patent/IL247978A0/en unknown
- 2016-09-30 CL CL2016002469A patent/CL2016002469A1/es unknown
-
2018
- 2018-04-27 US US15/965,597 patent/US20180320152A1/en not_active Abandoned
- 2018-09-24 CY CY181100983T patent/CY1120697T1/el unknown
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