MA38827A1 - Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives - Google Patents

Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives

Info

Publication number
MA38827A1
MA38827A1 MA38827A MA38827A MA38827A1 MA 38827 A1 MA38827 A1 MA 38827A1 MA 38827 A MA38827 A MA 38827A MA 38827 A MA38827 A MA 38827A MA 38827 A1 MA38827 A1 MA 38827A1
Authority
MA
Morocco
Prior art keywords
inhibitor
treatment
combination
hyperproliferative diseases
erk
Prior art date
Application number
MA38827A
Other languages
English (en)
Inventor
Marcia Belvin
John Moffat
Mark Merchant
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA38827A1 publication Critical patent/MA38827A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des combinaisons comprenant un inhibiteur de mek (comme gdc-0973 ou gdc-0623) ou d'un sel pharmaceutiquement acceptable de celui-ci et d'un inhibiteur d'erk (comme gdc-0994). Les combinaisons sont particulièrement utiles pour traiter des troubles hyperprolifératifs, tels que le cancer.
MA38827A 2013-09-05 2014-09-04 Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives MA38827A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361874206P 2013-09-05 2013-09-05
PCT/EP2014/068776 WO2015032840A1 (fr) 2013-09-05 2014-09-04 Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives

Publications (1)

Publication Number Publication Date
MA38827A1 true MA38827A1 (fr) 2017-10-31

Family

ID=51492945

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38827A MA38827A1 (fr) 2013-09-05 2014-09-04 Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives

Country Status (21)

Country Link
US (1) US9532987B2 (fr)
EP (1) EP3041471A1 (fr)
JP (2) JP2016531139A (fr)
KR (1) KR20160048807A (fr)
CN (1) CN105517548B (fr)
AR (1) AR097556A1 (fr)
AU (1) AU2014317119B2 (fr)
CA (1) CA2916619A1 (fr)
CL (1) CL2016000042A1 (fr)
EA (1) EA034872B1 (fr)
HK (1) HK1218072A1 (fr)
IL (1) IL243251B (fr)
MA (1) MA38827A1 (fr)
MX (1) MX370417B (fr)
PE (1) PE20160529A1 (fr)
PH (1) PH12016500270A1 (fr)
SG (1) SG11201600989VA (fr)
TW (1) TW201605477A (fr)
UA (1) UA120423C2 (fr)
WO (1) WO2015032840A1 (fr)
ZA (1) ZA201600091B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE053994T2 (hu) * 2012-03-01 2021-08-30 Array Biopharma Inc Szerin/treonin kináz inhibitorok
EP3077401B1 (fr) 2013-12-06 2018-04-18 Genentech, Inc. Inhibiteurs de sérine/thréonine kinase
JP6642942B2 (ja) * 2013-12-30 2020-02-12 アレイ バイオファーマ、インコーポレイテッド セリン／トレオニンキナーゼ阻害剤
WO2016162325A1 (fr) 2015-04-07 2016-10-13 Astrazeneca Ab Dérivés de 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2h)-ones substitués utilisés comme inhibiteurs de kinase
WO2017080980A1 (fr) 2015-11-09 2017-05-18 Astrazeneca Ab Dérivés de dihydropyrrolopyrazinone utiles dans le traitement du cancer
RS60155B1 (sr) 2015-11-09 2020-05-29 Astrazeneca Ab Derivati dihidroimidazopirazinona korisni za upotrebu u tretmanu raka
CN105330643B (zh) 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 卡比替尼的制备方法
WO2017180581A1 (fr) 2016-04-15 2017-10-19 Genentech, Inc. Procédés diagnostiques et thérapeutiques relatifs au cancer
AU2017316618A1 (en) * 2016-08-23 2019-02-07 Genentech, Inc. Combination therapy for the treatment of pancreatic cancer
BR112019009711A2 (pt) 2016-11-25 2019-08-13 Genuv Inc método de indução de neuro-regeneração, método de proteção de neurônios contra perda ou dano neuronal, método de prevenção ou tratamento de doença neurodegenerativa devido à perda ou dano neuronal, e método de triagem de candidatos de fármaco para o tratamento de doenças neurodegenerativas
JP2019019094A (ja) * 2017-07-19 2019-02-07 学校法人福岡大学 変異ｋｒａｓ関連シグナル阻害用組成物
AU2018329925B2 (en) 2017-09-08 2025-05-29 F. Hoffmann-La Roche Ag Diagnostic and therapeutic methods for cancer
US12435078B2 (en) 2017-09-18 2025-10-07 Gfb (Abc), Llc Pyridazinones and methods of use thereof
WO2019139970A1 (fr) * 2018-01-09 2019-07-18 Duke University Administration topique d'agents inhibiteurs de mek pour le traitement de troubles cutanés
EP3752200A1 (fr) 2018-02-13 2020-12-23 Vib Vzw Ciblage d'une maladie résiduelle minimale dans le cancer avec des antagonistes de rxr
WO2021007499A1 (fr) * 2019-07-11 2021-01-14 Emory University Polythérapies pour la gestion du cancer
KR102695469B1 (ko) * 2021-07-23 2024-08-14 차의과학대학교 산학협력단 2,4-디아미노피리미딘을 포함하는 암의 예방 또는 치료용 조성물
CN118001281B (zh) * 2023-12-11 2025-10-17 中国科学院深圳先进技术研究院 一种治疗或预防甲基苯丙胺成瘾的药物及应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20110498T1 (hr) 2005-10-07 2011-08-31 Exelixis Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
ES2528797T3 (es) 2006-08-21 2015-02-12 Genentech, Inc. Compuestos de aza-benzotiofenilo y métodos de uso
ES2376771T3 (es) 2006-08-21 2012-03-16 Genentech, Inc. Compuestos aza-benzofuranilo y métodos de utilización
EP2099796B1 (fr) 2006-11-30 2011-06-01 Genentech, Inc. Composés azaindolyliques et procédés d'utilisation de ceux-ci
WO2008076415A1 (fr) 2006-12-14 2008-06-26 Exelixis, Inc. Procédés d'utilisation d'inhibiteurs de mek
JP5580735B2 (ja) 2007-06-12 2014-08-27 ジェネンテック， インコーポレイテッド Ｎ−置換アザインドール類及び使用方法
AU2008343065B2 (en) * 2007-12-19 2012-04-05 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
PT2231662E (pt) 2007-12-19 2011-09-12 Genentech Inc 8-anilinoimidazopiridinas e o seu uso como agentes anticancerígenos e/ou anti-inflamatórios
NZ586575A (en) 2007-12-21 2012-03-30 Genentech Inc Azaindolizines and methods of use
MX2010014565A (es) 2008-07-01 2011-03-04 Genentech Inc Isoindolona y metodos de uso.
RU2509078C2 (ru) 2008-07-01 2014-03-10 Дженентек, Инк. Бициклические гетероциклы в качестве ингибиторов киназы мек
IN2012DN01403A (fr) 2009-08-24 2015-06-05 Genentech Inc
KR101489045B1 (ko) 2009-10-12 2015-02-02 에프. 호프만-라 로슈 아게 Ｐｉ3ｋ 억제자 및 ｍｅｋ 억제자의 조합
PT2643322T (pt) 2010-11-23 2017-11-13 Abbvie Inc Sais e formas cristalinas de um agente indutor de apoptose
CN103635472B (zh) 2011-02-28 2018-01-12 阵列生物制药公司 丝氨酸/苏氨酸激酶抑制剂
WO2012145503A1 (fr) 2011-04-21 2012-10-26 Novartis Ag Combinaisons pharmaceutiques
JP6097289B2 (ja) 2011-08-04 2017-03-15 アレイ バイオファーマ、インコーポレイテッド セリン／スレオニンキナーゼインヒビターとしてのキナゾリン化合物
HUE053994T2 (hu) 2012-03-01 2021-08-30 Array Biopharma Inc Szerin/treonin kináz inhibitorok
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
RU2014150494A (ru) 2012-05-30 2016-07-20 Ф. Хоффманн-Ля Рош Аг Пирролидиногетероциклы
DK2884979T3 (da) 2012-08-17 2019-09-02 Hoffmann La Roche Kombinationsbehandlinger mod melanom omfattende indgivelse af cobimetinib og vemurafenib
AR092253A1 (es) 2012-08-27 2015-04-08 Array Biopharma Inc Inhibidores de serina/treonina cinasa
MA38085B1 (fr) 2012-10-12 2018-11-30 Exelixis Inc Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer
JP2015533151A (ja) 2012-10-16 2015-11-19 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト セリン／スレオニンキナーゼ阻害剤
EP3077401B1 (fr) 2013-12-06 2018-04-18 Genentech, Inc. Inhibiteurs de sérine/thréonine kinase
KR102379517B1 (ko) 2013-12-30 2022-03-25 제넨테크, 인크. 세린/트레오닌 키나아제 억제제
JP6642942B2 (ja) 2013-12-30 2020-02-12 アレイ バイオファーマ、インコーポレイテッド セリン／トレオニンキナーゼ阻害剤
MY188526A (en) 2014-04-09 2021-12-18 Genentech Inc Process for the manufacturing of medicaments

Also Published As

Publication number Publication date
TW201605477A (zh) 2016-02-16
WO2015032840A1 (fr) 2015-03-12
HK1218072A1 (zh) 2017-02-03
EA034872B1 (ru) 2020-03-31
ZA201600091B (en) 2017-04-26
SG11201600989VA (en) 2016-03-30
MX2016002857A (es) 2016-06-22
US9532987B2 (en) 2017-01-03
MX370417B (es) 2019-12-10
PE20160529A1 (es) 2016-05-21
KR20160048807A (ko) 2016-05-04
UA120423C2 (uk) 2019-12-10
JP2016531139A (ja) 2016-10-06
EP3041471A1 (fr) 2016-07-13
JP2019031517A (ja) 2019-02-28
US20150111869A1 (en) 2015-04-23
AR097556A1 (es) 2016-03-23
CA2916619A1 (fr) 2015-03-12
AU2014317119A1 (en) 2016-03-03
IL243251B (en) 2019-02-28
PH12016500270A1 (en) 2016-05-16
CN105517548A (zh) 2016-04-20
AU2014317119B2 (en) 2019-12-05
CN105517548B (zh) 2020-01-21
CL2016000042A1 (es) 2016-08-05
EA201690513A1 (ru) 2016-07-29

Similar Documents

Publication Publication Date Title
MA38827A1 (fr) Combinaison d'un inhibiteur de mek et d'un inhibiteur d'erk pour l'utilisation dans le traitement de maladies hyperprolifératives
FR3021970B1 (fr) Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs
MA40755B1 (fr) Compositions comprenant des souches bactériennes
MA40754B1 (fr) Compositions comprenant des souches bactériennes
MA43828A (fr) Agents thérapeutiques pour maladies neurodégénératives
MA44659B1 (fr) Anticorps anti-tim-3 et compositions
GEP20247593B (en) Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders
PH12014500122A1 (en) Inhibitors of bruton's tyrosine kinase
MA42471B1 (fr) Compositions comprenant des souches bactériennes
MA45481A (fr) Utilisation d'exosomes pour le traitement de maladies
MA39984B1 (fr) Traitement d'affections malignes par lymphocytes b par un inhibiteur jak et pi3k combiné
BR112016018205A8 (pt) métodos de tratamento de mal de alzheimer, de seleção de pacientes, de identificação de pacientes, de previsão, de otimização da eficácia terapêutica, kit, uso de agente e uso in vitro de agente
MA39094A1 (fr) Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
WO2019173795A3 (fr) Réduction du fragment c99 de l'app localisé sur la membrane er-mam et méthodes de traitement de la maladie d'alzheimer
EP4603508A3 (fr) Anticorps anti-fzd et méthodes d'utilisation
BR112016018170A2 (pt) métodos para tratar doença de alzheimer
AU2016304856A8 (en) Mechanism of resistance to BET bromodomain inhibitors
MA41977B1 (fr) Imidazopyrazinones utilisées comme inhibiteurs de pde1
EP4286013A3 (fr) Inhibiteurs de lrrc33 et utilisations de ceux-ci
TW201625535A (en) Inhibitors of histone demethylases
WO2015171558A3 (fr) Benzènesulfonamido et composés apparentés utilisés en tant qu'agonistes de rorγ et pour le traitement de maladie
EP3426254C0 (fr) Utilisation d'inhibiteurs de braf pour le traitement de réactions cutanées
MA39837B1 (fr) Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1
MA39447B1 (fr) Pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine