MA39172A1 - Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines - Google Patents
Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomainesInfo
- Publication number
- MA39172A1 MA39172A1 MA39172A MA39172A MA39172A1 MA 39172 A1 MA39172 A1 MA 39172A1 MA 39172 A MA39172 A MA 39172A MA 39172 A MA39172 A MA 39172A MA 39172 A1 MA39172 A1 MA 39172A1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- bromodomaine
- bicyclic derivatives
- heterocyclic bicyclic
- heterocyclic
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000001805 Bromodomains Human genes 0.000 abstract 1
- 108050009021 Bromodomains Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La présente invention concerne des dérivés bicycliques hétérocycliques de formule (i), qui peuvent être thérapeutiquement utiles, plus particulièrement comme inhibiteurs de bromodomaines ; (i), dans laquelle r
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN125CH2014 | 2014-01-09 | ||
| PCT/IB2015/050090 WO2015104653A1 (fr) | 2014-01-09 | 2015-01-06 | Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA39172A1 true MA39172A1 (fr) | 2018-04-30 |
| MA39172B1 MA39172B1 (fr) | 2018-10-31 |
Family
ID=52462967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39172A MA39172B1 (fr) | 2014-01-09 | 2015-01-06 | Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US10077259B2 (fr) |
| EP (1) | EP3092227B1 (fr) |
| JP (1) | JP6480944B2 (fr) |
| KR (1) | KR102394518B1 (fr) |
| CN (1) | CN106061966B (fr) |
| AU (1) | AU2015205339B2 (fr) |
| BR (1) | BR112016015311B1 (fr) |
| CA (1) | CA2934788C (fr) |
| CL (1) | CL2016001737A1 (fr) |
| CY (1) | CY1122046T1 (fr) |
| DK (1) | DK3092227T3 (fr) |
| EA (1) | EA029224B1 (fr) |
| ES (1) | ES2687497T3 (fr) |
| HR (1) | HRP20181650T1 (fr) |
| HU (1) | HUE041546T2 (fr) |
| IL (1) | IL246140B (fr) |
| LT (1) | LT3092227T (fr) |
| MA (1) | MA39172B1 (fr) |
| MX (1) | MX2016009052A (fr) |
| MY (1) | MY190835A (fr) |
| PE (1) | PE20161021A1 (fr) |
| PH (1) | PH12016501355B1 (fr) |
| PL (1) | PL3092227T3 (fr) |
| PT (1) | PT3092227T (fr) |
| RS (1) | RS57586B1 (fr) |
| SA (1) | SA516371448B1 (fr) |
| SG (1) | SG11201604916YA (fr) |
| SI (1) | SI3092227T1 (fr) |
| UA (1) | UA117165C2 (fr) |
| WO (1) | WO2015104653A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9227985B2 (en) | 2013-03-15 | 2016-01-05 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| MY180775A (en) | 2014-04-23 | 2020-12-09 | Incyte Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| CA2989265A1 (fr) * | 2015-07-02 | 2017-01-05 | Orion Corporation | Derives d'heterocycles bicycliques comme inhibiteurs de bromodomaines |
| EP3334717B1 (fr) | 2015-08-11 | 2020-07-01 | Neomed Institute | Dihydroquinolinones substituées par un groupe aryle, leur préparation et leur utilisation comme agents pharmaceutiques |
| WO2017024406A1 (fr) | 2015-08-11 | 2017-02-16 | Neomed Institute | Lactames bicycliques n-substitués, leur préparation et leur utilisation en tant qu'agents pharmaceutiques |
| CA2994478C (fr) | 2015-08-12 | 2023-10-03 | Neomed Institute | Benzimidazoles substitues, preparation et utilisation de ceux-ci en tant qu'agents pharmaceutiques |
| WO2017066876A1 (fr) | 2015-10-21 | 2017-04-27 | Neomed Institute | Imidazopyridines substituées, leur préparation et leur utilisation comme médicaments |
| WO2017075377A1 (fr) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Forme solide amorphe d'un inhibiteur de protéine bet |
| CN105198871A (zh) * | 2015-11-06 | 2015-12-30 | 中国药科大学 | 一类喹喔啉酮类化合物及其制备方法和用途 |
| WO2017127930A1 (fr) | 2016-01-28 | 2017-08-03 | Neomed Institute | [1,2,4]triazolo[4,3-a]pyridines substituées, leur préparation et leur utilisation comme médicaments |
| WO2017184462A1 (fr) | 2016-04-18 | 2017-10-26 | Celgene Quanticel Research, Inc. | Composés thérapeutiques |
| DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
| KR102643344B1 (ko) | 2016-06-20 | 2024-03-07 | 인사이트 코포레이션 | Bet 저해제의 결정질 고체 형태 |
| US20190330192A1 (en) | 2016-12-22 | 2019-10-31 | Bayer Cropscience Aktiengesellschaft | Substituted azolylpyrrolones and azolylhydantoins and salts thereof and use thereof as herbicidal active substances |
| CN110337436A (zh) | 2016-12-22 | 2019-10-15 | 拜耳作物科学股份公司 | 取代的1,2,4-噻二唑基吡咯酮和1,2,4-噻二唑基乙内酰脲及其盐及其作为除草剂的用途 |
| US11078188B2 (en) * | 2017-03-08 | 2021-08-03 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof |
| WO2018195155A1 (fr) | 2017-04-18 | 2018-10-25 | Celgene Quanticel Research, Inc. | Composés thérapeutiques |
| CN110092782B (zh) * | 2018-01-30 | 2022-10-21 | 中国科学院广州生物医药与健康研究院 | 一种苯并六元氮杂环化合物及其制备方法和应用 |
| CN110960528A (zh) * | 2018-09-30 | 2020-04-07 | 四川大学 | Ar和bet双重抑制剂及其用途 |
| AU2019372121A1 (en) | 2018-10-30 | 2021-05-27 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| US20220204493A1 (en) | 2019-04-11 | 2022-06-30 | Orion Corporation | Crystalline form of a bet-inhibitor and manufacture thereof |
| AU2020299592A1 (en) | 2019-07-02 | 2022-02-17 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| KR102600176B1 (ko) * | 2021-10-18 | 2023-11-10 | 주식회사 사피엔스바이오 | 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| CN121909182A (zh) * | 2023-09-07 | 2026-04-21 | 泽农医药公司 | 苯并稠合杂环化合物及其用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10259176A (ja) * | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | 血管新生阻害作用を有する新規アミド誘導体及びその用途 |
| AU2005288080B2 (en) * | 2004-09-28 | 2011-10-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compound |
| MY144974A (en) * | 2005-06-14 | 2011-11-30 | Eisai R&D Man Co Ltd | 1,2-di(cyclic) substituted benzene derivatives |
| JP5191155B2 (ja) * | 2006-03-27 | 2013-04-24 | 大塚製薬株式会社 | カルボスチリル化合物からなる医薬 |
| JP2008156311A (ja) | 2006-12-26 | 2008-07-10 | Institute Of Physical & Chemical Research | Ｂｒｄ２ブロモドメイン結合剤 |
| TW200918058A (en) * | 2007-08-31 | 2009-05-01 | Organon Nv | TSH receptor antagonizing tetrahydroquinoline compounds |
| ATE547415T1 (de) * | 2007-09-21 | 2012-03-15 | Janssen Pharmaceutica Nv | Inhibitoren der wechselwirkung zwischen mdm2 und p53 |
| US8476260B2 (en) | 2007-12-28 | 2013-07-02 | Mitsubishi Tanabe Pharma Corporation | Antitumor agent |
| WO2010074807A1 (fr) * | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | Dérivés 3, 4-dihydroquinolin-2 (1h) -one utilisés comme modulateurs de canaux sodiques |
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| GB201106750D0 (en) * | 2011-04-21 | 2011-06-01 | Glaxosmithkline Llc | Novel compounds |
| GB201107325D0 (en) * | 2011-05-04 | 2011-06-15 | Glaxosmithkline Llc | Novel compounds |
| WO2013027168A1 (fr) | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de bromodomaine |
| US9321750B2 (en) * | 2012-04-20 | 2016-04-26 | Innov17 Llc | ROR modulators and their uses |
| WO2013166015A1 (fr) * | 2012-04-30 | 2013-11-07 | Anderson Gaweco | Modulateurs de ror et leurs utilisations |
| WO2014159837A1 (fr) | 2013-03-14 | 2014-10-02 | Convergene Llc | Procédés et compositions pour l'inhibition de protéines contenant un bromodomaine |
| US9199988B2 (en) * | 2013-03-27 | 2015-12-01 | Boehringer Ingelheim International Gmbh | Dihydroquinazolinone analogues |
-
2015
- 2015-01-06 JP JP2016545312A patent/JP6480944B2/ja not_active Expired - Fee Related
- 2015-01-06 RS RS20180847A patent/RS57586B1/sr unknown
- 2015-01-06 MA MA39172A patent/MA39172B1/fr unknown
- 2015-01-06 EA EA201691404A patent/EA029224B1/ru not_active IP Right Cessation
- 2015-01-06 HU HUE15703314A patent/HUE041546T2/hu unknown
- 2015-01-06 DK DK15703314.3T patent/DK3092227T3/en active
- 2015-01-06 HR HRP20181650TT patent/HRP20181650T1/hr unknown
- 2015-01-06 PE PE2016001002A patent/PE20161021A1/es active IP Right Grant
- 2015-01-06 WO PCT/IB2015/050090 patent/WO2015104653A1/fr not_active Ceased
- 2015-01-06 UA UAA201608674A patent/UA117165C2/uk unknown
- 2015-01-06 SG SG11201604916YA patent/SG11201604916YA/en unknown
- 2015-01-06 MX MX2016009052A patent/MX2016009052A/es unknown
- 2015-01-06 CA CA2934788A patent/CA2934788C/fr active Active
- 2015-01-06 ES ES15703314.3T patent/ES2687497T3/es active Active
- 2015-01-06 AU AU2015205339A patent/AU2015205339B2/en not_active Ceased
- 2015-01-06 EP EP15703314.3A patent/EP3092227B1/fr active Active
- 2015-01-06 MY MYPI2016001265A patent/MY190835A/en unknown
- 2015-01-06 US US15/110,361 patent/US10077259B2/en active Active
- 2015-01-06 BR BR112016015311-1A patent/BR112016015311B1/pt not_active IP Right Cessation
- 2015-01-06 SI SI201530357T patent/SI3092227T1/sl unknown
- 2015-01-06 KR KR1020167021643A patent/KR102394518B1/ko not_active Expired - Fee Related
- 2015-01-06 PT PT15703314T patent/PT3092227T/pt unknown
- 2015-01-06 CN CN201580004048.2A patent/CN106061966B/zh not_active Expired - Fee Related
- 2015-01-06 PL PL15703314T patent/PL3092227T3/pl unknown
- 2015-01-06 LT LTEP15703314.3T patent/LT3092227T/lt unknown
-
2016
- 2016-06-09 IL IL246140A patent/IL246140B/en active IP Right Grant
- 2016-07-03 SA SA516371448A patent/SA516371448B1/ar unknown
- 2016-07-07 CL CL2016001737A patent/CL2016001737A1/es unknown
- 2016-07-08 PH PH12016501355A patent/PH12016501355B1/en unknown
-
2018
- 2018-08-01 US US16/051,913 patent/US10590118B2/en active Active
- 2018-09-18 CY CY20181100961T patent/CY1122046T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA39172B1 (fr) | Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines | |
| EA201270257A1 (ru) | Производные n1-сульфонил-5-фторпиримидинона | |
| EA201792205A1 (ru) | Гетероциклические соединения как ингибиторы lsd1 | |
| EA201990615A1 (ru) | Пирролобензодиазепиновые конъюгаты | |
| EA201691070A1 (ru) | Новые трициклические соединения в качестве противораковых средств | |
| MX2015005015A (es) | Inhibidores heteroarilo de pde4. | |
| EA201892147A1 (ru) | Бициклические соединения | |
| EA201591728A1 (ru) | Гетероциклические соединения и способы их применения | |
| MA41251B1 (fr) | Dérivés de thiéno[2,3-c]pyrrol-4-one comme inhibiteurs erk | |
| EA201490912A1 (ru) | Производные [1,2,3]триазоло[4,5-d]пиримидина в качестве агонистов каннабиноидного рецептора 2 | |
| EA201490567A1 (ru) | Новые бициклические производные дигидрохинолин-2-она | |
| EA201792535A1 (ru) | Гетероциклические амиды в качестве ингибиторов киназ | |
| EA201591591A1 (ru) | Соединения карбазола, применяемые в качестве ингибиторов бромодомена | |
| EA201590534A1 (ru) | Новые бициклические производные | |
| UA108101C2 (xx) | Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів | |
| EA201300730A1 (ru) | Производные индазолилтриазола | |
| AU2014270524A8 (en) | 2-phenylimidazo [1,2-a]pyrimidines as imaging agents | |
| EA201591360A1 (ru) | Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств | |
| EA201790418A1 (ru) | Пиримидиниловые ингибиторы тирозинкиназы | |
| EA201490846A1 (ru) | Новые производные арилхинолина | |
| EA201500628A1 (ru) | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов | |
| UA111198C2 (uk) | Похідні 1-феніл-2-піридинілалкільних спиртів як інгібітори фосфодіестерази | |
| MA38645A1 (fr) | Nouveaux inhibiteurs de cyp17/antiandrogènes | |
| EA201270253A1 (ru) | Производные n1-ацил-5-фторпиримидинона | |
| EA201590552A1 (ru) | Аминохинолины в качестве ингибиторов киназы |