MA39219A1 - Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique - Google Patents

Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique

Info

Publication number
MA39219A1
MA39219A1 MA39219A MA39219A MA39219A1 MA 39219 A1 MA39219 A1 MA 39219A1 MA 39219 A MA39219 A MA 39219A MA 39219 A MA39219 A MA 39219A MA 39219 A1 MA39219 A1 MA 39219A1
Authority
MA
Morocco
Prior art keywords
alzheimer
lateral sclerosis
amyotrophic lateral
lrrk2 kinase
new
Prior art date
Application number
MA39219A
Other languages
English (en)
Other versions
MA39219B1 (fr
Inventor
Yingxia Sang
Zehong Wan
Xiao Ding
Qian Liu
Luigi Piero Stasi
Baowei Zhao
Colin Michael Edge
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MA39219A1 publication Critical patent/MA39219A1/fr
Publication of MA39219B1 publication Critical patent/MA39219B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des nouveaux composés qui inhibent l'activité de la kinase lrrk2, des procédés liés à leur préparation, des compositions les contenant, et leur utilisation dans le traitement ou la prévention de maladies caractérisées par une activité de la kinase lrrk2, par exemple, la maladie de parkinson, la maladie d'alzheimer et la sclérose latérale amyotrophique.
MA39219A 2014-01-29 2015-01-28 Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique MA39219B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014000139 2014-01-29
PCT/CN2015/000055 WO2015113452A1 (fr) 2014-01-29 2015-01-28 Composés

Publications (2)

Publication Number Publication Date
MA39219A1 true MA39219A1 (fr) 2017-09-29
MA39219B1 MA39219B1 (fr) 2018-11-30

Family

ID=53756224

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39219A MA39219B1 (fr) 2014-01-29 2015-01-28 Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique

Country Status (20)

Country Link
US (2) US10087186B2 (fr)
EP (1) EP3099695B1 (fr)
JP (1) JP6422986B2 (fr)
KR (1) KR20160106622A (fr)
CN (1) CN105940004B (fr)
AU (2) AU2015210593A1 (fr)
CA (1) CA2937431A1 (fr)
CL (1) CL2016001895A1 (fr)
CR (1) CR20160348A (fr)
DO (2) DOP2016000195A (fr)
EA (1) EA029774B1 (fr)
ES (1) ES2802174T3 (fr)
IL (1) IL246579B (fr)
MA (1) MA39219B1 (fr)
MX (1) MX367370B (fr)
PE (1) PE20161443A1 (fr)
PH (1) PH12016501307A1 (fr)
SG (1) SG11201605342UA (fr)
UA (1) UA118369C2 (fr)
WO (1) WO2015113452A1 (fr)

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CN105153131B (zh) * 2015-09-21 2017-10-17 马彦丽 一种在护理上治疗人神经胶质瘤的药物组合物
CN105348270B (zh) * 2015-11-09 2018-01-09 吕显艳 一种防治牙体牙髓感染的药物组合物
WO2017087905A1 (fr) * 2015-11-20 2017-05-26 Denali Therapeutics Inc. Composés, compositions, et procédés
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CN105418616B (zh) * 2015-12-26 2018-01-12 山东大学 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
IL299415B2 (en) 2016-06-16 2025-09-01 Denali Therapeutics Inc Pyrimidine-2-ylamino-1H-pyrazoles as LRRK2 inhibitors for use in the treatment of neurodegenerative disorders
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AU2018239798B2 (en) * 2017-03-23 2020-08-27 Daegu Gyeongbuk Institute Of Science And Technology Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
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CN108715834B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种富含cd41+、cd81+微囊的血小板裂解液制备方法
WO2020036437A1 (fr) * 2018-08-16 2020-02-20 재단법인 대구경북첨단의료산업진흥재단 Dérivé hétéroaryle substitué, son procédé de production, et composition pharmaceutique destinée à prévenir ou à traiter des maladies liées à la protéine kinase le contenant en tant que principe actif
EP3856188B1 (fr) * 2018-09-25 2023-06-21 Cardurion Pharmaceuticals, Inc. Composé d'aminopyrimidine
CA3168211A1 (fr) 2019-01-18 2020-07-23 Voronoi Co., Ltd. Derive de pyrrolopyridine et son utilisation dans la prevention et le traitement d'une maladie liee a la proteine kinase
CZ308800B6 (cs) * 2019-02-12 2021-05-26 Univerzita Palackého v Olomouci Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci
CN114426542B (zh) * 2020-10-29 2023-06-30 苏州亚宝药物研发有限公司 取代的二芳基胺化合物及其药物组合物、制备方法和用途
CA3195193A1 (fr) 2020-10-29 2022-05-05 Peter H. Fuller Amides isoquinoline lies a n en tant qu'inhibiteurs de lrrk2, compositions pharmaceutiques et utilisations associees
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Also Published As

Publication number Publication date
US10618901B2 (en) 2020-04-14
CN105940004B (zh) 2018-02-02
DOP2019000010A (es) 2019-03-15
CA2937431A1 (fr) 2015-08-06
EP3099695B1 (fr) 2020-04-08
AU2018200277B2 (en) 2019-09-26
MX367370B (es) 2019-08-16
US10087186B2 (en) 2018-10-02
EP3099695A1 (fr) 2016-12-07
DOP2016000195A (es) 2016-10-31
AU2018200277A1 (en) 2018-02-01
CN105940004A (zh) 2016-09-14
JP6422986B2 (ja) 2018-11-14
CL2016001895A1 (es) 2016-12-09
EA029774B1 (ru) 2018-05-31
UA118369C2 (uk) 2019-01-10
PH12016501307B1 (en) 2016-08-15
CR20160348A (es) 2017-04-28
SG11201605342UA (en) 2016-08-30
PE20161443A1 (es) 2017-01-06
US20170015668A1 (en) 2017-01-19
MA39219B1 (fr) 2018-11-30
PH12016501307A1 (en) 2016-08-15
WO2015113452A1 (fr) 2015-08-06
EA201691514A1 (ru) 2016-12-30
IL246579B (en) 2019-05-30
EP3099695A4 (fr) 2017-07-12
ES2802174T3 (es) 2021-01-15
MX2016009893A (es) 2016-10-31
US20180354956A1 (en) 2018-12-13
AU2015210593A1 (en) 2016-07-07
KR20160106622A (ko) 2016-09-12
JP2017504631A (ja) 2017-02-09
IL246579A0 (en) 2016-08-31

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