MA39952A - Programme de traitement pour composé de tiacumicin - Google Patents

Programme de traitement pour composé de tiacumicin

Info

Publication number
MA39952A
MA39952A MA039952A MA39952A MA39952A MA 39952 A MA39952 A MA 39952A MA 039952 A MA039952 A MA 039952A MA 39952 A MA39952 A MA 39952A MA 39952 A MA39952 A MA 39952A
Authority
MA
Morocco
Prior art keywords
days
tiacumicin compound
clostridium difficile
tiacumicin
administration
Prior art date
Application number
MA039952A
Other languages
English (en)
Other versions
MA39952B1 (fr
Inventor
Andreas Johannis Karas
Christopher Mark Longshaw
Original Assignee
Astellas Pharma Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Europe Ltd filed Critical Astellas Pharma Europe Ltd
Publication of MA39952A publication Critical patent/MA39952A/fr
Publication of MA39952B1 publication Critical patent/MA39952B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne un composé de tiacumicine, un stéréoisomère, un polymorphe ou un solvate pharmaceutiquement acceptable de celui-ci, et une composition pharmaceutique contenant un composé de tiacumicine, un stéréoisomère, un polymorphe ou un solvate pharmaceutiquement acceptable de celui-ci. Dans le traitement oral d'infections à clostridium difficile (cdi) ou de diarrhée ou maladie associée à clostridium difficile (cda) chez un patient conformément à un schéma posologique choisi dans le groupe comprenant: i. Administration de 200 mg du composé de tiacumicine bid pendant 5 jours suivis de 5 jours de repos, puis de 200 mg une fois par jour pendant 10 jours supplémentaires et ii. Administration de 200 mg du composé de tiacumicine bid pendant 5 jours, suivie d’une dose unique de 200 mg tous les deux jours pendant 20 jours. En outre, la présente invention concerne un procédé permettant de récupérer une population intestinale de bifidobactéries chez un patient souffrant d’infections à clostridium difficile (cdi) ou de diarrhée ou maladie associée à clostridium difficile (cd ad) et à recevoir un traitement par voie orale avec un composé de tiacumicine jusqu'à 50 à 90% des cas. La population intestinale de bifidobactéries avant l'administration du composé de tiacumicine pendant les jours 15 à 45 après le début du traitement, en administrant par voie orale le composé de tiacumicine au patient selon un schéma posologique choisi dans le groupe susmentionné.
MA39952A 2014-05-09 2015-05-11 Programme de traitement pour composé de tiacumicin MA39952B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14075031 2014-05-09
PCT/EP2015/000965 WO2015169451A1 (fr) 2014-05-09 2015-05-11 Composé de tiacumicine et régime de traitement associé
EP15731245.5A EP3139932B1 (fr) 2014-05-09 2015-05-11 Programme de traitement pour composé de tiacumicin

Publications (2)

Publication Number Publication Date
MA39952A true MA39952A (fr) 2017-03-15
MA39952B1 MA39952B1 (fr) 2018-12-31

Family

ID=50771031

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39952A MA39952B1 (fr) 2014-05-09 2015-05-11 Programme de traitement pour composé de tiacumicin

Country Status (23)

Country Link
US (1) US10137141B2 (fr)
EP (1) EP3139932B1 (fr)
JP (1) JP6579662B2 (fr)
KR (1) KR20160149288A (fr)
AU (1) AU2015258130B2 (fr)
CA (1) CA2948400A1 (fr)
CY (1) CY1120847T1 (fr)
DK (1) DK3139932T3 (fr)
EA (1) EA031756B1 (fr)
ES (1) ES2694028T3 (fr)
GE (2) GEP20186872B (fr)
HR (1) HRP20181756T1 (fr)
IL (1) IL248782B (fr)
LT (1) LT3139932T (fr)
MA (1) MA39952B1 (fr)
MD (1) MD4695C1 (fr)
PL (1) PL3139932T3 (fr)
PT (1) PT3139932T (fr)
RS (1) RS57994B1 (fr)
SI (1) SI3139932T1 (fr)
TR (1) TR201815891T4 (fr)
UA (1) UA122203C2 (fr)
WO (1) WO2015169451A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016289307A1 (en) * 2015-07-03 2018-01-18 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918174A (en) 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5583115A (en) 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
JP2005534332A (ja) 2002-07-29 2005-11-17 オプティマー ファーマシューティカルズ、インコーポレイテッド チアクマイシン生産
WO2006085838A1 (fr) 2005-01-31 2006-08-17 Optimer Pharmaceuticals, Inc. Macrocycles a 18 chainons et leurs analogues
PT2305245T (pt) * 2004-05-14 2019-03-19 Merck Sharp & Dohme Tratamento de doenças associadas com a utilização de antibióticos
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
CN102030791B (zh) 2010-10-28 2013-01-23 中国科学院南海海洋研究所 四种台勾霉素类化合物及其制备方法和在制备抗菌药物中的应用
CN102115757B (zh) 2010-12-14 2015-10-28 中国科学院南海海洋研究所 台勾霉素的生物合成基因簇及其应用
US20150157653A1 (en) 2012-03-16 2015-06-11 Optimer Pharmaceuticals, Inc. Prevention of Clostridium Difficile Infection in High Risk Patients
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين

Also Published As

Publication number Publication date
IL248782B (en) 2020-08-31
TR201815891T4 (tr) 2018-11-21
IL248782A0 (en) 2017-01-31
KR20160149288A (ko) 2016-12-27
MD20160131A2 (ro) 2017-05-31
CY1120847T1 (el) 2019-12-11
JP6579662B2 (ja) 2019-09-25
LT3139932T (lt) 2018-11-12
RS57994B1 (sr) 2019-01-31
AU2015258130A1 (en) 2016-12-15
WO2015169451A1 (fr) 2015-11-12
DK3139932T3 (en) 2018-11-12
PL3139932T3 (pl) 2019-02-28
SI3139932T1 (sl) 2018-12-31
PT3139932T (pt) 2018-11-14
ES2694028T3 (es) 2018-12-17
MD4695B1 (ro) 2020-05-31
US20170143750A1 (en) 2017-05-25
EP3139932A1 (fr) 2017-03-15
HRP20181756T1 (hr) 2018-12-28
JP2017514880A (ja) 2017-06-08
GEAP201814327A (en) 2018-02-26
MA39952B1 (fr) 2018-12-31
EA031756B1 (ru) 2019-02-28
UA122203C2 (uk) 2020-10-12
MD4695C1 (ro) 2021-02-28
US10137141B2 (en) 2018-11-27
CA2948400A1 (fr) 2015-11-12
EP3139932B1 (fr) 2018-08-01
GEP20186872B (en) 2018-06-25
AU2015258130B2 (en) 2019-10-31
EA201692107A1 (ru) 2017-04-28

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