MA39959A - Procédé de production de cellules progénitrices de foie adulte - Google Patents

Procédé de production de cellules progénitrices de foie adulte

Info

Publication number
MA39959A
MA39959A MA039959A MA39959A MA39959A MA 39959 A MA39959 A MA 39959A MA 039959 A MA039959 A MA 039959A MA 39959 A MA39959 A MA 39959A MA 39959 A MA39959 A MA 39959A
Authority
MA
Morocco
Prior art keywords
cells
progenitor cells
adult liver
liver progenitor
producing
Prior art date
Application number
MA039959A
Other languages
English (en)
Inventor
Tuba Baran
Luca Falciola
Kris Gellynck
Sarah Snykers
Etienne Sokal
Original Assignee
Promethera Biosciences S A /N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/068317 external-priority patent/WO2015028577A1/fr
Application filed by Promethera Biosciences S A /N V filed Critical Promethera Biosciences S A /N V
Publication of MA39959A publication Critical patent/MA39959A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)

Abstract

De nouvelles cellules progénitrices de foie adulte (appelées cellules souches h2) ont été caractérisées sur la base d'une série d'activités et de marqueurs biologiques. Des procédés de production de cellules souches h2 permettent d'obtenir ces cellules sous la forme de cellules adhérentes et de grappes de cellules tridimensionnelles en suspension qui peuvent être différenciées en cellules présentant de fortes activités spécifiques au foie et/ou qui peuvent être utilisées pour traiter des maladies hépatiques ou pour évaluer l'efficacité, le métabolisme et/ou la toxicité d'un composé.
MA039959A 2014-08-28 2015-08-28 Procédé de production de cellules progénitrices de foie adulte MA39959A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2014/068317 WO2015028577A1 (fr) 2013-08-28 2014-08-28 Procédé de production de cellules progénitrices de foie adulte
EP15157664 2015-03-04

Publications (1)

Publication Number Publication Date
MA39959A true MA39959A (fr) 2017-03-15

Family

ID=52705967

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039959A MA39959A (fr) 2014-08-28 2015-08-28 Procédé de production de cellules progénitrices de foie adulte

Country Status (21)

Country Link
US (2) US10538741B2 (fr)
EP (1) EP3140393B1 (fr)
JP (2) JP2017530697A (fr)
KR (2) KR102101060B1 (fr)
CN (1) CN106795489B (fr)
AU (1) AU2015308341B2 (fr)
BR (1) BR112017003996A2 (fr)
CA (1) CA2958851C (fr)
DK (1) DK3140393T3 (fr)
EA (1) EA035214B1 (fr)
ES (1) ES2954834T3 (fr)
FI (1) FI3140393T3 (fr)
IL (1) IL249232B (fr)
LT (1) LT3140393T (fr)
MA (1) MA39959A (fr)
MX (1) MX375678B (fr)
PL (1) PL3140393T3 (fr)
PT (1) PT3140393T (fr)
SA (1) SA517380984B1 (fr)
SG (1) SG11201701109WA (fr)
WO (1) WO2016030525A1 (fr)

Families Citing this family (35)

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WO2011140441A2 (fr) 2010-05-06 2011-11-10 Children's Hospital Medical Center Procédés et systèmes de conversion de cellules précurseurs en tissus intestinaux par différenciation dirigée
CN105658786B (zh) 2013-08-28 2020-07-03 普罗米迪拉生物科学公司 用于生产成人肝脏祖细胞的方法
EP3712254A1 (fr) 2014-05-28 2020-09-23 Children's Hospital Medical Center Procédés et systèmes de conversion de cellules précurseurs dans des tissus gastriques à travers la différenciation dirigée
PL3140393T3 (pl) * 2014-08-28 2023-11-06 Cellaïon SA Sposób wytwarzania komórek progenitorowych dorosłej wątroby
CA2963704A1 (fr) 2014-10-17 2016-04-21 Children's Hospital Medical Center Modele in vivo d'intestin grele humain faisant intervenir des cellules souches pluripotentes et ses procedes de fabrication et d'utilisation
EP4177335A1 (fr) 2016-05-05 2023-05-10 Children's Hospital Medical Center Procédés de fabrication in vitro de tissu de fundus d'estomac et compositions associées à celui-ci
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
EP3548507A4 (fr) 2016-12-05 2020-07-15 Children's Hospital Medical Center Organoïdes du côlon et leurs procédés de préparation et d'utilisation
EP3609997A4 (fr) 2017-04-14 2021-03-03 Children's Hospital Medical Center Compositions de cellules souches issues de multiples cellules donneuses et leurs procédés de préparation
CA3075475A1 (fr) * 2017-09-12 2019-03-21 Beth Israel Deaconess Medical Center, Inc. Compositions et methodes permettant de traiter une maladie hepatique et un dysfonctionnement hepatique
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (fr) 2017-12-21 2021-09-08 Children's Hospital Medical Center Organoïdes humains numérisés et méthodes d'utilisation de ceux-ci
EP3794107B1 (fr) * 2018-05-16 2026-04-29 Institut National de la Santé et de la Recherche Médicale (INSERM) Procédé de culture d'hépatocytes proliférants
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
KR102107057B1 (ko) * 2018-09-21 2020-05-07 오가노이드사이언스 주식회사 간 유래 줄기세포를 포함하는 간 오가노이드의 제조방법 및 이의 용도
CN117802031A (zh) * 2018-09-30 2024-04-02 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
AU2019398753A1 (en) 2018-12-14 2021-08-05 Promethera Therapeutics Sa Cell composition comprising liver progenitor cells expressing HLA-E
WO2020120666A1 (fr) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Cellules progénitrices hépatiques exprimant hla-g, et procédé d'obtention de ces compositions de cellules comprenant lesdites cellules et leur utilisation
WO2020160371A1 (fr) 2019-02-01 2020-08-06 The University Of Hong Kong Compositions d'organoïdes innervés et leurs procédés de fabrication
WO2020193715A1 (fr) 2019-03-26 2020-10-01 Promethera Biosciences S.A./N.V. Cellules progénitrices du foie adulte pour le traitement d'une stéatose hépatique non alcoolique
JP7452934B2 (ja) * 2019-03-26 2024-03-19 セライオン エスエイ 慢性肝不全の急性憎悪の治療のための成人肝前駆細胞
US20220220445A1 (en) 2019-04-30 2022-07-14 Promethera Therapeutics Sa Preparation of human allogeneic liver-derived progenitor cells
CN113939585A (zh) * 2019-04-30 2022-01-14 普罗米瑟拉疗法公司 人同种异体肝源性祖细胞的制备
CA3141814A1 (fr) 2019-05-31 2020-12-03 Children's Hospital Medical Center Compositions organoides faconnees et leurs procedes de fabrication
CN114174494A (zh) 2019-05-31 2022-03-11 儿童医院医学中心 产生和扩增造血干细胞的方法
CN110179970A (zh) * 2019-07-05 2019-08-30 浙江大学 Il-1r2细胞因子在制备治疗肝功能衰竭药剂中的应用
JP2022551293A (ja) 2019-10-09 2022-12-08 セライオン エスアー 血管透過性亢進を特徴とする疾患における肝臓前駆細胞または幹細胞、その溶解物、および／または馴化培地の使用
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
EP3881853A1 (fr) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Cellules progénitrices allogéniques humaines dérivées du foie à utiliser dans le traitement des maladies pulmonaires inflammatoires et infectieuses et de l'inflammation systémique
US12605496B2 (en) 2020-06-26 2026-04-21 Ykrita Lifesciences Private Limited Bioengineered artificial lateral liver (BALL) or bioengineered artificial ectopic liver (BAEL)
WO2023180122A1 (fr) 2022-03-24 2023-09-28 Université Catholique de Louvain Utilisation de cellules progénitrices allogéniques humaines dérivées du foie pour traiter et/ou prévenir la sénescence cellulaire
WO2024200809A1 (fr) 2023-03-31 2024-10-03 Université Catholique de Louvain Utilisation de cellules progénitrices allogéniques humaines dérivées du foie pour traiter et/ou prévenir le carcinome hépatocellulaire
EP4560009A1 (fr) 2023-11-27 2025-05-28 Cellaïon SA Procédé de préparation de cellules isolées dérivées du foie
CN120192915B (zh) * 2025-05-23 2025-09-02 淇嘉科技(苏州)有限公司 多谱系肝类器官代谢性成熟方法及应用

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ATE498005T1 (de) * 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
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DK3016665T3 (da) * 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
CN105658786B (zh) 2013-08-28 2020-07-03 普罗米迪拉生物科学公司 用于生产成人肝脏祖细胞的方法
PL3140393T3 (pl) * 2014-08-28 2023-11-06 Cellaïon SA Sposób wytwarzania komórek progenitorowych dorosłej wątroby

Also Published As

Publication number Publication date
FI3140393T3 (fi) 2023-09-07
CA2958851C (fr) 2023-05-09
KR20190003833A (ko) 2019-01-09
US20170240863A1 (en) 2017-08-24
EP3140393A1 (fr) 2017-03-15
CN106795489B (zh) 2021-07-06
SA517380984B1 (ar) 2022-02-14
MX375678B (es) 2025-03-06
PT3140393T (pt) 2023-09-04
US11339373B2 (en) 2022-05-24
EP3140393B1 (fr) 2023-06-14
US20200095554A1 (en) 2020-03-26
AU2015308341A1 (en) 2017-03-02
KR102101060B1 (ko) 2020-04-16
US10538741B2 (en) 2020-01-21
IL249232B (en) 2020-04-30
SG11201701109WA (en) 2017-03-30
PL3140393T3 (pl) 2023-11-06
JP2020127423A (ja) 2020-08-27
EA201790357A1 (ru) 2017-08-31
LT3140393T (lt) 2023-09-11
AU2015308341B2 (en) 2021-09-16
KR20170002664A (ko) 2017-01-06
ES2954834T3 (es) 2023-11-27
JP2017530697A (ja) 2017-10-19
CN106795489A (zh) 2017-05-31
EA035214B1 (ru) 2020-05-18
DK3140393T3 (da) 2023-09-18
CA2958851A1 (fr) 2016-03-03
MX2017002667A (es) 2017-10-02
IL249232A0 (en) 2017-02-28
WO2016030525A1 (fr) 2016-03-03
BR112017003996A2 (pt) 2017-12-12

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