MX2017002667A - Metodo para producir celulas progenitoras hepaticas adultas. - Google Patents

Metodo para producir celulas progenitoras hepaticas adultas.

Info

Publication number
MX2017002667A
MX2017002667A MX2017002667A MX2017002667A MX2017002667A MX 2017002667 A MX2017002667 A MX 2017002667A MX 2017002667 A MX2017002667 A MX 2017002667A MX 2017002667 A MX2017002667 A MX 2017002667A MX 2017002667 A MX2017002667 A MX 2017002667A
Authority
MX
Mexico
Prior art keywords
cells
progeniting
adult hepatic
produce adult
h2stem
Prior art date
Application number
MX2017002667A
Other languages
English (en)
Other versions
MX375678B (es
Inventor
Sokal Etienne
Snykers Sarah
BARAN Tuba
Gellynck Kris
Falciola Luca
Original Assignee
Promethera Biosciences S A/N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/068317 external-priority patent/WO2015028577A1/en
Application filed by Promethera Biosciences S A/N V filed Critical Promethera Biosciences S A/N V
Publication of MX2017002667A publication Critical patent/MX2017002667A/es
Publication of MX375678B publication Critical patent/MX375678B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)

Abstract

La presente invención se refiere a novedosas células progenitoras hepáticas adultas (denominadas Células H2Stem), que han sido caracterizadas con base en una serie de actividades y marcadores biológicos. Los métodos de producción de células H2Stem permiten proporcionar dichas células en forma de células adherentes y en cúmulos de células tridimensionales en suspensión, que pueden ser diferenciadas en células con una fuerte actividad específica del hígado y/o que se pueden usar para el tratamiento de enfermedades hepáticas o para la evaluación de la eficacia, metabolismo y/o toxicidad de un compuesto.
MX2017002667A 2014-08-28 2015-08-28 Metodo para producir celulas progenitoras hepaticas adultas. MX375678B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2014/068317 WO2015028577A1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells
EP15157664 2015-03-04
PCT/EP2015/069786 WO2016030525A1 (en) 2014-08-28 2015-08-28 Method for producing adult liver progenitor cells

Publications (2)

Publication Number Publication Date
MX2017002667A true MX2017002667A (es) 2017-10-02
MX375678B MX375678B (es) 2025-03-06

Family

ID=52705967

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002667A MX375678B (es) 2014-08-28 2015-08-28 Metodo para producir celulas progenitoras hepaticas adultas.

Country Status (21)

Country Link
US (2) US10538741B2 (es)
EP (1) EP3140393B1 (es)
JP (2) JP2017530697A (es)
KR (2) KR102101060B1 (es)
CN (1) CN106795489B (es)
AU (1) AU2015308341B2 (es)
BR (1) BR112017003996A2 (es)
CA (1) CA2958851C (es)
DK (1) DK3140393T3 (es)
EA (1) EA035214B1 (es)
ES (1) ES2954834T3 (es)
FI (1) FI3140393T3 (es)
IL (1) IL249232B (es)
LT (1) LT3140393T (es)
MA (1) MA39959A (es)
MX (1) MX375678B (es)
PL (1) PL3140393T3 (es)
PT (1) PT3140393T (es)
SA (1) SA517380984B1 (es)
SG (1) SG11201701109WA (es)
WO (1) WO2016030525A1 (es)

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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2764408T3 (es) 2013-08-28 2020-06-03 Promethera Biosciences S A / N V Procedimiento para la producción de células progenitoras hepáticas adultas
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
KR102101060B1 (ko) 2014-08-28 2020-04-16 프로메테라 바이오사이언시즈 에스.에이./엔.브이. 성체 간 전구 세포의 제조 방법
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
WO2019055345A1 (en) * 2017-09-12 2019-03-21 Beth Israel Deaconess Medical Center, Inc. COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE AND HEPATIC DYSFUNCTION
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
JP7530886B2 (ja) * 2018-05-16 2024-08-08 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 増殖性肝細胞を培養する方法
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
KR102107057B1 (ko) * 2018-09-21 2020-05-07 오가노이드사이언스 주식회사 간 유래 줄기세포를 포함하는 간 오가노이드의 제조방법 및 이의 용도
CN110982776B (zh) * 2018-09-30 2023-07-04 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
TW202043463A (zh) 2018-12-14 2020-12-01 比利時商普羅米修亞生物科技股份有限公司 包含表現hla-e之肝先驅細胞之細胞組成物
TW202035682A (zh) 2018-12-14 2020-10-01 比利時商普羅米修亞生物科技股份有限公司 表現hla-g之肝先驅細胞及取得包含該等細胞之此等細胞組成物之方法與其用途
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020245045A1 (en) * 2019-03-26 2021-11-18 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
WO2020193715A1 (en) 2019-03-26 2020-10-01 Promethera Biosciences S.A./N.V. Adult liver progenitor cells for treating non-alcoholic fatty liver disease
JP2022530620A (ja) * 2019-04-30 2022-06-30 プロメセラ セラピューティクス エスエイ ヒト同種肝臓由来前駆細胞の調製
TW202106874A (zh) 2019-04-30 2021-02-16 比利時商普羅米修亞生物科技股份有限公司 人類同種異體肝衍生前驅細胞的製備(一)
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN110179970A (zh) * 2019-07-05 2019-08-30 浙江大学 Il-1r2细胞因子在制备治疗肝功能衰竭药剂中的应用
JP2022551293A (ja) 2019-10-09 2022-12-08 セライオン エスアー 血管透過性亢進を特徴とする疾患における肝臓前駆細胞または幹細胞、その溶解物、および／または馴化培地の使用
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
WO2021260735A1 (en) * 2020-06-26 2021-12-30 Ykrita Lifesciences Private Limited Bioengineered artificial lateral liver (ball) or bioengineered artificial ectopic liver (bael)
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CN120192915B (zh) * 2025-05-23 2025-09-02 淇嘉科技(苏州)有限公司 多谱系肝类器官代谢性成熟方法及应用

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ES2764408T3 (es) * 2013-08-28 2020-06-03 Promethera Biosciences S A / N V Procedimiento para la producción de células progenitoras hepáticas adultas
KR102101060B1 (ko) 2014-08-28 2020-04-16 프로메테라 바이오사이언시즈 에스.에이./엔.브이. 성체 간 전구 세포의 제조 방법

Also Published As

Publication number Publication date
CN106795489A (zh) 2017-05-31
CA2958851A1 (en) 2016-03-03
EP3140393B1 (en) 2023-06-14
IL249232B (en) 2020-04-30
US10538741B2 (en) 2020-01-21
US20170240863A1 (en) 2017-08-24
CA2958851C (en) 2023-05-09
SG11201701109WA (en) 2017-03-30
EA035214B1 (ru) 2020-05-18
JP2017530697A (ja) 2017-10-19
DK3140393T3 (da) 2023-09-18
PL3140393T3 (pl) 2023-11-06
MA39959A (fr) 2017-03-15
MX375678B (es) 2025-03-06
AU2015308341A1 (en) 2017-03-02
PT3140393T (pt) 2023-09-04
US20200095554A1 (en) 2020-03-26
EA201790357A1 (ru) 2017-08-31
SA517380984B1 (ar) 2022-02-14
US11339373B2 (en) 2022-05-24
IL249232A0 (en) 2017-02-28
EP3140393A1 (en) 2017-03-15
KR20190003833A (ko) 2019-01-09
JP2020127423A (ja) 2020-08-27
ES2954834T3 (es) 2023-11-27
CN106795489B (zh) 2021-07-06
AU2015308341B2 (en) 2021-09-16
FI3140393T3 (fi) 2023-09-07
WO2016030525A1 (en) 2016-03-03
KR20170002664A (ko) 2017-01-06
BR112017003996A2 (pt) 2017-12-12
LT3140393T (lt) 2023-09-11
KR102101060B1 (ko) 2020-04-16

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