DK3140393T3 - Fremstillingsmetode for voksne leverstamceller - Google Patents

Fremstillingsmetode for voksne leverstamceller Download PDF

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Publication number
DK3140393T3
DK3140393T3 DK15759717.0T DK15759717T DK3140393T3 DK 3140393 T3 DK3140393 T3 DK 3140393T3 DK 15759717 T DK15759717 T DK 15759717T DK 3140393 T3 DK3140393 T3 DK 3140393T3
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DK
Denmark
Prior art keywords
stem cells
production method
adult liver
liver stem
adult
Prior art date
Application number
DK15759717.0T
Other languages
English (en)
Inventor
Etienne Sokal
Sarah Snykers
Tuba Baran
Kris Gellynck
Luca Falciola
Original Assignee
Cellaion Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/068317 external-priority patent/WO2015028577A1/en
Application filed by Cellaion Sa filed Critical Cellaion Sa
Application granted granted Critical
Publication of DK3140393T3 publication Critical patent/DK3140393T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
DK15759717.0T 2014-08-28 2015-08-28 Fremstillingsmetode for voksne leverstamceller DK3140393T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2014/068317 WO2015028577A1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells
EP15157664 2015-03-04
PCT/EP2015/069786 WO2016030525A1 (en) 2014-08-28 2015-08-28 Method for producing adult liver progenitor cells

Publications (1)

Publication Number Publication Date
DK3140393T3 true DK3140393T3 (da) 2023-09-18

Family

ID=52705967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15759717.0T DK3140393T3 (da) 2014-08-28 2015-08-28 Fremstillingsmetode for voksne leverstamceller

Country Status (21)

Country Link
US (2) US10538741B2 (da)
EP (1) EP3140393B1 (da)
JP (2) JP2017530697A (da)
KR (2) KR102101060B1 (da)
CN (1) CN106795489B (da)
AU (1) AU2015308341B2 (da)
BR (1) BR112017003996A2 (da)
CA (1) CA2958851C (da)
DK (1) DK3140393T3 (da)
EA (1) EA035214B1 (da)
ES (1) ES2954834T3 (da)
FI (1) FI3140393T3 (da)
IL (1) IL249232B (da)
LT (1) LT3140393T (da)
MA (1) MA39959A (da)
MX (1) MX375678B (da)
PL (1) PL3140393T3 (da)
PT (1) PT3140393T (da)
SA (1) SA517380984B1 (da)
SG (1) SG11201701109WA (da)
WO (1) WO2016030525A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CN105658786B (zh) 2013-08-28 2020-07-03 普罗米迪拉生物科学公司 用于生产成人肝脏祖细胞的方法
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
PL3140393T3 (pl) * 2014-08-28 2023-11-06 Cellaïon SA Sposób wytwarzania komórek progenitorowych dorosłej wątroby
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
CA3075475A1 (en) * 2017-09-12 2019-03-21 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating liver disease and dysfunction
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP3794107B1 (en) * 2018-05-16 2026-04-29 Institut National de la Santé et de la Recherche Médicale (INSERM) Method of culturing proliferative hepatocytes
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
KR102107057B1 (ko) * 2018-09-21 2020-05-07 오가노이드사이언스 주식회사 간 유래 줄기세포를 포함하는 간 오가노이드의 제조방법 및 이의 용도
CN117802031A (zh) * 2018-09-30 2024-04-02 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
AU2019398753A1 (en) 2018-12-14 2021-08-05 Promethera Therapeutics Sa Cell composition comprising liver progenitor cells expressing HLA-E
WO2020120666A1 (en) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Liver progenitor cells expressing hla-g, and method for obtaining these cells compositions comprising said cells and their use
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020193715A1 (en) 2019-03-26 2020-10-01 Promethera Biosciences S.A./N.V. Adult liver progenitor cells for treating non-alcoholic fatty liver disease
JP7452934B2 (ja) * 2019-03-26 2024-03-19 セライオン エスエイ 慢性肝不全の急性憎悪の治療のための成人肝前駆細胞
US20220220445A1 (en) 2019-04-30 2022-07-14 Promethera Therapeutics Sa Preparation of human allogeneic liver-derived progenitor cells
CN113939585A (zh) * 2019-04-30 2022-01-14 普罗米瑟拉疗法公司 人同种异体肝源性祖细胞的制备
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN114174494A (zh) 2019-05-31 2022-03-11 儿童医院医学中心 产生和扩增造血干细胞的方法
CN110179970A (zh) * 2019-07-05 2019-08-30 浙江大学 Il-1r2细胞因子在制备治疗肝功能衰竭药剂中的应用
JP2022551293A (ja) 2019-10-09 2022-12-08 セライオン エスアー 血管透過性亢進を特徴とする疾患における肝臓前駆細胞または幹細胞、その溶解物、および／または馴化培地の使用
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
US12605496B2 (en) 2020-06-26 2026-04-21 Ykrita Lifesciences Private Limited Bioengineered artificial lateral liver (BALL) or bioengineered artificial ectopic liver (BAEL)
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence
WO2024200809A1 (en) 2023-03-31 2024-10-03 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma
EP4560009A1 (en) 2023-11-27 2025-05-28 Cellaïon SA Method for the preparation of isolated liver-derived cells
CN120192915B (zh) * 2025-05-23 2025-09-02 淇嘉科技(苏州)有限公司 多谱系肝类器官代谢性成熟方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
JP2004510432A (ja) 2000-10-03 2004-04-08 ユニバーシティ　オブ　ノース　カロライナ 両能性肝前駆細胞の単離方法
SE527491C2 (sv) 2003-12-19 2006-03-21 Cmc Contrast Ab Kontraktsmedelskomposition för magnetisk resonanstomografi för oral administration
CN101356264B (zh) * 2005-12-21 2014-05-14 鲁汶大学 分离的肝脏干细胞
ATE498005T1 (de) * 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
US8415149B2 (en) * 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
DK3016665T3 (da) * 2013-07-05 2019-11-25 Univ Catholique Louvain Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
CN105658786B (zh) 2013-08-28 2020-07-03 普罗米迪拉生物科学公司 用于生产成人肝脏祖细胞的方法
PL3140393T3 (pl) * 2014-08-28 2023-11-06 Cellaïon SA Sposób wytwarzania komórek progenitorowych dorosłej wątroby

Also Published As

Publication number Publication date
FI3140393T3 (fi) 2023-09-07
CA2958851C (en) 2023-05-09
KR20190003833A (ko) 2019-01-09
US20170240863A1 (en) 2017-08-24
EP3140393A1 (en) 2017-03-15
CN106795489B (zh) 2021-07-06
MA39959A (fr) 2017-03-15
SA517380984B1 (ar) 2022-02-14
MX375678B (es) 2025-03-06
PT3140393T (pt) 2023-09-04
US11339373B2 (en) 2022-05-24
EP3140393B1 (en) 2023-06-14
US20200095554A1 (en) 2020-03-26
AU2015308341A1 (en) 2017-03-02
KR102101060B1 (ko) 2020-04-16
US10538741B2 (en) 2020-01-21
IL249232B (en) 2020-04-30
SG11201701109WA (en) 2017-03-30
PL3140393T3 (pl) 2023-11-06
JP2020127423A (ja) 2020-08-27
EA201790357A1 (ru) 2017-08-31
LT3140393T (lt) 2023-09-11
AU2015308341B2 (en) 2021-09-16
KR20170002664A (ko) 2017-01-06
ES2954834T3 (es) 2023-11-27
JP2017530697A (ja) 2017-10-19
CN106795489A (zh) 2017-05-31
EA035214B1 (ru) 2020-05-18
CA2958851A1 (en) 2016-03-03
MX2017002667A (es) 2017-10-02
IL249232A0 (en) 2017-02-28
WO2016030525A1 (en) 2016-03-03
BR112017003996A2 (pt) 2017-12-12

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