DK3140393T3 - Fremstillingsmetode for voksne leverstamceller - Google Patents

Fremstillingsmetode for voksne leverstamceller Download PDF

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Publication number
DK3140393T3
DK3140393T3 DK15759717.0T DK15759717T DK3140393T3 DK 3140393 T3 DK3140393 T3 DK 3140393T3 DK 15759717 T DK15759717 T DK 15759717T DK 3140393 T3 DK3140393 T3 DK 3140393T3
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DK
Denmark
Prior art keywords
stem cells
production method
adult liver
liver stem
adult
Prior art date
Application number
DK15759717.0T
Other languages
English (en)
Inventor
Etienne Sokal
Sarah Snykers
Tuba Baran
Kris Gellynck
Luca Falciola
Original Assignee
Cellaion Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/068317 external-priority patent/WO2015028577A1/en
Application filed by Cellaion Sa filed Critical Cellaion Sa
Application granted granted Critical
Publication of DK3140393T3 publication Critical patent/DK3140393T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
DK15759717.0T 2014-08-28 2015-08-28 Fremstillingsmetode for voksne leverstamceller DK3140393T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2014/068317 WO2015028577A1 (en) 2013-08-28 2014-08-28 Method for producing adult liver progenitor cells
EP15157664 2015-03-04
PCT/EP2015/069786 WO2016030525A1 (en) 2014-08-28 2015-08-28 Method for producing adult liver progenitor cells

Publications (1)

Publication Number Publication Date
DK3140393T3 true DK3140393T3 (da) 2023-09-18

Family

ID=52705967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15759717.0T DK3140393T3 (da) 2014-08-28 2015-08-28 Fremstillingsmetode for voksne leverstamceller

Country Status (21)

Country Link
US (2) US10538741B2 (da)
EP (1) EP3140393B1 (da)
JP (2) JP2017530697A (da)
KR (2) KR20190003833A (da)
CN (1) CN106795489B (da)
AU (1) AU2015308341B2 (da)
BR (1) BR112017003996A2 (da)
CA (1) CA2958851C (da)
DK (1) DK3140393T3 (da)
EA (1) EA035214B1 (da)
ES (1) ES2954834T3 (da)
FI (1) FI3140393T3 (da)
IL (1) IL249232B (da)
LT (1) LT3140393T (da)
MA (1) MA39959A (da)
MX (1) MX375678B (da)
PL (1) PL3140393T3 (da)
PT (1) PT3140393T (da)
SA (1) SA517380984B1 (da)
SG (1) SG11201701109WA (da)
WO (1) WO2016030525A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
DK3039123T3 (da) 2013-08-28 2020-01-20 Promethera Biosciences S A / N V Fremgangsmåde til at fremstille voksne leverprogenitorceller
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
MA39959A (fr) 2014-08-28 2017-03-15 Promethera Biosciences S A /N V Procédé de production de cellules progénitrices de foie adulte
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
ES2929758T3 (es) 2016-05-05 2022-12-01 Childrens Hospital Med Ct Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
JP7068305B2 (ja) 2016-12-05 2022-05-16 チルドレンズ ホスピタル メディカル センター 結腸オルガノイドならびにその作製方法および使用方法
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
WO2019055345A1 (en) * 2017-09-12 2019-03-21 Beth Israel Deaconess Medical Center, Inc. COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE AND HEPATIC DYSFUNCTION
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
JP7530886B2 (ja) * 2018-05-16 2024-08-08 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 増殖性肝細胞を培養する方法
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
KR102107057B1 (ko) * 2018-09-21 2020-05-07 오가노이드사이언스 주식회사 간 유래 줄기세포를 포함하는 간 오가노이드의 제조방법 및 이의 용도
CN117802031A (zh) * 2018-09-30 2024-04-02 中国科学院分子细胞科学卓越创新中心 肝细胞的体外扩增培养方法及应用
TW202035682A (zh) 2018-12-14 2020-10-01 比利時商普羅米修亞生物科技股份有限公司 表現hla-g之肝先驅細胞及取得包含該等細胞之此等細胞組成物之方法與其用途
BR112021011273A2 (pt) 2018-12-14 2021-09-28 Promethera Therapeutics Sa Composição celular que compreende células progenitoras do fígado que expressam hla-e
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020193715A1 (en) 2019-03-26 2020-10-01 Promethera Biosciences S.A./N.V. Adult liver progenitor cells for treating non-alcoholic fatty liver disease
EP3947644A1 (en) * 2019-03-26 2022-02-09 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
US20220220445A1 (en) 2019-04-30 2022-07-14 Promethera Therapeutics Sa Preparation of human allogeneic liver-derived progenitor cells
DK3963050T3 (da) * 2019-04-30 2023-12-11 Cellaion Sa Forberedelse af humane allogene leverderiverede progenitorceller
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN110179970A (zh) * 2019-07-05 2019-08-30 浙江大学 Il-1r2细胞因子在制备治疗肝功能衰竭药剂中的应用
US20230256027A1 (en) 2019-10-09 2023-08-17 Cellaïon SA Use of Liver Progenitor or Stem Cells, Lysates Thereof, and/or Conditioned Medium in Disorders Characterized by Vascular Hyperpermeability
CN111206013A (zh) * 2020-02-13 2020-05-29 上海交通大学医学院附属仁济医院 一种长时间维持人原代肝细胞的功能状态的培养方法
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
WO2021260735A1 (en) * 2020-06-26 2021-12-30 Ykrita Lifesciences Private Limited Bioengineered artificial lateral liver (ball) or bioengineered artificial ectopic liver (bael)
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence
WO2024200809A1 (en) 2023-03-31 2024-10-03 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma
EP4560009A1 (en) 2023-11-27 2025-05-28 Cellaïon SA Method for the preparation of isolated liver-derived cells
CN120192915B (zh) * 2025-05-23 2025-09-02 淇嘉科技(苏州)有限公司 多谱系肝类器官代谢性成熟方法及应用

Family Cites Families (10)

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US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
WO2002028997A2 (en) 2000-10-03 2002-04-11 University Of North Carolina Methods of isolating bipotent hepatic progenitor cells
SE527491C2 (sv) 2003-12-19 2006-03-21 Cmc Contrast Ab Kontraktsmedelskomposition för magnetisk resonanstomografi för oral administration
ATE498005T1 (de) * 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
CN101356264B (zh) * 2005-12-21 2014-05-14 鲁汶大学 分离的肝脏干细胞
US8415149B2 (en) * 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
ES2759228T3 (es) * 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
DK3039123T3 (da) 2013-08-28 2020-01-20 Promethera Biosciences S A / N V Fremgangsmåde til at fremstille voksne leverprogenitorceller
MA39959A (fr) * 2014-08-28 2017-03-15 Promethera Biosciences S A /N V Procédé de production de cellules progénitrices de foie adulte

Also Published As

Publication number Publication date
MX2017002667A (es) 2017-10-02
KR20170002664A (ko) 2017-01-06
IL249232A0 (en) 2017-02-28
PL3140393T3 (pl) 2023-11-06
PT3140393T (pt) 2023-09-04
BR112017003996A2 (pt) 2017-12-12
EA035214B1 (ru) 2020-05-18
US10538741B2 (en) 2020-01-21
CN106795489B (zh) 2021-07-06
EP3140393A1 (en) 2017-03-15
EP3140393B1 (en) 2023-06-14
MX375678B (es) 2025-03-06
AU2015308341A1 (en) 2017-03-02
CA2958851A1 (en) 2016-03-03
WO2016030525A1 (en) 2016-03-03
FI3140393T3 (fi) 2023-09-07
SG11201701109WA (en) 2017-03-30
KR102101060B1 (ko) 2020-04-16
US20200095554A1 (en) 2020-03-26
CN106795489A (zh) 2017-05-31
US11339373B2 (en) 2022-05-24
AU2015308341B2 (en) 2021-09-16
JP2020127423A (ja) 2020-08-27
JP2017530697A (ja) 2017-10-19
IL249232B (en) 2020-04-30
US20170240863A1 (en) 2017-08-24
SA517380984B1 (ar) 2022-02-14
KR20190003833A (ko) 2019-01-09
MA39959A (fr) 2017-03-15
CA2958851C (en) 2023-05-09
LT3140393T (lt) 2023-09-11
ES2954834T3 (es) 2023-11-27
EA201790357A1 (ru) 2017-08-31

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