MA40067A - Sels de chlorhydrate de n-(cyanométhyl)-4-(2-(4-morpholinophénylamino)pyrimidin-4-yl)benzamide - Google Patents
Sels de chlorhydrate de n-(cyanométhyl)-4-(2-(4-morpholinophénylamino)pyrimidin-4-yl)benzamideInfo
- Publication number
- MA40067A MA40067A MA040067A MA40067A MA40067A MA 40067 A MA40067 A MA 40067A MA 040067 A MA040067 A MA 040067A MA 40067 A MA40067 A MA 40067A MA 40067 A MA40067 A MA 40067A
- Authority
- MA
- Morocco
- Prior art keywords
- morpholinophenylamino
- cyanomethyl
- pyrimidin
- benzamide hydrochloride
- hydrochloride salts
- Prior art date
Links
- NGOUSYFDVUVHDA-UHFFFAOYSA-N n-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide;hydrochloride Chemical class Cl.C1=CC(C(NCC#N)=O)=CC=C1C1=CC=NC(NC=2C=CC(=CC=2)N2CCOCC2)=N1 NGOUSYFDVUVHDA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne des nouvelles formes de sels stables de
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011315P | 2014-06-12 | 2014-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA40067A true MA40067A (fr) | 2015-12-17 |
Family
ID=53674249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA040067A MA40067A (fr) | 2014-06-12 | 2015-06-11 | Sels de chlorhydrate de n-(cyanométhyl)-4-(2-(4-morpholinophénylamino)pyrimidin-4-yl)benzamide |
Country Status (36)
| Country | Link |
|---|---|
| US (5) | US9469613B2 (fr) |
| EP (3) | EP3154950B1 (fr) |
| JP (5) | JP6600649B2 (fr) |
| KR (1) | KR101928225B1 (fr) |
| CN (2) | CN110627728A (fr) |
| AP (1) | AP2016009551A0 (fr) |
| AR (1) | AR100818A1 (fr) |
| AU (1) | AU2015274554B9 (fr) |
| BR (1) | BR112016028749A2 (fr) |
| CA (1) | CA2951883C (fr) |
| CR (1) | CR20160575A (fr) |
| CU (1) | CU20160183A7 (fr) |
| CY (2) | CY1123604T1 (fr) |
| DK (1) | DK3154950T3 (fr) |
| EA (1) | EA032639B1 (fr) |
| EC (1) | ECSP16093323A (fr) |
| ES (1) | ES2822773T3 (fr) |
| FI (1) | FIC20240025I1 (fr) |
| FR (1) | FR24C1030I2 (fr) |
| HR (1) | HRP20201492T1 (fr) |
| HU (2) | HUE051360T2 (fr) |
| IL (3) | IL249038B (fr) |
| LT (2) | LT3154950T (fr) |
| MA (1) | MA40067A (fr) |
| MX (3) | MX374541B (fr) |
| NL (1) | NL301282I2 (fr) |
| NZ (1) | NZ725966A (fr) |
| PH (1) | PH12016502461A1 (fr) |
| PL (1) | PL3154950T3 (fr) |
| PT (1) | PT3154950T (fr) |
| RS (1) | RS61065B1 (fr) |
| SG (2) | SG10201911925TA (fr) |
| SI (1) | SI3154950T1 (fr) |
| TW (3) | TWI729644B (fr) |
| UY (1) | UY36166A (fr) |
| WO (1) | WO2015191846A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI729644B (zh) * | 2014-06-12 | 2021-06-01 | 美商西爾拉癌症醫學公司 | N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺 |
| CN106316963B (zh) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| US10245268B2 (en) | 2016-08-10 | 2019-04-02 | Sierra Oncology, Inc. | Treatment of ACVR1-mediated diseases |
| JP7550393B2 (ja) * | 2018-05-15 | 2024-09-13 | ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド | 低分子ｅｇｆｒ阻害剤を含む医薬組成物及びその製造方法 |
| US11963962B2 (en) | 2018-08-21 | 2024-04-23 | Glaxosmithkline Llc | Platelet count-agnostic methods of treating myelofibrosis |
| WO2020167845A1 (fr) * | 2019-02-12 | 2020-08-20 | Impact Biomedicines, Inc. | Formes cristallines d'un inhibiteur de jak2 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| CA3177830A1 (fr) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anticorps anti-hemojuveline (hjv) pour le traitement de la myelofibrose |
| EP4376849A1 (fr) | 2021-07-30 | 2024-06-05 | GlaxoSmithKline LLC | Biomarqueur et sélection de patient dans le traitement de la myélofibrose |
| CN117794546A (zh) | 2021-08-10 | 2024-03-29 | 葛兰素史密斯克莱有限责任公司 | 莫洛替尼组合疗法 |
| WO2023023473A1 (fr) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Méthodes d'utilisation de momélotinib pour traiter une maladie rénale chronique |
| CN115957221B (zh) * | 2021-10-09 | 2026-01-06 | 广东东阳光药业股份有限公司 | 抗纤维化组合物 |
| WO2023152773A1 (fr) * | 2022-02-14 | 2023-08-17 | Dr. Reddy's Institute Of Life Sciences | Formes solides de sels de momélotinib et procédés améliorés pour la préparation de momélotinib |
| CN119704552B (zh) * | 2025-02-08 | 2025-06-13 | 泰州南洋塑料制品有限公司 | 一种电池槽注塑模具及边缘毛刺废料处理回收装置 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481932A (en) | 1967-09-01 | 1969-12-02 | Searle & Co | 2-anilino-5-methyl-6-phenylpyrimidines and congeners |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5120764A (en) | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| US5559714A (en) | 1990-10-22 | 1996-09-24 | Hallmark Cards, Incorporated | Method and apparatus for display sequencing personalized social occasion products |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| US6376531B1 (en) * | 1998-11-13 | 2002-04-23 | Rupert Charles Bell | Method of treatment using deuterium compounds |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| JP2004528295A (ja) | 2001-01-30 | 2004-09-16 | サイトピア ピーティワイ リミテッド | キナーゼ阻害方法 |
| EP1373257B9 (fr) | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de kinases n-terminales c-jun (jnk) et autres proteineskinases |
| FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
| JP2005511502A (ja) | 2001-09-12 | 2005-04-28 | ヴィレックス リサーチ インコーポレイテッド | 固定化した血小板結合剤を有する血管閉塞固相剤 |
| NZ537155A (en) | 2002-05-23 | 2006-09-29 | Cytopia Pty Ltd | Protein kinase inhibitors |
| EP1546117A2 (fr) | 2002-08-14 | 2005-06-29 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la proteine kinase et leurs utilisations |
| AU2003286876A1 (en) | 2002-11-01 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| WO2004041814A1 (fr) | 2002-11-04 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Derives d'heteroaryle pyrimidine utilises comme inhibiteurs de jak (janus kinase) |
| US7348335B2 (en) | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| GB0317841D0 (en) | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
| EP1648875A1 (fr) | 2003-07-30 | 2006-04-26 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines utilisees comme inhibiteurs de kinases |
| PL1761540T3 (pl) | 2004-05-13 | 2017-06-30 | Icos Corporation | Chinazolinony jako inhibitory ludzkiej kinazy 3-fosfatydyloinozytolu delta |
| KR20070084067A (ko) | 2004-10-13 | 2007-08-24 | 와이어쓰 | Ｎ-벤젠설포닐 치환 아닐리노-피리미딘 동족체 |
| US7593820B2 (en) | 2005-05-12 | 2009-09-22 | Cytopia Research Pty Ltd | Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof |
| EA200870217A1 (ru) | 2006-01-30 | 2009-02-27 | Экселиксис, Инк. | 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции |
| AU2007220047B2 (en) | 2006-02-28 | 2013-08-01 | Ym Biosciences Australia Pty Ltd | Inhibition of JAK2 as a treatment of pulmonary arterial hypertension |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| AU2016200866B2 (en) | 2007-03-12 | 2017-06-22 | Glaxosmithkline Llc | Phenyl amino pyrimidine compounds and uses thereof |
| AU2013201306B2 (en) | 2007-03-12 | 2015-11-12 | Glaxosmithkline Llc | Phenyl Amino Pyrimidine Compounds and Uses Thereof |
| KR101737753B1 (ko) | 2007-03-12 | 2017-05-18 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| EP2200436B1 (fr) | 2007-09-04 | 2015-01-21 | The Scripps Research Institute | Pyrimidinyl-amines substituées en tant qu'inhibiteurs de la protéine kinase |
| WO2009029998A1 (fr) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Composés rétrométaboliques |
| WO2009073575A2 (fr) | 2007-11-30 | 2009-06-11 | Oregon Health & Science University | Procédés de traitement des troubles prolifératifs cellulaires induits |
| CA2732791A1 (fr) | 2008-08-05 | 2010-02-11 | Targegen, Inc. | Procedes de traitement de la thalassemie |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| US8580749B2 (en) | 2009-06-05 | 2013-11-12 | Cell Targeting, Inc. | Peptide-coated cell localization to diseased or damaged tissues and methods related thereto |
| JP5086385B2 (ja) * | 2010-03-08 | 2012-11-28 | 日立オートモティブシステムズ株式会社 | 電動パワーステアリング制御装置 |
| WO2011152351A1 (fr) | 2010-05-31 | 2011-12-08 | 小野薬品工業株式会社 | Dérivé de purinone |
| CA2819560A1 (fr) * | 2010-12-03 | 2012-06-07 | Ym Biosciences Australia Pty Ltd | Traitement d'affections mediees par jak2 |
| AP2013007281A0 (en) | 2011-05-02 | 2013-11-30 | Ym Biosciences Australia Pty | Multiple myeloma treatment |
| US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
| JPWO2014051056A1 (ja) * | 2012-09-28 | 2016-08-22 | 東レ株式会社 | グリシン誘導体の結晶及びその医薬用途 |
| MX2015008829A (es) | 2013-01-09 | 2016-04-25 | Concert Pharmaceuticals Inc | Momelotinib deuterado. |
| CN103965114B (zh) | 2013-01-28 | 2016-01-06 | 苏州泽璟生物制药有限公司 | 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物 |
| TWI729644B (zh) * | 2014-06-12 | 2021-06-01 | 美商西爾拉癌症醫學公司 | N-(氰基甲基)-4-(2-(4-𠰌啉基苯基胺基)嘧啶-4-基)苯甲醯胺 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
-
2015
- 2015-06-10 TW TW108146991A patent/TWI729644B/zh active
- 2015-06-10 TW TW110118088A patent/TW202134236A/zh unknown
- 2015-06-10 TW TW104118766A patent/TWI681954B/zh active
- 2015-06-11 LT LTEP15739042.8T patent/LT3154950T/lt unknown
- 2015-06-11 US US14/736,690 patent/US9469613B2/en not_active Ceased
- 2015-06-11 AU AU2015274554A patent/AU2015274554B9/en active Active
- 2015-06-11 AP AP2016009551A patent/AP2016009551A0/en unknown
- 2015-06-11 CN CN201910920874.1A patent/CN110627728A/zh active Pending
- 2015-06-11 DK DK15739042.8T patent/DK3154950T3/da active
- 2015-06-11 SI SI201531370T patent/SI3154950T1/sl unknown
- 2015-06-11 CA CA2951883A patent/CA2951883C/fr active Active
- 2015-06-11 SG SG10201911925TA patent/SG10201911925TA/en unknown
- 2015-06-11 MA MA040067A patent/MA40067A/fr unknown
- 2015-06-11 RS RS20201158A patent/RS61065B1/sr unknown
- 2015-06-11 KR KR1020177000573A patent/KR101928225B1/ko active Active
- 2015-06-11 EP EP15739042.8A patent/EP3154950B1/fr active Active
- 2015-06-11 AR ARP150101869A patent/AR100818A1/es unknown
- 2015-06-11 WO PCT/US2015/035316 patent/WO2015191846A1/fr not_active Ceased
- 2015-06-11 PT PT157390428T patent/PT3154950T/pt unknown
- 2015-06-11 CN CN201580031169.6A patent/CN106458929A/zh active Pending
- 2015-06-11 PL PL15739042T patent/PL3154950T3/pl unknown
- 2015-06-11 EP EP21174463.6A patent/EP3907219A1/fr active Pending
- 2015-06-11 SG SG11201610079VA patent/SG11201610079VA/en unknown
- 2015-06-11 ES ES15739042T patent/ES2822773T3/es active Active
- 2015-06-11 HU HUE15739042A patent/HUE051360T2/hu unknown
- 2015-06-11 JP JP2016572271A patent/JP6600649B2/ja active Active
- 2015-06-11 BR BR112016028749A patent/BR112016028749A2/pt not_active Application Discontinuation
- 2015-06-11 EP EP20161613.3A patent/EP3719005A1/fr active Pending
- 2015-06-11 MX MX2016016294A patent/MX374541B/es active IP Right Grant
- 2015-06-11 CR CR20160575A patent/CR20160575A/es unknown
- 2015-06-11 HR HRP20201492TT patent/HRP20201492T1/hr unknown
- 2015-06-11 EA EA201692356A patent/EA032639B1/ru not_active IP Right Cessation
- 2015-06-11 NZ NZ725966A patent/NZ725966A/en unknown
- 2015-06-12 UY UY0001036166A patent/UY36166A/es not_active Application Discontinuation
-
2016
- 2016-08-08 US US15/231,411 patent/US9809559B2/en active Active
- 2016-11-17 IL IL249038A patent/IL249038B/en unknown
- 2016-12-08 MX MX2019009564A patent/MX2019009564A/es unknown
- 2016-12-08 MX MX2022015558A patent/MX2022015558A/es unknown
- 2016-12-09 EC ECIEPI201693323A patent/ECSP16093323A/es unknown
- 2016-12-09 CU CUP2016000183A patent/CU20160183A7/es unknown
- 2016-12-12 PH PH12016502461A patent/PH12016502461A1/en unknown
-
2018
- 2018-09-03 JP JP2018164680A patent/JP6883560B2/ja active Active
- 2018-10-18 US US16/164,681 patent/USRE48285E1/en active Active
-
2020
- 2020-01-06 JP JP2020000332A patent/JP6840909B2/ja active Active
- 2020-08-26 IL IL276948A patent/IL276948B/en unknown
- 2020-09-04 US US17/013,342 patent/USRE49445E1/en active Active
- 2020-10-05 CY CY20201100931T patent/CY1123604T1/el unknown
-
2021
- 2021-05-10 JP JP2021079700A patent/JP7198867B2/ja active Active
- 2021-09-15 IL IL286442A patent/IL286442A/en unknown
-
2022
- 2022-12-19 JP JP2022202374A patent/JP7550205B2/ja active Active
-
2023
- 2023-01-25 US US18/159,328 patent/USRE50497E1/en active Active
-
2024
- 2024-07-11 FR FR24C1030C patent/FR24C1030I2/fr active Active
- 2024-07-11 LT LTPA2024523C patent/LTPA2024523I1/lt unknown
- 2024-07-12 FI FIC20240025C patent/FIC20240025I1/fi unknown
- 2024-07-12 NL NL301282C patent/NL301282I2/nl unknown
- 2024-07-15 HU HUS2400025C patent/HUS2400025I1/hu unknown
- 2024-07-17 CY CY2024024C patent/CY2024024I1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA40067A (fr) | Sels de chlorhydrate de n-(cyanométhyl)-4-(2-(4-morpholinophénylamino)pyrimidin-4-yl)benzamide | |
| IL274488B1 (en) | Crystal forms of n-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide | |
| HUE053564T2 (hu) | Heterociklusos amidok kinázinhibitorként | |
| LT3160958T (lt) | (s)-6-((1-acetilpiperidin-4-il)amino)-n-(3-(3,4-dihidroizochinolin-2(1h)-yl)-2-hidroksipropil)pirimidin-4-karboksamido kristalinės druskos | |
| HUE051693T2 (hu) | 5-Klór-N4-[2-(dimetilfoszforil)-fenil]-N2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)-piperidin-1-il] -pirimidin-2,4-diamin kristályos formái | |
| SG11201708613SA (en) | Novel crystal of uracil compound | |
| EA201891768A1 (ru) | Кристаллическая форма a агониста tlr7, ее способ получения и использование | |
| HUE051266T2 (hu) | A 2-(terc-butil-amino)-4-((1R, 3R, 4R)-3-hidroxi-4-metil-ciklohexil-amino)-pirimidin-5-karboxamid kristályos formái | |
| PH12015500795B1 (en) | N-(2-(cyclic amine)ethyl)benzamide derivatives as p2x7 inhibitors | |
| SG11201704431VA (en) | Novel salt of fused pyrimidine compound and crystal thereof | |
| MX2018000308A (es) | Modificacion cristalina termodinamicamente estable de 2-cloro-3-(metilsulfanil)-n-(1-metil-1h-tetrazol-5-il)-4-(trifluo rometil)benzamida. | |
| DOP2016000322A (es) | N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida |