MA40596A - Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2 - Google Patents

Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2

Info

Publication number
MA40596A
MA40596A MA040596A MA40596A MA40596A MA 40596 A MA40596 A MA 40596A MA 040596 A MA040596 A MA 040596A MA 40596 A MA40596 A MA 40596A MA 40596 A MA40596 A MA 40596A
Authority
MA
Morocco
Prior art keywords
inhibitor
bcl
therapeutic combinations
btk
btk inhibitor
Prior art date
Application number
MA040596A
Other languages
English (en)
Other versions
MA40596B1 (fr
Inventor
Tjeerd Barf
Todd Covey
Ahmed Hamdy
Raquel Izumi
Dave Johnson
Allard Kaptein
Brian Lannutti
Wayne Rothbaum
roger Ulrich
Original Assignee
Acerta Pharma Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54015145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40596(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Acerta Pharma Bv filed Critical Acerta Pharma Bv
Publication of MA40596A publication Critical patent/MA40596A/fr
Publication of MA40596B1 publication Critical patent/MA40596B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA40596A 2014-08-11 2015-08-11 Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2 MA40596B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462035795P 2014-08-11 2014-08-11
US201462088240P 2014-12-05 2014-12-05
US201562115497P 2015-02-12 2015-02-12
US201562181160P 2015-06-17 2015-06-17
PCT/IB2015/056126 WO2016024230A1 (fr) 2014-08-11 2015-08-11 Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, et/ou d'un inhibiteur de bcl-2

Publications (2)

Publication Number Publication Date
MA40596A true MA40596A (fr) 2021-05-05
MA40596B1 MA40596B1 (fr) 2021-12-31

Family

ID=54015145

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40596A MA40596B1 (fr) 2014-08-11 2015-08-11 Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2

Country Status (20)

Country Link
US (3) US20170231986A1 (fr)
EP (1) EP3179991B1 (fr)
AR (1) AR101505A1 (fr)
CY (1) CY1125588T1 (fr)
DK (1) DK3179991T3 (fr)
ES (1) ES2900184T3 (fr)
FI (1) FIC20253010I1 (fr)
FR (1) FR25C1046I1 (fr)
HR (1) HRP20211813T1 (fr)
HU (2) HUE056329T2 (fr)
LT (2) LT3179991T (fr)
MA (1) MA40596B1 (fr)
NO (1) NO2025050I1 (fr)
PL (1) PL3179991T3 (fr)
PT (1) PT3179991T (fr)
RS (1) RS62713B1 (fr)
SI (1) SI3179991T1 (fr)
SM (1) SMT202100674T1 (fr)
TW (1) TW201618772A (fr)
WO (1) WO2016024230A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169745A (en) 2010-05-31 2019-05-14 Ono Pharmaceutical Co Purinone derivative
CN103958513B (zh) 2011-11-29 2015-12-23 小野药品工业株式会社 6-羟基嘌呤衍生物盐酸盐
WO2015146159A1 (fr) 2014-03-25 2015-10-01 Ono Pharmaceutical Co., Ltd. Agent prophylactique et/ou agent thérapeutique pour lymphome diffus à grandes cellules b
ES2900184T3 (es) * 2014-08-11 2022-03-16 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de BTK y un inhibidor de BCL-2
WO2016163531A1 (fr) 2015-04-09 2016-10-13 小野薬品工業株式会社 Procédé de fabrication d'un dérivé de purinone
US20180353512A1 (en) * 2015-06-23 2018-12-13 Gilead Sciences, Inc. Combination therapies for treating b-cell malignancies
WO2017023584A1 (fr) * 2015-08-03 2017-02-09 Gilead Sciences, Inc. Polythérapies pour le traitement de cancers
IL295472B2 (en) 2016-03-28 2024-10-01 Presage Biosciences Inc Pharmaceutical combinations for the treatment of cancer
US20190225607A1 (en) * 2016-07-06 2019-07-25 Concert Pharmaceuticals, Inc. Deuterated Venetoclax
WO2018054782A1 (fr) * 2016-09-23 2018-03-29 Bayer Pharma Aktiengesellschaft Combinaison d'inhibiteurs de la pi3k
CA3045339A1 (fr) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methodes et compositions pour l'utilisation de lymphocytes t therapeutiques en association avec des inhibiteurs de kinase
US11136323B2 (en) 2016-12-07 2021-10-05 Beigene, Ltd. Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング，インコーポレイテッド Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療
MA49921A (fr) 2017-08-14 2021-05-12 Mei Pharma Inc Polythérapie
JP7128264B2 (ja) * 2017-09-08 2022-08-30 ベイジーン リミテッド ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
TW201924721A (zh) * 2017-12-08 2019-07-01 韓商保寧製藥股份公司 包含pi3激酶抑制劑與bcl-2抑制劑的組成物
US20190240198A1 (en) * 2018-02-05 2019-08-08 Dean G. Tang Formulations and methods for the treatment of cancers
US20190328729A1 (en) 2018-04-26 2019-10-31 Emory University Uses of Bcl-2 Antagonists for Treating Cancer and Diagnostics Related Thereto
WO2020024834A1 (fr) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Produit de combinaison d'un inhibiteur de bcl-2 et d'un agent chimiothérapeutique et utilisation associée dans la prévention et/ou le traitement de maladies
GEP20237460B (en) 2018-07-31 2023-01-25 Ascentage Pharma Suzhou Co Ltd Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop
CN110772521A (zh) * 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
GEP20237458B (en) 2018-07-31 2023-01-10 Ascentage Pharma Suzhou Co Ltd Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases
CN113164487B (zh) 2018-10-12 2024-11-26 内布拉斯加大学董事委员会 磷酸二酯酶抑制剂
TW202038945A (zh) * 2018-12-21 2020-11-01 美商梅製藥公司 組合療法
CN111377929A (zh) * 2018-12-28 2020-07-07 南京艾德凯腾生物医药有限责任公司 一种可用于治疗白血病阿卡替尼(Acalabrutinib)制备的方法
CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
WO2020223609A1 (fr) * 2019-05-01 2020-11-05 New York University Méthodes et compositions pour sensibiliser les cellules cancéreuses à une apoptose induite par un médicament
US12370197B2 (en) 2019-07-31 2025-07-29 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
EP4051676A4 (fr) 2019-10-28 2023-11-22 BeiGene, Ltd. Inhibiteurs de bcl-2
CN119097631A (zh) * 2019-12-03 2024-12-10 苏州亚盛药业有限公司 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
US20240024314A1 (en) 2020-01-08 2024-01-25 Telios Pharma, Inc. Methods of Treating Splenomegaly
TN2022000185A1 (en) * 2020-01-08 2024-04-01 Telios Pharma Inc Methods of treating splenomegaly
KR20210095495A (ko) * 2020-01-23 2021-08-02 주식회사 바이오웨이 신규한 퀴나졸리논 화합물 및 이를 포함하는 약학적 조성물
CA3167134A1 (fr) * 2020-02-07 2021-08-12 University Health Network (Uhn) Procedes d'amelioration de lymphocytes t par venetoclax
AU2021256580A1 (en) 2020-04-15 2022-09-29 Beone Medicines I Gmbh Bcl-2 inhibitor
CA3185040A1 (fr) 2020-05-26 2021-12-02 Truebinding, Inc. Methodes de traitement de maladies inflammatoires par blocage de la galectine-3
WO2022056092A1 (fr) * 2020-09-11 2022-03-17 Cti Biopharma Corp. Méthodes de traitement d'une infection virale
JP2024522008A (ja) * 2021-06-02 2024-06-06 ベイジーン スウィッツァーランド ゲーエムベーハー Ｂｃｌ－２阻害剤を使用したｂ細胞悪性腫瘍の治療方法
IL308951A (en) * 2021-06-04 2024-01-01 Janssen Pharmaceutica Nv Inhibitors of proton tyrosine kinase and methods of using them
WO2025124429A1 (fr) * 2023-12-11 2025-06-19 北京康辰药业股份有限公司 Composé amine aromatique, composition pharmaceutique et utilisation associées
WO2026017844A1 (fr) * 2024-07-19 2026-01-22 Epics Therapeutics Polythérapies comprenant un inhibiteur de mettl3 et un inhibiteur de bcl2

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101186T2 (tr) 1998-09-18 2001-10-22 Basf Aktiengesellschaft Protein kinaz engelleyiciler olarak pyrrolopyrimidin'ler
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
CN1390220A (zh) 1999-09-17 2003-01-08 艾博特股份有限两合公司 作为治疗剂的激酶抑制剂
US6998391B2 (en) 2002-02-07 2006-02-14 Supergen.Inc. Method for treating diseases associated with abnormal kinase activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
AU2004282219C1 (en) 2003-10-15 2009-12-17 Osi Pharmaceuticals, Inc. Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors
AU2005230818B2 (en) 2004-04-02 2010-11-25 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
ES2605792T3 (es) 2004-05-13 2017-03-16 Icos Corporation Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana
WO2006055831A2 (fr) 2004-11-17 2006-05-26 Miikana Therapeutics, Inc. Inhibiteurs de kinase
NZ555158A (en) 2004-11-18 2010-09-30 Synta Pharmaceuticals Corp Triazole compounds that modulate Hsp90 activity
BRPI0606793A8 (pt) 2005-02-04 2018-03-13 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação e uso do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de câncer e para a produção de um efeito anti-proliferativo em um animal de sangue quente, e, composição farmacêutica
AU2006214213B2 (en) 2005-02-18 2009-11-12 The Hong Kong Polytechnic University Method for asymmetric hydrosilylation of ketones
CA2622352C (fr) 2005-09-30 2014-05-27 Miikana Therapeutics, Inc. Composes pyrazole substitues
US20080287475A1 (en) 2005-10-28 2008-11-20 Astrazeneca Ab 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer
AU2006316072B2 (en) 2005-11-16 2011-12-22 S*Bio Pte Ltd Heteroalkyl linked pyrimidine derivatives
ES2436877T3 (es) 2005-11-17 2014-01-07 OSI Pharmaceuticals, LLC Intermedios para la preparación de inhibidores de mTOR bicíclicos condensados
AU2006316322B2 (en) 2005-11-22 2011-08-25 Merck Canada Inc. Tricyclic compounds useful as inhibitors of kinases
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
PT2348023E (pt) 2005-12-13 2015-09-15 Incyte Corp Pirrolo[2,3-b] pirimidinas e pirrolo[2,3-b]piridinas substituídas com heteroarilo como inibidores de janus quinase
EP1968579A1 (fr) 2005-12-30 2008-09-17 Astex Therapeutics Limited Composes pharmaceutiques
EP1996193A2 (fr) 2006-03-13 2008-12-03 OSI Pharmaceuticals, Inc. Traitement combiné avec un inhibiteur de kinase egfr et un agent sensibilisant les cellules tumorales aux effets des inhibiteurs de kinase egfr
PT2530083T (pt) 2006-09-22 2016-08-01 Pharmacyclics Llc Inibidores de tirosina cinase de bruton
BRPI0808888B8 (pt) 2007-03-12 2021-05-25 Cytopia Res Pty Ltd composto de fenil amino pirimidina para uso no tratamento de uma doença associada à quinase, processo para a preparação do composto, composição farmacêutica, e, implante
PL2137186T3 (pl) 2007-03-23 2016-09-30 Związki heterocykliczne i ich zastosowania
CA2874756C (fr) 2007-03-28 2018-05-29 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
US20120101113A1 (en) 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
CA2683152A1 (fr) 2007-06-11 2008-12-18 Miikana Therapeutics, Inc. Composes pyrazole substitues
ES2714092T3 (es) 2007-06-13 2019-05-27 Incyte Holdings Corp Uso de sales del inhibidor de quinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
JP2011506455A (ja) 2007-12-13 2011-03-03 ノバルティス アーゲー 癌を処置するための治療薬の組み合わせ剤
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
SI2288610T1 (sl) 2008-03-11 2016-11-30 Incyte Holdings Corporation Derivati azetidina in ciklobutana kot inhibitorji jak
AU2009262068C1 (en) 2008-06-27 2015-07-02 Celgene Car Llc Heteroaryl compounds and uses thereof
US9095592B2 (en) 2008-11-07 2015-08-04 The Research Foundation For The State University Of New York Bruton's tyrosine kinase as anti-cancer drug target
CN102227219A (zh) 2008-11-26 2011-10-26 迈卡纳治疗股份有限公司 取代的吡唑化合物
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
PA8851101A1 (es) 2008-12-16 2010-07-27 Lilly Co Eli Compuesto amino pirazol
MY163540A (en) 2009-01-15 2017-09-15 Incyte Holdings Corp Processes for preparing jak inhibitors and related intermediate compounds
NZ593594A (en) 2009-01-19 2013-08-30 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
PT2394999E (pt) 2009-02-06 2014-05-02 Nippon Shinyaku Co Ltd Derivado de aminopirazina e medicamento correspondente
PT2401267E (pt) 2009-02-27 2014-04-10 Ambit Biosciences Corp Derivados de quinazolina moduladores de quinase jak e sua utilização em métodos
EP2424368B1 (fr) 2009-04-29 2014-12-31 Locus Pharmaceuticals, Inc. Composés de pyrrolotriazine
ME03556B (fr) 2009-05-22 2020-07-20 Incyte Holdings Corp 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- ou heptane-nitrile en tant qu'inhibiteurs de jak
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102001418B1 (ko) 2009-05-26 2019-07-19 애브비 아일랜드 언리미티드 컴퍼니 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
US20120157500A1 (en) 2009-08-24 2012-06-21 Weikang Tao Jak inhibition blocks rna interference associated toxicities
SI2473510T1 (sl) 2009-09-03 2014-10-30 Bristol-Myers Squibb Company Jak2 inhibitorji in njihova uporaba za zdravljenje mieloproliferativnih bolezni in raka
US8486902B2 (en) 2009-10-09 2013-07-16 Incyte Corporation Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
US8658794B2 (en) 2010-02-08 2014-02-25 Merck Sharp & Dohme B.V. 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
MY169745A (en) 2010-05-31 2019-05-14 Ono Pharmaceutical Co Purinone derivative
MX342405B (es) 2010-06-03 2016-09-28 Pharmacyclics Inc El uso de inhibidores de la tirosina quinasa de bruton (btk).
US20120053189A1 (en) 2010-06-28 2012-03-01 Pharmacyclics, Inc. Btk inhibitors for the treatment of immune mediated conditions
PT2603081T (pt) 2010-08-10 2017-01-13 Celgene Avilomics Res Inc Sal de besilato de um inibidor de btk
WO2012020787A1 (fr) 2010-08-11 2012-02-16 日本新薬株式会社 Agent thérapeutique contre un lymphome malin
WO2012020786A1 (fr) 2010-08-11 2012-02-16 日本新薬株式会社 Composition pharmaceutique
EP2663553B1 (fr) 2010-09-01 2015-08-26 Ambit Biosciences Corporation Composés quinoléine et isoquinoléine en tant que modulateurs de jak
EP2611794A1 (fr) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Dérivés de 4-azolylaminoquinazoline et leurs méthodes d'utilisation
AU2011296078B2 (en) 2010-09-01 2015-06-18 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
CA2811805A1 (fr) 2010-10-29 2012-05-03 Abbvie Inc. Dispersions solides contenant un agent induisant l'apoptose
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
JP2014503500A (ja) 2010-11-18 2014-02-13 シンタ ファーマスーティカルズ コーポレーション 低酸素状態に基づく酸素感受性薬剤による治療に適した被験体の事前選択
WO2012068483A1 (fr) 2010-11-18 2012-05-24 Synta Pharmaceuticals Corp. Présélection de patients pour un traitement thérapeutique fondé sur un état hypoxique
EP2642999B1 (fr) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Procédés de traitement utilisant des inhibiteurs sélectifs de bcl-2
RU2628560C2 (ru) 2010-11-23 2017-08-18 Эббви Инк. Соли и кристаллические формы индуцирующего апоптоз агента
CN103370068A (zh) 2010-12-03 2013-10-23 Ym生物科学澳大利亚私人有限公司 Jak-2 介导的病症的治疗
US8809349B2 (en) 2011-01-10 2014-08-19 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
EP2678014A2 (fr) 2011-02-24 2014-01-01 Synta Pharmaceuticals Corp. Traitement du cancer de la prostate avec des composés inhibiteurs de hsp90
US20140045908A1 (en) 2011-02-25 2014-02-13 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
CA2760174A1 (fr) 2011-12-01 2013-06-01 Pharmascience Inc. Inhibiteurs de proteines kinases et leurs utilisations
MX343929B (es) 2011-04-04 2016-11-28 Pharmascience Inc Inhibidores de proteina cinasa.
WO2012155063A1 (fr) 2011-05-11 2012-11-15 Synta Pharmaceuticals Corp. Traitement du cancer avec un composé inhibiteur de hsp90
PL2710007T3 (pl) 2011-05-17 2020-06-01 The Regents Of The University Of California Inhibitory kinazy
WO2012162293A1 (fr) 2011-05-23 2012-11-29 Synta Pharmaceuticals Corp. Polythérapie de composés inhibiteurs de hsp90 avec inhibiteurs de mek
WO2012162372A1 (fr) 2011-05-24 2012-11-29 Synta Pharmaceuticals Corp. Thérapie combinée par des composés inhibiteurs de hsp90 et des inhibiteurs de mtor/p13k
US20140194388A1 (en) 2011-05-26 2014-07-10 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with chk inhibitors
BR112013033534A2 (pt) 2011-06-28 2017-02-07 Pharmacyclics Inc métodos e composições para inibição de reabsorção de osso
JP2014520808A (ja) 2011-07-07 2014-08-25 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０阻害化合物を用いた癌の治療
CA2841080A1 (fr) 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibiteurs de tyrosine kinase de bruton
EP2734530A1 (fr) 2011-07-19 2014-05-28 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
EP2548877A1 (fr) 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
CA2841886C (fr) 2011-07-19 2016-08-16 Merck Sharp & Dohme B.V. 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides en tant qu'inhibiteurs de btk
EP2734520B1 (fr) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
JP2014522860A (ja) 2011-07-19 2014-09-08 メルク・シャープ・アンド・ドーム・ベー・フェー Ｂｔｋ阻害剤としての４−イミダゾピリダジン−１−イル−ベンズアミドおよび４−イミダゾトリアジン−１−イル−ベンズアミド
AU2012299177A1 (en) 2011-08-19 2014-04-10 Synta Pharmaceuticals Corp. Combination cancer therapy of HSP90 inhibitor with antimetabolite
JP6029668B2 (ja) 2011-08-29 2016-11-24 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
MX391121B (es) 2011-10-19 2025-03-19 Pharmacyclics Llc Uso de inhibidores de la tirosina cinasa de bruton (btk).
US8628752B2 (en) 2011-10-28 2014-01-14 Synta Pharmaceuticals Corp. Methods of identifying HSP90 inhibitors with less ocular toxicity
AU2012332424A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with platinum-containing agents
JP2014532712A (ja) 2011-11-02 2014-12-08 シンタ ファーマシューティカルズ コーポレーション トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors
CN103958513B (zh) 2011-11-29 2015-12-23 小野药品工业株式会社 6-羟基嘌呤衍生物盐酸盐
US20140212425A1 (en) 2011-12-05 2014-07-31 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
CA2871540A1 (fr) 2012-05-10 2013-11-14 Synta Pharmaceuticals Corp. Traitement du cancer avec des composes inhibiteurs de hsp90
WO2013170182A1 (fr) 2012-05-11 2013-11-14 Synta Pharmaceuticals Corp. Traitement d'un cancer au moyen d'un composé inhibiteur de hsp90
AU2013262914A1 (en) 2012-05-16 2014-11-06 Synta Pharmaceuticals Corp. Pre-selection of subjects for therapeutic treatment with an Hsp90 inhibitor based on hypoxic status
HRP20170430T1 (hr) 2012-06-13 2017-06-16 Incyte Holdings Corporation Supstituirani triciklični spojevi kao inhibitori fgfr
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
BR112015003153A2 (pt) 2012-08-17 2017-07-04 Concert Pharmaceuticals Inc baricitinib deuterado
RU2648476C2 (ru) * 2012-09-07 2018-03-26 Дженентек, Инк. Комбинированная терапия с использованием антитела против cd20 типа ii и селективного ингибитора bcl-2
WO2014114185A1 (fr) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Inhibiteurs de btk
AU2014244518A1 (en) 2013-03-14 2015-09-17 Pharmacyclics Llc Combinations of Bruton's tyrosine kinase inhibitors and CYP3A4 inhibitors
WO2014143807A2 (fr) 2013-03-15 2014-09-18 Stromatt Scott Anticorps anti-cd37 et polythérapie par antagoniste de la voie bcr pour le traitement de malignités b et de troubles des lymphocytes b
WO2014168975A1 (fr) * 2013-04-08 2014-10-16 Pharmacyclics, Inc. Combinaison thérapeutique à base d'ibrutinib
RS55770B1 (sr) 2013-04-25 2017-07-31 Beigene Ltd Fuzionisana heterociklična jedinjenja kao inhibitori protein kinaze
CA2914284A1 (fr) * 2013-05-30 2014-12-04 Infinity Pharmaceuticals, Inc. Traitement anticancer au moyen de modulateurs isoformes de la kinase p13
US20150005277A1 (en) 2013-06-28 2015-01-01 Beigene, Ltd. Protein Kinase Inhibitors and Uses Thereof
WO2015018522A1 (fr) 2013-08-06 2015-02-12 Oncoethix Sa Inhibiteur de bromodomaine bet présentant une synergie avec plusieurs agents anti-cancéreux dans des modèles cliniques de lymphome diffus de cellule b de grande taille (dlbcl)
MX2016005283A (es) * 2013-10-25 2017-02-20 Pharmacyclics Llc Tratamiento que utiliza inhibidores de tirosina quinasa de bruton e inmunoterapia.
US10328080B2 (en) * 2013-12-05 2019-06-25 Acerta Pharma, B.V. Therapeutic combination of PI3K inhibitor and a BTK inhibitor
WO2015193740A2 (fr) * 2014-06-17 2015-12-23 Acerta Pharma B.V. Combinaisons thérapeutiques d'un inhibiteur de la tkb, d'un inhibiteur de la pi3k et/ou d'un inhibiteur de la jak-2
CN106714909A (zh) 2014-08-08 2017-05-24 药品循环有限责任公司 布鲁顿氏酪氨酸激酶抑制剂组合及其用途
US20170231995A1 (en) * 2014-08-11 2017-08-17 Acerta Pharma B.V. BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
ES2900184T3 (es) * 2014-08-11 2022-03-16 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de BTK y un inhibidor de BCL-2
AR101504A1 (es) * 2014-08-11 2016-12-21 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6
SMT202200285T1 (it) * 2014-08-11 2022-09-14 Acerta Pharma Bv Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1
US9717745B2 (en) * 2015-03-19 2017-08-01 Zhejiang DTRM Biopharma Co. Ltd. Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
KR20240115937A (ko) * 2015-07-02 2024-07-26 아세르타 파마. 비.브이. (S)-4-(8-아미노-3-(1-(부트-2-이노일)피롤리딘-2-일)이미다조[1,5-a]피라진-1-일)-N-(피리딘-2-일)벤즈아마이드의고체 형태 및 제제
US20170071962A1 (en) * 2015-09-11 2017-03-16 Acerta Pharma B.V. Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor
US20190201409A1 (en) * 2016-09-19 2019-07-04 Mei Pharma, Inc. Combination therapy
WO2018134786A1 (fr) * 2017-01-19 2018-07-26 Acerta Pharma B.V. Compositions et procédés pour l'évaluation de l'occupation d'une cible de médicament pour la tyrosine kinase de bruton

Also Published As

Publication number Publication date
MA40596B1 (fr) 2021-12-31
FR25C1046I1 (fr) 2026-01-02
PL3179991T3 (pl) 2022-02-14
US11654143B2 (en) 2023-05-23
US20220088013A1 (en) 2022-03-24
HUS2500046I1 (hu) 2025-12-28
AR101505A1 (es) 2016-12-21
EP3179991A1 (fr) 2017-06-21
HUE056329T2 (hu) 2022-02-28
EP3179991B1 (fr) 2021-10-06
WO2016024230A1 (fr) 2016-02-18
SI3179991T1 (sl) 2022-04-29
SMT202100674T1 (it) 2022-01-10
US20180250298A1 (en) 2018-09-06
LTPA2025539I1 (fr) 2025-12-29
US11166951B2 (en) 2021-11-09
PT3179991T (pt) 2021-11-26
US20170231986A1 (en) 2017-08-17
FIC20253010I1 (fi) 2025-11-26
DK3179991T3 (da) 2021-12-06
HRP20211813T1 (hr) 2022-03-04
LT3179991T (lt) 2021-11-10
CY1125588T1 (el) 2024-02-16
RS62713B1 (sr) 2022-01-31
TW201618772A (zh) 2016-06-01
ES2900184T3 (es) 2022-03-16
NO2025050I1 (no) 2025-11-28

Similar Documents

Publication Publication Date Title
FR25C1046I1 (fr) Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2
NL301322I2 (nl) Repotrectinib en/of farmaceutisch aanvaardbare zouten daarvan
IL258931A (en) Therapeutic compounds and methods
IL247215B (en) Salts and solid form of a btk inhibitor
IL252602B (en) Oral care compositions and methods of use
IL251526B (en) Use of cannabidiol in the treatment of tuberous sclerosis complex
HUE046000T2 (hu) Antiproferatív vegyületek és alkalmazásuk módszerei
IL252172A0 (en) Expandable drug delivery devices and method of use
MA40933A (fr) Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
BR112016003413A2 (pt) prancha ergometrica de uma esteira ergometrica e esteira ergometrica
DK2937422T3 (da) Fremgangsmåde og et kit til ikke-invasiv detektering af patogene genmutationer for fosterdøvhed
HUE039446T2 (hu) Diacilglicerol-aciltranszferáz-2 inhibitorok metabolikus rendellenességek és kapcsolódó rendellenességek kezelésében történõ alkalmazásra
HUE055155T2 (hu) Módszerek a tónusos gátlás növelésére és a másodlagos álmatlanság kezelésére
HUE052468T2 (hu) Arginázgátlók és terápiás alkalmazásaik
EP3174475C0 (fr) Dispositifs de cathéter et kits
HUE066644T2 (hu) CD19-inhibitor és BTK-inhibitor terápiás kombinációi
FR3019522B1 (fr) Ensemble sustentateur amovible d'un giravion et giravion
DK3219089T3 (da) Træning i afgivelse af et lægemiddel
PL3240777T3 (pl) Inhibitory arginazy oraz ich zastosowania terapeutyczne
EP3310376A4 (fr) Agents thérapeutiques modifiés et compositions associées
DK3151814T3 (da) Behandling af en hudlæsion
DK3125874T3 (da) Et terapeutisk middel til anvendelse i behandlingen af infektioner
DK3240821T3 (da) Lavdosis gashydrathæmmersammensætning og tilhørende fremgangsmåde
DK3215143T3 (da) Kombination omfattende spirulina og palmitoylethanolamid
DK3129398T3 (da) Nye medicinske midler og anvendelser deraf