MA40763A - Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh - Google Patents

Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh

Info

Publication number
MA40763A
MA40763A MA040763A MA40763A MA40763A MA 40763 A MA40763 A MA 40763A MA 040763 A MA040763 A MA 040763A MA 40763 A MA40763 A MA 40763A MA 40763 A MA40763 A MA 40763A
Authority
MA
Morocco
Prior art keywords
aggregative
stable
high affinity
antibodies based
vhh derivative
Prior art date
Application number
MA040763A
Other languages
English (en)
Other versions
MA40763B1 (fr
Inventor
Tatyana Veniaminovna Chernovskaya
Yulia Sergeevna Chernyh
Victoria Mikhailovna Ekimova
Stanislav Rudolfovich Evdokimov
Olga Vladimirovna Goncharova
Roman Alexeevich Ivanov
Dmitriy Valerievich Korzhavin
Dmitriy Valentinovich Morozov
Timofey Aleksandrovich Nemankin
Ekaterina Vladimirovna Sofronova
Valeriy Vladimirovich Soloviev
Andrey Borisovich Ulitin
Yakov Yurevich Ustyugov
Original Assignee
Biocad Cjsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Cjsc filed Critical Biocad Cjsc
Publication of MA40763A publication Critical patent/MA40763A/fr
Publication of MA40763B1 publication Critical patent/MA40763B1/fr

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K—PEPTIDES
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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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MA40763A 2014-09-26 2015-03-23 Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh MA40763B1 (fr)

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RU2014138740A RU2609627C2 (ru) 2014-09-26 2014-09-26 Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
PCT/RU2015/000163 WO2016048188A1 (fr) 2014-09-26 2015-03-23 Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh
EP15843607.1A EP3199550B8 (fr) 2014-09-26 2015-03-23 Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh

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EP4495142A3 (fr) 2017-12-22 2025-05-07 Argenx BVBA Construction bispécifique de liaison à un antigène
GB201802487D0 (en) 2018-02-15 2018-04-04 Argenx Bvba Cytokine combination therapy
JP7122672B2 (ja) * 2018-06-08 2022-08-22 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体
CN112912087A (zh) * 2018-09-14 2021-06-04 卢卡科学株式会社 线粒体向淋巴器官中的移植以及用于该移植的组合物
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
IL320091A (en) 2019-01-31 2025-06-01 Numab Therapeutics AG Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
RU2754760C2 (ru) 2019-04-02 2021-09-07 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция анти-il17a антитела и ее применение
CN112239501B (zh) * 2020-10-29 2022-01-07 东莞市朋志生物科技有限公司 抗新型冠状病毒的抗体、检测新型冠状病毒试剂和试剂盒
CN114380917B (zh) * 2022-03-25 2022-06-14 南京融捷康生物科技有限公司 针对IL-17A和TNFα的双特异性单域抗体及其用途
CN117106083A (zh) * 2022-03-25 2023-11-24 南京融捷康生物科技有限公司 一种抗il-17a的单域抗体及其用途
CN120518762B (zh) * 2023-06-05 2025-12-26 北京东方百泰生物科技股份有限公司 一种结合il-11的抗体、其抗原结合片段及应用
CN117843777B (zh) * 2023-12-21 2024-08-27 北京贝来药业有限公司 用于炎性疾病治疗的新型纳米抗体及其产品和方法
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CN117843802B (zh) * 2023-12-29 2024-09-06 北京贝来药业有限公司 串联抗体及其下游产品和应用
CN117843801B (zh) * 2023-12-29 2024-08-02 北京贝来药业有限公司 以白介素家族成员为靶点的新型抗体以及下游产品
CN118206654B (zh) * 2024-03-05 2024-09-20 北京贝来药业有限公司 用于疾病治疗的新型抗体及其产品和应用

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US11447574B2 (en) 2022-09-20
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JP2021072810A (ja) 2021-05-13
ZA201605265B (en) 2017-11-29
CA2941656A1 (fr) 2016-03-31
US10442869B2 (en) 2019-10-15
IL244762B1 (en) 2024-07-01
PH12016501391B1 (en) 2023-08-16
MY192853A (en) 2022-09-13
EP3199550A4 (fr) 2018-09-26
EP3199550A1 (fr) 2017-08-02
RU2014138740A (ru) 2016-04-20
GEP20217311B (en) 2021-11-10
KR20170063424A (ko) 2017-06-08
RU2609627C2 (ru) 2017-02-02
EP3199550B1 (fr) 2025-03-05
US20170066843A1 (en) 2017-03-09
EP3199550B8 (fr) 2025-05-14
AR101984A1 (es) 2017-01-25
PH12016501391A1 (en) 2016-08-15
TW201620935A (zh) 2016-06-16
EA201600277A1 (ru) 2017-08-31
CA2941656C (fr) 2022-03-08
GEAP202114257A (en) 2021-07-12
MA39254A1 (fr) 2018-05-31
AU2015322141B2 (en) 2018-12-20
JP7206303B2 (ja) 2023-01-17
US20200031952A1 (en) 2020-01-30
CN107001458A (zh) 2017-08-01
SMT202500244T1 (it) 2025-07-22
MA40763B1 (fr) 2025-06-30
UA125111C2 (uk) 2022-01-12
TWI585104B (zh) 2017-06-01
AU2015322141A1 (en) 2016-09-29
JP2017538656A (ja) 2017-12-28
NZ724306A (en) 2018-10-26
SG11201607283RA (en) 2017-04-27
UY36319A (es) 2016-04-29
IL244762B2 (en) 2024-11-01
MA39254B2 (fr) 2022-04-29
IL244762A0 (en) 2016-07-31
MX2016012769A (es) 2017-05-11
WO2016048188A8 (fr) 2016-09-22
RS66961B1 (sr) 2025-07-31
BR112016015867A2 (pt) 2018-06-05
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WO2016048188A1 (fr) 2016-03-31
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