MA40769A - Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue - Google Patents

Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Info

Publication number
MA40769A
MA40769A MA040769A MA40769A MA40769A MA 40769 A MA40769 A MA 40769A MA 040769 A MA040769 A MA 040769A MA 40769 A MA40769 A MA 40769A MA 40769 A MA40769 A MA 40769A
Authority
MA
Morocco
Prior art keywords
dengue virus
mono
indoles
compounds
virus replication
Prior art date
Application number
MA040769A
Other languages
English (en)
Other versions
MA40769B1 (fr
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54207512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40769(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA40769A publication Critical patent/MA40769A/fr
Publication of MA40769B1 publication Critical patent/MA40769B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des composés indolés mono- ou di-substitués de formule (i) utiles pour prévenir ou traiter les infections par le virus de la dengue et concerne également lesdits composés destinés à être utilisés en tant que médicament, de manière davantage préférée en tant que médicament pour traiter ou prévenir infections virales de la dengue. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations destinées à être utilisées en tant que médicament, plus préférablement pour la prévention ou le traitement des infections par le virus de la dengue. L'invention concerne également des procédés de préparation des composés.
MA40769A 2014-10-01 2015-09-30 Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue MA40769B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14187373 2014-10-01
EP15156073 2015-02-23
PCT/EP2015/072534 WO2016050831A1 (fr) 2014-10-01 2015-09-30 Indoles monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
EP15771593.9A EP3201177B1 (fr) 2014-10-01 2015-09-30 Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Publications (2)

Publication Number Publication Date
MA40769A true MA40769A (fr) 2017-09-09
MA40769B1 MA40769B1 (fr) 2019-03-29

Family

ID=54207512

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40769A MA40769B1 (fr) 2014-10-01 2015-09-30 Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue

Country Status (31)

Country Link
US (1) US10206902B2 (fr)
EP (1) EP3201177B1 (fr)
JP (1) JP6701185B2 (fr)
KR (1) KR102478309B1 (fr)
CN (1) CN107001265B (fr)
AU (1) AU2015326920A1 (fr)
BR (1) BR112017006708A2 (fr)
CA (1) CA2958022A1 (fr)
CL (1) CL2017000742A1 (fr)
CY (1) CY1121972T1 (fr)
DK (1) DK3201177T3 (fr)
EA (1) EA033845B1 (fr)
ES (1) ES2711117T3 (fr)
HR (1) HRP20190139T1 (fr)
HU (1) HUE042628T2 (fr)
IL (1) IL251401A0 (fr)
LT (1) LT3201177T (fr)
MA (1) MA40769B1 (fr)
ME (1) ME03344B (fr)
MX (1) MX2017004298A (fr)
PH (1) PH12017500503A1 (fr)
PL (1) PL3201177T3 (fr)
PT (1) PT3201177T (fr)
RS (1) RS58394B1 (fr)
SG (1) SG11201702464WA (fr)
SI (1) SI3201177T1 (fr)
SM (1) SMT201900093T1 (fr)
TW (1) TW201619130A (fr)
UY (1) UY36339A (fr)
WO (1) WO2016050831A1 (fr)
ZA (1) ZA201702299B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JP6662865B2 (ja) 2014-10-01 2020-03-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ボロン酸誘導体
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
WO2017167950A1 (fr) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
JOP20170069B1 (ar) * 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN109069482B (zh) * 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
PE20200342A1 (es) 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
MX393586B (es) 2017-05-22 2025-03-24 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
CN114989131B (zh) * 2022-05-30 2023-10-24 云南大学 N’-(2-(苯并[1,3]二氧戊烷-5-基)酰基)芳酰肼类化合物及其合成和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2733554A1 (fr) * 2008-08-18 2010-02-25 Yale University Modulateurs de mif
PT2523951E (pt) * 2010-01-15 2015-09-14 Gilead Sciences Inc Inibidores de vírus flaviviridae
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
EP3201176B1 (fr) * 2014-10-01 2018-12-12 Janssen Pharmaceuticals, Inc. Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Also Published As

Publication number Publication date
CN107001265B (zh) 2021-06-15
EP3201177B1 (fr) 2018-11-21
HRP20190139T1 (hr) 2019-03-22
UY36339A (es) 2016-04-01
ES2711117T3 (es) 2019-04-30
WO2016050831A1 (fr) 2016-04-07
SMT201900093T1 (it) 2019-02-28
JP2017531638A (ja) 2017-10-26
BR112017006708A2 (pt) 2017-12-26
ME03344B (fr) 2019-10-20
CL2017000742A1 (es) 2017-11-03
MX2017004298A (es) 2017-07-19
PL3201177T3 (pl) 2019-05-31
JP6701185B2 (ja) 2020-05-27
RS58394B1 (sr) 2019-04-30
KR20170063675A (ko) 2017-06-08
EA201790700A1 (ru) 2017-08-31
CY1121972T1 (el) 2020-10-14
AU2015326920A1 (en) 2017-03-02
PT3201177T (pt) 2019-02-12
HUE042628T2 (hu) 2019-07-29
SI3201177T1 (sl) 2019-05-31
CN107001265A (zh) 2017-08-01
PH12017500503A1 (en) 2017-08-30
KR102478309B1 (ko) 2022-12-15
EP3201177A1 (fr) 2017-08-09
EA033845B1 (ru) 2019-12-02
LT3201177T (lt) 2019-03-12
TW201619130A (zh) 2016-06-01
US10206902B2 (en) 2019-02-19
IL251401A0 (en) 2017-05-29
CA2958022A1 (fr) 2016-04-07
SG11201702464WA (en) 2017-04-27
MA40769B1 (fr) 2019-03-29
DK3201177T3 (en) 2019-03-04
ZA201702299B (en) 2018-12-19
US20170224658A1 (en) 2017-08-10

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