MA37763A1 - Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 - Google Patents

Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1

Info

Publication number
MA37763A1
MA37763A1 MA37763A MA37763A MA37763A1 MA 37763 A1 MA37763 A1 MA 37763A1 MA 37763 A MA37763 A MA 37763A MA 37763 A MA37763 A MA 37763A MA 37763 A1 MA37763 A1 MA 37763A1
Authority
MA
Morocco
Prior art keywords
hexahydro
difluoro
benzooxazinyls
cyclopentaoxazinyl
bace1 inhibitors
Prior art date
Application number
MA37763A
Other languages
English (en)
Other versions
MA37763B1 (fr
Inventor
Hans Hilpert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA37763A1 publication Critical patent/MA37763A1/fr
Publication of MA37763B1 publication Critical patent/MA37763B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des difluorocyclopentaoxazinyles et des difluorobenzooxazinyles de formule (i), présentant une activité inhibitrice de bace1, leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances actives sur le plan thérapeutique. Les composés actifs de la présente invention sont utiles dans le traitement thérapeutique et/ou prophylactique de, par exemple, la maladie d'alzheimer.
MA37763A 2012-06-26 2013-06-24 Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 MA37763B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12173690 2012-06-26
PCT/EP2013/063086 WO2014001228A1 (fr) 2012-06-26 2013-06-24 Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1

Publications (2)

Publication Number Publication Date
MA37763A1 true MA37763A1 (fr) 2016-08-31
MA37763B1 MA37763B1 (fr) 2017-05-31

Family

ID=48672630

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37763A MA37763B1 (fr) 2012-06-26 2013-06-24 Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1

Country Status (21)

Country Link
US (1) US9181232B2 (fr)
EP (1) EP2864324B1 (fr)
JP (1) JP6251257B2 (fr)
KR (1) KR20150023450A (fr)
CN (1) CN104470915B (fr)
AU (1) AU2013283524B2 (fr)
BR (1) BR112014029742A2 (fr)
CA (1) CA2872181A1 (fr)
CL (1) CL2014003325A1 (fr)
CO (1) CO7151509A2 (fr)
CR (1) CR20140528A (fr)
EA (1) EA025273B1 (fr)
IL (1) IL236138A (fr)
MA (1) MA37763B1 (fr)
MX (1) MX2014014937A (fr)
NZ (1) NZ702253A (fr)
PE (1) PE20142450A1 (fr)
PH (1) PH12014502623A1 (fr)
SG (1) SG11201407576YA (fr)
UA (1) UA113309C2 (fr)
WO (1) WO2014001228A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
MX2012006491A (es) 2009-12-11 2012-07-03 Shionogi & Co Derivados de oxazina.
EP2912035A4 (fr) 2012-10-24 2016-06-15 Shionogi & Co Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1
WO2014134341A1 (fr) 2013-03-01 2014-09-04 Amgen Inc. Composés perfluorés 5,6-dihydro-4h-1,3-oxazine-2-amine substitués en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation correspondants
MX374512B (es) 2013-03-08 2025-03-06 Amgen Inc Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso.
TW201623295A (zh) 2014-04-11 2016-07-01 塩野義製藥股份有限公司 具有ｂａｃｅ１抑制活性之二氫噻及二氫衍生物
CN106795147B (zh) 2014-08-08 2020-09-22 美国安进公司 作为β-分泌酶抑制剂的环丙基稠合噻嗪-2-胺化合物和使用方法
EP3271355B1 (fr) 2015-03-20 2020-07-29 H. Hoffnabb-La Roche Ag Inhibiteurs de bace1
AU2019258575A1 (en) * 2018-04-27 2020-10-29 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
GB0912778D0 (en) * 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
MX2012006491A (es) * 2009-12-11 2012-07-03 Shionogi & Co Derivados de oxazina.
UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2

Also Published As

Publication number Publication date
CA2872181A1 (fr) 2014-01-03
IL236138A0 (en) 2015-02-01
WO2014001228A1 (fr) 2014-01-03
SG11201407576YA (en) 2015-03-30
EA201590066A1 (ru) 2015-04-30
AU2013283524A1 (en) 2014-11-13
CR20140528A (es) 2015-01-12
MX2014014937A (es) 2015-03-09
US9181232B2 (en) 2015-11-10
CN104470915A (zh) 2015-03-25
MA37763B1 (fr) 2017-05-31
HK1206344A1 (en) 2016-01-08
PH12014502623B1 (en) 2015-01-21
JP2015521640A (ja) 2015-07-30
EP2864324A1 (fr) 2015-04-29
JP6251257B2 (ja) 2017-12-20
UA113309C2 (xx) 2017-01-10
PH12014502623A1 (en) 2015-01-21
CN104470915B (zh) 2019-07-26
EA025273B1 (ru) 2016-12-30
KR20150023450A (ko) 2015-03-05
PE20142450A1 (es) 2015-01-28
EP2864324B1 (fr) 2018-03-28
CL2014003325A1 (es) 2015-04-24
BR112014029742A2 (pt) 2017-06-27
NZ702253A (en) 2016-06-24
IL236138A (en) 2016-10-31
US20150133440A1 (en) 2015-05-14
CO7151509A2 (es) 2014-12-29
AU2013283524B2 (en) 2017-03-30

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