MA41778A - Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine - Google Patents
Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaineInfo
- Publication number
- MA41778A MA41778A MA041778A MA41778A MA41778A MA 41778 A MA41778 A MA 41778A MA 041778 A MA041778 A MA 041778A MA 41778 A MA41778 A MA 41778A MA 41778 A MA41778 A MA 41778A
- Authority
- MA
- Morocco
- Prior art keywords
- benzimidazole derivatives
- bromodomain inhibitors
- compounds
- formula
- salts
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title abstract 2
- 108050009021 Bromodomains Proteins 0.000 title abstract 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
Composés de formule (i) et leurs sels: dans lesquels r1, r2, r3, r4 sont définis ici. Les composés de formule (i) et leurs sels inhibent la liaison de la famille bet des protéines de bromodomaïne à, par exemple, des résidus de lysine acétylés et peuvent donc être utilisés en thérapie, par exemple dans le traitement de maladies auto-immunes et inflammatoires, comme la polyarthrite rhumatoïde; et les cancers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1504689.9A GB201504689D0 (en) | 2015-03-19 | 2015-03-19 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA41778A true MA41778A (fr) | 2018-01-24 |
Family
ID=53052091
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046981A MA46981A (fr) | 2015-03-19 | 2016-03-17 | Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine |
| MA041778A MA41778A (fr) | 2015-03-19 | 2016-03-17 | Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046981A MA46981A (fr) | 2015-03-19 | 2016-03-17 | Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US10442786B2 (fr) |
| EP (2) | EP3271349B1 (fr) |
| JP (1) | JP6419990B2 (fr) |
| KR (1) | KR102072850B1 (fr) |
| CN (1) | CN107635989B (fr) |
| AR (1) | AR103934A1 (fr) |
| AU (1) | AU2016232217B2 (fr) |
| BR (1) | BR112017019779B1 (fr) |
| CA (1) | CA2979504C (fr) |
| CL (1) | CL2017002332A1 (fr) |
| CO (1) | CO2017009992A2 (fr) |
| CR (1) | CR20170430A (fr) |
| CY (1) | CY1121855T1 (fr) |
| DK (1) | DK3271349T3 (fr) |
| DO (1) | DOP2017000213A (fr) |
| EA (1) | EA033594B1 (fr) |
| ES (1) | ES2735417T3 (fr) |
| GB (1) | GB201504689D0 (fr) |
| HR (1) | HRP20191186T1 (fr) |
| HU (1) | HUE044414T2 (fr) |
| IL (1) | IL254318B (fr) |
| LT (1) | LT3271349T (fr) |
| MA (2) | MA46981A (fr) |
| ME (1) | ME03485B (fr) |
| MX (1) | MX2017012023A (fr) |
| PE (1) | PE20180032A1 (fr) |
| PH (1) | PH12017501620A1 (fr) |
| PL (1) | PL3271349T3 (fr) |
| PT (1) | PT3271349T (fr) |
| RS (1) | RS59056B1 (fr) |
| SG (1) | SG11201707356QA (fr) |
| SI (1) | SI3271349T1 (fr) |
| SM (1) | SMT201900428T1 (fr) |
| TW (1) | TW201706257A (fr) |
| UY (1) | UY36589A (fr) |
| WO (1) | WO2016146738A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201504689D0 (en) * | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| JP2018527340A (ja) | 2015-08-11 | 2018-09-20 | ネオメド インスティテュートＮｅｏｍｅｄ Ｉｎｓｔｉｔｕｔｅ | アリール置換ジヒドロキノリノン、その調製及び医薬品としてのその使用 |
| WO2017024406A1 (fr) | 2015-08-11 | 2017-02-16 | Neomed Institute | Lactames bicycliques n-substitués, leur préparation et leur utilisation en tant qu'agents pharmaceutiques |
| KR102784592B1 (ko) | 2015-08-12 | 2025-03-19 | 에피제네틱스, 인크. | 치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도 |
| US10501459B2 (en) | 2015-10-21 | 2019-12-10 | Neomed Institute | Substituted imidazo[1,2-a]pyridines as bromodomain inhibitors |
| US10519151B2 (en) | 2016-01-28 | 2019-12-31 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals |
| GB201614940D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| GB201614934D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| GB201614939D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Ip Dev Ltd | Crystalline hydrate |
| WO2018195155A1 (fr) | 2017-04-18 | 2018-10-25 | Celgene Quanticel Research, Inc. | Composés thérapeutiques |
| CN109280046B (zh) * | 2017-07-21 | 2021-02-02 | 浙江海正药业股份有限公司 | 苯并咪唑类衍生物及其制备方法及其在医药上的用途 |
| JP2021512960A (ja) * | 2018-02-06 | 2021-05-20 | シャンハイ ハイファ ファーマシューティカル カンパニー，リミティッド | Ｂｅｔ阻害活性を有する化合物並びにその製造方法及び使用 |
| CN109369432B (zh) * | 2018-11-02 | 2021-06-25 | 永农生物科学有限公司 | (s)-4-氯-2-氨基丁酸酯的制备方法 |
| JP2022053557A (ja) * | 2019-02-08 | 2022-04-06 | マルホ株式会社 | ピリドン誘導体 |
| BR112021016921A2 (pt) * | 2019-03-15 | 2021-11-03 | Forma Therapeutics Inc | Inibição de proteína de ligação a elemento responsivo a amp cíclico (creb) |
| WO2020219168A1 (fr) * | 2019-04-24 | 2020-10-29 | Convergene, Llc | Inhibiteurs de bromodomaines à petites molécules et leurs utilisations |
| WO2020223370A1 (fr) * | 2019-04-29 | 2020-11-05 | The Board Of Regents Of The University Of Texas System | Compositions et méthodes de traitement d'infections à schistosomes |
| CN116217416A (zh) * | 2022-12-31 | 2023-06-06 | 黄淮学院 | 一种苯并咪唑类药物中间体3-硝基-4-乙基氨基苯甲醇的制备方法 |
| CN121568924A (zh) * | 2023-05-30 | 2026-02-24 | 16380026加拿大公司 | Cyp26b1抑制剂化合物及其使用方法 |
| CN119219631B (zh) * | 2024-12-04 | 2025-04-18 | 山东大学 | 一种bet蛋白溴结构域bd1选择性共价抑制剂及其制备方法与应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| PL2007752T3 (pl) | 2006-03-31 | 2011-02-28 | Janssen Pharmaceutica Nv | Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4 |
| WO2011056635A1 (fr) * | 2009-10-27 | 2011-05-12 | Glaxosmithkline Llc | Benzimidazoles utilisés en tant qu'inhibiteurs de l'acide gras synthase |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| MY170236A (en) | 2010-10-06 | 2019-07-11 | Glaxosmithkline Llc | Benzimidazole derivatives as pi3 kinase inhibitors |
| GB201114103D0 (en) * | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
| WO2013097052A1 (fr) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Inhibiteurs de bromodomaine |
| JP2016507496A (ja) * | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． | ブロモドメイン阻害剤としての新規複素環式化合物 |
| DK2970265T3 (en) | 2013-03-15 | 2018-10-01 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF |
| TWI530499B (zh) | 2013-03-28 | 2016-04-21 | 吉李德科學股份有限公司 | 作為溴結構域（ｂｒｏｍｏｄｏｍａｉｎ）抑制劑之苯並咪唑酮衍生物類 |
| TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
| JP6461118B2 (ja) * | 2013-06-21 | 2019-01-30 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての新規の置換された二環式化合物 |
| US20150051208A1 (en) * | 2013-08-14 | 2015-02-19 | Boehringer Ingelheim International Gmbh | Pyridinones |
| US9428515B2 (en) * | 2014-05-09 | 2016-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazole derivatives |
| GB201504694D0 (en) * | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| GB201504689D0 (en) * | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201614939D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Ip Dev Ltd | Crystalline hydrate |
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2015
- 2015-03-19 GB GBGB1504689.9A patent/GB201504689D0/en not_active Ceased
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2016
- 2016-03-15 AR ARP160100683A patent/AR103934A1/es unknown
- 2016-03-17 PT PT16710214T patent/PT3271349T/pt unknown
- 2016-03-17 KR KR1020177030073A patent/KR102072850B1/ko not_active Expired - Fee Related
- 2016-03-17 CA CA2979504A patent/CA2979504C/fr active Active
- 2016-03-17 PL PL16710214T patent/PL3271349T3/pl unknown
- 2016-03-17 SG SG11201707356QA patent/SG11201707356QA/en unknown
- 2016-03-17 TW TW105108340A patent/TW201706257A/zh unknown
- 2016-03-17 US US15/559,556 patent/US10442786B2/en active Active
- 2016-03-17 EP EP16710214.4A patent/EP3271349B1/fr active Active
- 2016-03-17 SI SI201630321T patent/SI3271349T1/sl unknown
- 2016-03-17 LT LTEP16710214.4T patent/LT3271349T/lt unknown
- 2016-03-17 MX MX2017012023A patent/MX2017012023A/es unknown
- 2016-03-17 EA EA201791973A patent/EA033594B1/ru not_active IP Right Cessation
- 2016-03-17 AU AU2016232217A patent/AU2016232217B2/en not_active Ceased
- 2016-03-17 CR CR20170430A patent/CR20170430A/es unknown
- 2016-03-17 CN CN201680027314.8A patent/CN107635989B/zh not_active Expired - Fee Related
- 2016-03-17 UY UY0001036589A patent/UY36589A/es not_active Application Discontinuation
- 2016-03-17 HR HRP20191186TT patent/HRP20191186T1/hr unknown
- 2016-03-17 JP JP2017548404A patent/JP6419990B2/ja not_active Expired - Fee Related
- 2016-03-17 DK DK16710214.4T patent/DK3271349T3/da active
- 2016-03-17 HU HUE16710214 patent/HUE044414T2/hu unknown
- 2016-03-17 MA MA046981A patent/MA46981A/fr unknown
- 2016-03-17 ES ES16710214T patent/ES2735417T3/es active Active
- 2016-03-17 EP EP19174047.1A patent/EP3549939A1/fr not_active Withdrawn
- 2016-03-17 RS RS20190986A patent/RS59056B1/sr unknown
- 2016-03-17 MA MA041778A patent/MA41778A/fr unknown
- 2016-03-17 BR BR112017019779-0A patent/BR112017019779B1/pt not_active IP Right Cessation
- 2016-03-17 PE PE2017001543A patent/PE20180032A1/es unknown
- 2016-03-17 SM SM20190428T patent/SMT201900428T1/it unknown
- 2016-03-17 ME MEP-2019-171A patent/ME03485B/fr unknown
- 2016-03-17 WO PCT/EP2016/055792 patent/WO2016146738A1/fr not_active Ceased
-
2017
- 2017-09-04 IL IL254318A patent/IL254318B/en active IP Right Grant
- 2017-09-07 PH PH12017501620A patent/PH12017501620A1/en unknown
- 2017-09-14 CL CL2017002332A patent/CL2017002332A1/es unknown
- 2017-09-19 DO DO2017000213A patent/DOP2017000213A/es unknown
- 2017-09-29 CO CONC2017/0009992A patent/CO2017009992A2/es unknown
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2019
- 2019-07-26 CY CY20191100796T patent/CY1121855T1/el unknown
- 2019-08-22 US US16/547,909 patent/US11053212B2/en not_active Expired - Fee Related
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