MA41977A - Imidazopyrazinones utilisées comme inhibiteurs de pde1 - Google Patents

Imidazopyrazinones utilisées comme inhibiteurs de pde1

Info

Publication number
MA41977A
MA41977A MA041977A MA41977A MA41977A MA 41977 A MA41977 A MA 41977A MA 041977 A MA041977 A MA 041977A MA 41977 A MA41977 A MA 41977A MA 41977 A MA41977 A MA 41977A
Authority
MA
Morocco
Prior art keywords
imidazopyrazinones
pde1 inhibitors
pde1
inhibitors
imidazopyrazinones used
Prior art date
Application number
MA041977A
Other languages
English (en)
Other versions
MA41977B1 (fr
Inventor
Mikkel Jessing
Karsten Juhl
Jan Kehler
Morten Langgård
Lars Kyhn Rasmussen
Paulo Jorge Vieira Vital
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MA41977A publication Critical patent/MA41977A/fr
Publication of MA41977B1 publication Critical patent/MA41977B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA41977A 2015-04-30 2016-04-29 Imidazopyrazinones utilisées comme inhibiteurs de pde1 MA41977B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201500261 2015-04-30
DKPA201500666 2015-10-29
DKPA201600202 2016-04-04
PCT/EP2016/059583 WO2016174188A1 (fr) 2015-04-30 2016-04-29 Imidazopyrazinones utilisées comme inhibiteurs de pde1
EP16720101.1A EP3288944B1 (fr) 2015-04-30 2016-04-29 Imidazopyrazinones utilisées comme inhibiteurs de pde1

Publications (2)

Publication Number Publication Date
MA41977A true MA41977A (fr) 2018-07-23
MA41977B1 MA41977B1 (fr) 2019-08-30

Family

ID=55910242

Family Applications (1)

Application Number Title Priority Date Filing Date
MA41977A MA41977B1 (fr) 2015-04-30 2016-04-29 Imidazopyrazinones utilisées comme inhibiteurs de pde1

Country Status (42)

Country Link
US (4) US20160318939A1 (fr)
EP (1) EP3288944B1 (fr)
JP (1) JP6663930B2 (fr)
KR (1) KR102605759B1 (fr)
CN (1) CN107531714B (fr)
AU (1) AU2016256573B2 (fr)
BR (1) BR112017023182B1 (fr)
CA (1) CA2983563A1 (fr)
CL (1) CL2017002719A1 (fr)
CO (1) CO2017010399A2 (fr)
CY (1) CY1121806T1 (fr)
DK (1) DK3288944T3 (fr)
DO (1) DOP2017000254A (fr)
EA (1) EA031946B1 (fr)
EC (1) ECSP17072228A (fr)
ES (1) ES2735422T3 (fr)
GE (2) GEP20207058B (fr)
GT (1) GT201700223A (fr)
HK (1) HK1252098B (fr)
HR (1) HRP20191180T1 (fr)
HU (1) HUE044244T2 (fr)
IL (1) IL255316B (fr)
JO (1) JO3627B1 (fr)
LT (1) LT3288944T (fr)
MA (1) MA41977B1 (fr)
ME (1) ME03414B (fr)
MX (1) MX375737B (fr)
MY (1) MY182382A (fr)
PE (1) PE20180121A1 (fr)
PH (1) PH12017501990B1 (fr)
PL (1) PL3288944T3 (fr)
PT (1) PT3288944T (fr)
RS (1) RS59051B1 (fr)
RU (1) RU2712219C2 (fr)
SG (1) SG11201708822PA (fr)
SI (1) SI3288944T1 (fr)
SM (1) SMT201900393T1 (fr)
TN (1) TN2017000428A1 (fr)
TW (1) TWI695838B (fr)
UA (1) UA123050C2 (fr)
WO (1) WO2016174188A1 (fr)
ZA (1) ZA201706847B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
CN109843884B (zh) 2016-10-18 2022-03-04 H.隆德贝克有限公司 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮
EP3532064B1 (fr) 2016-10-28 2020-07-29 H. Lundbeck A/S Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs
KR20190077349A (ko) 2016-10-28 2019-07-03 하. 룬드벡 아크티에셀스카브 이미다조피라지논의 투여를 포함하는 병용 치료
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
JP7254078B2 (ja) 2017-11-27 2023-04-07 ダート・ニューロサイエンス・エルエルシー Ｐｄｅ１阻害剤としての置換フラノピリミジン化合物
AR113926A1 (es) * 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
EP3728250A1 (fr) 2017-12-20 2020-10-28 H. Lundbeck A/S PYRAZOLO[3,4-beta]PYRIDINES ET IMIDAZO[1,5-beta]PYRIDAZINES UTILISÉES EN TANT QU'INHIBITEURS DE PDE1
EP3802545A4 (fr) 2018-05-25 2022-03-16 Intra-Cellular Therapies, Inc. Composés organiques
WO2020210614A1 (fr) 2019-04-12 2020-10-15 Intra-Cellular Therapies, Inc. Composés organiques
IT202200024948A1 (it) * 2022-12-05 2024-06-05 Angelini Pharma S P A Composti attivatori dei canali potassio KV7.2/KV7.3

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973361A (en) 1960-05-11 1964-10-28 Ciba Ltd Pyrazolo-pyrimidines and process for their manufacture
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
MY144532A (en) 2001-08-20 2011-09-30 Lundbeck & Co As H Novel method for down-regulation of amyloid
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
WO2004099211A1 (fr) 2003-05-09 2004-11-18 Bayer Healthcare Ag Pyrazolopyrimidines substituees par 6-cyclylmethyle et 6-alkylmethyle
DE602005014964D1 (de) * 2004-04-02 2009-07-30 Osi Pharm Inc Mit einem 6,6-bicyclischen ring substituierte heterobicyclische proteinkinaseinhibitoren
EP1828192B1 (fr) * 2004-12-21 2014-12-03 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
US20080194592A1 (en) * 2005-08-23 2008-08-14 Intra-Cellular Therapies, Inc. Organic Compounds
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
DK2152712T3 (da) 2007-05-11 2012-03-26 Pfizer Aminoheterocykliske fobindelser
AU2008329072A1 (en) 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-A) pyrazines as inhibitors of phosphodiesterase 10
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
PE20110383A1 (es) * 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
BRPI0922809A2 (pt) * 2008-12-06 2018-05-29 Intracellular Therapies Inc compostos orgânicos
EP2367430B1 (fr) 2008-12-06 2014-08-13 Intra-Cellular Therapies, Inc. Composés organiques
TWI404721B (zh) * 2009-01-26 2013-08-11 Pfizer 胺基－雜環化合物
WO2010144711A2 (fr) 2009-06-10 2010-12-16 New York University Ciblage immunologique de protéines tau pathologiques
US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
LT3339323T (lt) 2010-08-12 2020-02-10 Eli Lilly And Company Amiloido beta peptido antikūnai prieš n3glu ir jų panaudojimas
RU2603140C2 (ru) 2010-09-20 2016-11-20 Айронвуд Фармасьютикалз, Инк. Соединения имидазотриазинона
EP2619204A4 (fr) 2010-09-21 2014-08-27 Merck Sharp & Dohme Triazolopyrazinones comme antagonistes des récepteurs p2x7
JO3089B1 (ar) 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
WO2012136552A1 (fr) 2011-04-08 2012-10-11 H. Lundbeck A/S Anticorps spécifiquement dirigés contre la protéine bêta-amyloïde pyroglutamatée
WO2012171016A1 (fr) 2011-06-10 2012-12-13 Intra-Cellular Therapies, Inc. Composés organiques
HK1211023A1 (zh) * 2011-10-10 2016-05-13 H. Lundbeck A/S 具有咪唑并吡嗪骨架pde9i
AP2014007820A0 (en) 2012-01-26 2014-07-31 Lundbeck & Co As H PDE9 inhibitors with imidazo triazinone backbone
JP2013166727A (ja) 2012-02-16 2013-08-29 Dainippon Sumitomo Pharma Co Ltd ジヒドロイミダゾピラジノン誘導体
AU2013277294C1 (en) 2012-06-18 2018-02-08 Dart Neuroscience (Cayman) Ltd Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
PL2970279T3 (pl) 2013-03-15 2021-05-31 Intra-Cellular Therapies, Inc. Związki organiczne
JP5783297B2 (ja) 2013-08-06 2015-09-24 株式会社デンソー 力学量センサ
GEAP201814248A (en) 2014-02-19 2018-04-10 H Lundbeck As 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease
JP5797815B1 (ja) 2014-06-27 2015-10-21 細田建設株式会社 後施工アンカー及びその施工方法
US20160083400A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
WO2016042775A1 (fr) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Dérivé tricyclique
US20160083391A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic piperazine derivative
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
MA40941A (fr) 2014-11-10 2017-09-19 H Lundbeck As 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
JO3458B1 (ar) 2014-11-10 2020-07-05 H Lundbeck As 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1
CR20170187A (es) 2014-11-10 2018-02-01 H Lundbeck As 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer
US20180044343A1 (en) 2015-03-16 2018-02-15 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative
TW201643167A (zh) 2015-04-22 2016-12-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之咪唑並三酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
JP2018531889A (ja) 2015-08-12 2018-11-01 ハー・ルンドベック・アクチエゼルスカベット Ｂａｃｅ１阻害剤としての２−アミノ−３−フルオロ−３−（フルオロメチル）−６−メチル−６−フェニル−３，４，５，６−テトラヒドロピリジン
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
CN109843884B (zh) 2016-10-18 2022-03-04 H.隆德贝克有限公司 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮
KR20190077349A (ko) 2016-10-28 2019-07-03 하. 룬드벡 아크티에셀스카브 이미다조피라지논의 투여를 포함하는 병용 치료
EP3532064B1 (fr) 2016-10-28 2020-07-29 H. Lundbeck A/S Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs

Also Published As

Publication number Publication date
RU2017137514A3 (fr) 2019-07-17
HRP20191180T1 (hr) 2019-10-04
US20190062335A1 (en) 2019-02-28
ME03414B (fr) 2020-01-20
HUE044244T2 (hu) 2019-10-28
EP3288944A1 (fr) 2018-03-07
ECSP17072228A (es) 2018-02-28
CY1121806T1 (el) 2020-07-31
CN107531714A (zh) 2018-01-02
EA201792157A1 (ru) 2018-03-30
US11472810B2 (en) 2022-10-18
GT201700223A (es) 2018-12-19
PT3288944T (pt) 2019-07-19
AU2016256573A1 (en) 2017-12-14
US20210238182A1 (en) 2021-08-05
CN107531714B (zh) 2019-07-19
LT3288944T (lt) 2019-07-25
MY182382A (en) 2021-01-22
RS59051B1 (sr) 2019-08-30
HK1252098A1 (en) 2019-05-17
PL3288944T3 (pl) 2019-11-29
CO2017010399A2 (es) 2018-01-05
US10011606B2 (en) 2018-07-03
ZA201706847B (en) 2019-01-30
DOP2017000254A (es) 2018-01-15
SG11201708822PA (en) 2017-11-29
BR112017023182A2 (fr) 2018-10-02
MX375737B (es) 2025-03-06
PE20180121A1 (es) 2018-01-18
RU2712219C2 (ru) 2020-01-27
CL2017002719A1 (es) 2018-04-20
KR20170140216A (ko) 2017-12-20
KR102605759B1 (ko) 2023-11-23
PH12017501990A1 (en) 2018-03-26
CA2983563A1 (fr) 2016-11-03
EP3288944B1 (fr) 2019-06-12
ES2735422T3 (es) 2019-12-18
AU2016256573B2 (en) 2019-11-21
SMT201900393T1 (it) 2019-09-09
SI3288944T1 (sl) 2019-08-30
EA031946B1 (ru) 2019-03-29
JO3627B1 (ar) 2020-08-27
IL255316A0 (en) 2017-12-31
JP2018514552A (ja) 2018-06-07
TN2017000428A1 (en) 2019-04-12
PH12017501990B1 (en) 2021-01-13
JP6663930B2 (ja) 2020-03-13
US20160318939A1 (en) 2016-11-03
US10858362B2 (en) 2020-12-08
GEP20207058B (en) 2020-01-27
TWI695838B (zh) 2020-06-11
IL255316B (en) 2021-10-31
RU2017137514A (ru) 2019-05-31
MA41977B1 (fr) 2019-08-30
MX2017013785A (es) 2018-03-27
DK3288944T3 (da) 2019-07-22
US20170291903A1 (en) 2017-10-12
TW201700477A (zh) 2017-01-01
HK1252098B (en) 2020-02-07
GEAP201914615A (en) 2019-09-25
WO2016174188A1 (fr) 2016-11-03
BR112017023182B1 (pt) 2023-10-31
UA123050C2 (uk) 2021-02-10

Similar Documents

Publication Publication Date Title
CY2024003I1 (el) Ενωσεις χρησιμες ως αναστολεις κινασης
MA41977A (fr) Imidazopyrazinones utilisées comme inhibiteurs de pde1
EP3541932A4 (fr) Inhibiteurs de crispr-cas9
LT3436461T (lt) Pirolotriazino junginiai kaip tam inhibitoriai
IL251420A0 (en) Triazolopyrazinones as pde1 inhibitors
LT3303334T (lt) Tirozinkinazės inhibitoriai
EP3347008A4 (fr) Inhibiteurs de bêta-lactamases
DK3072835T3 (da) Fremgangsmåde til fremføring
EP3313828A4 (fr) Inhibiteurs de métallo-bêta-lactamases
MA41677A (fr) Composés alpha-cinnamide et compositions comme inhibiteurs de hdac8
MA44006A (fr) Inhibiteur pde1
EP3347333C0 (fr) Compositions inhibitrices de polymérisation
EP3334726A4 (fr) Compositions de plinabuline
DK3250182T3 (da) Dispergible sammensætninger
DK3116475T3 (da) Dopa-decarboxylasehæmmersammensætninger
MA42597A (fr) 2-amino-3-fluoro-3-(fluorométhyl)-6-méthyl-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
MA43367A (fr) Inhibiteurs de métallo-bêta-lactamases
DK3717488T3 (da) Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
EP2976340A4 (fr) Cycloalkylnitrile pyrazolopyridones utilisées comme inhibiteurs de la janus kinase
IL248078B (en) Halogenated quinazolin-thf-amines as pde1 inhibitors
DK3331498T3 (da) Nasalsammensætning
DK3316857T3 (da) Multifasiske sammensætninger
IL246718A0 (en) Hexahydrofuropyrroles as pde1 inhibitors
EP3414334C0 (fr) Procédé
EP3368013C0 (fr) Formulations liquides de buprénorphine