MA42701B1 - Compositions d'insuline à action rapide - Google Patents

Compositions d'insuline à action rapide

Info

Publication number
MA42701B1
MA42701B1 MA42701A MA42701A MA42701B1 MA 42701 B1 MA42701 B1 MA 42701B1 MA 42701 A MA42701 A MA 42701A MA 42701 A MA42701 A MA 42701A MA 42701 B1 MA42701 B1 MA 42701B1
Authority
MA
Morocco
Prior art keywords
acting insulin
rapid acting
insulin compositions
insulin
analogue
Prior art date
Application number
MA42701A
Other languages
English (en)
Other versions
MA42701A (fr
Inventor
Michael Patrick Akers
Ranajoy Majumdar
Chi A Nguyen
Chad D Paavola
Virender Kumar Sarin
Nanette Elizabeth Schulte
Michael Edward Christe
Thomas Andrew Hardy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57003563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA42701(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA42701A publication Critical patent/MA42701A/fr
Publication of MA42701B1 publication Critical patent/MA42701B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une composition pharmaceutique d'insuline humaine ou d'analogue d'insuline, qui comprend du citrate, du tréprostinil et des agents de stabilisation, qui a une action pharmacocinétique et/ou pharmacodynamique plus rapide que des formulations commerciales de produits analogues d'insuline existants, et qui est stable pour une utilisation commerciale.
MA42701A 2015-08-27 2016-08-19 Compositions d'insuline à action rapide MA42701B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562210469P 2015-08-27 2015-08-27
PCT/US2016/047723 WO2017034956A1 (fr) 2015-08-27 2016-08-19 Compositions d'insuline à action rapide

Publications (2)

Publication Number Publication Date
MA42701A MA42701A (fr) 2018-07-04
MA42701B1 true MA42701B1 (fr) 2023-01-31

Family

ID=57003563

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42701A MA42701B1 (fr) 2015-08-27 2016-08-19 Compositions d'insuline à action rapide

Country Status (38)

Country Link
US (3) US9901623B2 (fr)
EP (2) EP3340966B1 (fr)
JP (2) JP6359780B2 (fr)
KR (1) KR102018998B1 (fr)
CN (1) CN107920992B (fr)
AR (2) AR105712A1 (fr)
AU (1) AU2016310475B2 (fr)
CA (1) CA2994427C (fr)
CL (1) CL2018000503A1 (fr)
CO (1) CO2018002026A2 (fr)
CR (1) CR20180118A (fr)
DK (1) DK3340966T3 (fr)
DO (1) DOP2018000059A (fr)
EA (1) EA033396B1 (fr)
EC (1) ECSP18014922A (fr)
ES (1) ES2928664T3 (fr)
FI (1) FI3340966T3 (fr)
HR (1) HRP20221367T1 (fr)
HU (1) HUE060626T2 (fr)
IL (1) IL256939B (fr)
JO (1) JO3749B1 (fr)
LT (1) LT3340966T (fr)
MA (1) MA42701B1 (fr)
MD (1) MD3340966T2 (fr)
MX (1) MX379267B (fr)
MY (1) MY195781A (fr)
NZ (1) NZ739338A (fr)
PE (1) PE20180782A1 (fr)
PH (1) PH12018500422B1 (fr)
PL (1) PL3340966T3 (fr)
PT (1) PT3340966T (fr)
RS (1) RS63731B1 (fr)
SV (1) SV2018005643A (fr)
TN (1) TN2018000056A1 (fr)
TW (1) TWI614025B (fr)
UA (1) UA120142C2 (fr)
WO (1) WO2017034956A1 (fr)
ZA (1) ZA201800511B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104902922B (zh) 2012-11-13 2017-12-12 阿道恰公司 包含经取代阴离子化合物的速效胰岛素制剂
TW201630622A (zh) * 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) * 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
JP2019529506A (ja) 2016-09-29 2019-10-17 アレコル リミテッド 新規の製剤
CN110662551B (zh) * 2017-06-01 2023-07-18 伊莱利利公司 速效胰岛素组合物
WO2019050749A1 (fr) * 2017-09-08 2019-03-14 Eli Lilly And Company Combinaisons pharmaceutiques comprenant de l'insuline et au moins un agent sélectionné parmi le méloxicam, le bromfénac sodique, l'acide acétylsalicylique, l'acide salicylique et le paracétamol
US20210113763A1 (en) * 2018-04-04 2021-04-22 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
US12357562B2 (en) 2018-04-04 2025-07-15 Arecor Limited Injection pen system for the delivery of an insulin compound
KR102833828B1 (ko) * 2018-04-04 2025-07-15 아레콜 리미티드 인슐린 화합물의 전달을 위한 의료용 주입 펌프 시스템
FR3083984A1 (fr) 2018-07-23 2020-01-24 Adocia Dispositif pour injecter une solution d'insuline(s)
WO2019243627A1 (fr) 2018-06-23 2019-12-26 Adocia Dispositif pour injecter une solution d'insuline(s)
FR3083985A1 (fr) 2018-07-23 2020-01-24 Adocia Dispositif pour injecter une solution d'insuline(s)
ES2976468T3 (es) * 2018-09-18 2024-08-01 Lilly Co Eli Sal de treprostinil erbumina
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
TW202214292A (zh) * 2020-06-30 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 速效胰島素組成物及其醫藥用途

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2740953A1 (de) 1977-09-12 1979-03-22 Thera Ges Fuer Patente Verwendung von prostaglandinen zur senkung des blutzuckerspiegels
DE3064888D1 (en) 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
ZA821243B (en) * 1981-03-10 1983-01-26 Novo Industri As Stabilized insulin preparation and method for their production
FI78616C (fi) 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK503386D0 (da) * 1986-10-20 1986-10-20 Novo Industri As Peptidpraeparater
IE62879B1 (en) 1987-02-25 1995-03-08 Novo Nordisk As Novel insulin derivatives
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
HUT56857A (en) 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
JPH11292787A (ja) * 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US5866538A (en) 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
AUPO066096A0 (en) 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
JPH10251146A (ja) 1997-03-11 1998-09-22 Toray Ind Inc 糖尿病性神経障害の治療方法
WO1999034821A1 (fr) 1998-01-09 1999-07-15 Novo Nordisk A/S Compositions d'insuline stabilisees
WO2000043034A2 (fr) 1999-01-26 2000-07-27 Eli Lilly And Company Formulations d'analogues d'insuline acyles hexameres monodisperses
EP1231907A2 (fr) 1999-11-15 2002-08-21 Hanamaraddi T. Gangal Preparation de fluides a base de dextrose et d'insuline destinee a une infusion intraveineuse
US20020141946A1 (en) 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
JP5599543B2 (ja) 2002-05-07 2014-10-01 ノヴォ ノルディスク アー／エス 単量体インスリン及びアシル化インスリンを含む可溶性製剤
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
DE602004028155D1 (de) * 2003-12-16 2010-08-26 United Therapeutics Corp Verwendung von treprostinil zur behandlung von ischämischen läsionen
US7279457B2 (en) 2004-03-12 2007-10-09 Biodel, Inc. Rapid acting drug delivery compositions
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
WO2005099680A2 (fr) 2004-04-12 2005-10-27 United Therapeutics, Inc. Utilisation de treprostinile pour traiter des ulceres diabetiques neuropathiques du pied
US20080171695A1 (en) * 2005-02-02 2008-07-17 Novo Nordisk A/S Insulin Derivatives
EP2256130B1 (fr) * 2005-02-02 2013-09-25 Novo Nordisk A/S Nouveaux dérivés d'insuline
WO2007041481A1 (fr) 2005-09-29 2007-04-12 Biodel, Inc. Preparations d'insuline a action rapide et prolongee
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
WO2007038670A2 (fr) * 2005-09-30 2007-04-05 Perlegen Sciences, Inc. Troubles de la regulation de la glycemie :methodes et depistage et traitement
DE102006047613A1 (de) * 2006-10-07 2008-04-10 Sanofi-Aventis Deutschland Gmbh Peristaltische Mikropumpe mit wechselbarem Pumpenkopf
DE102006047538A1 (de) * 2006-10-07 2008-04-10 Sanofi-Aventis Deutschland Gmbh Medikamentendosiersystem mittels Mikropumpe
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
EP2545920A1 (fr) * 2007-08-22 2013-01-16 Abbott GmbH & Co. KG Thérapie pour complications du diabète
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
TWI451876B (zh) * 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
DK2328636T3 (da) 2008-08-28 2013-09-02 Medingo Ltd Anordning til forbedret subkutan insulinabsorption
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
US20120094902A1 (en) 2009-03-27 2012-04-19 Adocia Fast-acting insulin formulation
KR101775000B1 (ko) 2009-06-26 2017-09-04 노보 노르디스크 에이/에스 인슐린, 니코틴아미드 및 아미노산을 포함하는 제제
CN102655866B (zh) 2009-11-13 2013-11-13 东丽株式会社 糖尿病的治疗或预防药
CA2805031A1 (fr) 2010-07-07 2012-01-12 Biodel, Inc. Compositions et procedes pour la modulation de la pharmacocinetique et de la pharmacodynamie de l'insuline
KR20140030125A (ko) 2010-12-14 2014-03-11 노보 노르디스크 에이/에스 인슐린, 니코틴아미드 및 아미노산을 포함하는 제제
CA2839512C (fr) 2011-06-17 2018-01-02 Halozyme, Inc. Procedes de perfusion d'insuline sous-cutanee continue utilisant une enzyme de degradation de l'hyaluronane
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
JP5912426B2 (ja) * 2011-11-07 2016-04-27 ヤマハ発動機株式会社 リニアコンベア
WO2013102144A2 (fr) 2011-12-30 2013-07-04 Halozyme, Inc. Variants du polypeptide ph20, formulations en contenant et leurs utilisations
US9381247B2 (en) * 2012-04-16 2016-07-05 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9399065B2 (en) 2012-04-16 2016-07-26 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
WO2013177565A1 (fr) 2012-05-25 2013-11-28 Amylin Pharmaceuticals, Llc Compositions d'insuline/pramlintide et leurs procédés de fabrication et d'utilisation
US20150065423A1 (en) * 2013-08-30 2015-03-05 Perosphere, Inc. Rapid acting injectable formulations
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
WO2015120457A1 (fr) * 2014-02-10 2015-08-13 Biodel Inc. Formulations d'insuline à action ultrarapide stabilisées
TWI685348B (zh) * 2014-05-08 2020-02-21 美國禮來大藥廠 速效胰島素組合物
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
WO2017015760A1 (fr) 2015-07-28 2017-02-02 Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines, S.E.C. Préparation pharmaceutique pour améliorer l'absorption et l'action hypoglycémique postprandiale de l'insuline
JO3749B1 (ar) * 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول

Also Published As

Publication number Publication date
SV2018005643A (es) 2018-10-09
JO3749B1 (ar) 2021-01-31
PL3340966T3 (pl) 2023-01-30
ZA201800511B (en) 2019-07-31
PH12018500422A1 (en) 2018-08-29
CA2994427C (fr) 2019-07-09
JP2018172404A (ja) 2018-11-08
DOP2018000059A (es) 2018-04-15
DK3340966T3 (da) 2022-10-24
EP3340966A1 (fr) 2018-07-04
CN107920992B (zh) 2021-06-18
IL256939A (en) 2018-03-29
PT3340966T (pt) 2022-12-05
HRP20221367T1 (hr) 2023-01-06
IL256939B (en) 2019-10-31
US20170056478A1 (en) 2017-03-02
EA033396B1 (ru) 2019-10-31
MX2018002482A (es) 2018-06-15
TW201717997A (zh) 2017-06-01
KR20180033276A (ko) 2018-04-02
CR20180118A (es) 2018-03-20
EP4169505A1 (fr) 2023-04-26
CL2018000503A1 (es) 2018-08-03
JP6359780B2 (ja) 2018-07-18
JP6935364B2 (ja) 2021-09-15
PH12018500422B1 (en) 2022-04-01
RS63731B1 (sr) 2022-12-30
PE20180782A1 (es) 2018-05-07
FI3340966T3 (fi) 2023-01-13
MD3340966T2 (ro) 2023-04-30
AR134413A2 (es) 2026-01-14
TWI614025B (zh) 2018-02-11
BR112018001755A2 (pt) 2018-09-18
EA201890343A1 (ru) 2018-07-31
MX379267B (es) 2025-03-11
UA120142C2 (uk) 2019-10-10
CA2994427A1 (fr) 2017-03-02
EP3340966B1 (fr) 2022-10-12
AR105712A1 (es) 2017-11-01
JP2018507869A (ja) 2018-03-22
US20210169988A1 (en) 2021-06-10
ES2928664T3 (es) 2022-11-21
LT3340966T (lt) 2022-11-25
CN107920992A (zh) 2018-04-17
WO2017034956A1 (fr) 2017-03-02
KR102018998B1 (ko) 2019-09-05
CO2018002026A2 (es) 2018-05-21
AU2016310475A1 (en) 2018-02-15
AU2016310475B2 (en) 2018-10-18
MY195781A (en) 2023-02-13
MA42701A (fr) 2018-07-04
US20180140676A1 (en) 2018-05-24
US10925931B2 (en) 2021-02-23
US9901623B2 (en) 2018-02-27
ECSP18014922A (es) 2018-04-30
HUE060626T2 (hu) 2023-03-28
NZ739338A (en) 2019-06-28
TN2018000056A1 (en) 2019-07-08

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