MA42780A - Sels d'un inhibiteur de la kinase pim - Google Patents

Sels d'un inhibiteur de la kinase pim

Info

Publication number
MA42780A
MA42780A MA042780A MA42780A MA42780A MA 42780 A MA42780 A MA 42780A MA 042780 A MA042780 A MA 042780A MA 42780 A MA42780 A MA 42780A MA 42780 A MA42780 A MA 42780A
Authority
MA
Morocco
Prior art keywords
salts
pim inhibitor
kinase pim
kinase
inhibitor
Prior art date
Application number
MA042780A
Other languages
English (en)
Inventor
Ganfeng Cao
Zhongjiang Jia
Qun Li
Qiyan Lin
Yongchun Pan
Lei Qiao
Vaqar Sharief
Chongsheng Eric Shi
Michael Xia
Changsheng Zheng
Jiacheng Zhou
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MA42780A publication Critical patent/MA42780A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Plant Substances (AREA)
MA042780A 2015-09-09 2016-09-09 Sels d'un inhibiteur de la kinase pim MA42780A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562216045P 2015-09-09 2015-09-09
US201562244933P 2015-10-22 2015-10-22

Publications (1)

Publication Number Publication Date
MA42780A true MA42780A (fr) 2018-07-18

Family

ID=56985689

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042780A MA42780A (fr) 2015-09-09 2016-09-09 Sels d'un inhibiteur de la kinase pim

Country Status (24)

Country Link
US (6) US9862705B2 (fr)
EP (1) EP3347351B1 (fr)
JP (1) JP6943844B2 (fr)
KR (1) KR102720267B1 (fr)
CN (2) CN108349938B (fr)
AR (1) AR105967A1 (fr)
AU (2) AU2016320892C1 (fr)
CA (1) CA2997768C (fr)
CL (3) CL2018000611A1 (fr)
CO (1) CO2018003739A2 (fr)
EA (1) EA201890663A1 (fr)
EC (1) ECSP18026386A (fr)
ES (1) ES2914686T3 (fr)
IL (2) IL306054A (fr)
MA (1) MA42780A (fr)
MX (2) MX388988B (fr)
MY (2) MY187993A (fr)
PE (1) PE20181337A1 (fr)
PH (1) PH12018500511A1 (fr)
SG (1) SG10201912287XA (fr)
TW (1) TWI734699B (fr)
UA (1) UA124877C2 (fr)
WO (1) WO2017044730A1 (fr)
ZA (1) ZA201802267B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
CN105658653A (zh) 2013-08-23 2016-06-08 因赛特公司 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (fr) 2015-05-29 2016-12-08 Incyte Corporation Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (fr) 2015-10-02 2017-04-06 Incyte Corporation Composés hétérocycliques utiles en tant qu'inhibiteurs de la kinase pim
WO2019113487A1 (fr) 2017-12-08 2019-06-13 Incyte Corporation Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
EP3967307A1 (fr) 2020-09-15 2022-03-16 Instytut Hematologii I Transfuzologii Utilisation d'inhibiteurs de la pim kinase pour augmenter l'efficacité des thérapies anti-cd20 à base d'anticorps dans les malignités hématologiques et les affections non malignes

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60105023T2 (de) 2000-06-28 2005-08-18 Smithkline Beecham P.L.C., Brentford Nassvermahlungsverfahren
WO2002055489A2 (fr) 2000-12-27 2002-07-18 Univ Columbia Techniques liees a la kinase pim
MXPA03008936A (es) * 2001-03-30 2005-03-07 King Pharmaceuticals Res & Dev Compuestos farmaceuticamente activos y metodos de uso.
DE10123055A1 (de) 2001-05-11 2003-03-20 Gruenenthal Gmbh Screeningverfahren mit PIM1-Kinase oder PIM3-Kinase
DE10226702A1 (de) 2002-06-14 2004-09-09 Grünenthal GmbH Antisense Oligonukleotide gegen PIM1
CA2503905A1 (fr) 2002-09-16 2004-03-25 Plexxikon, Inc. Structure cristalline de la proteine kinase pim-1
WO2006078228A1 (fr) 2002-09-16 2006-07-27 Plexxikon, Inc. Procedes de conception d'echafaudages moleculaires et de ligands
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
WO2004090106A2 (fr) 2003-04-04 2004-10-21 Vertex Pharmaceuticals Incorporated Structures cristallines de complexes proteiques humains de la pim-1 kinase et poches de liaison de ces structures, et leurs utilisations dans la conception de medicaments
WO2005028624A2 (fr) 2003-09-15 2005-03-31 Plexxikon, Inc. Echafaudages moleculaires pour le developpement de ligands des proteines kinases
WO2005033310A1 (fr) 2003-10-01 2005-04-14 Grünenthal GmbH Composes dsrna pim-1-specifiques
WO2006006569A1 (fr) 2004-07-12 2006-01-19 Nihon Nohyaku Co., Ltd. Dérivé de phénylpyridine ou sel de celui-ci, herbicide contenant celui-ci comme ingrédient actif et procédé d'utilisation de celui-ci
WO2006071960A2 (fr) 2004-12-28 2006-07-06 Kinex Pharmaceuticals, Llc Compositions et procedes de traitement de troubles de la proliferation cellulaire
PL2395004T3 (pl) 2005-06-22 2016-08-31 Plexxikon Inc Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
WO2007011760A2 (fr) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibiteurs de la kinesine mitotique
DE602005010421D1 (de) * 2005-08-05 2008-11-27 Hybrigenics Sa Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen
US7776865B2 (en) 2005-10-06 2010-08-17 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
WO2007044724A2 (fr) 2005-10-06 2007-04-19 Exelixis, Inc. Inhibiteurs de pim-1 et/ou de pim-3 a base de pyridopyrimidinone
JP5119157B2 (ja) 2005-10-21 2013-01-16 エクセリクシス， インク． カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピラゾロ−ピリミジン類
WO2007052843A1 (fr) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited Compose amide heterocyclique et son utilisation
WO2007084857A2 (fr) 2006-01-13 2007-07-26 President And Fellows Of Harvard College Procédés et compositions de traitement de troubles prolifératifs cellulaires
WO2007131191A2 (fr) 2006-05-05 2007-11-15 Perkinelmer Life And Analytical Sciences Méthodes de spectrométrie de masse pour quantification multiplex de protéines kinases et de phosphatases
AU2007265373B2 (en) 2006-06-29 2013-02-21 Atnx Spv, Llc Biaryl compositions and methods for modulating a kinase cascade
WO2008002676A2 (fr) 2006-06-29 2008-01-03 Kinex Pharmaceuticals, Llc Compositions de biaryle et procédés de modulation d'une cascade de kinases
ATE517868T1 (de) 2006-08-16 2011-08-15 Boehringer Ingelheim Int Pyrazinverbindungen, ihre verwendung und herstellungsverfahren
WO2008045252A2 (fr) 2006-10-04 2008-04-17 The Board Of Trustees Of The Leland Stanford Junior University Peptides modifies de liaison aux integrines
PE20080928A1 (es) 2006-10-31 2008-08-15 Schering Corp Derivados de anilinopiperazina como inhibidores de proteina quinasa
WO2008058126A2 (fr) 2006-11-06 2008-05-15 Supergen, Inc. Dérivés d'imidazo[1,2-b]pyridazine et de pyrazolo[1,5-a]pyrimidine et utilisation de ceux-ci comme inhibiteurs de protéines kinases
WO2008082840A1 (fr) 2006-12-29 2008-07-10 Abbott Laboratories Inhibiteurs de la pim kinase utilisés comme agents chimiothérapeutiques contre le cancer
WO2008082839A2 (fr) 2006-12-29 2008-07-10 Abbott Laboratories Inhibiteurs de la pim kinase comme agents chimiothérapeutiques destinés à lutter contre le cancer
ES2431163T3 (es) 2007-03-01 2013-11-25 Novartis Ag Inhibidores de PIM quinasa y métodos para su uso
EP2139888A2 (fr) 2007-03-28 2010-01-06 Array Biopharma, Inc. Composés imidazoý1,2-a¨pyridine en tant qu'inhibiteurs de la tyrosine kinase récepteur
WO2008124323A1 (fr) 2007-04-03 2008-10-16 Array Biopharma Inc. Composés imidazo[1,2-a]pyridine utilisés comme inhibiteurs des récepteurs à activité tyrosine kinase
KR20100017359A (ko) 2007-04-25 2010-02-16 엑셀리시스, 인코포레이티드 카제인 키나제 ⅱ （ｃｋ２）조절제로서의 피리미디논
CN102317266A (zh) 2007-04-25 2012-01-11 埃克塞利希斯股份有限公司 作为pim调节剂的6-苯基嘧啶酮类
US8293747B2 (en) 2007-07-19 2012-10-23 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
EP2182986A2 (fr) 2007-07-31 2010-05-12 Schering Corporation Combinaison d'agent antimitotique et d'inhibiteur de l'aurora kinase comme traitement anti-cancer
PA8792401A1 (es) * 2007-08-06 2009-03-31 Janssen Pharmaceutica Nv Fenilendiaminas
EP2217235A4 (fr) 2007-11-15 2011-01-12 Musc Found For Res Dev Inhibiteurs de protéines kinases pim, compositions et procédés pour traiter le cancer
WO2009065080A1 (fr) 2007-11-16 2009-05-22 San Diego State University Research Foundation Compositions et procédé pour manipuler l'activité pim-1 dans les cellules du système circulatoire
AU2009219154A1 (en) 2008-02-29 2009-09-03 Cylene Pharmaceuticals, Inc. Protein kinase modulators
UY31679A1 (es) 2008-03-03 2009-09-30 Inhibidores de cinasa pim y metodos para su uso
US8168794B2 (en) 2008-03-03 2012-05-01 Novartis Ag Pim kinase inhibitors and methods of their use
WO2009151845A1 (fr) 2008-05-12 2009-12-17 Amnestix, Inc. Composés pour inhiber les rho kinases et pour améliorer l'apprentissage et la mémoire
BRPI0914942A2 (pt) 2008-06-30 2015-08-11 Cylene Pharmaceuticals Inc Compostos de oxindol
UY31952A (es) 2008-07-02 2010-01-29 Astrazeneca Ab 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim
FR2933409B1 (fr) 2008-07-03 2010-08-27 Centre Nat Rech Scient NOUVEAUX PYRROLO °2,3-a! CARBAZOLES ET LEUR UTILISATION COMME INHIBITEURS DES KINASES PIM
TWI496779B (zh) 2008-08-19 2015-08-21 Array Biopharma Inc 作為ｐｉｍ激酶抑制劑之三唑吡啶化合物
US8557809B2 (en) 2008-08-19 2013-10-15 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
CA2735782A1 (fr) 2008-09-02 2010-03-11 Novartis Ag Inhibiteurs heterocycliques de la kinase pim
BRPI0918496A2 (pt) 2008-09-02 2019-09-24 Novartis Ag composto inibidor bicíclico de quinase, uso do mesmo, composição farmacêutica e método para inibir a atividade da quinase pim em uma célula
CN104311480A (zh) 2008-09-02 2015-01-28 诺华股份有限公司 作为激酶抑制剂的吡啶甲酰胺衍生物
PT3106463T (pt) 2008-10-22 2018-05-18 Array Biopharma Inc Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk
GB0821307D0 (en) 2008-11-21 2008-12-31 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
WO2010071885A1 (fr) 2008-12-19 2010-06-24 Cephalon, Inc. Pyrrolotriazines en tant qu'inhibiteurs d'alk et de jak2
CA3025627C (fr) * 2009-04-20 2021-08-31 Auspex Pharmaceuticals, Inc. Inhibiteurs piperidiniques de la janus kinase 3
US20120128631A1 (en) 2009-05-19 2012-05-24 San Diego State University (SDSU) Foundation, dba San Diego State University (SDSU) Research Compositions and methods for kinase-mediated cytoprotection and enhanced cellular engraftment and persistence
WO2010135571A1 (fr) 2009-05-20 2010-11-25 Cylene Pharmaceuticals, Inc. Modulateurs inédits des protéines kinases
AU2010249493A1 (en) 2009-05-20 2011-12-08 Cylene Pharmaceuticals, Inc. Pyrazolopyrimidines and related heterocycles as kinase inhibitors
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
WO2010148351A1 (fr) 2009-06-18 2010-12-23 Cylene Pharmaceuticals, Inc. Rhodanines et hétérocycles associés en tant qu'inhibiteurs de kinase
EP2448938B9 (fr) 2009-06-29 2015-06-10 Incyte Corporation Pyrimidinones comme inhibiteurs de pi3k
JP2013503178A (ja) 2009-08-26 2013-01-31 サイリーン ファーマシューティカルズ インコーポレーティッド タンパク質キナーゼ調節物質としての縮合キノリン
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
US8435976B2 (en) 2009-09-08 2013-05-07 F. Hoffmann-La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
SG10201405568UA (en) 2009-09-08 2014-11-27 Hoffmann La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
CA2773854A1 (fr) 2009-09-11 2011-03-17 Cylene Pharmaceuticals Inc. Lactames substitues par heterocycle pharmaceutiquement utiles
SG179163A1 (en) 2009-09-16 2012-05-30 Cylene Pharmaceuticals Inc Novel tricyclic protein kinase modulators
AU2010295622A1 (en) 2009-09-16 2012-05-10 Cylene Pharmaceuticals, Inc. Tricyclic compounds and pharmaceutical uses thereof
ES2658290T3 (es) 2009-10-29 2018-03-09 Genosco Inhibidores de cinasa
EP2332917B1 (fr) 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Composés pour l'inhibition de kinase PIM et pour le traitement des tumeurs
JP2013510824A (ja) 2009-11-12 2013-03-28 セルビタ エス．エー． セリン／トレオニンキナーゼを調節または制御するための化合物、その調製のための方法、医薬組成物、化合物の使用、方法ならびにセリン／トレオニンキナーゼ調節剤
JP5740409B2 (ja) 2009-11-13 2015-06-24 ジェノスコ キナーゼ阻害剤
WO2011063398A1 (fr) 2009-11-23 2011-05-26 Cylene Pharamaceuticals, Inc. Polymorphes et sels d'un inhibiteur de kinase
KR101851130B1 (ko) 2009-12-04 2018-04-23 센화 바이오사이언시즈 인코포레이티드 Ｃｋ2 억제제로서 피라졸로피리미딘 및 관련된 헤테로사이클
AR079529A1 (es) 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
WO2011075643A1 (fr) 2009-12-18 2011-06-23 Incyte Corporation Dérivés condensés d'hétéroaryles substitués à titre d'inhibiteurs de pi3k
WO2011075613A1 (fr) 2009-12-18 2011-06-23 Sanofi Dérivés d'azaindole, leur préparation et leur application thérapeutique
US8563539B2 (en) 2009-12-23 2013-10-22 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
GB201002861D0 (en) 2010-02-19 2010-04-07 Cxr Biosciences Ltd Compositions
EP3050882B1 (fr) 2010-03-10 2018-01-31 Incyte Holdings Corporation Dérivés de pipéridin -4-yl azétidine utilisés en tant qu'inhibiteurs de jak1
SG184475A1 (en) 2010-04-07 2012-11-29 Hoffmann La Roche Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
EP2558463A1 (fr) 2010-04-14 2013-02-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de i3
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
JP2013530199A (ja) 2010-07-06 2013-07-25 ノバルティス アーゲー キナーゼ阻害剤として有用な環状エーテル化合物
KR101995013B1 (ko) 2010-07-13 2019-07-02 에프. 호프만-라 로슈 아게 Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체
CA2806341C (fr) 2010-07-29 2020-03-24 Rigel Pharmaceuticals, Inc. Composes heterocycliques d'activation de l'ampk et procedes d'utilisation de ceux-ci
US8227773B2 (en) 2010-07-29 2012-07-24 Axcelis Technologies, Inc. Versatile beam glitch detection system
EP2637650A2 (fr) 2010-11-10 2013-09-18 National Jewish Health Procédés de test d'états allergiques
WO2012065297A1 (fr) 2010-11-16 2012-05-24 Impact Therapeutics, Inc. 3-aryl-6-aryl-[1,2,4]triazolo[4,3-a]pyridines en tant qu'inhibiteurs de la prolifération cellulaire et leur utilisation
CN103415515B (zh) 2010-11-19 2015-08-26 因塞特公司 作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物
US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
MX2013006467A (es) 2010-12-09 2013-10-01 Amgen Inc Compuestos biciclicos como inhibidores pim.
RU2652638C2 (ru) 2010-12-17 2018-04-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Замещенные пиразолхиназолиновые производные в качестве ингибиторов киназы
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
CN103339134B (zh) 2011-01-26 2015-12-23 内尔维阿诺医学科学有限公司 三环吡咯并衍生物、它们的制备方法和它们作为激酶抑制剂的应用
EP2668188B1 (fr) 2011-01-26 2016-05-18 Nerviano Medical Sciences S.r.l. Dérivés tricycliques, leur procédé de préparation et leur utilisation à titre d'inhibiteurs de kinases
PH12013501754A1 (en) 2011-02-25 2013-10-14 Array Biopharma Inc Triazolopyridine compounds as pim kinase inhibitors
UY33929A (es) 2011-03-04 2012-10-31 Novartis Ag Compuestos de ciclohexilo tetrasustituido como inhibidores de quinasas
UY33930A (es) 2011-03-04 2012-10-31 Novartis Ag Inhibidores novedosos de quinasas
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
EP2688886A1 (fr) 2011-03-22 2014-01-29 Amgen Inc. Composés d'azole utilisés en tant qu'inhibiteurs des pim
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
PE20141050A1 (es) 2011-04-05 2014-08-30 Pfizer Ltd Inhibidores de quinasa relacionados con pirrolo (2,3-d) pirimidina tropomiosina
EP2702055A1 (fr) 2011-04-11 2014-03-05 Nerviano Medical Sciences S.r.l. Dérivés pyrazolyl-pyrimidine en tant qu'inhibiteurs des kinases
EP2699569B1 (fr) 2011-04-22 2017-08-30 Jasco Pharmaceuticals, LLC Inhibiteurs d'aminopyrimidine kinase
GB201107176D0 (en) 2011-04-28 2011-06-15 Cxr Biosciences Ltd Pyrrolnitrin derivatives
GB201107197D0 (en) 2011-04-28 2011-06-15 Cxr Biosciences Ltd Compounds
CA2834166A1 (fr) 2011-04-29 2012-11-01 Amgen Inc. Composes pyridazines bicycliques en tant qu'inhibiteurs de pim
WO2012156367A1 (fr) 2011-05-17 2012-11-22 Bayer Intellectual Property Gmbh Imidazopyridazines amino-substituées en tant qu'inhibiteurs de kinase mknk1
KR101953210B1 (ko) 2011-05-19 2019-02-28 푼다시온 센트로 나시오날 드 인베스티가시오네스 온콜로기카스 카를로스Ⅲ 단백질 키나아제 억제제로서의 대환식 화합물
AU2012262489A1 (en) 2011-05-27 2013-04-04 Icahn School Of Medicine At Mount Sinai Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof
US9730929B2 (en) 2011-06-01 2017-08-15 Bayer Intellectual Property Gmbh Substituted aminoimidazopyridazines
WO2012170827A2 (fr) 2011-06-08 2012-12-13 Cylene Pharmaceuticals, Inc. Pyrazolopyrimidines et hétérocycles associés comme inhibiteurs de ck2
PE20140832A1 (es) 2011-06-20 2014-07-14 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
US9284319B2 (en) 2011-06-22 2016-03-15 Bayer Intellectual Property Gmbh Heterocyclyl aminoimidazopyridazines
PL3409278T3 (pl) 2011-07-21 2021-02-22 Sumitomo Pharma Oncology, Inc. Heterocykliczne inhibitory kinazy białkowej
CN102924444B (zh) 2011-08-11 2015-07-08 上海吉铠医药科技有限公司 Pim激酶抑制剂及其制备方法与在制药中的应用
BR112014003296A2 (pt) 2011-08-12 2017-03-14 Hoffmann La Roche composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, método para o tratamento de uma doença ou distúrbio, conjunto para o tratamento de uma condição mediada pela quinase pim e utilização do composto
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
JP5843524B2 (ja) 2011-09-02 2016-01-13 キヤノン株式会社 有機無機複合組成物、有機無機複合材料、光学素子および積層型回折光学素子
KR102030609B1 (ko) 2011-09-02 2019-10-11 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US8735528B1 (en) * 2011-09-20 2014-05-27 The United States Of America As Represented By The Secretary Of The Air Force Two-photon absorbing cross-linked polyurethanes containing diphenylamino-dialkylfluorene-1,3,5-triazine units
EP2758400A1 (fr) 2011-09-23 2014-07-30 Bayer Intellectual Property GmbH Imidazopyridazines substituées
US8614206B2 (en) 2011-09-27 2013-12-24 F. Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
WO2013050448A1 (fr) 2011-10-07 2013-04-11 Nerviano Medical Sciences S.R.L. Dérivés 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2h)-one substitué par 4-alkyle en tant qu'inhibiteurs de kinases
US9145418B2 (en) 2011-10-07 2015-09-29 Nerviano Medical Sciences S.R.L. Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
ES2629690T3 (es) 2011-11-04 2017-08-14 Jasco Pharmaceuticals, LLC Inhibidores de aminopirimidina quinasa
WO2013130660A1 (fr) 2012-02-28 2013-09-06 Amgen Inc. Amides convenant comme inhibiteurs des pim
WO2013134079A1 (fr) 2012-03-05 2013-09-12 Amgen Inc. Composés d'oxazolidinone et leurs dérivés
US9777004B2 (en) 2012-03-29 2017-10-03 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CA2869212A1 (fr) 2012-04-04 2013-10-10 Bayer Pharma Aktiengesellschaft Imidazopyridazines amino-substituees
PT2841437T (pt) 2012-04-26 2017-09-28 Univ Montreal Derivados de imidazotiadiazol e imidazopirazina como inibidores de recetor 4 ativado por protease (par4) para o tratamento de agregação plaquetária
EP2852590B1 (fr) 2012-04-27 2017-02-01 Novartis AG Dérivés éthers cycliques substitués en tête de pont utiles comme inhibiteur dgat1
SMT202000347T1 (it) 2012-05-09 2020-07-08 Biogen Ma Inc Modulatori di trasporto nucleare e loro usi
JP6078639B2 (ja) 2012-05-15 2017-02-08 ノバルティス アーゲー Ａｂｌ１、ａｂｌ２およびｂｃｒ−ａｂｌ１の活性を阻害するためのベンズアミド誘導体
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CA2873672A1 (fr) 2012-05-21 2013-11-28 Novartis Ag Nouveaux n-pyridinylamides substitues par un cycle a titre d'inhibiteurs de kinase
GEP20176800B (en) 2012-05-22 2018-01-10 Idenix Pharmaceuticals Llk D-amino acid compounds for liver disease
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
EP2867232B1 (fr) 2012-06-27 2018-08-08 F.Hoffmann-La Roche Ag Composés de 5-azaindazole et procédés d'utilisation
TW201408652A (zh) 2012-07-11 2014-03-01 Hoffmann La Roche 作爲ＲＯＲｃ調節劑之芳基磺內醯胺衍生物
TW201414737A (zh) 2012-07-13 2014-04-16 必治妥美雅史谷比公司 作爲激酶抑制劑之咪唑并三□甲腈
WO2014022752A1 (fr) 2012-08-03 2014-02-06 Amgen Inc. Macrocycles en tant qu'inhibiteurs de pim
WO2014033630A1 (fr) 2012-08-31 2014-03-06 Novartis Ag Nouveaux carboxamides d'aminothiazole en tant qu'inhibiteurs de kinase
WO2014033631A1 (fr) 2012-08-31 2014-03-06 Novartis Ag N- (3-pyridyl)-biarylamides en tant qu'inhibiteurs de kinase
CN103664878A (zh) 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 杂芳环及其衍生物类酪氨酸激酶抑制剂
US10118926B2 (en) 2012-09-14 2018-11-06 AbbVie Deutschland GmbH & Co. KG Tricyclic quinoline and quinoxaline derivatives
JP6666147B2 (ja) 2012-09-26 2020-03-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 環状エーテルピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物と使用方法
WO2014053568A1 (fr) 2012-10-02 2014-04-10 Sanofi Dérivés d'indolyldihydroimidazopyrimidinone, leur préparation et utilisation thérapeutique
LT2909195T (lt) 2012-10-16 2017-09-25 Janssen Sciences Ireland Uc Antivirusiniai rsv junginiai
AU2013337824B2 (en) 2012-11-01 2018-03-08 Incyte Holdings Corporation Tricyclic fused thiophene derivatives as JAK inhibitors
US9783543B2 (en) 2012-11-19 2017-10-10 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
WO2014079011A1 (fr) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Composés hétérocycliques pour inhiber la glutaminase et procédés d'utilisation de ceux-ci
WO2014089379A1 (fr) 2012-12-07 2014-06-12 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs d'atr kinase
US9598454B2 (en) 2012-12-18 2017-03-21 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
ES2715682T3 (es) 2012-12-19 2019-06-05 Novartis Ag Inhibidores de la autotaxina
US20150336960A1 (en) 2012-12-19 2015-11-26 Novartis Ag Aryl-substituted fused bicyclic pyridazine compounds
PL2935222T3 (pl) 2012-12-21 2019-02-28 Epizyme Inc Inhibitory PRMT5 i ich zastosowania
SI2822954T1 (sl) 2012-12-21 2016-07-29 Gilead Sciences, Inc. Policiklične karbamoilpiridonske spojine in njihova farmacevtska uporaba
FR3000569B1 (fr) 2013-01-03 2015-02-13 Peugeot Citroen Automobiles Sa Dispositif d'eclairage a ecran a bord(s) lumineux
CA2897200C (fr) 2013-01-14 2021-07-06 Incyte Corporation Composes de carboxamide aromatique bicyclique utiles comme inhibiteurs de pim kinase
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
TWI736135B (zh) 2013-03-01 2021-08-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
CN105189509B (zh) 2013-03-06 2017-12-19 因赛特公司 用于制备jak抑制剂的方法及中间体
JO3383B1 (ar) 2013-03-14 2019-03-13 Lilly Co Eli مثبطات cdc7
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
US20140275108A1 (en) 2013-03-15 2014-09-18 Galderma Research & Development Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
RU2672584C2 (ru) 2013-03-15 2018-11-16 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи 4-амино-6-(гетероциклил)пиколинаты и 6-амино-2-(гетероциклил)пиримидин-4-карбоксилаты и их применение в качестве гербицидов
EP3919056B1 (fr) 2013-03-15 2024-08-28 Global Blood Therapeutics, Inc. Composés et leurs utilisations pour la modulation de l'hémoglobine
WO2014139145A1 (fr) 2013-03-15 2014-09-18 Hutchison Medipharma Limited Nouveaux composés pyrimidines et pyridines et leur utilisation
UY35421A (es) 2013-03-15 2014-10-31 Nihon Nohyaku Co Ltd Compuesto heterocíclico condensado o su sal, insecticida agrícola u hortícola que comprende el comp uesto y método de uso del insecticida
EP2968299B1 (fr) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Composés et leurs utilisations pour la modulation de l'hémoglobine
MX366703B (es) 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
MX363545B (es) 2013-03-15 2019-03-27 Idorsia Pharmaceuticals Ltd Derivados piridin-4-ilo.
JP6325078B2 (ja) 2013-03-15 2018-05-16 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． ヘテロ環式化合物およびその使用
TWI742541B (zh) 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
AR095443A1 (es) 2013-03-15 2015-10-14 Fundación Centro Nac De Investig Oncológicas Carlos Iii Heterociclos condensados con acción sobre atr
JO3279B1 (ar) 2013-03-15 2018-09-16 Respivert Ltd مشتقات 2-((4- امينو -3- (3- فلورو-5- هيدروكسي فينيل)-h1- بيرازولو [d-3,4] بيرمدين-1-يل )ميثيل )- 3- (2- تراي فلورو ميثيل ) بينزيل ) كوينازولين -4 (h3)- واحد واستخدامها كمثبطات فوسفواينوسيتايد 3- كاينيز
TWI689490B (zh) 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
WO2014142290A1 (fr) 2013-03-15 2014-09-18 日本たばこ産業株式会社 Composé de pyrazole-amide et utilisations médicinales s'y rapportant
SG10201912203XA (en) 2013-08-07 2020-02-27 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
CN105658653A (zh) 2013-08-23 2016-06-08 因赛特公司 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
CA2940659C (fr) 2014-02-28 2023-01-03 Incyte Corporation Inhibiteurs des jak1 pour le traitement de syndromes myelodysplasiques
KR20240153401A (ko) 2014-04-08 2024-10-22 인사이트 홀딩스 코포레이션 Ｊａｋ 및 ｐｉ3ｋ 억제제 조합에 의한 ｂ-세포 악성종양의 치료
JP2017514832A (ja) 2014-04-30 2017-06-08 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ１抑制剤を調製する方法及びその新しい形態
WO2015184305A1 (fr) 2014-05-30 2015-12-03 Incyte Corporation Traitement de la leucémie neutrophile chronique (cnl) et de la leucémie myéloïde chronique atypique (acml) par des inhibiteurs de jak1
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (fr) 2015-05-29 2016-12-08 Incyte Corporation Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (fr) 2015-10-02 2017-04-06 Incyte Corporation Composés hétérocycliques utiles en tant qu'inhibiteurs de la kinase pim

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MA42780A (fr) Sels d'un inhibiteur de la kinase pim
IL269812A (en) Ferroportin-inhibitor salts
IL259719A (en) Tank-binding kinase inhibitor compounds
DK3497103T3 (da) Pyridopyrimdinon-cdk2/4/6-inhibitorer
EP3964503C0 (fr) Une forme cristalline d'un inhibiteur de magl
EP3152210C0 (fr) Composés inhibiteurs de kinases se liant à tank
HUE050842T2 (hu) Janus-kináz inhibitor
ME03334B (fr) Composés hétéroaryle d'inhibition de la kinase
MA41350A (fr) Synthèse d'un inhibiteur de la tyrosine kinase de bruton
EP3347018A4 (fr) Inhibiteurs de kinases cycline-dépendantes
HRP20190324T1 (hr) Inhibitor aurora a kinaze
PT3831833T (pt) Processos para a preparação de um inibidor pi3k
IL255310A0 (en) Thioether compounds as nitrification inhibitors
DK3668955T3 (da) Korrosionsinhibitor
MA41827A (fr) Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
EP3562487A4 (fr) Composés inhibiteurs des métalloenzymes
EP3556758A4 (fr) Inhibiteur de cdk4/6
EP3365477A4 (fr) Inhibition de la corrosion
IL255625B (en) Salts and prodrugs of 1-methyl-d-tryptophan
EP3415524A4 (fr) INHIBITEUR D'EXPRESSION DE L'a-SYNUCLÉINE
EP2976339A4 (fr) Cyanoéthylpyrazolopyridones à substitution géminale utilisées comme inhibiteurs de la janus kinase
EP3394070A4 (fr) Formes cristallines d'analogues de quinolone et leurs sels
MA44607A (fr) Inhibiteurs de kinase