MA43671A - Analogues de nucléosides substitués destinés à être utilisés en tant qu'inhibiteurs de prmt5 - Google Patents
Analogues de nucléosides substitués destinés à être utilisés en tant qu'inhibiteurs de prmt5Info
- Publication number
- MA43671A MA43671A MA043671A MA43671A MA43671A MA 43671 A MA43671 A MA 43671A MA 043671 A MA043671 A MA 043671A MA 43671 A MA43671 A MA 43671A MA 43671 A MA43671 A MA 43671A
- Authority
- MA
- Morocco
- Prior art keywords
- analogues
- substituted nucleosides
- prmt5 inhibitors
- prmt5
- inhibitors
- Prior art date
Links
- 102100034607 Protein arginine N-methyltransferase 5 Human genes 0.000 title 1
- 101710084427 Protein arginine N-methyltransferase 5 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662306222P | 2016-03-10 | 2016-03-10 | |
| EP16162731 | 2016-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43671A true MA43671A (fr) | 2018-11-28 |
Family
ID=65443152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043671A MA43671A (fr) | 2016-03-10 | 2017-02-24 | Analogues de nucléosides substitués destinés à être utilisés en tant qu'inhibiteurs de prmt5 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10898504B2 (fr) |
| JP (1) | JP6909799B2 (fr) |
| BR (1) | BR112018067789B1 (fr) |
| EA (1) | EA201892031A1 (fr) |
| ES (1) | ES2891320T3 (fr) |
| MA (1) | MA43671A (fr) |
| MX (1) | MX374813B (fr) |
| PH (1) | PH12018501895A1 (fr) |
| TN (1) | TN2018000310A1 (fr) |
| UA (1) | UA123637C2 (fr) |
| ZA (1) | ZA201806016B (fr) |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4224438A (en) * | 1970-07-14 | 1980-09-23 | Boehringer Mannheim Gmbh | Adenosine-5'-carboxylic acid amides |
| US6143749A (en) | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
| AU2002351077A1 (en) | 2001-11-05 | 2003-05-19 | Exiqon A/S | Oligonucleotides modified with novel alpha-l-rna analogues |
| US7034147B2 (en) | 2001-11-29 | 2006-04-25 | Irm Llc | Nucleoside analog libraries |
| PL372145A1 (en) | 2002-02-19 | 2005-07-11 | Cv Therapeutics, Inc. | Partial and full agonists of a sb 1 /sb adenosine receptors |
| US20040043959A1 (en) * | 2002-03-04 | 2004-03-04 | Bloom Laura A. | Combination therapies for treating methylthioadenosine phosphorylase deficient cells |
| WO2005065150A2 (fr) | 2003-12-19 | 2005-07-21 | Koronis Pharmaceuticals, Inc. | Heterocycles mutagenes |
| EP1844062A2 (fr) | 2005-01-21 | 2007-10-17 | Methylgene, Inc. | Inhibiteurs d'adn-methyltransferase |
| US20080132525A1 (en) | 2006-12-04 | 2008-06-05 | Methylgene Inc. | Inhibitors of DNA Methyltransferase |
| EP3587434A1 (fr) | 2008-09-23 | 2020-01-01 | Alnylam Pharmaceuticals Inc. | Modifications chimiques de monomères et d'oligonucléotides avec des composants click capables de conjugaison de ligands |
| MX2012007026A (es) | 2009-12-18 | 2013-03-18 | Joslin Diabetes Center Inc | Compuestos que promueven la replicacion de celula beta y metodos de su uso. |
| EP2646454B1 (fr) | 2010-12-03 | 2015-07-08 | Epizyme, Inc. | Modulateurs à base de 7-déazapurine de l'histone méthyltransférase et procédés d'utilisation de ceux-ci |
| WO2012082436A2 (fr) * | 2010-12-03 | 2012-06-21 | Epizyme, Inc. | Modulateurs d'histone méthyltransférase et leurs procédés d'utilisation |
| EP2651885A1 (fr) | 2010-12-16 | 2013-10-23 | Abbvie Inc. | Composés antiviraux |
| ES2587512T3 (es) | 2011-04-04 | 2016-10-25 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Derivados de 2'-O-aminooximetil nucleósido para su uso en la síntesis y modificación de nucleósidos, nucleótidos y oligonucleótidos |
| US20150057243A1 (en) | 2012-04-02 | 2015-02-26 | Northern University | Compositions and Methods for the Inhibition of Methyltransferases |
| WO2014035140A2 (fr) | 2012-08-30 | 2014-03-06 | Kainos Medicine, Inc. | Composés et compositions pour la modulation de l'activité histone méthyltransférase |
| US20140100184A1 (en) | 2012-08-31 | 2014-04-10 | Baylor College Of Medicine | Selective inhibitors of histone methyltransferase dot1l |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100695A1 (fr) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Inhibiteurs de prmt5 et leurs utilisations |
| PL2935222T3 (pl) | 2012-12-21 | 2019-02-28 | Epizyme Inc | Inhibitory PRMT5 i ich zastosowania |
| WO2015106025A1 (fr) | 2014-01-09 | 2015-07-16 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Benzoxazine substituée et composés associés |
| EP3160477A4 (fr) | 2014-06-25 | 2018-07-04 | Epizyme, Inc. | Inhibiteurs de prmt5 et leurs utilisations |
| CU20170105A7 (es) | 2015-02-24 | 2017-10-05 | Pfizer | Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos |
| TWI870767B (zh) * | 2015-08-26 | 2025-01-21 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
| US10685416B2 (en) | 2015-12-10 | 2020-06-16 | Uber Technologies, Inc. | Suggested pickup location for ride services |
| CA3016096C (fr) | 2016-03-10 | 2023-10-17 | Janssen Pharmaceutica Nv | Analogues de nucleosides substitues destines a etre utilises en tant qu'inhibiteurs de prmt5 |
| WO2018065365A1 (fr) | 2016-10-03 | 2018-04-12 | Janssen Pharmaceutica Nv | Nouveaux analogues de carbanucléoside substitués par un système cyclique, monocyclique et bicyclique destinés à être utilisés en tant qu'inhibiteurs de prmt5 |
| CA3049739A1 (fr) | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5 |
-
2017
- 2017-02-24 MA MA043671A patent/MA43671A/fr unknown
- 2017-02-24 BR BR112018067789-2A patent/BR112018067789B1/pt not_active IP Right Cessation
- 2017-02-24 JP JP2018547293A patent/JP6909799B2/ja active Active
- 2017-02-24 MX MX2018010923A patent/MX374813B/es active IP Right Grant
- 2017-02-24 ES ES17706513T patent/ES2891320T3/es active Active
- 2017-02-24 EA EA201892031A patent/EA201892031A1/ru unknown
- 2017-02-24 TN TNP/2018/000310A patent/TN2018000310A1/en unknown
- 2017-02-24 US US16/082,020 patent/US10898504B2/en active Active
- 2017-02-24 UA UAA201810095A patent/UA123637C2/uk unknown
-
2018
- 2018-09-05 PH PH12018501895A patent/PH12018501895A1/en unknown
- 2018-09-07 ZA ZA2018/06016A patent/ZA201806016B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA123637C2 (uk) | 2021-05-05 |
| US10898504B2 (en) | 2021-01-26 |
| EA201892031A1 (ru) | 2019-02-28 |
| JP2019507778A (ja) | 2019-03-22 |
| ZA201806016B (en) | 2022-04-28 |
| TN2018000310A1 (en) | 2020-01-16 |
| JP6909799B2 (ja) | 2021-07-28 |
| BR112018067789A2 (pt) | 2019-04-30 |
| MX374813B (es) | 2025-03-06 |
| ES2891320T3 (es) | 2022-01-27 |
| PH12018501895A1 (en) | 2019-05-20 |
| NZ745827A (en) | 2025-05-02 |
| BR112018067789B1 (pt) | 2023-12-12 |
| US20200289539A1 (en) | 2020-09-17 |
| MX2018010923A (es) | 2019-02-13 |
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