MA43717A - Anticorps anti-tnf et fragments fonctionnels de ceux-ci - Google Patents

Anticorps anti-tnf et fragments fonctionnels de ceux-ci

Info

Publication number: MA43717A
Authority: MA; Morocco
Prior art keywords: functional fragments; tnf antibodies; tnf; antibodies; fragments
Prior art date: 2016-03-17

Application number

MA043717A

Other languages

English (en)

Other versions

MA43717B1 (fr

Inventor

Esther Maria Furrer

Tea Gunde

Sebastian Meyer

Original Assignee

Tillotts Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-03-17

Filing date

2017-03-16

Publication date

2018-11-28

2017-03-16 Application filed by Tillotts Pharma Ag filed Critical Tillotts Pharma Ag

2018-11-28 Publication of MA43717A publication Critical patent/MA43717A/fr

2023-11-30 Publication of MA43717B1 publication Critical patent/MA43717B1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

MA43717A 2016-03-17 2017-03-16 Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci MA43717B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP16160907.8A EP3219726B1 (fr)	2016-03-17	2016-03-17	Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci
PCT/EP2017/056237 WO2017158092A1 (fr)	2016-03-17	2017-03-16	Anticorps anti-tnfα et fragments fonctionnels de ceux-ci

Publications (2)

Publication Number	Publication Date
MA43717A true MA43717A (fr)	2018-11-28
MA43717B1 MA43717B1 (fr)	2023-11-30

Family

ID=55542576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA43717A MA43717B1 (fr)	2016-03-17	2017-03-16	Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci

Country Status (40)

Country	Link
US (3)	US11459383B2 (fr)
EP (3)	EP3219726B1 (fr)
JP (2)	JP7129398B2 (fr)
KR (2)	KR102470235B1 (fr)
CN (1)	CN109071650B (fr)
AR (1)	AR107917A1 (fr)
AU (2)	AU2017235387B2 (fr)
CA (1)	CA3011784C (fr)
CL (1)	CL2018002649A1 (fr)
CO (1)	CO2018009783A2 (fr)
CR (1)	CR20180448A (fr)
CY (1)	CY1123784T1 (fr)
DK (2)	DK3219726T3 (fr)
EA (1)	EA039760B1 (fr)
ES (3)	ES2836349T3 (fr)
FI (1)	FI3430043T3 (fr)
GE (2)	GEAP202114876A (fr)
HR (2)	HRP20231464T1 (fr)
HU (2)	HUE052773T2 (fr)
IL (2)	IL322669A (fr)
JO (2)	JOP20170064B1 (fr)
LT (2)	LT3219726T (fr)
MA (1)	MA43717B1 (fr)
MD (1)	MD3430043T2 (fr)
MX (1)	MX2018011258A (fr)
MY (1)	MY194041A (fr)
PH (1)	PH12018501907A1 (fr)
PL (2)	PL3219726T3 (fr)
PT (2)	PT3219726T (fr)
RS (2)	RS61374B1 (fr)
SA (1)	SA518400027B1 (fr)
SG (1)	SG11201807062RA (fr)
SI (2)	SI3219726T1 (fr)
SM (2)	SMT202000706T1 (fr)
TN (1)	TN2018000298A1 (fr)
TW (2)	TWI829444B (fr)
UA (1)	UA128715C2 (fr)
UY (1)	UY37157A (fr)
WO (1)	WO2017158092A1 (fr)
ZA (5)	ZA201805919B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3219726B1 (fr) *	2016-03-17	2020-12-02	Tillotts Pharma AG	Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci
WO2017158079A1 (fr)	2016-03-17	2017-09-21	Numab Innovation Ag	Anticorps anti-tnfα et fragments fonctionnels correspondants
PT3219727T (pt)	2016-03-17	2021-01-21	Tillotts Pharma Ag	Anticorpos anti-tnf alfa e fragmentos funcionais dos mesmos
JP7184746B2 (ja)	2016-03-17	2022-12-06	ヌマブイノヴェイションアーゲー	抗ＴＮＦα抗体およびそれらの機能的断片
SMT202100313T1 (it) *	2017-09-19	2021-07-12	Tillotts Pharma Ag	Composti 1-ciano-pirrolidinici come inibitori di usp30
EP3456737B1 (fr) *	2017-09-19	2024-02-14	Tillotts Pharma Ag	Variantes d'anticorps
EP4424707A3 (fr) *	2017-09-19	2024-11-13	Tillotts Pharma AG	Variantes d'anticorps
WO2020114616A1 (fr)	2018-12-07	2020-06-11	Tillotts Pharma Ag	Traitement topique d'une diarrhée, d'une colite ou d'une entérocolite induite par un inhibiteur de point de contrôle immunitaire au moyen d'anticorps et de fragments de ceux-ci

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444887A (en)	1979-12-10	1984-04-24	Sloan-Kettering Institute	Process for making human antibody producing B-lymphocytes
US4716111A (en)	1982-08-11	1987-12-29	Trustees Of Boston University	Process for producing human antibodies
GB8308235D0 (en)	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US5807715A (en)	1984-08-27	1998-09-15	The Board Of Trustees Of The Leland Stanford Junior University	Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8422238D0 (en)	1984-09-03	1984-10-10	Neuberger M S	Chimeric proteins
GB8607679D0 (en)	1986-03-27	1986-04-30	Winter G P	Recombinant dna product
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
GB8720833D0 (en)	1987-09-04	1987-10-14	Celltech Ltd	Recombinant dna product
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
GB8907617D0 (en)	1989-04-05	1989-05-17	Celltech Ltd	Drug delivery system
US5413923A (en)	1989-07-25	1995-05-09	Cell Genesys, Inc.	Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en)	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
ES2284161T3 (es)	1990-01-12	2007-11-01	Amgen Fremont Inc.	Generacion de anticuerpos xenogenicos.
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
AU8507191A (en)	1990-08-29	1992-03-30	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en)	1990-08-29	1998-09-29	Genpharm International Inc.	Transgenic non-human animals for producing heterologous antibodies
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
GB9109645D0 (en)	1991-05-03	1991-06-26	Celltech Ltd	Recombinant antibodies
US5919452A (en)	1991-03-18	1999-07-06	New York University	Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
DE69233482T2 (de)	1991-05-17	2006-01-12	Merck & Co., Inc.	Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
MX9204374A (es)	1991-07-25	1993-03-01	Idec Pharma Corp	Anticuerpo recombinante y metodo para su produccion.
US5565332A (en)	1991-09-23	1996-10-15	Medical Research Council	Production of chimeric antibodies - a combinatorial approach
PT1696031E (pt)	1991-12-02	2010-06-25	Medical Res Council	Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5639641A (en)	1992-09-09	1997-06-17	Immunogen Inc.	Resurfacing of rodent antibodies
NO309690B1 (no)	1995-01-23	2001-03-12	Western Atlas Int Inc	Detonasjonsanordning av type eksploderende brotråd for bruk med et perforeringsverktöy i en brönn
EP0822830B1 (fr)	1995-04-27	2008-04-02	Amgen Fremont Inc.	Anticorps anti-IL-8 dérivés de xenosouris immunisées
WO1996034096A1 (fr)	1995-04-28	1996-10-31	Abgenix, Inc.	Anticorps humains derives de xeno-souris immunisees
HU230048B1 (hu) *	1996-02-09	2015-06-29	Abbvie Biotechnology Ltd	Humán TNFalfa-kötő antitestek alkalmazása
US5916771A (en)	1996-10-11	1999-06-29	Abgenix, Inc.	Production of a multimeric protein by cell fusion method
ATE549918T1 (de)	1996-12-03	2012-04-15	Amgen Fremont Inc	Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
GB9625640D0 (en)	1996-12-10	1997-01-29	Celltech Therapeutics Ltd	Biological products
TR199902553T2 (xx)	1997-04-14	2000-03-21	Micromet Gesellschaft F�R Biomedizinische Forschung Mbh	�nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�.
US6235883B1 (en)	1997-05-05	2001-05-22	Abgenix, Inc.	Human monoclonal antibodies to epidermal growth factor receptor
DE69938054T2 (de)	1998-11-18	2009-02-12	Genentech, Inc., South San Francisco	Antikörpervarianten mit höheren bindungsaffinitäten im vergleich zu parentalen antikörpern
GB0412181D0 (en)	2004-06-01	2004-06-30	Celltech R&D Ltd	Biological products
US7431927B2 (en)	2005-03-24	2008-10-07	Epitomics, Inc.	TNFα-neutralizing antibodies
DK2390267T3 (da)	2005-06-07	2013-08-26	Esbatech A Novartis Co Llc	Stabile og opløselige antistoffer, der hæmmer TNF(alfa)
ES2687259T5 (es)	2008-06-25	2022-10-14	Novartis Ag	Anticuerpos estables y solubles que inhiben TNF
HUE038432T2 (hu)	2008-06-25	2018-10-29	Esbatech Alcon Biomed Res Unit	Nyúl antitestek humanizálása egy univerzális antitest keret alkalmazásával
EP2303230A2 (fr)	2008-07-10	2011-04-06	ESBATech, an Alcon Biomedical Research Unit LLC	Procédés et compositions favorisant l'administration de macromolécules
PH12012501991A1 (en) *	2010-04-07	2017-07-26	Abbvie Inc	Tnf-alpha binding proteins
WO2012007880A2 (fr) *	2010-07-16	2012-01-19	Ablynx Nv	Molécules de liaison à un antigène à domaine unique modifiées et leurs utilisations
CN102443063B (zh) *	2010-09-30	2013-10-23	成都康弘生物科技有限公司	抗TNFα的人源化Fab和人源化抗体及其用途
CA2914829A1 (fr)	2013-06-26	2014-12-31	Numab Therapeutics AG	Structures d'anticorps
CA2924520C (fr) *	2013-11-01	2023-09-26	Ibc Pharmaceuticals, Inc.	Anticorps bispecifiques qui neutralisent a la fois tnf-alpha et il-6 : nouvel agent therapeutique pour traiter une maladie auto-immune
EP3122777B1 (fr) *	2014-03-26	2020-12-23	Cell Medica Switzerland AG	Éléments de liaison dirigés contre tnf alpha
JP7184746B2 (ja)	2016-03-17	2022-12-06	ヌマブイノヴェイションアーゲー	抗ＴＮＦα抗体およびそれらの機能的断片
EP3219726B1 (fr) *	2016-03-17	2020-12-02	Tillotts Pharma AG	Anticorps anti-tnf alpha et fragments fonctionnels de ceux-ci
WO2017158079A1 (fr)	2016-03-17	2017-09-21	Numab Innovation Ag	Anticorps anti-tnfα et fragments fonctionnels correspondants
PT3219727T (pt)	2016-03-17	2021-01-21	Tillotts Pharma Ag	Anticorpos anti-tnf alfa e fragmentos funcionais dos mesmos
SMT202100313T1 (it) *	2017-09-19	2021-07-12	Tillotts Pharma Ag	Composti 1-ciano-pirrolidinici come inibitori di usp30

2016
- 2016-03-17 EP EP16160907.8A patent/EP3219726B1/fr active Active
- 2016-03-17 PT PT161609078T patent/PT3219726T/pt unknown
- 2016-03-17 ES ES16160907T patent/ES2836349T3/es active Active
- 2016-03-17 SI SI201631040T patent/SI3219726T1/sl unknown
- 2016-03-17 LT LTEP16160907.8T patent/LT3219726T/lt unknown
- 2016-03-17 SM SM20200706T patent/SMT202000706T1/it unknown
- 2016-03-17 PL PL16160907T patent/PL3219726T3/pl unknown
- 2016-03-17 DK DK16160907.8T patent/DK3219726T3/da active
- 2016-03-17 RS RS20210112A patent/RS61374B1/sr unknown
- 2016-03-17 HU HUE16160907A patent/HUE052773T2/hu unknown
2017
- 2017-03-16 AU AU2017235387A patent/AU2017235387B2/en active Active
- 2017-03-16 SI SI201731446T patent/SI3430043T1/sl unknown
- 2017-03-16 SG SG11201807062RA patent/SG11201807062RA/en unknown
- 2017-03-16 EP EP23192170.1A patent/EP4275745B1/fr active Active
- 2017-03-16 ES ES23192170T patent/ES3043897T3/es active Active
- 2017-03-16 GE GEAP202114876A patent/GEAP202114876A/en unknown
- 2017-03-16 LT LTEPPCT/EP2017/056237T patent/LT3430043T/lt unknown
- 2017-03-16 TN TNP/2018/000298A patent/TN2018000298A1/en unknown
- 2017-03-16 RS RS20231087A patent/RS64830B1/sr unknown
- 2017-03-16 IL IL322669A patent/IL322669A/en unknown
- 2017-03-16 HR HRP20231464TT patent/HRP20231464T1/hr unknown
- 2017-03-16 EA EA201891788A patent/EA039760B1/ru unknown
- 2017-03-16 MD MDE20190099T patent/MD3430043T2/ro unknown
- 2017-03-16 HU HUE17710748A patent/HUE064238T2/hu unknown
- 2017-03-16 EP EP17710748.9A patent/EP3430043B1/fr active Active
- 2017-03-16 KR KR1020187022632A patent/KR102470235B1/ko active Active
- 2017-03-16 WO PCT/EP2017/056237 patent/WO2017158092A1/fr not_active Ceased
- 2017-03-16 FI FIEP17710748.9T patent/FI3430043T3/fi active
- 2017-03-16 ES ES17710748T patent/ES2963221T3/es active Active
- 2017-03-16 PT PT177107489T patent/PT3430043T/pt unknown
- 2017-03-16 DK DK17710748.9T patent/DK3430043T5/da active
- 2017-03-16 MA MA43717A patent/MA43717B1/fr unknown
- 2017-03-16 PL PL17710748.9T patent/PL3430043T3/pl unknown
- 2017-03-16 JO JOP/2017/0064A patent/JOP20170064B1/ar active
- 2017-03-16 CN CN201780015298.5A patent/CN109071650B/zh active Active
- 2017-03-16 IL IL261031A patent/IL261031B2/en unknown
- 2017-03-16 US US16/085,506 patent/US11459383B2/en active Active
- 2017-03-16 CA CA3011784A patent/CA3011784C/fr active Active
- 2017-03-16 GE GEAP201714876A patent/GEP20217307B/en unknown
- 2017-03-16 MX MX2018011258A patent/MX2018011258A/es unknown
- 2017-03-16 MY MYPI2018001566A patent/MY194041A/en unknown
- 2017-03-16 UA UAA201809317A patent/UA128715C2/uk unknown
- 2017-03-16 CR CR20180448A patent/CR20180448A/es unknown
- 2017-03-16 KR KR1020227040533A patent/KR20220158877A/ko not_active Ceased
- 2017-03-16 JP JP2019500013A patent/JP7129398B2/ja active Active
- 2017-03-16 SM SM20230429T patent/SMT202300429T1/it unknown
- 2017-03-17 TW TW111145252A patent/TWI829444B/zh active
- 2017-03-17 TW TW106108832A patent/TWI784945B/zh active
- 2017-03-17 AR ARP170100675A patent/AR107917A1/es unknown
- 2017-03-17 UY UY0001037157A patent/UY37157A/es not_active Application Discontinuation
2018
- 2018-09-04 ZA ZA2018/05919A patent/ZA201805919B/en unknown
- 2018-09-06 PH PH12018501907A patent/PH12018501907A1/en unknown
- 2018-09-14 CL CL2018002649A patent/CL2018002649A1/es unknown
- 2018-09-16 SA SA518400027A patent/SA518400027B1/ar unknown
- 2018-09-17 CO CONC2018/0009783A patent/CO2018009783A2/es unknown
2021
- 2021-01-13 CY CY20211100021T patent/CY1123784T1/el unknown
- 2021-01-22 HR HRP20210123TT patent/HRP20210123T1/hr unknown
- 2021-04-22 JO JOJO/P/2021/0085A patent/JOP20210085B1/ar active
- 2021-11-04 ZA ZA2021/08601A patent/ZA202108601B/en unknown
- 2021-11-04 ZA ZA2021/08599A patent/ZA202108599B/en unknown
- 2021-11-04 ZA ZA2021/08602A patent/ZA202108602B/en unknown
- 2021-11-04 ZA ZA2021/08600A patent/ZA202108600B/en unknown
2022
- 2022-06-06 JP JP2022091271A patent/JP2022130407A/ja active Pending
- 2022-08-18 US US17/890,857 patent/US12043663B2/en active Active
- 2022-10-03 US US17/958,759 patent/US12209122B2/en active Active
2024
- 2024-09-18 AU AU2024219840A patent/AU2024219840A1/en active Pending

Also Published As

Publication number	Publication date
IL261031B1 (en)	2025-09-01
EP3430043A1 (fr)	2019-01-23
EP4275745A3 (fr)	2023-12-20
TWI829444B (zh)	2024-01-11
PL3219726T3 (pl)	2021-07-19
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FI3430043T3 (fi)	2023-11-17
EA039760B1 (ru)	2022-03-10
LT3430043T (lt)	2023-12-27
CA3011784A1 (fr)	2017-09-21
HUE064238T2 (hu)	2024-02-28
MA43717B1 (fr)	2023-11-30
ZA202108602B (en)	2022-03-30
RS61374B1 (sr)	2021-02-26
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CN109071650A (zh)	2018-12-21
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PT3219726T (pt)	2020-12-15
BR112018016667A2 (pt)	2019-02-05
US12209122B2 (en)	2025-01-28
SMT202000706T1 (it)	2021-01-05
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CL2018002649A1 (es)	2018-11-09
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US12043663B2 (en)	2024-07-23
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GEP20217307B (en)	2021-10-25
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AU2024219840A1 (en)	2024-10-10
AU2017235387A1 (en)	2018-09-27
SA518400027B1 (ar)	2022-03-06
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CR20180448A (es)	2019-01-25
MD3430043T2 (ro)	2024-02-29
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IL261031A (en)	2018-10-31
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US20230279091A1 (en)	2023-09-07
EA201891788A1 (ru)	2019-01-31
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DK3430043T3 (da)	2023-11-27
US20230272059A1 (en)	2023-08-31
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SG11201807062RA (en)	2018-09-27
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MY194041A (en)	2022-11-09
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UA128715C2 (uk)	2024-10-09
GEAP202114876A (en)	2021-05-13
HRP20231464T1 (hr)	2024-03-01
ZA202108600B (en)	2022-03-30
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KR20180120149A (ko)	2018-11-05

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