MA43823A - Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation - Google Patents
Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisationInfo
- Publication number
- MA43823A MA43823A MA043823A MA43823A MA43823A MA 43823 A MA43823 A MA 43823A MA 043823 A MA043823 A MA 043823A MA 43823 A MA43823 A MA 43823A MA 43823 A MA43823 A MA 43823A
- Authority
- MA
- Morocco
- Prior art keywords
- menin
- mll
- methods
- bridged bicyclic
- bicyclic inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662309362P | 2016-03-16 | 2016-03-16 | |
| US201662431387P | 2016-12-07 | 2016-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43823A true MA43823A (fr) | 2018-11-28 |
Family
ID=59851929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043823A MA43823A (fr) | 2016-03-16 | 2017-03-15 | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10752639B2 (fr) |
| EP (1) | EP3429585B1 (fr) |
| JP (1) | JP7000333B2 (fr) |
| KR (1) | KR102419524B1 (fr) |
| CN (1) | CN109640987B (fr) |
| AU (1) | AU2017235462B2 (fr) |
| BR (1) | BR112018068702A2 (fr) |
| CA (1) | CA3015845A1 (fr) |
| IL (1) | IL261625B (fr) |
| MA (1) | MA43823A (fr) |
| MX (1) | MX387806B (fr) |
| MY (1) | MY199965A (fr) |
| PH (1) | PH12018501955B1 (fr) |
| SG (1) | SG11201807834WA (fr) |
| TW (1) | TWI743096B (fr) |
| WO (1) | WO2017161002A1 (fr) |
| ZA (1) | ZA201805845B (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040330A1 (fr) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Composés de thiénopyrimidine et de thiénopyridine et leurs procédés d'utilisation |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| BR112018068703B1 (pt) | 2016-03-16 | 2024-02-06 | Kura Oncology, Inc. | Inibidores substituídos de menin-mll e métodos de uso |
| KR102419524B1 (ko) | 2016-03-16 | 2022-07-08 | 쿠라 온콜로지, 인크. | 메닌-mll의 가교된 이환식 억제제 및 사용 방법 |
| WO2017192543A1 (fr) | 2016-05-02 | 2017-11-09 | Regents Of The University Of Michigan | Pipéridines en tant qu'inhibiteurs de ménine |
| CA3024180A1 (fr) | 2016-06-10 | 2017-12-14 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de l'interaction menine-mll |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| ES2966316T3 (es) | 2016-09-14 | 2024-04-19 | Janssen Pharmaceutica Nv | Inhibidores bicíclicos fusionados de interacción de MENIN-MLL |
| BR112019004691A2 (pt) | 2016-09-14 | 2019-06-25 | Janssen Pharmaceutica Nv | inibidores bicíclicos em espiro da interação menina-mll |
| KR102513564B1 (ko) | 2016-12-15 | 2023-03-22 | 얀센 파마슈티카 엔.브이. | 메닌-mll 상호작용의 아제판 억제제 |
| EA201991448A1 (ru) | 2017-01-06 | 2019-12-30 | Янссен Фармацевтика Нв | Азепановые ингибиторы взаимодействия менин-mll |
| US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
| CA3058448A1 (fr) | 2017-03-31 | 2018-10-04 | The Regents Of The University Of Michigan | Piperidines en tant qu'inhibiteurs covalents de la menine |
| WO2018226976A1 (fr) | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Procédés et compositions d'inhibition de l'interaction de la ménine avec les protéines mll |
| WO2019060365A1 (fr) * | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | Inhibiteurs substitués de ménine-mll et méthodes d'utilisation |
| WO2019120209A1 (fr) | 2017-12-20 | 2019-06-27 | Janssen Pharmaceutica Nv | Inhibiteurs spiro exo-aza de l'interaction ménine-mll |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| CN110204552B (zh) * | 2018-02-28 | 2021-08-17 | 中国科学院上海药物研究所 | 一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途 |
| US11325921B2 (en) | 2018-03-30 | 2022-05-10 | Sumitomo Dainippon Pharma Co., Ltd. | Optically active crosslinked cyclic secondary amine derivative |
| CN113164443A (zh) * | 2018-09-26 | 2021-07-23 | 库拉肿瘤学公司 | 用多发性内分泌抑癌蛋白抑制剂治疗血液系统恶性肿瘤 |
| CN110964016B (zh) * | 2018-09-29 | 2021-05-28 | 南京药捷安康生物科技有限公司 | 氨基降茨烷衍生物及其制备方法与应用 |
| BR112021007421A2 (pt) * | 2018-12-06 | 2021-08-03 | Daiichi Sankyo Company, Limited | derivado de cicloalcano-1,3-diamina |
| EP3906029A4 (fr) * | 2018-12-31 | 2022-09-21 | Biomea Fusion, LLC | Inhibiteurs de l'interaction ménine-mll |
| EA202191852A1 (ru) | 2018-12-31 | 2022-03-18 | Биомеа Фьюжн, Ллс | Необратимые ингибиторы взаимодействия менин-mll |
| EP3924333A1 (fr) | 2019-02-15 | 2021-12-22 | Bristol-Myers Squibb Company | Composés amide substitués utiles en tant que modulateurs du récepteur farnésoïde x |
| EP3924337A1 (fr) | 2019-02-15 | 2021-12-22 | Bristol-Myers Squibb Company | Composés bicycliques substitués utilisés en tant que modulateurs du récepteur farnésoïde x |
| JP7449300B2 (ja) | 2019-02-15 | 2024-03-13 | ブリストル－マイヤーズ スクイブ カンパニー | ファルネソイドｘ受容体モジュレータとして有用な置換アミド化合物 |
| CN118255773A (zh) | 2019-12-19 | 2024-06-28 | 詹森药业有限公司 | 取代的直链螺环衍生物 |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| EP4132932A4 (fr) * | 2020-04-07 | 2024-04-17 | Syndax Pharmaceuticals, Inc. | Combinaisons d'inhibiteurs de ménine et d'inhibiteurs de cyp3a4 et procédés d'utilisation associés |
| US20230405008A1 (en) * | 2020-10-21 | 2023-12-21 | Kura Oncology, Inc. | Treatment of hematological malignancies with inhibitors of menin |
| KR20240005747A (ko) | 2021-05-08 | 2024-01-12 | 얀센 파마슈티카 엔브이 | 치환된 스피로 유도체 |
| CA3215379A1 (fr) | 2021-05-08 | 2022-11-17 | Olivier Alexis Georges Querolle | Derives spiro substitues |
| WO2022241265A1 (fr) | 2021-05-14 | 2022-11-17 | Syndax Pharmaceuticals, Inc. | Inhibiteurs de l'interaction ménine-mll |
| JP2024521879A (ja) | 2021-06-01 | 2024-06-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換フェニル－１Ｈ－ピロロ［２，３－ｃ］ピリジン誘導体 |
| BR112023025436A2 (pt) | 2021-06-03 | 2024-02-27 | Janssen Pharmaceutica Nv | Piridazinas ou 1,2,4-triazinas substituídas por aminas espirocíclicas |
| JP2024525145A (ja) | 2021-06-17 | 2024-07-10 | ヤンセン ファーマシューティカ エヌ．ベー． | がんなどの疾患の治療のための（ｒ）－ｎ－エチル－５－フルオロ－ｎ－イソプロピル－２－（（５－（２－（６－（（２－メトキシエチル）（メチル）アミノ）－２－メチルヘキサン－３－イル）－２，６－ジアザスピロ［３．４］オクタン－６－イル）－１，２，４－トリアジン－６－イル）オキシ）ベンズアミドベシル酸塩 |
| AU2022325861A1 (en) | 2021-08-11 | 2024-02-29 | Biomea Fusion, Inc. | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| IL310717A (en) | 2021-08-20 | 2024-04-01 | Biomea Fusion Inc | Crystalline form of N-[4-[4-(4-morpholinyl)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO ] -2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE, IRREVERSIBLE MENIN-MLL INHIBITOR FOR CANCER TREATMENT |
| KR20240121720A (ko) * | 2021-12-15 | 2024-08-09 | 다나-파버 캔서 인스티튜트 인크. | 메닌-mll 후성유전학적 복합체 파괴에 의한 위장관 기질 종양(gist)의 치료 표적화 |
| AU2023269033A1 (en) * | 2022-05-09 | 2024-11-21 | Syndax Pharmaceuticals, Inc. | Menin-mll inhibitors for the treatment of cancer |
| CN120529900A (zh) | 2022-11-24 | 2025-08-22 | 奥莱松基因组股份有限公司 | 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合 |
| TW202430528A (zh) | 2023-01-18 | 2024-08-01 | 美商拜歐米富士恩股份有限公司 | Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑 |
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-
2017
- 2017-03-15 KR KR1020187029700A patent/KR102419524B1/ko active Active
- 2017-03-15 WO PCT/US2017/022535 patent/WO2017161002A1/fr not_active Ceased
- 2017-03-15 AU AU2017235462A patent/AU2017235462B2/en active Active
- 2017-03-15 MX MX2018011092A patent/MX387806B/es unknown
- 2017-03-15 TW TW106108619A patent/TWI743096B/zh active
- 2017-03-15 CN CN201780030449.4A patent/CN109640987B/zh active Active
- 2017-03-15 MY MYPI2018001516A patent/MY199965A/en unknown
- 2017-03-15 EP EP17767444.7A patent/EP3429585B1/fr active Active
- 2017-03-15 SG SG11201807834WA patent/SG11201807834WA/en unknown
- 2017-03-15 PH PH1/2018/501955A patent/PH12018501955B1/en unknown
- 2017-03-15 BR BR112018068702A patent/BR112018068702A2/pt not_active Application Discontinuation
- 2017-03-15 US US16/082,645 patent/US10752639B2/en active Active
- 2017-03-15 MA MA043823A patent/MA43823A/fr unknown
- 2017-03-15 JP JP2018544323A patent/JP7000333B2/ja active Active
- 2017-03-15 CA CA3015845A patent/CA3015845A1/fr active Pending
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2018
- 2018-08-30 ZA ZA2018/05845A patent/ZA201805845B/en unknown
- 2018-09-05 IL IL261625A patent/IL261625B/en unknown
-
2020
- 2020-07-13 US US16/927,844 patent/US11555041B2/en active Active
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2025
- 2025-01-10 US US19/017,093 patent/US20250340566A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190092783A1 (en) | 2019-03-28 |
| JP2019508426A (ja) | 2019-03-28 |
| EP3429585A4 (fr) | 2019-10-09 |
| IL261625B (en) | 2021-08-31 |
| KR102419524B1 (ko) | 2022-07-08 |
| ZA201805845B (en) | 2023-03-29 |
| MY199965A (en) | 2023-11-30 |
| US20250340566A1 (en) | 2025-11-06 |
| CN109640987B (zh) | 2022-12-02 |
| IL261625A (en) | 2018-10-31 |
| TWI743096B (zh) | 2021-10-21 |
| CA3015845A1 (fr) | 2017-09-21 |
| TW201742870A (zh) | 2017-12-16 |
| WO2017161002A1 (fr) | 2017-09-21 |
| BR112018068702A2 (pt) | 2019-01-15 |
| SG11201807834WA (en) | 2018-10-30 |
| PH12018501955B1 (en) | 2024-01-24 |
| MX387806B (es) | 2025-03-19 |
| EP3429585A1 (fr) | 2019-01-23 |
| AU2017235462B2 (en) | 2021-07-01 |
| PH12018501955A1 (en) | 2019-06-17 |
| KR20180127406A (ko) | 2018-11-28 |
| HK1258821A1 (en) | 2019-11-22 |
| EP3429585B1 (fr) | 2021-11-24 |
| AU2017235462A1 (en) | 2018-09-27 |
| JP7000333B2 (ja) | 2022-02-10 |
| CN109640987A (zh) | 2019-04-16 |
| MX2018011092A (es) | 2018-11-22 |
| US20210107917A1 (en) | 2021-04-15 |
| US10752639B2 (en) | 2020-08-25 |
| US11555041B2 (en) | 2023-01-17 |
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