MA44179B1 - Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations - Google Patents

Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations

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Publication number
MA44179B1
MA44179B1 MA44179A MA44179A MA44179B1 MA 44179 B1 MA44179 B1 MA 44179B1 MA 44179 A MA44179 A MA 44179A MA 44179 A MA44179 A MA 44179A MA 44179 B1 MA44179 B1 MA 44179B1
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MA
Morocco
Prior art keywords
orf
control
expression
antibody constructs
associated virus
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Application number
MA44179A
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English (en)
Other versions
MA44179A1 (fr
Inventor
James Wilson
Anna Tretiakova
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Univ Pennsylvania
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Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of MA44179A1 publication Critical patent/MA44179A1/fr
Publication of MA44179B1 publication Critical patent/MA44179B1/fr

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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Abstract

La présente invention concerne un virus adéno-associé recombiné (aav) comprenant un capside d'aav et un acide nucléique hétérologue inclus dans celui-ci qui exprime deux constructions d'anticorps fonctionnels dans une cellule. L'invention concerne également des anticorps comprenant une chaîne lourde et une chaîne légère d'un anticorps hétérologue. Dans un mode de réalisation, les anticorps sont co-exprimés à partir d'un vecteur contenant : une première cassette d'expression qui code pour au moins un premier cadre ouvert de lecture (orf) pour une première immunoglobuline sous le contrôle de séquences régulatrices de contrôle qui dirigent son expression ; et une seconde cassette d'expression qui comprend un deuxième orf, un lieur, et un troisième orf sous le contrôle de séquences régulatrices de contrôle qui dirigent son expression, le deuxième et le troisième orf codant pour une deuxième et une troisième construction d'immunoglobuline. Dans un mode de réalisation, le vecteur exprimant conjointement ces deux constructions d'anticorps est un aav, dans lequel les séquences répétées inversées terminales en 5' et 3' encadrent les cassettes d'expression et les séquences régulatrices
MA44179A 2014-05-13 2015-05-13 Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations MA44179B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461992649P 2014-05-13 2014-05-13
PCT/US2015/030533 WO2015175639A1 (fr) 2014-05-13 2015-05-13 Compositions comprenant un virus adéno-associé exprimant des constructions à double anticorps et leurs utilisations

Publications (2)

Publication Number Publication Date
MA44179A1 MA44179A1 (fr) 2019-07-31
MA44179B1 true MA44179B1 (fr) 2020-10-28

Family

ID=54480597

Family Applications (2)

Application Number Title Priority Date Filing Date
MA44179A MA44179B1 (fr) 2014-05-13 2015-05-13 Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations
MA39437A MA39437A1 (fr) 2014-05-13 2016-11-04 Compositions comprenant un virus adéno-associé exprimant des constructions à double anticorps et leurs utilisations

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA39437A MA39437A1 (fr) 2014-05-13 2016-11-04 Compositions comprenant un virus adéno-associé exprimant des constructions à double anticorps et leurs utilisations

Country Status (27)

Country Link
US (4) US10138295B2 (fr)
EP (1) EP3142750B1 (fr)
JP (3) JP6974943B2 (fr)
KR (1) KR102550926B1 (fr)
CN (1) CN106470736B (fr)
AU (2) AU2015259188B2 (fr)
CA (1) CA2947614C (fr)
CL (1) CL2016002840A1 (fr)
CR (1) CR20160519A (fr)
DK (1) DK3142750T3 (fr)
EA (1) EA037980B1 (fr)
ES (1) ES2833230T3 (fr)
HR (1) HRP20201530T1 (fr)
HU (1) HUE050609T2 (fr)
IL (1) IL248508B2 (fr)
MA (2) MA44179B1 (fr)
MX (1) MX365658B (fr)
MY (1) MY186389A (fr)
PE (1) PE20170261A1 (fr)
PH (1) PH12016502239A1 (fr)
PL (1) PL3142750T3 (fr)
PT (1) PT3142750T (fr)
SA (1) SA516380285B1 (fr)
SG (1) SG11201609207SA (fr)
SI (1) SI3142750T1 (fr)
UA (1) UA123986C2 (fr)
WO (1) WO2015175639A1 (fr)

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MY186389A (en) 2014-05-13 2021-07-22 Univ Pennsylvania Compositions comprising aav expressing dual antibody constructs and uses thereof
EA201792500A1 (ru) 2015-05-13 2018-04-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Aav-опосредованная экспрессия антител против гриппа и способы их использования
WO2017096363A1 (fr) * 2015-12-04 2017-06-08 Board Of Regents, The University Of Texas System Système rapporteur pour la détection et le ciblage de cellules activées
CA3008142A1 (fr) * 2015-12-11 2017-06-15 The Trustees Of The University Of Pennsylvania Therapie genique pour traiter l'hypercholesterolemie familiale
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