MA44205A - Comprimé orodispersible comprenant estetrol - Google Patents

Comprimé orodispersible comprenant estetrol

Info

Publication number
MA44205A
MA44205A MA044205A MA44205A MA44205A MA 44205 A MA44205 A MA 44205A MA 044205 A MA044205 A MA 044205A MA 44205 A MA44205 A MA 44205A MA 44205 A MA44205 A MA 44205A
Authority
MA
Morocco
Prior art keywords
dosage unit
estetrol
particles
charged particles
weight
Prior art date
Application number
MA044205A
Other languages
English (en)
Other versions
MA44205B1 (fr
Inventor
Séverine Francine Isabelle Jaspart
Johannes Jan Platteeuw
Den Heuvel Denny Johan Marijn Van
Original Assignee
Estetra Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra Sprl filed Critical Estetra Sprl
Publication of MA44205A publication Critical patent/MA44205A/fr
Publication of MA44205B1 publication Critical patent/MA44205B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une unité posologique pharmaceutique solide orodispersible ayant un poids compris entre 30 et 1 000 mg, ladite unité posologique contenant au moins 100 μg d'un composant estétrol choisi parmi l'estétrol, des esters d'estétrol et des combinaisons de ceux-ci; l'unité posologique solide pouvant être obtenue par un procédé qui comprend les étapes consistant à: fournir un liquide de charge comprenant un solvant organique; le composant estétrol et éventuellement un ou plusieurs autres ingrédients acceptables sur le plan pharmaceutique; mélanger 1 partie en poids du liquide de charge avec 0,5 à 20 parties en poids de particules porteuses pour produire des particules humides; à éliminer le solvant organique des particules humides pour produire des particules chargées; mélanger éventuellement les particules chargées avec un ou plusieurs excipients de fabrication de comprimés; et à former les particules chargées ou le mélange de particules chargées et les un ou plusieurs excipients de fabrication de comprimés en une unité posologique solide. L'unité posologique solide de la présente invention est facile à fabriquer et parfaitement adaptée à une administration sublinguale, buccale ou sublabiale.
MA44205A 2015-06-18 2016-06-17 Comprimé orodispersible comprenant estetrol MA44205B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15172751 2015-06-18
PCT/EP2016/064071 WO2016203009A1 (fr) 2015-06-18 2016-06-17 Comprimé orodispersible contenant de l'estétrol

Publications (2)

Publication Number Publication Date
MA44205A true MA44205A (fr) 2018-04-25
MA44205B1 MA44205B1 (fr) 2021-04-30

Family

ID=53476700

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44205A MA44205B1 (fr) 2015-06-18 2016-06-17 Comprimé orodispersible comprenant estetrol

Country Status (19)

Country Link
US (1) US10894014B2 (fr)
EP (1) EP3310345B1 (fr)
JP (1) JP6866561B2 (fr)
CN (1) CN107810001A (fr)
CA (1) CA2988485A1 (fr)
CY (1) CY1124104T1 (fr)
DK (1) DK3310345T3 (fr)
ES (1) ES2877186T3 (fr)
HR (1) HRP20210668T1 (fr)
HU (1) HUE054589T2 (fr)
LT (1) LT3310345T (fr)
MA (1) MA44205B1 (fr)
MD (1) MD3310345T2 (fr)
PL (1) PL3310345T3 (fr)
PT (1) PT3310345T (fr)
RS (1) RS61812B1 (fr)
SI (1) SI3310345T1 (fr)
SM (1) SMT202100370T1 (fr)
WO (1) WO2016203009A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013030833B1 (pt) 2011-06-01 2019-09-03 Estetra S A processo para a preparação de um composto de fórmula (i) e processo para a preparação de estetrol
WO2012164096A1 (fr) 2011-06-01 2012-12-06 Estetra S.A. Procédé pour la production d'intermédiaires d'estétrol
EP2383279A1 (fr) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Procédé de préparation d'estetrol
NZ737945A (en) * 2015-06-18 2023-06-30 Estetra Sprl Orodispersible dosage unit containing an estetrol component
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
WO2016203044A1 (fr) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Comprimé orodispersible contenant de l'estétrol
RS57328B1 (sr) 2015-06-18 2018-08-31 Mithra Pharmaceuticals S A Orodisperzibilna dozna jedinica koja sadrži estetrolsku komponentu
CA3178291A1 (fr) 2016-08-05 2018-04-12 Estetra Srl Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
CR20200486A (es) 2018-04-19 2021-01-27 Estetra Sprl Compuestos y sus usos para aliviar los síntomas asociados a la menopausa
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
EP4056638A4 (fr) * 2019-11-07 2022-11-30 Asahi Kasei Kabushiki Kaisha Composition de cellulose, comprimé et comprimé orodispersible
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
AU2021351921A1 (en) 2020-09-29 2023-04-06 Millicent Pharma Limited Orodispersible formulations

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
WO1997004752A1 (fr) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Compositions pharmaceutiques d'oestrogenes conjugues et leurs modes d'emploi
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
US6706700B2 (en) 1999-12-02 2004-03-16 Akzo-Nobel, N.V. 14β,15β-methylene-17α-hydroxymethyl-androgens
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
DE10044241A1 (de) * 2000-09-07 2002-03-21 Mahle Gmbh Kolbenring für Kolben-Maschine
EP1216713A1 (fr) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions de complexes de estrogen-cyclodextrine
EP1260225A1 (fr) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. Compositions pharmaceutiques pour le traitement hormonal substitutif
DE60217324T2 (de) 2001-05-18 2007-04-26 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung für die hormonersatztherapie
EP1390041B1 (fr) 2001-05-23 2009-11-25 Pantarhei Bioscience B.V. Systeme d'administration de medicament a base d'oestrogenes tetrahydroxyles pour la contraception hormonale
US7732430B2 (en) 2001-05-23 2010-06-08 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxilated estrogen for use in hormonal contraception
WO2003018026A1 (fr) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Utilisation de composes oestrogeniques combines avec des composes progestogeniques dans une hormonotherapie substitutive
ATE347365T1 (de) 2001-11-15 2006-12-15 Pantarhei Bioscience Bv Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
CA2476940C (fr) 2002-02-21 2011-11-01 Bayer Intellectual Property Gmbh Compositions pharmaceutiques contenant un ou plusieurs steroides, un ou plusieurs tetrahydrofolates et de la vitamine b12
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
AU2003274946A1 (en) 2002-06-11 2003-12-22 Pantarhei Bioscience B.V. Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein
CA2489270C (fr) 2002-06-11 2012-08-07 Pantarhei Bioscience B.V. Procede de traitement de la peau humaine et composition cosmetique applicable
US9034854B2 (en) 2002-07-12 2015-05-19 Pantarhei Bioscience B.V. Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy
MXPA05002294A (es) 2002-08-28 2005-09-12 Casper Robert Regimen de sustitucion de estrogeno.
US8987240B2 (en) 2002-10-23 2015-03-24 Pantarhei Bioscience B.V. Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy
ES2338781T3 (es) 2002-11-05 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Uso de la drospirenona para el tratamiento de una hipertension.
AU2003279624A1 (en) 2002-11-08 2004-06-07 Pantarhei Bioscience B.V. Synthesis of estetrol via estrone derived steroids
DK1624878T3 (da) 2003-05-22 2007-01-08 Pantarhei Bioscience Bv Anvendelse af præparater som omfatter en östrogen komponent til behandling og forebyggelse af muskel-skelet-smerte
EP2409690B1 (fr) 2003-09-29 2022-11-09 Novo Nordisk Health Care AG Stabilité améliorée de formulations de progestogène
PL1670440T3 (pl) 2003-09-29 2014-11-28 Novo Nordisk Healthcare Ag Preparaty HRT
EP1535618A1 (fr) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Préparation pharmaceutique pour le traitement hormonal continuel sur plus de 21-28 jours comprenant deux compositions d'estrogène et/ou de progestine
MY151322A (en) 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
GB0410616D0 (en) 2004-05-13 2004-06-16 Unilever Plc Antiperspirant or deodorant compositions
PT1755562E (pt) 2004-05-28 2013-12-26 Richter Gedeon Nyrt Contraceptivo contendo ácido fólico
DE102004026670A1 (de) 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
EP1888615B1 (fr) 2005-05-26 2012-05-16 Abbott Products GmbH Inhibiteurs de 17-hsd1 et sts
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
EP1971344B1 (fr) 2006-01-09 2010-09-22 Pantarhei Bioscience B.V. Procédé de traitement d'un trouble vasculaire aigu
ES2558030T3 (es) 2006-03-02 2016-02-01 Warner Chilcott Company, Llc Método anticonceptivo oral multifásico de ciclo prolongado
ES2659316T3 (es) 2006-06-08 2018-03-14 Allergan Pharmaceuticals International Limited Procedimientos para administrar formas de dosificación sólidas de etinilestradiol y profármacos del mismo con biodisponibilidad mejorada
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
DE112007001600A5 (de) 2006-07-06 2009-04-30 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Zusammensetzung zur Kontrazeption und zur Verminderung des Risikos angeborener Fehlbildungen
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
CN101541326A (zh) 2006-11-29 2009-09-23 惠氏公司 雌激素/选择性雌激素受体调节剂（serm）和雌激素/孕酮双层药片
ES2531929T3 (es) 2006-12-20 2015-03-20 Teva Women's Health, Inc. Formas de dosificación solidas que se disgregan en la boca que comprenden progestina y métodos para hacer y usar las mismas
CN101583363B (zh) 2007-01-08 2013-08-21 潘塔希生物科学股份有限公司 治疗或预防雌性哺乳动物不育症的方法和此类方法中使用的药物试剂盒
KR20090104862A (ko) 2007-01-12 2009-10-06 와이어쓰 정제내 정제 조성물
US8367647B2 (en) 2007-06-21 2013-02-05 Pantarhei Bioscience B.V. Treatment of meconium aspiration syndrome with estrogens
WO2009011576A1 (fr) 2007-07-19 2009-01-22 Pantarhei Bioscience B.V. Traitement ou prévention de troubles de l'hypertension de grossesse ou d'un retard de croissance fœtal
US20110250274A1 (en) * 2008-09-19 2011-10-13 Shaked Ze Ev Estriol formulations
CN101780073B (zh) * 2009-01-21 2013-07-03 重庆圣华曦药业股份有限公司 非布司他分散片药物及其制备方法
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
KR20120044307A (ko) 2009-06-23 2012-05-07 바이엘 파마 악티엔게젤샤프트 긴급 피임용 제약 조성물
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
MX356702B (es) 2010-04-15 2018-06-11 Bayer Ip Gmbh Formas de dosificación sólidas orales con dosis muy bajas para la hrt.
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012055840A1 (fr) 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition et préparation pour le traitement de la dysménorrhée et de la douleur menstruelle et utilisation d'un agent hormonal et d'un sel de zinc pour le traitement de troubles menstruels
WO2012164096A1 (fr) 2011-06-01 2012-12-06 Estetra S.A. Procédé pour la production d'intermédiaires d'estétrol
BR112013030833B1 (pt) 2011-06-01 2019-09-03 Estetra S A processo para a preparação de um composto de fórmula (i) e processo para a preparação de estetrol
EP2383279A1 (fr) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Procédé de préparation d'estetrol
HUE025350T2 (en) 2011-07-19 2016-02-29 Pantarhei Bioscience Bv Tablets containing dehydroepiandrosterone (DHEA)
BR112014003113A2 (pt) 2011-08-11 2017-03-14 Estetra Sprl método de contracepção de emergência em uma fêmea mamífero
BR112014005134A2 (pt) 2011-09-16 2017-04-18 Ferring Bv composição farmacêutica de dissolução rápida
EP2764008B1 (fr) 2011-10-07 2016-08-17 Estetra S.P.R.L. Procédé de production d'estetrol
WO2013090117A1 (fr) 2011-12-13 2013-06-20 Arstat, Inc. Schéma de contraception multiphase pour préparation orale associant un progestatif et un œstrogène
EP2653163A1 (fr) 2012-04-19 2013-10-23 Université de Liège Constituants estrogènes pour l'utilisation dans le traitement de troubles neurologiques
US9808470B2 (en) 2012-04-19 2017-11-07 Universite De Liege Estrogenic components for use in the treatment of neurological disorders
US9238265B2 (en) * 2012-09-27 2016-01-19 General Electric Company Backstrike protection during machining of cooling features
WO2014159377A1 (fr) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Composition contenant du tanaproget et des œstrogènes naturels
EP3943079A1 (fr) 2013-05-21 2022-01-26 Predictive Therapeutics, LLC Thérapeutique et procédé d'utilisation
EP3046928B1 (fr) 2013-09-18 2017-02-08 Crystal Pharma, S.A.U. Procédé de préparation d'estetrol
MX2016006896A (es) * 2013-12-04 2016-08-17 Galderma Res & Dev Microcapsulas de lipidos que comprenden preferiblemente una substancia activa lipofilica y composicion que las contiene, su metodo de preparacion y su uso en dermatolgia y cosmetica.
HUE035848T2 (en) 2013-12-12 2018-05-28 Donesta Bioscience B V Solid dispensing unit containing an estetrol compound in the mouth
ES2957543T3 (es) 2014-09-29 2024-01-22 Univ California Composiciones y métodos para mantener la función cognitiva
CA2986039A1 (fr) 2015-05-18 2016-11-24 Agile Therapeutics, Inc. Compositions contraceptives et procedes d'amelioration de l'efficacite et de modulation d'effets secondaires
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
WO2016203044A1 (fr) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Comprimé orodispersible contenant de l'estétrol
RS57328B1 (sr) 2015-06-18 2018-08-31 Mithra Pharmaceuticals S A Orodisperzibilna dozna jedinica koja sadrži estetrolsku komponentu
NZ737945A (en) * 2015-06-18 2023-06-30 Estetra Sprl Orodispersible dosage unit containing an estetrol component
DK3313408T3 (da) 2015-06-23 2024-01-29 Laboratorios Leon Farma Sa Drospirenon-baseret svangerskabsforebyggende middel til en kvindelig patient, som lider af overvægt
US20200046729A1 (en) 2016-08-05 2020-02-13 Estetra Sprl Methods using combined oral contraceptive compositions with reduced cardiovascular effects
CA3178291A1 (fr) 2016-08-05 2018-04-12 Estetra Srl Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles
CA3041016C (fr) 2016-10-28 2023-09-05 Estetra Sprl Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles
UA126746C2 (uk) 2018-02-07 2023-01-18 Естетра Спрл Композиція контрацептива зі зниженими ефектами щодо серцево-судинної системи

Also Published As

Publication number Publication date
PT3310345T (pt) 2021-05-28
HUE054589T2 (hu) 2021-09-28
US10894014B2 (en) 2021-01-19
JP2018517718A (ja) 2018-07-05
MA44205B1 (fr) 2021-04-30
CA2988485A1 (fr) 2016-12-22
SI3310345T1 (sl) 2021-05-31
WO2016203009A1 (fr) 2016-12-22
DK3310345T3 (da) 2021-05-25
MD3310345T2 (ro) 2021-07-31
PL3310345T3 (pl) 2021-10-18
US20180185271A1 (en) 2018-07-05
RS61812B1 (sr) 2021-06-30
ES2877186T3 (es) 2021-11-16
EP3310345B1 (fr) 2021-03-31
JP6866561B2 (ja) 2021-04-28
CY1124104T1 (el) 2022-05-27
LT3310345T (lt) 2021-06-25
CN107810001A (zh) 2018-03-16
EP3310345A1 (fr) 2018-04-25
HRP20210668T1 (hr) 2021-05-28
SMT202100370T1 (it) 2021-07-12

Similar Documents

Publication Publication Date Title
MA44205B1 (fr) Comprimé orodispersible comprenant estetrol
MA44206B1 (fr) Comprimé orodispersible comprenant estetrol
MA45972B1 (fr) Unité posologique orodispersible contenant un composant d'estétrol
AU2014205529B2 (en) Methods and compositions for treatment of demyelinating diseases
CA2801241C (fr) Procedes de traitement du trouble bipolaire
US12246004B2 (en) Therapeutic treatment of microsatellite unstable cancers
MA37610B1 (fr) Formulations de testostérone proliposomales
MA37958B1 (fr) Pde9i ayant un squelette imidazo pyrazinone
MA33533B1 (fr) Compositions pharmaceutiques pour le traitement du cancer et d'autres maladies ou troubles
MA33836B1 (fr) Compositions pharmaceutiques contenant des ligands des récepteurs sigma
MA33491B1 (fr) Composition pharmaceutique pour un inhibiteur de protease virale de l'hépatite c
GT201700270A (es) Unidad de dosificación orodispersable que contiene un componente estetrol
PE20010480A1 (es) PRODUCTOS DE DROGAS ß-CARBOLINE
MA34158B1 (fr) Combinaisons contenant une 2,3-dihydroimidazo{1,2-c]quinazoline substituée
CN113164490B (zh) 采用p2x3拮抗剂治疗瘙痒症
US20210230113A1 (en) Cannabinoid derivatives
AU2010217615C1 (en) Uses of NK receptor antagonists
US20150306112A1 (en) Zhankuic acid A, a JAK2/3 tyrosine kinase inhibitor, and a potential therapeutic agent for hepatitis
MA33602B1 (fr) Composition pharmaceutique permettant de prévenir ou de traiter l'arthrite rhumatoïde, contenant du rébamipide
MA53189A1 (fr) Composition pharmaceutique destinée au traitement de l'anémie aplasique
US12435377B2 (en) Cancers with loss of chromosome 16Q and/or low expression of metallothionein proteins
HRP20050355A2 (en) Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
AR117150A1 (es) Formulaciones farmacéuticas de análogos de ciclosporina
MA45202A1 (fr) Composition pharmaceutique comprenant un antagoniste du récepteur minéralocorticoïde et son utilisation
WO2021191455A1 (fr) Nouvelles cibles thérapeutiques à effet anti-inflammatoire et anti-interféron