MA44546B1 - Virus adéno-associés variants et procédés d'utilisation - Google Patents

Virus adéno-associés variants et procédés d'utilisation

Info

Publication number
MA44546B1
MA44546B1 MA44546A MA44546A MA44546B1 MA 44546 B1 MA44546 B1 MA 44546B1 MA 44546 A MA44546 A MA 44546A MA 44546 A MA44546 A MA 44546A MA 44546 B1 MA44546 B1 MA 44546B1
Authority
MA
Morocco
Prior art keywords
methods
associated viruses
variant adeno
adeno
variant
Prior art date
Application number
MA44546A
Other languages
English (en)
Other versions
MA44546A1 (fr
Inventor
Loren Looger
Adam Hantman
Dougal Gowanlock Robinson Tervo
Joshua Dudman
Kimberly Ritola
Sarada Viswanathan
Alla Karpova
Bum-Yeol Hwang
David Schaffer
Original Assignee
Univ California
Hughes Howard Med Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Hughes Howard Med Inst filed Critical Univ California
Publication of MA44546A1 publication Critical patent/MA44546A1/fr
Publication of MA44546B1 publication Critical patent/MA44546B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6027—Vectors comprising as targeting moiety peptide derived from defined protein from viruses ssDNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)

Abstract

La présente invention concerne des variantes d'aav qui présentent une préférence pour un mouvement rétrograde dans les neurones et des procédés d'utilisation de telles variantes.
MA44546A 2016-06-15 2017-06-14 Virus adéno-associés variants et procédés d'utilisation MA44546B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350361P 2016-06-15 2016-06-15
US201662404585P 2016-10-05 2016-10-05
PCT/US2017/037781 WO2017218842A1 (fr) 2016-06-15 2017-06-15 Virus adéno-associés variants et procédés d'utilisation

Publications (2)

Publication Number Publication Date
MA44546A1 MA44546A1 (fr) 2019-07-31
MA44546B1 true MA44546B1 (fr) 2021-03-31

Family

ID=59258370

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44546A MA44546B1 (fr) 2016-06-15 2017-06-14 Virus adéno-associés variants et procédés d'utilisation

Country Status (28)

Country Link
US (2) US10961282B2 (fr)
EP (2) EP3472183B1 (fr)
JP (2) JP7094277B2 (fr)
KR (2) KR102522661B1 (fr)
CN (2) CN116003532A (fr)
AU (2) AU2017286652B2 (fr)
BR (1) BR112018076090A2 (fr)
CA (1) CA3028113A1 (fr)
DK (1) DK3472183T5 (fr)
EA (1) EA201990033A1 (fr)
ES (1) ES2962611T3 (fr)
FI (1) FI3472183T3 (fr)
HR (1) HRP20231403T1 (fr)
HU (1) HUE063755T2 (fr)
IL (2) IL263719B2 (fr)
LT (1) LT3472183T (fr)
MA (1) MA44546B1 (fr)
MX (2) MX2018015770A (fr)
MY (1) MY190221A (fr)
PH (1) PH12018502664A1 (fr)
PL (1) PL3472183T3 (fr)
PT (1) PT3472183T (fr)
RS (1) RS64769B1 (fr)
SG (1) SG11201811189RA (fr)
SI (1) SI3472183T1 (fr)
SM (1) SMT202300372T1 (fr)
WO (1) WO2017218842A1 (fr)
ZA (1) ZA201900278B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3693025T3 (da) * 2011-04-22 2022-01-10 Univ California Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf
US11136557B2 (en) 2013-05-31 2021-10-05 The Regents Of The University Of California Adeno-associated virus variants and methods of use thereof
WO2017197355A2 (fr) 2016-05-13 2017-11-16 4D Molecular Therapeutics Inc. Variantes de capsides de virus adéno-associé et leurs procédés d'utilisation
MA44546B1 (fr) * 2016-06-15 2021-03-31 Univ California Virus adéno-associés variants et procédés d'utilisation
CN109640949B (zh) 2016-07-29 2022-11-25 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体和其使用方法
KR20250023600A (ko) 2017-06-30 2025-02-18 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 변이체 캡시드를 보유한 아데노-부속 바이러스 비리온 및 이의 사용 방법
MX2020001997A (es) 2017-08-28 2020-07-20 Univ California Variantes de capside de virus adenoasociado y metodos de uso de estas.
AU2018350700B2 (en) 2017-10-16 2025-04-24 VeonGen Therapeutics GmbH AAV vectors
BR112021001878A2 (pt) * 2018-07-31 2021-04-27 Cornell University métodos de terapia genética para o controle da função do órgão
US11149256B2 (en) 2018-09-26 2021-10-19 California Institute Of Technology Adeno-associated virus compositions for targeted gene therapy
EP4007609A1 (fr) * 2019-08-01 2022-06-08 Cornell University Thérapie génique ciblée pour traiter des maladies neurologiques
US20230265453A1 (en) * 2020-07-08 2023-08-24 Baylor College Of Medicine Gene therapy for stxbp1 encephalopathy
CN111825772B (zh) * 2020-07-30 2023-10-20 中国科学院精密测量科学与技术创新研究院 具有变异衣壳蛋白的腺相关病毒及其应用
CA3181024A1 (fr) 2020-08-06 2022-02-10 Fundacion Para La Investigacion Medica Aplicada Particules virales a utiliser dans le traitement de tauopathies de type maladie d'alzheimer par therapie genique
WO2022098893A2 (fr) * 2020-11-06 2022-05-12 The Children's Medical Center Corporation Vecteurs de virus adéno-associés
US20240067678A1 (en) * 2020-12-16 2024-02-29 Children's Medical Research Institute Adeno-associated virus capsids and vectors
US20240059743A1 (en) * 2020-12-16 2024-02-22 Chidren's Medical Research Institute Aav capsids and vectors
BR112023026523A2 (pt) 2021-06-17 2024-03-05 Meiragtx Uk Ii Ltd Métodos para fabricar aav
CA3225080A1 (fr) 2021-07-14 2023-01-19 Anastasios GEORGIADIS Therapie genique kcnv2
EP4370695A1 (fr) 2021-07-14 2024-05-22 Meiragtx UK II Limited Thérapie génique de retgc
US20250281639A1 (en) * 2021-07-14 2025-09-11 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for treating chronic pain and for retrograde transduction of neurons
CA3239128A1 (fr) 2021-12-15 2023-07-13 Xuecui GUO Expression polycistronique de peptides intestinaux
TW202346600A (zh) * 2022-03-30 2023-12-01 高等教育聯邦系統 匹茲堡大學 用於將核酸遞送至視網膜神經節細胞和/或視網膜色素上皮細胞的腺相關病毒載體
EP4499669A4 (fr) * 2022-03-30 2026-06-24 Univ Pittsburgh Commonwealth Sys Higher Education Vecteurs viraux adéno-associés
EP4598941A2 (fr) * 2022-09-13 2025-08-13 Dyno Therapeutics, Inc. Variants de capside et leurs méthodes d'utilisation
WO2024056902A2 (fr) 2022-09-16 2024-03-21 Christopher Shaw Compositions et méthodes de traitement de maladies neurologiques
EP4601679A1 (fr) 2022-10-11 2025-08-20 MeiraGTx UK II Limited Formulations pour thérapie génique de virus adéno-associé
JP2025535118A (ja) 2022-10-11 2025-10-22 メイラグティーエックス ユーケー アイアイ リミティド Ａａｖカプシドの精製のためのクロマトグラフィー方法
WO2024079662A1 (fr) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Constructions d'expression d'upf1
EP4602173A1 (fr) 2022-10-11 2025-08-20 MeiraGTx UK II Limited Éléments régulateurs d'acide nucléique pour l'expression génique dans le système nerveux central et méthodes d'utilisation
JP2025533994A (ja) 2022-10-11 2025-10-09 メイラグティーエックス ユーケー アイアイ リミティド Ａｔｐ７ｂ遺伝子療法
AU2023392154A1 (en) 2022-12-14 2025-06-26 King's College London Compositions and methods for treating neurological diseases
CN120752255A (zh) * 2023-01-05 2025-10-03 恩沐辑医药有限责任公司 神经元启动子及其用途
EP4646429A2 (fr) * 2023-01-05 2025-11-12 Emugen Therapeutics LLC Rétro-aav et utilisation dans le traitement de maladies neurodégénératives
WO2024161022A2 (fr) 2023-02-03 2024-08-08 King's College London Compositions et méthodes de traitement de maladies neurologiques
EP4694906A1 (fr) 2023-04-13 2026-02-18 MeiraGTx Gene Regulation Limited Promoteurs inductibles par inflammation
WO2024220316A1 (fr) * 2023-04-18 2024-10-24 University Of Massachusetts Variants de capside et utilisations associées
WO2024252182A1 (fr) 2023-06-08 2024-12-12 Meiragtx Uk Ii Limited Chromatographie par échange de cations pour capture de vaa
WO2025126153A2 (fr) 2023-12-14 2025-06-19 Aviadobio Ltd. Compositions et méthodes de traitement de maladies neurologiques à médiation par sod1
WO2026087373A1 (fr) 2024-10-21 2026-04-30 MeiraGTx Ocular UK Limited Promoteurs pour guider l'expression génique dans des photorécepteurs à bâtonnets et utilisations associées
WO2026154123A1 (fr) 2025-01-17 2026-07-23 Aviadobio Limited Compositions et méthodes de traitement de maladies neurologiques

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156303A (en) 1997-06-11 2000-12-05 University Of Washington Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
US9233131B2 (en) * 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
US20090215870A1 (en) * 2005-04-29 2009-08-27 Terwilliger Ernest F Compositions and methods for targeting of viral vectors
WO2009108274A2 (fr) 2008-02-26 2009-09-03 The University Of North Carolina At Chapel Hill Procédés et compositions pour virus adéno-associés (aav) présentant des mutations de la boucle hi
EP2396343B1 (fr) 2009-02-11 2017-05-17 The University of North Carolina At Chapel Hill Vecteurs viraux modifiés et procédés de fabrication et d'utilisation de ceux-ci
DK3693025T3 (da) * 2011-04-22 2022-01-10 Univ California Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf
US9719992B2 (en) 2011-10-07 2017-08-01 Howard Hughes Medical Institute Genetically encoded biosensors
WO2013174760A1 (fr) 2012-05-25 2013-11-28 Deutsches Krebsforschungszentrum Vecteurs aav optimisés pour des taux de transduction élevés dans des cellules dendritiques
US9518980B2 (en) 2012-10-10 2016-12-13 Howard Hughes Medical Institute Genetically encoded calcium indicators
US9518996B2 (en) 2013-08-05 2016-12-13 Howard Hughes Medical Institute Fluorescent protein-based calcium integrators
EP3564379A1 (fr) * 2013-09-13 2019-11-06 California Institute of Technology Récupération sélective
CN104592364B (zh) * 2013-10-30 2018-05-01 北京大学 定点突变和定点修饰的腺相关病毒、其制备方法及应用
GB201403684D0 (en) * 2014-03-03 2014-04-16 King S College London Vector
US10746742B2 (en) * 2014-04-25 2020-08-18 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
US10370432B2 (en) * 2014-10-03 2019-08-06 University Of Massachusetts Heterologous targeting peptide grafted AAVS
AU2015349759B2 (en) * 2014-11-21 2022-01-06 The University Of North Carolina At Chapel Hill Aav vectors targeted to the central nervous system
US9644007B2 (en) 2014-12-23 2017-05-09 Howard Hughes Medical Institute Red genetically encoded calcium indicators and methods of use
WO2017197355A2 (fr) * 2016-05-13 2017-11-16 4D Molecular Therapeutics Inc. Variantes de capsides de virus adéno-associé et leurs procédés d'utilisation
MA44546B1 (fr) * 2016-06-15 2021-03-31 Univ California Virus adéno-associés variants et procédés d'utilisation
CN109640949B (zh) * 2016-07-29 2022-11-25 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体和其使用方法

Also Published As

Publication number Publication date
PL3472183T3 (pl) 2024-02-12
SI3472183T1 (sl) 2023-11-30
FI3472183T3 (fi) 2023-11-03
EP3472183A1 (fr) 2019-04-24
CN109641939A (zh) 2019-04-16
SMT202300372T1 (it) 2023-11-13
DK3472183T3 (da) 2023-11-06
EP3472183B1 (fr) 2023-08-09
RS64769B1 (sr) 2023-11-30
US20210230231A1 (en) 2021-07-29
EP4268852A3 (fr) 2024-02-07
PT3472183T (pt) 2023-11-16
AU2017286652A1 (en) 2019-01-24
IL263719A (en) 2019-01-31
JP2022126759A (ja) 2022-08-30
US10961282B2 (en) 2021-03-30
ZA201900278B (en) 2022-04-28
CN109641939B (zh) 2022-11-08
AU2021225247B2 (en) 2023-02-16
AU2021225247A1 (en) 2021-09-30
MX2018015770A (es) 2019-08-29
HUE063755T2 (hu) 2024-01-28
IL300981A (en) 2023-04-01
DK3472183T5 (da) 2024-09-09
KR20190039930A (ko) 2019-04-16
CA3028113A1 (fr) 2017-12-21
ES2962611T3 (es) 2024-03-20
JP7094277B2 (ja) 2022-07-01
AU2017286652B2 (en) 2021-10-07
EP4268852A2 (fr) 2023-11-01
IL263719B1 (en) 2023-05-01
IL263719B2 (en) 2023-09-01
KR102800951B1 (ko) 2025-04-25
SG11201811189RA (en) 2019-01-30
KR20230054754A (ko) 2023-04-25
BR112018076090A2 (pt) 2019-03-26
PH12018502664A1 (en) 2019-10-07
JP7579301B2 (ja) 2024-11-07
CN116003532A (zh) 2023-04-25
MX2024000505A (es) 2024-03-19
WO2017218842A1 (fr) 2017-12-21
JP2019518793A (ja) 2019-07-04
MY190221A (en) 2022-04-06
KR102522661B1 (ko) 2023-04-18
MA44546A1 (fr) 2019-07-31
US11939355B2 (en) 2024-03-26
EA201990033A1 (ru) 2019-06-28
LT3472183T (lt) 2023-09-25
US20190300579A1 (en) 2019-10-03
HRP20231403T1 (hr) 2024-02-16

Similar Documents

Publication Publication Date Title
MA44546A1 (fr) Virus adéno-associés variants et procédés d'utilisation
EP4061427A4 (fr) Variants de vecteurs viraux adéno-associés
MA38498B1 (fr) Protéines de liaison anti-lag-3
EP3953478A4 (fr) Procédés et compositions pour améliorer l'assemblage de virus adéno-associés (aav)
MA43982A (fr) Anticorps anti-tnf, compositions, méthodes et utilisation pour le traitement ou la prévention du diabète de type 1
EP3841109A4 (fr) Compositions et procédés pour moduler l'efficacité de transduction de virus adéno-associés
MA46836A (fr) Agents, utilisations et procédés pour le traitement d'une synucléinopathie
PH12018502673A1 (en) Anti-zika virus antibodies and methods of use
EA202090124A1 (ru) Аденовирус, вооруженный биспецифическим рекрутером t-клеток (bite)
EP3857127A4 (fr) Dispositif d'allumage à l'épreuve des enfants
ZA201807595B (en) Protoporphyrinogen oxidase variants and methods and compositions for conferring and/or enhancing herbicide tolerance using the same
MA40682A (fr) Anticorps anti-ox40 et procédés d'utilisation correspondants
MA51630A (fr) Utilisation de virus oncolytiques, seuls ou en combinaison avec un inhibiteur de point de contrôle immunitaire, pour le traitement du cancer
EA201791754A1 (ru) АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
EP3645044A4 (fr) Utilisation d'anticorps dirigés contre une famille à similarité de séquence 19, membre a5, pour le traitement du glaucome
EA200970916A1 (ru) Соединения 5,6-дигидро-1н-пиридин-2-она
EP3500278A4 (fr) Méthodes et compositions pour le traitement d'affections à l'aide d'un virus adéno-associé recombinant auto-complémentaire
EP3403673A4 (fr) Composition pour empêcher ou améliorer la chute et le grisonnement des cheveux, et utilisation de cette dernière
EP3898445A4 (fr) Récipient à l'épreuve des enfants
EP3403675A4 (fr) Virion viral adéno-associé pour son utilisation dans le traitement de l'épilepsie
FR3072973B1 (fr) Particules pseudo-virales utiles pour traiter des dysfonctionnements immunitaires
EP3467593A4 (fr) Ensemble de réception de force d'entraînement et boîte de traitement utilisant l'ensemble
EP3503928A4 (fr) Méthodes et compositions pour le traitement d'états canins au moyen d'un virus adéno-associé recombinant auto-complémentaire.
EP3458038A4 (fr) Transporteurs d'oxygène réduit et leur utilisation destinés au traitement de la carboxyhémoglobinémie
EP3294313A4 (fr) Méthodes associées à la prévention et et au traitement d'une pharmacorésistance