MA44972A - Procédés d'identification de modulateurs du cftr - Google Patents

Procédés d'identification de modulateurs du cftr

Info

Publication number
MA44972A
MA44972A MA044972A MA44972A MA44972A MA 44972 A MA44972 A MA 44972A MA 044972 A MA044972 A MA 044972A MA 44972 A MA44972 A MA 44972A MA 44972 A MA44972 A MA 44972A
Authority
MA
Morocco
Prior art keywords
identification processes
cftr modulator
modulator identification
cftr
processes
Prior art date
Application number
MA044972A
Other languages
English (en)
Inventor
Lawrence J Ii Drew
Po-Shun Lee
John Miller
Original Assignee
Proteostasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteostasis Therapeutics Inc filed Critical Proteostasis Therapeutics Inc
Publication of MA44972A publication Critical patent/MA44972A/fr

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/38Pediatrics
    • G01N2800/382Cystic fibrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MA044972A 2016-05-09 2017-05-09 Procédés d'identification de modulateurs du cftr MA44972A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662333537P 2016-05-09 2016-05-09

Publications (1)

Publication Number Publication Date
MA44972A true MA44972A (fr) 2019-03-20

Family

ID=58739383

Family Applications (1)

Application Number Title Priority Date Filing Date
MA044972A MA44972A (fr) 2016-05-09 2017-05-09 Procédés d'identification de modulateurs du cftr

Country Status (6)

Country Link
US (1) US20190154661A1 (fr)
EP (1) EP3455624A1 (fr)
AU (1) AU2017264612A1 (fr)
CA (1) CA3023512A1 (fr)
MA (1) MA44972A (fr)
WO (1) WO2017196843A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107922338A (zh) * 2015-06-02 2018-04-17 艾伯维公司 经取代的吡啶及使用方法
US10548878B2 (en) 2015-07-24 2020-02-04 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods of increasing CFTR activity
NZ741093A (en) 2015-10-06 2022-12-23 Proteostasis Therapeutics Inc Compounds, compositions, and methods for modulating cftr
BR112018070747B1 (pt) 2016-04-07 2024-01-09 Proteostasis Therapeutics, Inc Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos
EP3472156B1 (fr) 2016-06-21 2023-06-07 Proteostasis Therapeutics, Inc. Composés, compositions et procédés pour augmenter l'activité du cftr
WO2020006269A1 (fr) 2018-06-27 2020-01-02 Proteostasis Therapeutics, Inc. Composés améliorant l'activité du protéasome
KR20220019015A (ko) * 2019-06-10 2022-02-15 노파르티스 아게 Cf, copd, 및 기관지확장증 치료를 위한 피리딘 및 피라진 유도체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2751215A1 (fr) * 2009-02-02 2010-08-05 Chromocell Corporation Lignees cellulaires exprimant cftr et procedes d'utilisation associes
EP2816034B1 (fr) * 2010-09-14 2018-12-12 Instytut Biochemii I Biofizyki Polskiej Akademii Nauk Composés modulateurs d'une protéine cftr mutante et leur utilisation pour le traitement de maladies associées à un dysfonctionnement de la protéine cftr
US20160151335A1 (en) 2013-06-26 2016-06-02 Proteostasis Therapeutics, Inc. Methods of modulating cftr activity
EP3116870A1 (fr) 2014-03-13 2017-01-18 Proteostasis Therapeutics, Inc. Composés, compositions et procédés pour augmenter l'activité cftr
EP3116501A1 (fr) 2014-03-13 2017-01-18 Proteostasis Therapeutics, Inc. Composés, compositions et procédés pour augmenter l'activité du cftr
CA2952862A1 (fr) 2014-06-19 2015-12-23 Proteostasis Therapeutics, Inc. Composes, compositions et procedes pour augmenter l'activite du cftr
NZ741093A (en) 2015-10-06 2022-12-23 Proteostasis Therapeutics Inc Compounds, compositions, and methods for modulating cftr

Also Published As

Publication number Publication date
WO2017196843A1 (fr) 2017-11-16
AU2017264612A1 (en) 2018-11-22
EP3455624A1 (fr) 2019-03-20
US20190154661A1 (en) 2019-05-23
CA3023512A1 (fr) 2017-11-16

Similar Documents

Publication Publication Date Title
EP3468725C0 (fr) Appareil de revêtement de tuyaux
EP3436581A4 (fr) Procédés d'amplification de transcriptome entier
MA55748A (fr) Procédés de détection d'aav
EP3430731A4 (fr) Architecture d'iugw
EP3485773A4 (fr) Buse d'aspirateur
MA44972A (fr) Procédés d'identification de modulateurs du cftr
EP3478229A4 (fr) Dispositif d'ouverture optimale des voies respiratoires.
EP3387023A4 (fr) Procédés de récupération d'hydrocarbure
PL3311169T3 (pl) Oznaczenie do identyfikacji modulatorów
EP3507335A4 (fr) Revêtements polymères
EP3439412A4 (fr) Procédés de configuration et d'envoi de préambule, et dispositifs associés
EP3474165A4 (fr) Système de conception d'assistance
EP3443293A4 (fr) Capteurs d'effort
MA41296A (fr) Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
EP3558312A4 (fr) Procédés d'amélioration de la densité vasculaire
EP3556455A4 (fr) Appareil de production d'urée
EP3371730A4 (fr) Évaluation automatisée de la qualité d'un échantillon
EP3433383A4 (fr) Procédés d'amplification quantitative
EP3426262A4 (fr) Agents de réticulation et procédés associés
MA41298A (fr) Procédés de marquage de banques codées par de l'adn
EP3512403A4 (fr) Système d'inspection d'orifice
CH712426C1 (de) Vorrichtung zur Herstellung eines Granulats.
EP3429690A4 (fr) Procédés pour moduler keap1
EP3535061A4 (fr) Buse microstructurée
EP3431808A4 (fr) Butée d'arrêt