MA45397A - Composés, compositions et procédés pour augmenter l'activité du cftr - Google Patents
Composés, compositions et procédés pour augmenter l'activité du cftrInfo
- Publication number
- MA45397A MA45397A MA045397A MA45397A MA45397A MA 45397 A MA45397 A MA 45397A MA 045397 A MA045397 A MA 045397A MA 45397 A MA45397 A MA 45397A MA 45397 A MA45397 A MA 45397A
- Authority
- MA
- Morocco
- Prior art keywords
- cftr
- compositions
- activity
- compounds
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352672P | 2016-06-21 | 2016-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45397A true MA45397A (fr) | 2019-04-24 |
Family
ID=59337861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045397A MA45397A (fr) | 2016-06-21 | 2017-06-21 | Composés, compositions et procédés pour augmenter l'activité du cftr |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10899751B2 (fr) |
| EP (1) | EP3472156B1 (fr) |
| AU (2) | AU2017280206A1 (fr) |
| ES (1) | ES2954658T3 (fr) |
| MA (1) | MA45397A (fr) |
| WO (1) | WO2017223188A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3798214B1 (fr) | 2014-10-06 | 2022-09-14 | Vertex Pharmaceuticals Incorporated | Modulateurs de régulateur de conductance transmembranaire de la fibrose kystique |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| NZ741093A (en) | 2015-10-06 | 2022-12-23 | Proteostasis Therapeutics Inc | Compounds, compositions, and methods for modulating cftr |
| BR112018070747B1 (pt) | 2016-04-07 | 2024-01-09 | Proteostasis Therapeutics, Inc | Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos |
| EP3472156B1 (fr) | 2016-06-21 | 2023-06-07 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
| SG10201913595YA (en) | 2016-09-30 | 2020-02-27 | Vertex Pharma | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| MA49235B1 (fr) | 2016-12-09 | 2021-02-26 | Vertex Pharma | Modulateur de régulateur de conductance transmembranaire de fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur |
| WO2018180864A1 (fr) * | 2017-03-29 | 2018-10-04 | 住友精化株式会社 | Résine absorbant l'eau |
| EP3634402B1 (fr) | 2017-06-08 | 2026-01-21 | Vertex Pharmaceuticals Incorporated | Méthodes de traitement de la fibrose kystique |
| BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| TWI799435B (zh) | 2017-08-02 | 2023-04-21 | 美商維泰克斯製藥公司 | 製備化合物之製程 |
| IL273831B2 (en) | 2017-10-19 | 2024-10-01 | Vertex Pharma | Crystalline forms and compositions of cftr modulators |
| CN111757874B (zh) | 2017-12-08 | 2024-03-08 | 弗特克斯药品有限公司 | 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| WO2019156946A2 (fr) * | 2018-02-06 | 2019-08-15 | Research Institute At Nationwide Children's Hospital | Compositions et procédés pour améliorer la fonction cftr dans des cellules affectées par la fibrose kystique |
| EP3752510B1 (fr) | 2018-02-15 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Macrocycles utilisés en tant que modulateurs du régulateur de la conductance transmembranaire de fibrose kystique, compositions pharmaceutiques de ceux-ci, leur utilisation dans le traitement de la fibrose kystique et procédé de fabrication associé |
| WO2019195739A1 (fr) | 2018-04-05 | 2019-10-10 | Alexander Russell Abela | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique |
| US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| WO2020006269A1 (fr) | 2018-06-27 | 2020-01-02 | Proteostasis Therapeutics, Inc. | Composés améliorant l'activité du protéasome |
| KR20210086660A (ko) | 2018-10-30 | 2021-07-08 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 낭포성 섬유증을 치료하기 위한 아미노산 조성물 및 방법 |
| WO2020115231A1 (fr) * | 2018-12-06 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions destinées au traitement des voies respiratoires atteintes de mucoviscidose |
| TWI848092B (zh) | 2019-04-03 | 2024-07-11 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| KR20220064366A (ko) | 2019-08-14 | 2022-05-18 | 버텍스 파마슈티칼스 인코포레이티드 | Cftr 조절제의 결정질 형태 |
| WO2021041997A1 (fr) | 2019-08-28 | 2021-03-04 | The Regents Of The University Of California | Co-potentialisateurs pour thérapie de la fibrose kystique provoquée par des mutants cftr à fonction minimale |
| CN115427050B (zh) * | 2020-02-07 | 2025-02-14 | 南佛罗里达大学 | 对tau蛋白病中的β-抑制蛋白寡聚化的抑制 |
| CA3188787A1 (fr) | 2020-08-13 | 2022-02-17 | Vertex Pharmaceuticals Incorporated | Formes cristallines de modulateurs de cftr |
| EP3970718A1 (fr) * | 2020-09-18 | 2022-03-23 | Charité - Universitätsmedizin Berlin | Nouvelle utilisation médicale des modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique (cftr) |
| CA3204725A1 (fr) | 2020-12-10 | 2022-06-16 | Vertex Pharmaceuticals Incorporated | Methodes de traitement de la mucoviscidose |
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| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US20180147187A1 (en) | 2015-01-12 | 2018-05-31 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| WO2017040606A1 (fr) | 2015-08-31 | 2017-03-09 | Proteostasis Therapeutics, Inc. | Dérivés d'isoxazole destinés à être utilisés dans le traitement de maladies et de troubles pulmonaires |
| NZ741093A (en) | 2015-10-06 | 2022-12-23 | Proteostasis Therapeutics Inc | Compounds, compositions, and methods for modulating cftr |
| EP3393465A1 (fr) | 2015-12-22 | 2018-10-31 | Proteostasis Therapeutics, Inc. | Méthodes de traitement de maladies et troubles pulmonaires |
| BR112018070747B1 (pt) | 2016-04-07 | 2024-01-09 | Proteostasis Therapeutics, Inc | Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos |
| EP3455624A1 (fr) | 2016-05-09 | 2019-03-20 | Proteostasis Therapeutics, Inc. | Procédés d'identification de modulateurs du cftr |
| EP3472156B1 (fr) | 2016-06-21 | 2023-06-07 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
-
2017
- 2017-06-21 EP EP17739769.2A patent/EP3472156B1/fr active Active
- 2017-06-21 ES ES17739769T patent/ES2954658T3/es active Active
- 2017-06-21 US US16/311,397 patent/US10899751B2/en active Active
- 2017-06-21 MA MA045397A patent/MA45397A/fr unknown
- 2017-06-21 WO PCT/US2017/038521 patent/WO2017223188A1/fr not_active Ceased
- 2017-06-21 AU AU2017280206A patent/AU2017280206A1/en not_active Abandoned
-
2021
- 2021-08-10 AU AU2021215136A patent/AU2021215136B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3472156A1 (fr) | 2019-04-24 |
| ES2954658T3 (es) | 2023-11-23 |
| AU2017280206A1 (en) | 2019-01-17 |
| AU2021215136A1 (en) | 2021-09-02 |
| EP3472156B1 (fr) | 2023-06-07 |
| US20200010461A1 (en) | 2020-01-09 |
| AU2021215136B2 (en) | 2023-07-27 |
| CA3028966A1 (fr) | 2017-12-28 |
| WO2017223188A1 (fr) | 2017-12-28 |
| US10899751B2 (en) | 2021-01-26 |
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