MA45154B1 - Procédés de préparation d'oligomères - Google Patents

Procédés de préparation d'oligomères

Info

Publication number
MA45154B1
MA45154B1 MA45154A MA45154A MA45154B1 MA 45154 B1 MA45154 B1 MA 45154B1 MA 45154 A MA45154 A MA 45154A MA 45154 A MA45154 A MA 45154A MA 45154 B1 MA45154 B1 MA 45154B1
Authority
MA
Morocco
Prior art keywords
oligomer
oligomers
processes
preparation
scaling
Prior art date
Application number
MA45154A
Other languages
English (en)
Other versions
MA45154A (fr
Inventor
Bao Cai
Mitchell MARTINI
Ross SHIMABUKU
Katie THOMAS
Diane Elizabeth Frank
Richard K. Bestwick
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of MA45154A publication Critical patent/MA45154A/fr
Publication of MA45154B1 publication Critical patent/MA45154B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

L'invention concerne des procédés de préparation d'un oligomère (par exemple, un oligomère morpholino). Les procédés de synthèse décrits dans l'invention peuvent être avantageux pour la mise à l'échelle de la synthèse d'oligomères tout en maintenant le rendement global et la pureté d'un oligomère synthétisé.
MA45154A 2016-05-24 2017-05-24 Procédés de préparation d'oligomères MA45154B1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662341049P 2016-05-24 2016-05-24
US201662357166P 2016-06-30 2016-06-30
US201662357153P 2016-06-30 2016-06-30
US201662357072P 2016-06-30 2016-06-30
US201662356923P 2016-06-30 2016-06-30
US201762508256P 2017-05-18 2017-05-18
EP17731336.8A EP3464305B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères
PCT/US2017/034235 WO2017205496A1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères

Publications (2)

Publication Number Publication Date
MA45154A MA45154A (fr) 2019-04-10
MA45154B1 true MA45154B1 (fr) 2024-11-29

Family

ID=59078165

Family Applications (2)

Application Number Title Priority Date Filing Date
MA049775A MA49775A (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate
MA45154A MA45154B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA049775A MA49775A (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Country Status (21)

Country Link
US (2) US10875880B2 (fr)
EP (2) EP3464305B1 (fr)
JP (2) JP7008642B2 (fr)
KR (1) KR102506298B1 (fr)
CN (1) CN109563114B (fr)
AU (1) AU2017269355B2 (fr)
BR (2) BR122022014984B1 (fr)
CA (1) CA3025339A1 (fr)
CO (1) CO2018013838A2 (fr)
DK (1) DK3464305T3 (fr)
ES (1) ES2993738T3 (fr)
FI (1) FI3464305T3 (fr)
HR (1) HRP20241428T1 (fr)
IL (1) IL263149B2 (fr)
MA (2) MA49775A (fr)
MD (1) MD3464305T2 (fr)
MX (2) MX384727B (fr)
SA (1) SA518400500B1 (fr)
SG (1) SG10202101830WA (fr)
TW (2) TWI801843B (fr)
WO (1) WO2017205496A1 (fr)

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TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
MX384727B (es) 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros
TWI737736B (zh) * 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
US10947533B2 (en) * 2016-05-24 2021-03-16 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
MX390906B (es) 2016-05-24 2025-03-21 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
CN109152775B (zh) * 2016-06-30 2022-04-26 萨勒普塔医疗公司 制备磷酸二酰胺吗啉代寡聚物的方法
CA3024153A1 (fr) * 2016-06-30 2017-11-30 Sarepta Therapeutics, Inc. Procedes de preparation d'oligomeres morpholino de phosphorodiamidate
TWI812647B (zh) 2017-09-25 2023-08-21 美商薩羅塔治療公司 經由速流合成以製備磷醯二胺嗎啉代寡聚物之製程
WO2019209764A2 (fr) * 2018-04-26 2019-10-31 Sarepta Therapeutics, Inc. Oligomères induisant le saut d'exon et conjugués d'oligomères pour la dystrophie musculaire
EP4658280A2 (fr) * 2023-02-01 2025-12-10 Alnylam Pharmaceuticals, Inc. Cycle à six chaînons contenant des oligomères

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Also Published As

Publication number Publication date
EP3564248A1 (fr) 2019-11-06
CN109563114A (zh) 2019-04-02
US20210198296A1 (en) 2021-07-01
EP3464305B1 (fr) 2024-08-21
JP7008642B2 (ja) 2022-01-25
KR102506298B1 (ko) 2023-03-06
TWI801843B (zh) 2023-05-11
TW202200599A (zh) 2022-01-01
ES2993738T3 (en) 2025-01-08
EP3464305A1 (fr) 2019-04-10
BR112018074346B1 (pt) 2023-01-03
CO2018013838A2 (es) 2019-01-18
JP2019518832A (ja) 2019-07-04
US10875880B2 (en) 2020-12-29
CA3025339A1 (fr) 2017-11-30
MA49775A (fr) 2020-06-10
DK3464305T3 (da) 2024-10-28
AU2017269355A1 (en) 2019-01-17
MD3464305T2 (ro) 2025-01-31
MX2018014472A (es) 2019-05-23
SA518400500B1 (ar) 2022-09-01
BR122022014984B1 (pt) 2024-03-05
JP2021176967A (ja) 2021-11-11
MA45154A (fr) 2019-04-10
US11384105B2 (en) 2022-07-12
TW201806962A (zh) 2018-03-01
MX384727B (es) 2025-03-14
IL263149A (en) 2019-01-31
IL263149B2 (en) 2023-05-01
US20200040020A1 (en) 2020-02-06
AU2017269355B2 (en) 2021-04-15
IL263149B1 (en) 2023-01-01
MX2021008539A (es) 2022-10-18
KR20190015311A (ko) 2019-02-13
SG10202101830WA (en) 2021-04-29
HRP20241428T1 (hr) 2025-01-03
FI3464305T3 (fi) 2024-10-30
TWI738784B (zh) 2021-09-11
WO2017205496A1 (fr) 2017-11-30
CN109563114B (zh) 2022-08-12
BR112018074346A2 (pt) 2019-03-06

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