MA45155B1 - Procédés de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents

Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Info

Publication number
MA45155B1
MA45155B1 MA45155A MA45155A MA45155B1 MA 45155 B1 MA45155 B1 MA 45155B1 MA 45155 A MA45155 A MA 45155A MA 45155 A MA45155 A MA 45155A MA 45155 B1 MA45155 B1 MA 45155B1
Authority
MA
Morocco
Prior art keywords
phosphorodiamidate
processes
preparation
oligomer
morpholino oligomers
Prior art date
Application number
MA45155A
Other languages
English (en)
Other versions
MA45155A (fr
Inventor
Bao Cai
Mitchell MARTINI
Katie THOMAS
Ross SHIMABUKU
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of MA45155A publication Critical patent/MA45155A/fr
Publication of MA45155B1 publication Critical patent/MA45155B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/062—Organo-phosphoranes without P-C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des procédés de préparation d'un oligomère (par exemple, un oligomère morpholino). Les procédés de synthèse décrits ici peuvent être avantageux pour la mise à l'échelle de la synthèse d'oligomères tout en maintenant le rendement global et la pureté d'un oligomère synthétisé.
MA45155A 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate MA45155B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662340953P 2016-05-24 2016-05-24
US201662357134P 2016-06-30 2016-06-30
EP17731337.6A EP3464306B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate
PCT/US2017/034284 WO2017205513A1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Publications (2)

Publication Number Publication Date
MA45155A MA45155A (fr) 2019-04-10
MA45155B1 true MA45155B1 (fr) 2024-06-28

Family

ID=59078166

Family Applications (2)

Application Number Title Priority Date Filing Date
MA71469A MA71469A (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate
MA45155A MA45155B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA71469A MA71469A (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate

Country Status (28)

Country Link
US (3) US10961262B2 (fr)
EP (2) EP4406600A3 (fr)
JP (1) JP6987081B2 (fr)
KR (1) KR102504759B1 (fr)
CN (1) CN109311920B (fr)
AU (1) AU2017271524B2 (fr)
BR (1) BR112018074270B1 (fr)
CA (1) CA3024182A1 (fr)
CO (1) CO2018013827A2 (fr)
DK (1) DK3464306T3 (fr)
ES (1) ES2987586T3 (fr)
FI (1) FI3464306T3 (fr)
HR (1) HRP20240583T1 (fr)
HU (1) HUE066393T2 (fr)
IL (1) IL263033B2 (fr)
LT (1) LT3464306T (fr)
MA (2) MA71469A (fr)
MD (1) MD3464306T2 (fr)
MX (1) MX383656B (fr)
PL (1) PL3464306T3 (fr)
PT (1) PT3464306T (fr)
RS (1) RS65504B1 (fr)
SA (1) SA518400462B1 (fr)
SG (1) SG11201809499UA (fr)
SI (1) SI3464306T1 (fr)
SM (1) SMT202400183T1 (fr)
TW (1) TWI737736B (fr)
WO (1) WO2017205513A1 (fr)

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US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
MX384727B (es) * 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros
MX390906B (es) 2016-05-24 2025-03-21 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
US10947533B2 (en) * 2016-05-24 2021-03-16 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
TWI737736B (zh) 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
CN109152775B (zh) * 2016-06-30 2022-04-26 萨勒普塔医疗公司 制备磷酸二酰胺吗啉代寡聚物的方法
CA3024153A1 (fr) * 2016-06-30 2017-11-30 Sarepta Therapeutics, Inc. Procedes de preparation d'oligomeres morpholino de phosphorodiamidate
TWI812647B (zh) 2017-09-25 2023-08-21 美商薩羅塔治療公司 經由速流合成以製備磷醯二胺嗎啉代寡聚物之製程
WO2020028832A1 (fr) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Complexes de ciblage musculaire et leurs utilisations pour le traitement de dystrophinopathies
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN109704980B (zh) * 2019-02-16 2022-05-13 安徽大学 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法
EP4123023A4 (fr) * 2020-03-16 2024-07-17 National University Corporation Tokyo Medical and Dental University Acide hétéro-nucléique contenant un acide nucléique morpholino
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
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EP4426356A1 (fr) * 2021-11-01 2024-09-11 Dyne Therapeutics, Inc. Complexes de ciblage musculaire pour traiter des dystrophinopathies

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Also Published As

Publication number Publication date
MA45155A (fr) 2019-04-10
WO2017205513A1 (fr) 2017-11-30
AU2017271524B2 (en) 2021-06-24
LT3464306T (lt) 2024-05-10
HUE066393T2 (hu) 2024-07-28
US20250276988A1 (en) 2025-09-04
TW201825506A (zh) 2018-07-16
JP2019523754A (ja) 2019-08-29
PT3464306T (pt) 2024-05-17
FI3464306T3 (fi) 2024-05-16
MD3464306T2 (ro) 2024-08-31
IL263033B2 (en) 2023-02-01
EP3464306B1 (fr) 2024-03-27
EP4406600A3 (fr) 2024-10-30
US20190276480A1 (en) 2019-09-12
BR112018074270B1 (pt) 2021-02-02
DK3464306T3 (da) 2024-05-21
MX2018014162A (es) 2019-04-01
SG11201809499UA (en) 2018-12-28
EP3464306A1 (fr) 2019-04-10
CN109311920B (zh) 2021-11-09
AU2017271524A1 (en) 2018-11-15
JP6987081B2 (ja) 2021-12-22
US10961262B2 (en) 2021-03-30
SMT202400183T1 (it) 2024-07-09
CA3024182A1 (fr) 2017-11-30
RS65504B1 (sr) 2024-06-28
US12258362B2 (en) 2025-03-25
EP4406600A2 (fr) 2024-07-31
SI3464306T1 (sl) 2024-08-30
ES2987586T3 (es) 2024-11-15
CO2018013827A2 (es) 2018-12-28
KR20190013844A (ko) 2019-02-11
HRP20240583T1 (hr) 2024-07-19
IL263033B (en) 2022-10-01
SA518400462B1 (ar) 2022-06-12
MX383656B (es) 2025-03-14
MA71469A (fr) 2025-04-30
CN109311920A (zh) 2019-02-05
KR102504759B1 (ko) 2023-02-28
IL263033A (en) 2018-12-31
US20220340605A1 (en) 2022-10-27
PL3464306T3 (pl) 2024-07-22
BR112018074270A2 (pt) 2019-03-12
TWI737736B (zh) 2021-09-01

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