MA49775A - Procédés de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents

Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Info

Publication number
MA49775A
MA49775A MA049775A MA49775A MA49775A MA 49775 A MA49775 A MA 49775A MA 049775 A MA049775 A MA 049775A MA 49775 A MA49775 A MA 49775A MA 49775 A MA49775 A MA 49775A
Authority
MA
Morocco
Prior art keywords
phosphorodiamidate
processes
preparation
morpholino oligomers
morpholino
Prior art date
Application number
MA049775A
Other languages
English (en)
Inventor
Richard K Bestwick
Bao Cai
Diane Elizabeth Frank
Mtichell Martini
Ross Shimabuku
Katie Thomas
Original Assignee
Sarepta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics Inc filed Critical Sarepta Therapeutics Inc
Publication of MA49775A publication Critical patent/MA49775A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
MA049775A 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate MA49775A (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662341049P 2016-05-24 2016-05-24
US201662357166P 2016-06-30 2016-06-30
US201662357153P 2016-06-30 2016-06-30
US201662357072P 2016-06-30 2016-06-30
US201662356923P 2016-06-30 2016-06-30
US201762508256P 2017-05-18 2017-05-18

Publications (1)

Publication Number Publication Date
MA49775A true MA49775A (fr) 2020-06-10

Family

ID=59078165

Family Applications (2)

Application Number Title Priority Date Filing Date
MA049775A MA49775A (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate
MA45154A MA45154B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA45154A MA45154B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères

Country Status (21)

Country Link
US (2) US10875880B2 (fr)
EP (2) EP3464305B1 (fr)
JP (2) JP7008642B2 (fr)
KR (1) KR102506298B1 (fr)
CN (1) CN109563114B (fr)
AU (1) AU2017269355B2 (fr)
BR (2) BR122022014984B1 (fr)
CA (1) CA3025339A1 (fr)
CO (1) CO2018013838A2 (fr)
DK (1) DK3464305T3 (fr)
ES (1) ES2993738T3 (fr)
FI (1) FI3464305T3 (fr)
HR (1) HRP20241428T1 (fr)
IL (1) IL263149B2 (fr)
MA (2) MA49775A (fr)
MD (1) MD3464305T2 (fr)
MX (2) MX384727B (fr)
SA (1) SA518400500B1 (fr)
SG (1) SG10202101830WA (fr)
TW (2) TWI801843B (fr)
WO (1) WO2017205496A1 (fr)

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TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
MX384727B (es) 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros
TWI737736B (zh) * 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
US10947533B2 (en) * 2016-05-24 2021-03-16 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
MX390906B (es) 2016-05-24 2025-03-21 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
CN109152775B (zh) * 2016-06-30 2022-04-26 萨勒普塔医疗公司 制备磷酸二酰胺吗啉代寡聚物的方法
CA3024153A1 (fr) * 2016-06-30 2017-11-30 Sarepta Therapeutics, Inc. Procedes de preparation d'oligomeres morpholino de phosphorodiamidate
TWI812647B (zh) 2017-09-25 2023-08-21 美商薩羅塔治療公司 經由速流合成以製備磷醯二胺嗎啉代寡聚物之製程
WO2019209764A2 (fr) * 2018-04-26 2019-10-31 Sarepta Therapeutics, Inc. Oligomères induisant le saut d'exon et conjugués d'oligomères pour la dystrophie musculaire
EP4658280A2 (fr) * 2023-02-01 2025-12-10 Alnylam Pharmaceuticals, Inc. Cycle à six chaînons contenant des oligomères

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Also Published As

Publication number Publication date
EP3564248A1 (fr) 2019-11-06
CN109563114A (zh) 2019-04-02
US20210198296A1 (en) 2021-07-01
EP3464305B1 (fr) 2024-08-21
JP7008642B2 (ja) 2022-01-25
KR102506298B1 (ko) 2023-03-06
TWI801843B (zh) 2023-05-11
TW202200599A (zh) 2022-01-01
ES2993738T3 (en) 2025-01-08
EP3464305A1 (fr) 2019-04-10
BR112018074346B1 (pt) 2023-01-03
CO2018013838A2 (es) 2019-01-18
JP2019518832A (ja) 2019-07-04
US10875880B2 (en) 2020-12-29
CA3025339A1 (fr) 2017-11-30
DK3464305T3 (da) 2024-10-28
AU2017269355A1 (en) 2019-01-17
MD3464305T2 (ro) 2025-01-31
MX2018014472A (es) 2019-05-23
SA518400500B1 (ar) 2022-09-01
MA45154B1 (fr) 2024-11-29
BR122022014984B1 (pt) 2024-03-05
JP2021176967A (ja) 2021-11-11
MA45154A (fr) 2019-04-10
US11384105B2 (en) 2022-07-12
TW201806962A (zh) 2018-03-01
MX384727B (es) 2025-03-14
IL263149A (en) 2019-01-31
IL263149B2 (en) 2023-05-01
US20200040020A1 (en) 2020-02-06
AU2017269355B2 (en) 2021-04-15
IL263149B1 (en) 2023-01-01
MX2021008539A (es) 2022-10-18
KR20190015311A (ko) 2019-02-13
SG10202101830WA (en) 2021-04-29
HRP20241428T1 (hr) 2025-01-03
FI3464305T3 (fi) 2024-10-30
TWI738784B (zh) 2021-09-11
WO2017205496A1 (fr) 2017-11-30
CN109563114B (zh) 2022-08-12
BR112018074346A2 (pt) 2019-03-06

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