MA71469A - Procédé de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents

Procédé de préparation d'oligomères morpholino de phosphorodiamidate

Info

Publication number
MA71469A
MA71469A MA71469A MA71469A MA71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A
Authority
MA
Morocco
Prior art keywords
phosphorodiamidate
preparation
morpholino oligomers
morpholino
oligomers
Prior art date
Application number
MA71469A
Other languages
English (en)
Inventor
Bao Cai
Mitchell MARTINI
Ross SHIMABUKU
Katie THOMAS
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of MA71469A publication Critical patent/MA71469A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/062—Organo-phosphoranes without P-C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA71469A 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate MA71469A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662340953P 2016-05-24 2016-05-24
US201662357134P 2016-06-30 2016-06-30
EP24161437.9A EP4406600A3 (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate

Publications (1)

Publication Number Publication Date
MA71469A true MA71469A (fr) 2025-04-30

Family

ID=59078166

Family Applications (2)

Application Number Title Priority Date Filing Date
MA71469A MA71469A (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate
MA45155A MA45155B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA45155A MA45155B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Country Status (28)

Country Link
US (3) US10961262B2 (fr)
EP (2) EP3464306B1 (fr)
JP (1) JP6987081B2 (fr)
KR (1) KR102504759B1 (fr)
CN (1) CN109311920B (fr)
AU (1) AU2017271524B2 (fr)
BR (1) BR112018074270B1 (fr)
CA (1) CA3024182A1 (fr)
CO (1) CO2018013827A2 (fr)
DK (1) DK3464306T3 (fr)
ES (1) ES2987586T3 (fr)
FI (1) FI3464306T3 (fr)
HR (1) HRP20240583T1 (fr)
HU (1) HUE066393T2 (fr)
IL (1) IL263033B2 (fr)
LT (1) LT3464306T (fr)
MA (2) MA71469A (fr)
MD (1) MD3464306T2 (fr)
MX (1) MX383656B (fr)
PL (1) PL3464306T3 (fr)
PT (1) PT3464306T (fr)
RS (1) RS65504B1 (fr)
SA (1) SA518400462B1 (fr)
SG (1) SG11201809499UA (fr)
SI (1) SI3464306T1 (fr)
SM (1) SMT202400183T1 (fr)
TW (1) TWI737736B (fr)
WO (1) WO2017205513A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
CN109563114B (zh) 2016-05-24 2022-08-12 萨勒普塔医疗公司 用于制备寡聚物的方法
SG11201809497RA (en) 2016-05-24 2018-12-28 Sarepta Therapeutics Inc Processes for preparing phosphorodiamidate morpholino oligomers
MX383656B (es) 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
SG10202101834QA (en) * 2016-05-24 2021-04-29 Sarepta Therapeutics Inc Processes for preparing phosphorodiamidate morpholino oligomers
JP7022079B2 (ja) * 2016-06-30 2022-02-17 サレプタ セラピューティクス， インコーポレイテッド ホスホロジアミダートモルホリノオリゴマーを調製するためのプロセス
KR102523527B1 (ko) * 2016-06-30 2023-04-20 사렙타 쎄러퓨틱스 인코퍼레이티드 포스포로디아미데이트 모르폴리노 올리고머의 제조 방법
TWI812647B (zh) * 2017-09-25 2023-08-21 美商薩羅塔治療公司 經由速流合成以製備磷醯二胺嗎啉代寡聚物之製程
WO2020028832A1 (fr) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Complexes de ciblage musculaire et leurs utilisations pour le traitement de dystrophinopathies
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN109704980B (zh) * 2019-02-16 2022-05-13 安徽大学 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法
WO2021187392A1 (fr) * 2020-03-16 2021-09-23 国立大学法人東京医科歯科大学 Acide hétéro-nucléique contenant un acide nucléique morpholino
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
JP2024525608A (ja) 2021-07-09 2024-07-12 ダイン セラピューティクス，インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体および製剤
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN118201640A (zh) * 2021-11-01 2024-06-14 达因疗法公司 用于治疗肌养蛋白病的肌肉靶向复合物

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521063A (en) 1985-03-15 1996-05-28 Antivirals Inc. Polynucleotide reagent containing chiral subunits and methods of use
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
AU5661386A (en) 1985-03-15 1986-10-13 Stirchak, E. Stereoregular polynucleotide-binding polymers
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
CA1339987C (fr) 1988-09-01 1998-08-04 Robert Bruce Merrifield Methode pour la synthese de peptides; support solide utile a cette fin
HUT76280A (en) 1993-12-29 1997-07-28 Fujisawa Pharmaceutical Co Pyrazolopyridine derivatives, pharmaceutical compositions containing them, process for proiducing them and their use
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
AU776362B2 (en) 1999-05-04 2004-09-09 Roche Innovation Center Copenhagen A/S L-ribo-LNA analogues
US6784291B2 (en) 2000-05-04 2004-08-31 Avi Biopharma, Inc. Splice-region antisense composition and method
CA2459347C (fr) 2001-09-04 2012-10-09 Exiqon A/S Compositions d'acides nucleiques bloques et leurs utilisations
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
WO2004044140A2 (fr) 2002-11-05 2004-05-27 Isis Pharmaceticals, Inc. Composes oligomeres 2'-substitues et compositions destinees a etre utilisees dans des modulations genetiques
US7759513B2 (en) 2003-02-21 2010-07-20 Nigu Chemie Gmbh Photolabile protective groups for improved processes to prepare oligonucleotide arrays
SI2206781T1 (sl) 2004-06-28 2016-05-31 The University Of Western Australia Protismiselni oligonukleotidi za induciranje preskakovanja eksona in postopki njihove uporabe
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US9371348B2 (en) 2006-11-27 2016-06-21 The Trustees Of The University Of Pennsylvania Photocleavable oligonucleotide and uses thereof
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
US8076476B2 (en) 2007-11-15 2011-12-13 Avi Biopharma, Inc. Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
CA2884340C (fr) * 2007-11-15 2017-07-25 Sarepta Therapeutics, Inc. Procede de synthese d'oligomeres morpholino
CN102625840A (zh) 2009-04-10 2012-08-01 肌肉学研究协会 用于治疗疾病的三环dna反义寡核苷酸、组合物和方法
SMT201800579T1 (it) 2009-11-12 2019-01-11 Univ Western Australia Molecole antisenso e metodi per trattare patologie
JP2013530154A (ja) * 2010-05-28 2013-07-25 サレプタ セラピューティクス， インコーポレイテッド 修飾されたサブユニット間結合および／または末端基を有するオリゴヌクレオチドアナログ
TWI463423B (zh) 2010-05-28 2014-12-01 Poynt Corp 用以針對基於三維形狀之廣告系統使用位置資訊的方法
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
PL2623507T3 (pl) * 2010-09-30 2017-03-31 Nippon Shinyaku Co., Ltd. Pochodna kwasu morfolinonukleinowego
EP2672977A1 (fr) * 2011-02-08 2013-12-18 The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System Oligonucléotides antisens
CN103889999B (zh) 2011-08-23 2021-06-01 皇家学习促进学会/麦吉尔大学 用于合成寡核糖核苷酸的离子标记
ES2535654T3 (es) 2011-10-13 2015-05-13 Association Institut De Myologie ADN triciclo-fosforotioato
BR112014011875B1 (pt) 2011-11-18 2022-01-04 Sarepta Therapeutics, Inc Oligonucleotídeos funcionalmente modificados e subunidades dos mesmos
AU2012345638C1 (en) * 2011-11-30 2018-10-18 Sarepta Therapeutics, Inc. Induced exon inclusion in spinal muscle atrophy
CN108611349A (zh) * 2011-12-28 2018-10-02 日本新药株式会社 反义核酸
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
CN102702265A (zh) * 2012-05-14 2012-10-03 天津特安化学科技有限公司 一种固相合成磷酰二胺吗啉代寡核苷酸及方法
AU2014236140B2 (en) * 2013-03-14 2019-10-03 Sarepta Therapeutics, Inc. Exon skipping compositions for treating muscular dystrophy
KR20230074606A (ko) * 2013-03-14 2023-05-30 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이영양증의 치료를 위한 엑손 스키핑 조성물
US8999152B2 (en) * 2013-03-15 2015-04-07 Uop Llc Process and apparatus for recovering and blending hydroprocessed hydrocarbons and composition
NZ732507A (en) 2013-03-15 2018-08-31 Sarepta Therapeutics Inc Improved compositions for treating muscular dystrophy
CN105228999B (zh) * 2013-05-24 2021-03-02 味之素株式会社 吗啉代寡核苷酸的制备方法
CN109563114B (zh) 2016-05-24 2022-08-12 萨勒普塔医疗公司 用于制备寡聚物的方法
SG11201809497RA (en) 2016-05-24 2018-12-28 Sarepta Therapeutics Inc Processes for preparing phosphorodiamidate morpholino oligomers
SG10202101834QA (en) * 2016-05-24 2021-04-29 Sarepta Therapeutics Inc Processes for preparing phosphorodiamidate morpholino oligomers
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
MX383656B (es) 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
KR102810425B1 (ko) 2016-12-19 2025-05-21 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체

Also Published As

Publication number Publication date
MA45155B1 (fr) 2024-06-28
SA518400462B1 (ar) 2022-06-12
HRP20240583T1 (hr) 2024-07-19
EP3464306A1 (fr) 2019-04-10
SI3464306T1 (sl) 2024-08-30
US20220340605A1 (en) 2022-10-27
US12258362B2 (en) 2025-03-25
PL3464306T3 (pl) 2024-07-22
FI3464306T3 (fi) 2024-05-16
SMT202400183T1 (it) 2024-07-09
JP6987081B2 (ja) 2021-12-22
MA45155A (fr) 2019-04-10
MX383656B (es) 2025-03-14
CN109311920B (zh) 2021-11-09
EP3464306B1 (fr) 2024-03-27
CN109311920A (zh) 2019-02-05
ES2987586T3 (es) 2024-11-15
KR20190013844A (ko) 2019-02-11
WO2017205513A1 (fr) 2017-11-30
JP2019523754A (ja) 2019-08-29
IL263033B2 (en) 2023-02-01
TWI737736B (zh) 2021-09-01
EP4406600A3 (fr) 2024-10-30
BR112018074270B1 (pt) 2021-02-02
EP4406600A2 (fr) 2024-07-31
CA3024182A1 (fr) 2017-11-30
TW201825506A (zh) 2018-07-16
SG11201809499UA (en) 2018-12-28
AU2017271524B2 (en) 2021-06-24
IL263033B (en) 2022-10-01
KR102504759B1 (ko) 2023-02-28
CO2018013827A2 (es) 2018-12-28
DK3464306T3 (da) 2024-05-21
HUE066393T2 (hu) 2024-07-28
US20250276988A1 (en) 2025-09-04
IL263033A (en) 2018-12-31
US10961262B2 (en) 2021-03-30
RS65504B1 (sr) 2024-06-28
BR112018074270A2 (pt) 2019-03-12
MX2018014162A (es) 2019-04-01
LT3464306T (lt) 2024-05-10
US20190276480A1 (en) 2019-09-12
PT3464306T (pt) 2024-05-17
MD3464306T2 (ro) 2024-08-31
AU2017271524A1 (en) 2018-11-15

Similar Documents

Publication Publication Date Title
MA71469A (fr) Procédé de préparation d'oligomères morpholino de phosphorodiamidate
MA45183A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
EP3448918A4 (fr) Procédé de préparation de résines d'organopolysiloxane
MA49775A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
EP3398960A4 (fr) Procédé de préparation du sermaglutide
EP3683205A4 (fr) Procédé de préparation d'isocyanate aliphatique
EP3342801A4 (fr) Procédé de préparation d'une résine superabsorbante, et résine superabsorbante
EP3421503A4 (fr) Procédé de préparation et de purification de sugammadex
EP3383436A4 (fr) Procédé amélioré de préparation de vert d'indocyanine
MA50169A (fr) Procédé de production d'un électrocatalyseur
EP3766869A4 (fr) Procédé simple de préparation d'avibactam
EP3341359A4 (fr) Procédé de préparation d'aprémilast
EP3376870A4 (fr) Procédé de préparation d'inhibiteurs de kinase et de leurs intermédiaires
MA45362A (fr) Procédés de préparation d'oligomères morpholino de phosphorodiamidate
EP3356033A4 (fr) Procédé d'hydrogénation catalytique d'halonitroaromatiques
EP3402837A4 (fr) Procédé de préparation de nanocomposite de polyéthylène
MA42423A (fr) Procédé de préparation d'un revêtement
EP3500551A4 (fr) Procédé de préparation de biphényles substitués
EP3696168A4 (fr) Procédé de préparation de 2-chloro-5-trifluorométhylpyridine
EP3539941A4 (fr) Procédé de préparation triméthylolpropane
EP3511313A4 (fr) Procédé de préparation de 1,3-cyclohexanediméthanol
EP3768487C0 (fr) Procédé de micromoulages d'articles
EP3444253A4 (fr) Procédé de préparation de ad-35
EP3505525A4 (fr) Procédé de préparation de rubusoside
EP3455210A4 (fr) Procédé de préparation de boscalide