MA71469A - Procédé de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents

Procédé de préparation d'oligomères morpholino de phosphorodiamidate

Info

Publication number
MA71469A
MA71469A MA71469A MA71469A MA71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A MA 71469 A MA71469 A MA 71469A
Authority
MA
Morocco
Prior art keywords
phosphorodiamidate
preparation
morpholino oligomers
morpholino
oligomers
Prior art date
Application number
MA71469A
Other languages
English (en)
Inventor
Bao Cai
Mitchell MARTINI
Ross SHIMABUKU
Katie THOMAS
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of MA71469A publication Critical patent/MA71469A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/062—Organo-phosphoranes without P-C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA71469A 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate MA71469A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662340953P 2016-05-24 2016-05-24
US201662357134P 2016-06-30 2016-06-30
EP24161437.9A EP4406600A3 (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate

Publications (1)

Publication Number Publication Date
MA71469A true MA71469A (fr) 2025-04-30

Family

ID=59078166

Family Applications (2)

Application Number Title Priority Date Filing Date
MA71469A MA71469A (fr) 2016-05-24 2017-05-24 Procédé de préparation d'oligomères morpholino de phosphorodiamidate
MA45155A MA45155B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA45155A MA45155B1 (fr) 2016-05-24 2017-05-24 Procédés de préparation d'oligomères morpholino de phosphorodiamidate

Country Status (28)

Country Link
US (3) US10961262B2 (fr)
EP (2) EP4406600A3 (fr)
JP (1) JP6987081B2 (fr)
KR (1) KR102504759B1 (fr)
CN (1) CN109311920B (fr)
AU (1) AU2017271524B2 (fr)
BR (1) BR112018074270B1 (fr)
CA (1) CA3024182A1 (fr)
CO (1) CO2018013827A2 (fr)
DK (1) DK3464306T3 (fr)
ES (1) ES2987586T3 (fr)
FI (1) FI3464306T3 (fr)
HR (1) HRP20240583T1 (fr)
HU (1) HUE066393T2 (fr)
IL (1) IL263033B2 (fr)
LT (1) LT3464306T (fr)
MA (2) MA71469A (fr)
MD (1) MD3464306T2 (fr)
MX (1) MX383656B (fr)
PL (1) PL3464306T3 (fr)
PT (1) PT3464306T (fr)
RS (1) RS65504B1 (fr)
SA (1) SA518400462B1 (fr)
SG (1) SG11201809499UA (fr)
SI (1) SI3464306T1 (fr)
SM (1) SMT202400183T1 (fr)
TW (1) TWI737736B (fr)
WO (1) WO2017205513A1 (fr)

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TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
MX384727B (es) * 2016-05-24 2025-03-14 Sarepta Therapeutics Inc Procesos para preparar oligómeros
MX390906B (es) 2016-05-24 2025-03-21 Sarepta Therapeutics Inc Procesos para preparar oligómeros de morfolino fosforodiamidato.
US10947533B2 (en) * 2016-05-24 2021-03-16 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
TWI737736B (zh) 2016-05-24 2021-09-01 美商薩羅塔治療公司 製備磷醯二胺嗎啉代寡聚物之方法
CN109152775B (zh) * 2016-06-30 2022-04-26 萨勒普塔医疗公司 制备磷酸二酰胺吗啉代寡聚物的方法
CA3024153A1 (fr) * 2016-06-30 2017-11-30 Sarepta Therapeutics, Inc. Procedes de preparation d'oligomeres morpholino de phosphorodiamidate
TWI812647B (zh) 2017-09-25 2023-08-21 美商薩羅塔治療公司 經由速流合成以製備磷醯二胺嗎啉代寡聚物之製程
WO2020028832A1 (fr) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Complexes de ciblage musculaire et leurs utilisations pour le traitement de dystrophinopathies
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN109704980B (zh) * 2019-02-16 2022-05-13 安徽大学 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法
EP4123023A4 (fr) * 2020-03-16 2024-07-17 National University Corporation Tokyo Medical and Dental University Acide hétéro-nucléique contenant un acide nucléique morpholino
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
WO2023283623A1 (fr) 2021-07-09 2023-01-12 Dyne Therapeutics, Inc. Complexes ciblant le muscle et formulations de traitement de dystrophinopathies
EP4426356A1 (fr) * 2021-11-01 2024-09-11 Dyne Therapeutics, Inc. Complexes de ciblage musculaire pour traiter des dystrophinopathies

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Also Published As

Publication number Publication date
MA45155A (fr) 2019-04-10
WO2017205513A1 (fr) 2017-11-30
AU2017271524B2 (en) 2021-06-24
LT3464306T (lt) 2024-05-10
HUE066393T2 (hu) 2024-07-28
US20250276988A1 (en) 2025-09-04
TW201825506A (zh) 2018-07-16
JP2019523754A (ja) 2019-08-29
PT3464306T (pt) 2024-05-17
FI3464306T3 (fi) 2024-05-16
MD3464306T2 (ro) 2024-08-31
IL263033B2 (en) 2023-02-01
EP3464306B1 (fr) 2024-03-27
EP4406600A3 (fr) 2024-10-30
US20190276480A1 (en) 2019-09-12
BR112018074270B1 (pt) 2021-02-02
DK3464306T3 (da) 2024-05-21
MX2018014162A (es) 2019-04-01
SG11201809499UA (en) 2018-12-28
EP3464306A1 (fr) 2019-04-10
CN109311920B (zh) 2021-11-09
AU2017271524A1 (en) 2018-11-15
JP6987081B2 (ja) 2021-12-22
US10961262B2 (en) 2021-03-30
SMT202400183T1 (it) 2024-07-09
CA3024182A1 (fr) 2017-11-30
RS65504B1 (sr) 2024-06-28
US12258362B2 (en) 2025-03-25
EP4406600A2 (fr) 2024-07-31
SI3464306T1 (sl) 2024-08-30
ES2987586T3 (es) 2024-11-15
CO2018013827A2 (es) 2018-12-28
KR20190013844A (ko) 2019-02-11
HRP20240583T1 (hr) 2024-07-19
IL263033B (en) 2022-10-01
SA518400462B1 (ar) 2022-06-12
MX383656B (es) 2025-03-14
CN109311920A (zh) 2019-02-05
KR102504759B1 (ko) 2023-02-28
IL263033A (en) 2018-12-31
US20220340605A1 (en) 2022-10-27
MA45155B1 (fr) 2024-06-28
PL3464306T3 (pl) 2024-07-22
BR112018074270A2 (pt) 2019-03-12
TWI737736B (zh) 2021-09-01

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