MA50636A - Compositions et procédés pour inhiber l'activité d'arginase - Google Patents

Compositions et procédés pour inhiber l'activité d'arginase

Info

Publication number
MA50636A
MA50636A MA050636A MA50636A MA50636A MA 50636 A MA50636 A MA 50636A MA 050636 A MA050636 A MA 050636A MA 50636 A MA50636 A MA 50636A MA 50636 A MA50636 A MA 50636A
Authority
MA
Morocco
Prior art keywords
arginase
inhibiting
compositions
activity
methods
Prior art date
Application number
MA050636A
Other languages
English (en)
Inventor
Jim Li
Eric B Sjogren
Zandt Michael Van
Darren Whitehouse
Original Assignee
Calithera Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calithera Biosciences Inc filed Critical Calithera Biosciences Inc
Publication of MA50636A publication Critical patent/MA50636A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
MA050636A 2015-10-30 2016-10-28 Compositions et procédés pour inhiber l'activité d'arginase MA50636A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562248632P 2015-10-30 2015-10-30
US201662281964P 2016-01-22 2016-01-22
US201662323034P 2016-04-15 2016-04-15

Publications (1)

Publication Number Publication Date
MA50636A true MA50636A (fr) 2021-04-14

Family

ID=58631120

Family Applications (2)

Application Number Title Priority Date Filing Date
MA43131A MA43131B1 (fr) 2015-10-30 2016-10-28 Compositions et procédés d'inhibition de l'activité de l'arginase
MA050636A MA50636A (fr) 2015-10-30 2016-10-28 Compositions et procédés pour inhiber l'activité d'arginase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA43131A MA43131B1 (fr) 2015-10-30 2016-10-28 Compositions et procédés d'inhibition de l'activité de l'arginase

Country Status (36)

Country Link
US (4) US10065974B2 (fr)
EP (3) EP3693375B1 (fr)
JP (3) JP6833844B2 (fr)
KR (2) KR20220118559A (fr)
CN (4) CN113150015A (fr)
AU (3) AU2016343656B2 (fr)
BR (3) BR112018008746B1 (fr)
CA (1) CA3003271A1 (fr)
CL (4) CL2018001134A1 (fr)
CO (1) CO2018004750A2 (fr)
CR (3) CR20210390A (fr)
CY (1) CY1123557T1 (fr)
DK (2) DK3368541T3 (fr)
EA (1) EA038276B1 (fr)
EC (1) ECSP18040250A (fr)
ES (3) ES2808988T3 (fr)
HR (1) HRP20201046T1 (fr)
HU (1) HUE054972T2 (fr)
IL (3) IL258731B (fr)
LT (1) LT3368541T (fr)
MA (2) MA43131B1 (fr)
MD (1) MD3368541T2 (fr)
MX (1) MX2018005294A (fr)
MY (1) MY201783A (fr)
NZ (1) NZ742742A (fr)
PH (2) PH12018500899B1 (fr)
PL (1) PL3368541T3 (fr)
PT (1) PT3368541T (fr)
RS (1) RS60695B1 (fr)
SG (4) SG11201802961PA (fr)
SI (1) SI3368541T1 (fr)
SM (1) SMT202000469T1 (fr)
TW (3) TWI775556B (fr)
UA (1) UA125289C2 (fr)
WO (1) WO2017075363A1 (fr)
ZA (4) ZA201803556B (fr)

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PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
AU2017356942A1 (en) 2016-11-08 2019-05-23 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
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CN110615753A (zh) * 2019-09-02 2019-12-27 南京新酶合医药科技有限公司 一种(3r,4s)-1-取代-4-乙基吡咯-3-羧酸的合成方法
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US20230140132A1 (en) * 2020-01-07 2023-05-04 Merck Sharp & Dohme Llc Arginase inhibitors and methods of use
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
WO2021257857A1 (fr) 2020-06-19 2021-12-23 Incyte Corporation Composés naphtyridinone en tant qu'inhibiteurs de jak2 v617f
KR20230057341A (ko) 2020-07-02 2023-04-28 인사이트 코포레이션 Jak2 v617f 억제제로서 삼환계 우레아 화합물
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
TW202216662A (zh) * 2020-07-17 2022-05-01 美商英塞特公司 製備精胺酸酶抑制劑及其合成中間物之方法
WO2022046989A1 (fr) 2020-08-27 2022-03-03 Incyte Corporation Composés d'urée tricycliques en tant qu'inhibiteurs de v617f de jak2
WO2022140231A1 (fr) 2020-12-21 2022-06-30 Incyte Corporation Composés de déazaguanine utilisés en tant qu'inhibiteurs de v617f de jak2
TW202228720A (zh) * 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
PE20251706A1 (es) 2022-03-17 2025-07-02 Incyte Corp Compuestos de urea triciclica como inhibidores de v617f de jak2
US20240190876A1 (en) 2022-10-21 2024-06-13 Incyte Corporation Tricyclic Urea Compounds As JAK2 V617F Inhibitors
CN121079299A (zh) 2023-03-13 2025-12-05 因赛特公司 作为激酶抑制剂的双环脲

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PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne

Also Published As

Publication number Publication date
RS60695B1 (sr) 2020-09-30
IL288225A (en) 2022-01-01
CL2018001134A1 (es) 2018-10-26
JP7032583B2 (ja) 2022-03-08
PH12018500899B1 (en) 2023-02-08
ECSP18040250A (es) 2018-10-31
IL281503A (en) 2021-04-29
SG10201911406TA (en) 2020-01-30
KR20180084063A (ko) 2018-07-24
CR20180282A (es) 2018-11-30
KR20220118559A (ko) 2022-08-25
EP3693375A1 (fr) 2020-08-12
HUE054972T2 (hu) 2021-10-28
CA3003271A1 (fr) 2017-05-04
ES2808988T3 (es) 2021-03-02
EP3693375B1 (fr) 2022-02-16
EP3368541B1 (fr) 2020-05-27
TW202146028A (zh) 2021-12-16
ZA201803556B (en) 2021-02-24
EP4011887B1 (fr) 2024-07-31
SG10201911402YA (en) 2020-02-27
BR122020022280B1 (pt) 2022-05-03
SI3368541T1 (sl) 2020-10-30
CN108271371B (zh) 2021-02-09
AU2016343656B2 (en) 2020-09-17
ES2991555T3 (es) 2024-12-04
AU2022203703A1 (en) 2022-06-16
AU2016343656A1 (en) 2018-06-07
ES2910928T3 (es) 2022-05-17
CN113150016A (zh) 2021-07-23
JP2022071010A (ja) 2022-05-13
BR122020022275B1 (pt) 2022-05-03
MD3368541T2 (ro) 2020-09-30
CO2018004750A2 (es) 2018-10-31
CR20210389A (es) 2021-09-16
ZA201907092B (en) 2021-04-28
PH12022551082A1 (en) 2023-03-13
NZ742742A (en) 2023-04-28
SG10202003966RA (en) 2020-06-29
BR112018008746A8 (pt) 2019-02-26
CY1123557T1 (el) 2022-03-24
AU2020286278A1 (en) 2021-01-14
TWI734630B (zh) 2021-07-21
BR112018008746B1 (pt) 2021-11-16
IL281503B (en) 2022-01-01
DK4011887T3 (da) 2024-10-28
SG11201802961PA (en) 2018-05-30
ZA201907091B (en) 2021-05-26
CN113201002A (zh) 2021-08-03
EP3368541A4 (fr) 2019-07-17
HRP20201046T1 (hr) 2020-10-16
EA038276B1 (ru) 2021-08-04
CR20210390A (es) 2021-10-19
ZA201907093B (en) 2021-03-31
PL3368541T3 (pl) 2020-11-02
EP4011887A1 (fr) 2022-06-15
UA125289C2 (uk) 2022-02-16
MA43131B1 (fr) 2020-07-29
TWI775556B (zh) 2022-08-21
MY201783A (en) 2024-03-18
BR112018008746A2 (pt) 2018-10-30
PT3368541T (pt) 2020-07-06
MX2018005294A (es) 2018-09-21
SMT202000469T1 (it) 2020-11-10
US20200223872A1 (en) 2020-07-16
CL2019000819A1 (es) 2019-08-09
US10065974B2 (en) 2018-09-04
US20180346489A1 (en) 2018-12-06
US10844080B2 (en) 2020-11-24
CN108271371A (zh) 2018-07-10
US10851118B2 (en) 2020-12-01
KR102434308B1 (ko) 2022-08-19
DK3368541T3 (da) 2020-06-29
JP6833844B2 (ja) 2021-02-24
AU2020286278B2 (en) 2022-03-17
CL2019000820A1 (es) 2019-08-09
JP2018533582A (ja) 2018-11-15
US20210061822A1 (en) 2021-03-04
IL258731B (en) 2021-04-29
WO2017075363A1 (fr) 2017-05-04
IL258731A (en) 2018-06-28
TW201726692A (zh) 2017-08-01
TWI710565B (zh) 2020-11-21
US20170121352A1 (en) 2017-05-04
EP3368541A1 (fr) 2018-09-05
CN113150015A (zh) 2021-07-23
PH12018500899A1 (en) 2018-10-29
HK1252560A1 (en) 2019-05-31
CL2019000821A1 (es) 2019-08-09
EA201891057A1 (ru) 2018-12-28
JP2021075543A (ja) 2021-05-20
LT3368541T (lt) 2020-09-25
TW202110858A (zh) 2021-03-16

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