MA45747A - Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines - Google Patents
Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humainesInfo
- Publication number
- MA45747A MA45747A MA045747A MA45747A MA45747A MA 45747 A MA45747 A MA 45747A MA 045747 A MA045747 A MA 045747A MA 45747 A MA45747 A MA 45747A MA 45747 A MA45747 A MA 45747A
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- generation
- souh
- human pluripotent
- functional beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/80—Neurotransmitters; Neurohormones
- C12N2501/845—Gamma amino butyric acid [GABA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne la génération de cellules bêta fonctionnelles à partir de progéniteurs endocriniens dérivés de cellules souches pluripotentes humaines. La présente invention concerne également des cellules bêta fonctionnelles produites par lesdits procédés et utilisations de ces cellules bêta.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157181 | 2016-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45747A true MA45747A (fr) | 2019-01-02 |
Family
ID=55588039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045747A MA45747A (fr) | 2016-02-24 | 2017-02-24 | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11274280B2 (fr) |
| EP (1) | EP3420073B1 (fr) |
| JP (1) | JP7123802B2 (fr) |
| CN (1) | CN108699515A (fr) |
| ES (1) | ES2967942T3 (fr) |
| MA (1) | MA45747A (fr) |
| WO (1) | WO2017144695A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI2794857T3 (fi) | 2011-12-22 | 2026-03-25 | Janssen Biotech Inc | Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| WO2015175307A1 (fr) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Utilisation de petites molécules pour améliorer l'expression du gène mafa dans des cellules endocrines pancréatiques |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| MD4194548T2 (ro) * | 2016-06-21 | 2026-02-28 | Janssen Biotech Inc | Generarea de celule beta funcționale derivate din celule stem pluripotente umane care posedă respirație mitocondrială dependentă - de glucoză și răspuns la secreția de insulină în două faze |
| KR102738995B1 (ko) | 2017-09-11 | 2024-12-06 | 노보 노르디스크 에이/에스 | 시험관 내 줄기 세포로부터 유래된 nkx6.1 및 c-펩티드 공발현 세포의 농축 |
| EP3710021A4 (fr) | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | Compositions pour la fabrication de cellules d'ilôts et procédés d'utilisation |
| EP3758719A4 (fr) * | 2018-03-02 | 2021-12-08 | Vertex Pharmaceuticals Inc. | Procédés d'amélioration de la différenciation de cellules souches en cellules bêta |
| WO2020033879A1 (fr) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Différenciation d'ilot dérivé de cellules souches |
| WO2020043292A1 (fr) * | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocriniens dérivés de cellules souches pluripotentes humaines |
| US20220177849A1 (en) | 2019-04-08 | 2022-06-09 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
| TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| CN114729323B (zh) | 2019-11-22 | 2024-09-17 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
| WO2021174201A1 (fr) * | 2020-02-28 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Milieu de culture tissulaire pour la survie et la prise de greffe d'îlots pancréatiques humains |
| WO2021175768A1 (fr) | 2020-03-02 | 2021-09-10 | Novo Nordisk A/S | Utilisation de marqueurs pluripotents pour détecter des cellules souches pluripotentes indifférenciées résiduelles contaminantes |
| US20230313145A1 (en) | 2020-08-28 | 2023-10-05 | Novo Nordisk A/S | Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof |
| WO2022129472A1 (fr) | 2020-12-18 | 2022-06-23 | Novo Nordisk A/S | Cellules immuno-furtives sûres |
| WO2022136215A1 (fr) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Cellules immuno-furtives sûres |
| CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
| EP4423254A4 (fr) * | 2021-10-28 | 2026-01-14 | Memorial Sloan Kettering Cancer Center | Compositions et procédés pour favoriser la maturation de cellules in vitro |
| WO2023118050A1 (fr) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Utilisation de nouveaux marqueurs pour détecter des cellules souches pluripotentes |
| WO2024151541A1 (fr) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Souris auto-immune présentant un diabète de type 1 |
| EP4716541A2 (fr) | 2023-05-22 | 2026-04-01 | Sana Biotechnology, Inc. | Procédés d'administration de cellules des îlots pancréatiques et procédés associés |
| WO2025093467A1 (fr) | 2023-10-31 | 2025-05-08 | Novo Nordisk A/S | Procédés pour empêcher l'apparition de cellules indésirables pendant la différenciation de cellules souches pluripotentes humaines |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| EP2723852B1 (fr) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Induction efficace d'endoderme définitif à partir de cellules hes |
| HRP20191677T1 (hr) | 2012-04-30 | 2019-12-13 | Univ Health Network | POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC |
| CN104903440B (zh) * | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| ES2666465T3 (es) * | 2012-09-27 | 2018-05-04 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos para producir una población de células beta pancreáticas |
| DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
| US20150368616A1 (en) * | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| CN105531365A (zh) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | 分离的幼稚多能干细胞和产生所述细胞的方法 |
| US9540613B2 (en) | 2013-04-29 | 2017-01-10 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| CN105683361B (zh) * | 2013-08-30 | 2021-04-02 | 诺和诺德股份有限公司 | 使用小分子从人多能干细胞产生内分泌祖细胞 |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| WO2015175307A1 (fr) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Utilisation de petites molécules pour améliorer l'expression du gène mafa dans des cellules endocrines pancréatiques |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| WO2020043292A1 (fr) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocriniens dérivés de cellules souches pluripotentes humaines |
-
2017
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/fr active Active
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/fr not_active Ceased
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3420073C0 (fr) | 2023-11-08 |
| EP3420073A1 (fr) | 2019-01-02 |
| JP7123802B2 (ja) | 2022-08-23 |
| JP2019510482A (ja) | 2019-04-18 |
| CN108699515A (zh) | 2018-10-23 |
| WO2017144695A9 (fr) | 2017-10-19 |
| ES2967942T3 (es) | 2024-05-06 |
| US20190085295A1 (en) | 2019-03-21 |
| US11274280B2 (en) | 2022-03-15 |
| EP3420073B1 (fr) | 2023-11-08 |
| WO2017144695A1 (fr) | 2017-08-31 |
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