MA54653B1 - Modulateurs du récepteur de cxcr7 pipéridine - Google Patents
Modulateurs du récepteur de cxcr7 pipéridineInfo
- Publication number
- MA54653B1 MA54653B1 MA54653A MA54653A MA54653B1 MA 54653 B1 MA54653 B1 MA 54653B1 MA 54653 A MA54653 A MA 54653A MA 54653 A MA54653 A MA 54653A MA 54653 B1 MA54653 B1 MA 54653B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- cxcr7
- receptor
- piperidine
- img
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention concerne des dérivés de pipéridine de formule (i) <img file="imga0001.Tif" frnum="0001" he="51" id="ia01" img-content="chem" img-format="tif" inline="no" orientation="portrait" pgnum="0001" wi="56"/> dans laquelle ar1, ar2, rar1, r1, r2 et r3 sont tels que décrits dans la description, leur préparation, leurs sels pharmaceutiquement acceptables, et leur utilisation comme produits pharmaceutiques, les compositions pharmaceutiques contenant un ou plusieurs composés de formule (i), et notamment leur utilisation comme modulateurs du récepteur cxcr7.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2016068052 | 2016-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA54653A MA54653A (fr) | 2021-12-29 |
| MA54653B1 true MA54653B1 (fr) | 2023-04-28 |
Family
ID=59656027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA45782A MA45782B1 (fr) | 2016-07-28 | 2017-07-27 | Modulateurs du récepteur de cxcr7 pipéridine |
| MA54653A MA54653B1 (fr) | 2016-07-28 | 2017-07-27 | Modulateurs du récepteur de cxcr7 pipéridine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA45782A MA45782B1 (fr) | 2016-07-28 | 2017-07-27 | Modulateurs du récepteur de cxcr7 pipéridine |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10752620B2 (fr) |
| EP (2) | EP3490986B1 (fr) |
| JP (2) | JP6655754B2 (fr) |
| KR (2) | KR102497091B1 (fr) |
| CN (2) | CN110563717B (fr) |
| AR (2) | AR109180A1 (fr) |
| AU (2) | AU2017302079B2 (fr) |
| CA (1) | CA3032017C (fr) |
| CL (2) | CL2019000169A1 (fr) |
| CY (1) | CY1125016T1 (fr) |
| DK (2) | DK3490986T3 (fr) |
| EA (2) | EA202091262A1 (fr) |
| ES (2) | ES2954152T3 (fr) |
| FI (1) | FI3798217T3 (fr) |
| HR (2) | HRP20230313T1 (fr) |
| HU (2) | HUE062019T2 (fr) |
| IL (2) | IL264424B (fr) |
| LT (2) | LT3798217T (fr) |
| MA (2) | MA45782B1 (fr) |
| MX (2) | MX383804B (fr) |
| MY (2) | MY199657A (fr) |
| NZ (1) | NZ751006A (fr) |
| PH (2) | PH12021552605A1 (fr) |
| PL (2) | PL3798217T3 (fr) |
| PT (2) | PT3798217T (fr) |
| RS (2) | RS64130B1 (fr) |
| SG (2) | SG10201906942PA (fr) |
| SI (2) | SI3490986T1 (fr) |
| TW (3) | TWI683812B (fr) |
| UA (2) | UA129887C2 (fr) |
| WO (1) | WO2018019929A1 (fr) |
| ZA (1) | ZA201901256B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE066704T2 (hu) * | 2018-01-26 | 2024-08-28 | Idorsia Pharmaceuticals Ltd | CXCR7 receptor antagonista (3S,4S)-1-ciklopropilmetil-4-{[5-(2,4-difluor-fenil)-izoxazol-3-karbonil]-amino} -piperidin-3-karbonsav-(1-pirimidin-2-il-ciklopropil)-amid kristályos formái |
| TW202131921A (zh) * | 2019-10-31 | 2021-09-01 | 瑞士商愛杜西亞製藥有限公司 | Cxcr7拮抗劑與s1p1受體調節劑之組合 |
| EP4267579A1 (fr) * | 2020-12-22 | 2023-11-01 | Luxembourg Institute of Health (LIH) | Analogues de la conolidine servant de modulateurs sélectifs d'ackr3 pour traiter le cancer |
| US12448373B2 (en) * | 2021-04-19 | 2025-10-21 | Amgen Inc. | Azetidinyl-acetamides as CXCR7 inhibitors |
| IL310395A (en) | 2021-08-02 | 2024-03-01 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
| MX2023013961A (es) | 2021-10-01 | 2023-12-11 | Nextgen Bioscience Co Ltd | Nuevos derivados de la piperidina y composiciones farmaceuticas que los contienen, para inhibir la autotaxina. |
| US20250011314A1 (en) | 2021-12-17 | 2025-01-09 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
| EP4238970A1 (fr) | 2022-03-03 | 2023-09-06 | InterAx Biotech AG | Modulateurs de ackr3 et leurs utilisations |
| CN115403510B (zh) * | 2022-08-11 | 2023-04-25 | 南方医科大学 | 一种pd-l1/cxcl12双靶点抑制剂、制备方法和用途 |
| TW202434579A (zh) | 2022-11-16 | 2024-09-01 | 瑞士商先正達農作物保護股份公司 | 殺微生物的四氫異喹啉衍生物 |
| WO2024115512A1 (fr) | 2022-11-30 | 2024-06-06 | Syngenta Crop Protection Ag | Dérivés de tétrahydroisoquinoline microbiocides |
| TW202439972A (zh) | 2022-11-30 | 2024-10-16 | 瑞士商先正達農作物保護股份公司 | 殺真菌組成物 |
| PY2403614A (es) | 2023-01-27 | 2025-09-11 | Syngenta Crop Protection Ag | Derivados de pirazol microbiocidas |
| PY2404467A (es) | 2023-02-01 | 2025-03-31 | Syngenta Crop Protection Ag | Composiciones fungicidas |
| PY2447478A (es) | 2023-06-14 | 2025-03-18 | Syngenta Crop Protection Ag | Composiciones fungicidas |
| PY24116080A (es) | 2024-01-03 | 2025-08-04 | Pi Industries Ltd | Amidas heterociclicas biciclicas para combatir hongos fitopatógenos |
| PY24116120A (es) | 2024-01-03 | 2025-07-30 | Pi Industries Ltd | Compuestos de pirazol para combatir hongos fitopatógenos |
| WO2025163143A1 (fr) | 2024-02-02 | 2025-08-07 | Syngenta Crop Protection Ag | Dérivés de pyrazole microbiocides |
| WO2025172368A1 (fr) | 2024-02-13 | 2025-08-21 | Syngenta Crop Protection Ag | Dérivés de (5-isoxazol-3-yl)-[4-(pyrazol-4-yl)-3,4-dihydro-1h-isoquinolin-2-yl]méthanone destinés à être utilisés en tant que fongicides |
| WO2026030052A1 (fr) | 2024-07-31 | 2026-02-05 | Fmc Corporation | Azoles substitués fongicides |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102324A1 (en) * | 2002-02-28 | 2004-05-27 | Annis Gary David | Heterocyclic diamide invertebrate pest control agents |
| PL376925A1 (pl) | 2002-11-27 | 2006-01-09 | Incyte Corporation | Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| EP1670739A4 (fr) | 2003-10-08 | 2007-08-08 | Bristol Myers Squibb Co | Diamines cycliques et derives comme inhibiteurs du facteur xa |
| NZ561613A (en) | 2005-02-18 | 2010-12-24 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| CN102271681B (zh) * | 2008-11-04 | 2014-11-12 | 凯莫森特里克斯股份有限公司 | Cxcr7调节剂 |
| JP6094578B2 (ja) | 2011-06-09 | 2017-03-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン |
| WO2013084241A1 (fr) * | 2011-12-09 | 2013-06-13 | Cadila Healthcare Limited | Composés inhibiteurs de rénine |
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| ES2681593T3 (es) * | 2012-11-29 | 2018-09-14 | Chemocentryx, Inc. | Antagonistas de CXCR7 |
| CA2912133C (fr) | 2013-05-30 | 2021-06-22 | Actelion Pharmaceuticals Ltd | Modulateurs du recepteur de cxcr7 |
| ES2642074T3 (es) | 2013-09-04 | 2017-11-15 | Bristol-Myers Squibb Company | Compuestos útiles como inmunomoduladores |
| CN105814028B (zh) | 2013-09-06 | 2018-02-16 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1，2，4‑*二唑衍生物 |
| WO2015044900A1 (fr) | 2013-09-27 | 2015-04-02 | Aurigene Discovery Technologies Limited | Composés immunomodulateurs thérapeutiques |
| JP2017528464A (ja) | 2014-09-10 | 2017-09-28 | エピザイム，インコーポレイティド | 置換ピペリジン化合物 |
| EP3227263B1 (fr) * | 2014-12-01 | 2019-04-10 | Idorsia Pharmaceuticals Ltd | Modulateurs du recepteur de cxcr7 |
| HUE066704T2 (hu) | 2018-01-26 | 2024-08-28 | Idorsia Pharmaceuticals Ltd | CXCR7 receptor antagonista (3S,4S)-1-ciklopropilmetil-4-{[5-(2,4-difluor-fenil)-izoxazol-3-karbonil]-amino} -piperidin-3-karbonsav-(1-pirimidin-2-il-ciklopropil)-amid kristályos formái |
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2017
- 2017-07-27 PL PL20201796.8T patent/PL3798217T3/pl unknown
- 2017-07-27 DK DK17754283.4T patent/DK3490986T3/da active
- 2017-07-27 EA EA202091262A patent/EA202091262A1/ru unknown
- 2017-07-27 CN CN201910748606.6A patent/CN110563717B/zh active Active
- 2017-07-27 KR KR1020197005980A patent/KR102497091B1/ko active Active
- 2017-07-27 MA MA45782A patent/MA45782B1/fr unknown
- 2017-07-27 HR HRP20230313TT patent/HRP20230313T1/hr unknown
- 2017-07-27 EA EA201990388A patent/EA037507B1/ru not_active IP Right Cessation
- 2017-07-27 MY MYPI2021006484A patent/MY199657A/en unknown
- 2017-07-27 UA UAA202002568A patent/UA129887C2/uk unknown
- 2017-07-27 MX MX2019001042A patent/MX383804B/es unknown
- 2017-07-27 TW TW106125273A patent/TWI683812B/zh active
- 2017-07-27 PT PT202017968T patent/PT3798217T/pt unknown
- 2017-07-27 FI FIEP20201796.8T patent/FI3798217T3/fi active
- 2017-07-27 LT LTEP20201796.8T patent/LT3798217T/lt unknown
- 2017-07-27 MY MYPI2019000420A patent/MY198113A/en unknown
- 2017-07-27 PT PT177542834T patent/PT3490986T/pt unknown
- 2017-07-27 CN CN201780046279.9A patent/CN109563085B/zh active Active
- 2017-07-27 EP EP17754283.4A patent/EP3490986B1/fr active Active
- 2017-07-27 TW TW108111240A patent/TWI691497B/zh active
- 2017-07-27 TW TW108111236A patent/TWI691494B/zh active
- 2017-07-27 SG SG10201906942PA patent/SG10201906942PA/en unknown
- 2017-07-27 EP EP20201796.8A patent/EP3798217B1/fr active Active
- 2017-07-27 HR HRP20211988TT patent/HRP20211988T1/hr unknown
- 2017-07-27 RS RS20230297A patent/RS64130B1/sr unknown
- 2017-07-27 AU AU2017302079A patent/AU2017302079B2/en active Active
- 2017-07-27 MA MA54653A patent/MA54653B1/fr unknown
- 2017-07-27 UA UAA201901844A patent/UA122987C2/uk unknown
- 2017-07-27 SI SI201731053T patent/SI3490986T1/sl unknown
- 2017-07-27 HU HUE20201796A patent/HUE062019T2/hu unknown
- 2017-07-27 NZ NZ751006A patent/NZ751006A/en unknown
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