MA46038A - Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale - Google Patents
Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection viraleInfo
- Publication number
- MA46038A MA46038A MA046038A MA46038A MA46038A MA 46038 A MA46038 A MA 46038A MA 046038 A MA046038 A MA 046038A MA 46038 A MA46038 A MA 46038A MA 46038 A MA46038 A MA 46038A
- Authority
- MA
- Morocco
- Prior art keywords
- prophylaxis
- treatment
- viral infection
- compounds substituted
- sulfonimidoylpurinone
- Prior art date
Links
- 150000001875 compounds Chemical group 0.000 title abstract 4
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés de formule (i), dans laquelle r1, r2 et r3 sont tels que décrits ici, et leurs promédicaments ou leur sel, énantiomère ou diastéréoisomère pharmaceutiquement acceptables de ceux-ci, des compositions comprenant les composés et des procédés d'utilisation des composés comme agonistes de tlr7 pour le traitement et la prophylaxie d'infections virales.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016097140 | 2016-08-29 | ||
| CN2017092653 | 2017-07-12 | ||
| PCT/EP2017/071514 WO2018041763A1 (fr) | 2016-08-29 | 2017-08-28 | Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA46038A true MA46038A (fr) | 2019-07-03 |
| MA46038B1 MA46038B1 (fr) | 2021-05-31 |
Family
ID=59738346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA46038A MA46038B1 (fr) | 2016-08-29 | 2017-08-28 | Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10233184B2 (fr) |
| EP (2) | EP3865482A1 (fr) |
| JP (2) | JP7013467B2 (fr) |
| KR (2) | KR20220147702A (fr) |
| CN (1) | CN109641904B (fr) |
| AU (3) | AU2017320742B2 (fr) |
| CA (1) | CA3034148A1 (fr) |
| CL (1) | CL2019000512A1 (fr) |
| CO (1) | CO2019000932A2 (fr) |
| CR (1) | CR20190087A (fr) |
| DK (1) | DK3504210T3 (fr) |
| ES (1) | ES2867849T3 (fr) |
| HR (1) | HRP20210621T1 (fr) |
| HU (1) | HUE053944T2 (fr) |
| IL (3) | IL293475B2 (fr) |
| MA (1) | MA46038B1 (fr) |
| MX (2) | MX383500B (fr) |
| MY (1) | MY197408A (fr) |
| PE (1) | PE20190476A1 (fr) |
| PH (1) | PH12019500432B1 (fr) |
| PL (1) | PL3504210T3 (fr) |
| PT (1) | PT3504210T (fr) |
| RS (1) | RS61752B1 (fr) |
| RU (1) | RU2751349C2 (fr) |
| SG (2) | SG10202010520SA (fr) |
| SI (1) | SI3504210T1 (fr) |
| TW (1) | TWI671300B (fr) |
| UA (1) | UA124270C2 (fr) |
| WO (1) | WO2018041763A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107580596B (zh) * | 2015-05-08 | 2020-07-14 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物 |
| PE20190476A1 (es) * | 2016-08-29 | 2019-04-04 | Hoffmann La Roche | Compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infeccion virica |
| CN109715214B (zh) * | 2016-09-13 | 2022-03-04 | 豪夫迈·罗氏有限公司 | Tlr7激动剂和hbv衣壳组装抑制剂的组合治疗 |
| EP3752505B1 (fr) | 2018-02-12 | 2023-01-11 | F. Hoffmann-La Roche AG | Nouveaux composés et dérivés de sulfone pour le traitement et la prophylaxie d'une infection virale |
| WO2019166432A1 (fr) * | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | Nouveaux composés sulfonimidoylpurinone substitués en position 7 et dérivés pour le traitement et la prophylaxie du cancer du foie |
| JP2022500414A (ja) | 2018-09-12 | 2022-01-04 | シルバーバック セラピューティックス インコーポレイテッド | 免疫刺激性コンジュゲートにより疾患を処置する方法および組成物 |
| BR112021015577A8 (pt) | 2019-02-08 | 2021-10-05 | Research & Business Found Sungkyunkwan Univ | Complexo-colesterol agonista do receptor toll-like 7/8, composição de nanopartícula, composição adjuvante, composição de vacina, composição para regular uma função imunológica, composição farmacêutica e uso do complexo |
| CA3151322A1 (fr) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Polytherapie comprenant des conjugues immunostimulants |
| WO2021168274A1 (fr) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Conjugués d'anticorps de nectine-4 et leurs utilisations |
| EP4115901A4 (fr) | 2020-03-02 | 2024-04-10 | Progeneer Inc. | Nanoparticules mimétiques d'agent pathogène vivant basées sur un squelette de paroi cellulaire d'agent pathogène, et leur procédé de production |
| AU2021300362A1 (en) | 2020-07-01 | 2023-02-23 | ARS Pharmaceuticals, Inc. | Anti-ASGR1 antibody conjugates and uses thereof |
| EP4194008A4 (fr) | 2020-08-04 | 2025-01-08 | Progeneer Inc. | Ensemble adjuvant à action cinétique |
| WO2022031021A1 (fr) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | Vaccin à arnm comprenant un adjuvant permettant un contrôle cinétique |
| EP4194010A4 (fr) | 2020-08-04 | 2025-03-26 | Progeneer Inc. | Conjugué d'un médicament fonctionnel et d'un agoniste de récepteur de type toll 7 ou 8, dont le site actif est temporairement inactivé et utilisation associée |
| WO2022063278A1 (fr) * | 2020-09-27 | 2022-03-31 | 上海维申医药有限公司 | Agoniste de tlr7 macrocyclique, son procédé de préparation, composition pharmaceutique et son utilisation |
| GB202306325D0 (en) | 2023-04-28 | 2023-06-14 | Iksuda Therapeutics Ltd | Antibody-drug conjugate compounds, and methods of use and treatment |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141927B1 (fr) * | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Dérivés de guanine antiviraux |
| TW552261B (en) | 1996-07-03 | 2003-09-11 | Japan Energy Corp | Novel purine derivative |
| AUPO912997A0 (en) * | 1997-09-11 | 1997-10-02 | Commonwealth Scientific And Industrial Research Organisation | Antiviral agents |
| CA2311742C (fr) * | 1997-11-28 | 2009-06-16 | Sumitomo Pharmaceuticals Co., Ltd. | Nouveaux composes heterocycliques |
| JPH11180981A (ja) * | 1997-12-19 | 1999-07-06 | Sumitomo Pharmaceut Co Ltd | 複素環誘導体 |
| TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
| JP4189048B2 (ja) | 1997-12-26 | 2008-12-03 | 大日本住友製薬株式会社 | 複素環化合物 |
| WO2004006867A2 (fr) * | 2002-03-15 | 2004-01-22 | Wayne State University | Nouvelles 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines utilisees en tant qu'agents antiviraux |
| KR101111085B1 (ko) * | 2002-09-27 | 2012-04-12 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규 아데닌 화합물 및 그 용도 |
| MX2007013780A (es) | 2005-05-04 | 2008-02-05 | Pfizer Ltd | Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c. |
| DE102006053049A1 (de) | 2006-11-10 | 2008-05-15 | Daimler Ag | Staufach mit einer Abdeckeinrichtung |
| SI2170888T1 (sl) * | 2007-06-29 | 2015-10-30 | Gilead Sciences, Inc. | Purinski derivati in njihova uporaba kot modulatorjev receptorja tipa toll-7 |
| CN101239980B (zh) | 2008-02-18 | 2011-06-22 | 靳广毅 | 免疫受体调节剂偶联体前体和偶联体及其应用 |
| AU2009333559B2 (en) * | 2008-12-09 | 2015-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| MX2012004706A (es) * | 2009-10-22 | 2012-06-08 | Gilead Sciences Inc | Derivados de purina o deazapurina utiles para el tratamiento de (inter alia) infecciones virales. |
| US20110150836A1 (en) | 2009-12-22 | 2011-06-23 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
| US8501724B1 (en) * | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
| MX386981B (es) | 2014-08-15 | 2025-03-19 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Compuestos de pirrolopirimidina usados como agonistas del receptor de tipo toll 7 (tlr7). |
| CN107580596B (zh) * | 2015-05-08 | 2020-07-14 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的磺亚氨酰基嘌呤酮化合物和衍生物 |
| PE20190476A1 (es) * | 2016-08-29 | 2019-04-04 | Hoffmann La Roche | Compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infeccion virica |
-
2017
- 2017-08-28 PE PE2019000346A patent/PE20190476A1/es unknown
- 2017-08-28 ES ES17758527T patent/ES2867849T3/es active Active
- 2017-08-28 EP EP20207475.3A patent/EP3865482A1/fr not_active Withdrawn
- 2017-08-28 RS RS20210489A patent/RS61752B1/sr unknown
- 2017-08-28 JP JP2019532184A patent/JP7013467B2/ja active Active
- 2017-08-28 AU AU2017320742A patent/AU2017320742B2/en active Active
- 2017-08-28 CN CN201780052692.6A patent/CN109641904B/zh active Active
- 2017-08-28 RU RU2019107957A patent/RU2751349C2/ru active
- 2017-08-28 DK DK17758527.0T patent/DK3504210T3/da active
- 2017-08-28 HR HRP20210621TT patent/HRP20210621T1/hr unknown
- 2017-08-28 HU HUE17758527A patent/HUE053944T2/hu unknown
- 2017-08-28 SG SG10202010520SA patent/SG10202010520SA/en unknown
- 2017-08-28 WO PCT/EP2017/071514 patent/WO2018041763A1/fr not_active Ceased
- 2017-08-28 PL PL17758527T patent/PL3504210T3/pl unknown
- 2017-08-28 EP EP17758527.0A patent/EP3504210B1/fr active Active
- 2017-08-28 KR KR1020227036198A patent/KR20220147702A/ko not_active Ceased
- 2017-08-28 PT PT177585270T patent/PT3504210T/pt unknown
- 2017-08-28 SI SI201730728T patent/SI3504210T1/sl unknown
- 2017-08-28 MA MA46038A patent/MA46038B1/fr unknown
- 2017-08-28 CR CR20190087A patent/CR20190087A/es unknown
- 2017-08-28 PH PH1/2019/500432A patent/PH12019500432B1/en unknown
- 2017-08-28 TW TW106129087A patent/TWI671300B/zh active
- 2017-08-28 SG SG11201901633WA patent/SG11201901633WA/en unknown
- 2017-08-28 MY MYPI2019001082A patent/MY197408A/en unknown
- 2017-08-28 MX MX2019002129A patent/MX383500B/es unknown
- 2017-08-28 UA UAA201903059A patent/UA124270C2/uk unknown
- 2017-08-28 KR KR1020197008982A patent/KR102459155B1/ko active Active
- 2017-08-28 IL IL293475A patent/IL293475B2/en unknown
- 2017-08-28 IL IL284255A patent/IL284255B/en unknown
- 2017-08-28 CA CA3034148A patent/CA3034148A1/fr active Pending
- 2017-08-29 US US15/689,136 patent/US10233184B2/en active Active
-
2019
- 2019-01-29 US US16/260,744 patent/US10752630B2/en active Active
- 2019-01-30 CO CONC2019/0000932A patent/CO2019000932A2/es unknown
- 2019-02-07 IL IL264710A patent/IL264710B/en unknown
- 2019-02-21 MX MX2021006902A patent/MX2021006902A/es unknown
- 2019-02-26 CL CL2019000512A patent/CL2019000512A1/es unknown
-
2020
- 2020-08-24 US US17/001,572 patent/US20200385387A1/en not_active Abandoned
-
2021
- 2021-06-24 AU AU2021204303A patent/AU2021204303B2/en active Active
-
2022
- 2022-01-17 JP JP2022004832A patent/JP7214900B2/ja active Active
- 2022-06-30 AU AU2022204697A patent/AU2022204697A1/en not_active Abandoned
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