MA46038A - Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale - Google Patents
Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection viraleInfo
- Publication number
- MA46038A MA46038A MA046038A MA46038A MA46038A MA 46038 A MA46038 A MA 46038A MA 046038 A MA046038 A MA 046038A MA 46038 A MA46038 A MA 46038A MA 46038 A MA46038 A MA 46038A
- Authority
- MA
- Morocco
- Prior art keywords
- prophylaxis
- treatment
- viral infection
- compounds substituted
- sulfonimidoylpurinone
- Prior art date
Links
- 150000001875 compounds Chemical group 0.000 title abstract 4
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés de formule (i), dans laquelle r1, r2 et r3 sont tels que décrits ici, et leurs promédicaments ou leur sel, énantiomère ou diastéréoisomère pharmaceutiquement acceptables de ceux-ci, des compositions comprenant les composés et des procédés d'utilisation des composés comme agonistes de tlr7 pour le traitement et la prophylaxie d'infections virales.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016097140 | 2016-08-29 | ||
| CN2017092653 | 2017-07-12 | ||
| PCT/EP2017/071514 WO2018041763A1 (fr) | 2016-08-29 | 2017-08-28 | Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA46038A true MA46038A (fr) | 2019-07-03 |
| MA46038B1 MA46038B1 (fr) | 2021-05-31 |
Family
ID=59738346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA46038A MA46038B1 (fr) | 2016-08-29 | 2017-08-28 | Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10233184B2 (fr) |
| EP (2) | EP3865482A1 (fr) |
| JP (2) | JP7013467B2 (fr) |
| KR (2) | KR102459155B1 (fr) |
| CN (1) | CN109641904B (fr) |
| AU (3) | AU2017320742B2 (fr) |
| CA (1) | CA3034148A1 (fr) |
| CL (1) | CL2019000512A1 (fr) |
| CO (1) | CO2019000932A2 (fr) |
| CR (1) | CR20190087A (fr) |
| DK (1) | DK3504210T3 (fr) |
| ES (1) | ES2867849T3 (fr) |
| HR (1) | HRP20210621T1 (fr) |
| HU (1) | HUE053944T2 (fr) |
| IL (3) | IL284255B (fr) |
| MA (1) | MA46038B1 (fr) |
| MX (2) | MX383500B (fr) |
| MY (1) | MY197408A (fr) |
| PE (1) | PE20190476A1 (fr) |
| PH (1) | PH12019500432B1 (fr) |
| PL (1) | PL3504210T3 (fr) |
| PT (1) | PT3504210T (fr) |
| RS (1) | RS61752B1 (fr) |
| RU (1) | RU2751349C2 (fr) |
| SG (2) | SG11201901633WA (fr) |
| SI (1) | SI3504210T1 (fr) |
| TW (1) | TWI671300B (fr) |
| UA (1) | UA124270C2 (fr) |
| WO (1) | WO2018041763A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ775222A (en) * | 2015-05-08 | 2024-09-27 | Hoffmann La Roche | Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection |
| RU2751349C2 (ru) * | 2016-08-29 | 2021-07-13 | Ф. Хоффманн-Ля Рош Аг | 7-замещенные сульфонимидоилпуриноны для лечения и профилактики вирусной инфекции |
| CA3034185A1 (fr) * | 2016-09-13 | 2018-03-22 | F. Hoffmann-La Roche Ag | Traitement combine avec un agoniste tlr7 et un inhibiteur d'assemblage de capside du virus de l'hepatite b |
| WO2019155042A1 (fr) | 2018-02-12 | 2019-08-15 | F. Hoffmann-La Roche Ag | Nouveaux composés et dérivés de sulfone pour le traitement et la prophylaxie d'une infection virale |
| PE20211456A1 (es) * | 2018-02-28 | 2021-08-05 | Hoffmann La Roche | Compuestos de sulfonimidoilpurinona 7-sustituidos y sus derivados para el tratamiento y prevencion del cancer de higado |
| SG11202101980VA (en) | 2018-09-12 | 2021-03-30 | Silverback Therapeutics Inc | Methods and composition for the treatment of disease with immune stimulatory conjugates |
| BR112021015577A2 (pt) | 2019-02-08 | 2021-10-05 | Research & Business Foundation Sungkyunkwan University | Complexo-colesterol agonista do receptor toll-like 7 ou 8 e uso do mesmo |
| WO2021067644A1 (fr) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Polythérapie comprenant des conjugués immunostimulants |
| US11179473B2 (en) | 2020-02-21 | 2021-11-23 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| CN115666637A (zh) | 2020-03-02 | 2023-01-31 | 蛋白科技先锋 | 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法 |
| KR20230047361A (ko) | 2020-07-01 | 2023-04-07 | 아르스 파마슈티컬스 인크. | 항-asgr1 항체 접합체 및 이의 용도 |
| EP4194008A4 (fr) | 2020-08-04 | 2025-01-08 | Progeneer Inc. | Ensemble adjuvant à action cinétique |
| WO2022031021A1 (fr) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | Vaccin à arnm comprenant un adjuvant permettant un contrôle cinétique |
| US20230277525A1 (en) | 2020-08-04 | 2023-09-07 | Progeneer Inc | Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof |
| EP4219504A4 (fr) * | 2020-09-27 | 2024-10-16 | Shanghai Visonpharma Co., Ltd. | Agoniste de tlr7 macrocyclique, son procédé de préparation, composition pharmaceutique et son utilisation |
| GB202306325D0 (en) | 2023-04-28 | 2023-06-14 | Iksuda Therapeutics Ltd | Antibody-drug conjugate compounds, and methods of use and treatment |
| WO2025110816A1 (fr) | 2023-11-23 | 2025-05-30 | 프로지니어 주식회사 | Polythérapie de traitement anticancéreux avec un agoniste du récepteur de type toll 7 ou 8 ayant un site actif temporairement inactivé pour traiter le cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141927B1 (fr) * | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Dérivés de guanine antiviraux |
| JP4667543B2 (ja) | 1996-07-03 | 2011-04-13 | 大日本住友製薬株式会社 | 新規プリン誘導体 |
| AUPO912997A0 (en) | 1997-09-11 | 1997-10-02 | Commonwealth Scientific And Industrial Research Organisation | Antiviral agents |
| JP4375901B2 (ja) * | 1997-11-28 | 2009-12-02 | 大日本住友製薬株式会社 | 新規な複素環化合物 |
| JPH11180981A (ja) * | 1997-12-19 | 1999-07-06 | Sumitomo Pharmaceut Co Ltd | 複素環誘導体 |
| TW572758B (en) | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
| JP4189048B2 (ja) * | 1997-12-26 | 2008-12-03 | 大日本住友製薬株式会社 | 複素環化合物 |
| AU2003276824B8 (en) | 2002-03-15 | 2009-01-22 | The Regents Of The University Of Michigan | Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents |
| CA2497765A1 (fr) * | 2002-09-27 | 2004-04-08 | Sumitomo Pharmaceuticals Co., Ltd. | Nouveau compose d'adenine et son application |
| EA200702235A1 (ru) | 2005-05-04 | 2008-04-28 | Пфайзер Лимитед | Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с |
| DE102006053049A1 (de) | 2006-11-10 | 2008-05-15 | Daimler Ag | Staufach mit einer Abdeckeinrichtung |
| EP2170888B1 (fr) * | 2007-06-29 | 2015-04-22 | Gilead Sciences, Inc. | Dérivés de purine et leur utilisation comme modulateurs du récepteur de type toll-7 |
| CN101239980B (zh) | 2008-02-18 | 2011-06-22 | 靳广毅 | 免疫受体调节剂偶联体前体和偶联体及其应用 |
| UY32306A (es) * | 2008-12-09 | 2010-07-30 | Gilead Sciences Inc | Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos |
| BR112012009329A2 (pt) * | 2009-10-22 | 2016-06-07 | Gilead Sciences Inc | derivados de purina ou deazapurina úteis para o tratamento de infecções virais (inter alia) |
| US20110150836A1 (en) | 2009-12-22 | 2011-06-23 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
| US8501724B1 (en) * | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
| CN112898308B (zh) | 2014-08-15 | 2026-08-07 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| NZ775222A (en) * | 2015-05-08 | 2024-09-27 | Hoffmann La Roche | Novel sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection |
| RU2751349C2 (ru) * | 2016-08-29 | 2021-07-13 | Ф. Хоффманн-Ля Рош Аг | 7-замещенные сульфонимидоилпуриноны для лечения и профилактики вирусной инфекции |
-
2017
- 2017-08-28 RU RU2019107957A patent/RU2751349C2/ru active
- 2017-08-28 RS RS20210489A patent/RS61752B1/sr unknown
- 2017-08-28 KR KR1020197008982A patent/KR102459155B1/ko active Active
- 2017-08-28 SG SG11201901633WA patent/SG11201901633WA/en unknown
- 2017-08-28 HR HRP20210621TT patent/HRP20210621T1/hr unknown
- 2017-08-28 TW TW106129087A patent/TWI671300B/zh not_active IP Right Cessation
- 2017-08-28 EP EP20207475.3A patent/EP3865482A1/fr not_active Withdrawn
- 2017-08-28 DK DK17758527.0T patent/DK3504210T3/da active
- 2017-08-28 ES ES17758527T patent/ES2867849T3/es active Active
- 2017-08-28 KR KR1020227036198A patent/KR20220147702A/ko not_active Ceased
- 2017-08-28 PT PT177585270T patent/PT3504210T/pt unknown
- 2017-08-28 MA MA46038A patent/MA46038B1/fr unknown
- 2017-08-28 SG SG10202010520SA patent/SG10202010520SA/en unknown
- 2017-08-28 PE PE2019000346A patent/PE20190476A1/es unknown
- 2017-08-28 IL IL284255A patent/IL284255B/en unknown
- 2017-08-28 HU HUE17758527A patent/HUE053944T2/hu unknown
- 2017-08-28 UA UAA201903059A patent/UA124270C2/uk unknown
- 2017-08-28 WO PCT/EP2017/071514 patent/WO2018041763A1/fr not_active Ceased
- 2017-08-28 PL PL17758527T patent/PL3504210T3/pl unknown
- 2017-08-28 MY MYPI2019001082A patent/MY197408A/en unknown
- 2017-08-28 MX MX2019002129A patent/MX383500B/es unknown
- 2017-08-28 CA CA3034148A patent/CA3034148A1/fr active Pending
- 2017-08-28 JP JP2019532184A patent/JP7013467B2/ja active Active
- 2017-08-28 IL IL293475A patent/IL293475B2/en unknown
- 2017-08-28 AU AU2017320742A patent/AU2017320742B2/en active Active
- 2017-08-28 CR CR20190087A patent/CR20190087A/es unknown
- 2017-08-28 PH PH1/2019/500432A patent/PH12019500432B1/en unknown
- 2017-08-28 CN CN201780052692.6A patent/CN109641904B/zh active Active
- 2017-08-28 SI SI201730728T patent/SI3504210T1/sl unknown
- 2017-08-28 EP EP17758527.0A patent/EP3504210B1/fr active Active
- 2017-08-29 US US15/689,136 patent/US10233184B2/en active Active
-
2019
- 2019-01-29 US US16/260,744 patent/US10752630B2/en active Active
- 2019-01-30 CO CONC2019/0000932A patent/CO2019000932A2/es unknown
- 2019-02-07 IL IL264710A patent/IL264710B/en unknown
- 2019-02-21 MX MX2021006902A patent/MX2021006902A/es unknown
- 2019-02-26 CL CL2019000512A patent/CL2019000512A1/es unknown
-
2020
- 2020-08-24 US US17/001,572 patent/US20200385387A1/en not_active Abandoned
-
2021
- 2021-06-24 AU AU2021204303A patent/AU2021204303B2/en active Active
-
2022
- 2022-01-17 JP JP2022004832A patent/JP7214900B2/ja active Active
- 2022-06-30 AU AU2022204697A patent/AU2022204697A1/en not_active Abandoned
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