MA40523A - 2-(morpholin-4-yl)-1,7-naphthyridines - Google Patents

2-(morpholin-4-yl)-1,7-naphthyridines

Info

Publication number
MA40523A
MA40523A MA040523A MA40523A MA40523A MA 40523 A MA40523 A MA 40523A MA 040523 A MA040523 A MA 040523A MA 40523 A MA40523 A MA 40523A MA 40523 A MA40523 A MA 40523A
Authority
MA
Morocco
Prior art keywords
compounds
morpholin
preparation
naphthyridines
disease
Prior art date
Application number
MA040523A
Other languages
English (en)
Other versions
MA40523B1 (fr
Inventor
Benjamin Bader
Wilhelm Bone
Hans Briem
Uwe Eberspächer
Knut Eis
Joanna Grudzinska-Goebel
Marcus Koppitz
Julien Lefranc
Philip Lienau
Ulrich Lücking
Dieter Moosmayer
Hans Schick
Gerhard Siemeister
Nussbaum Franz Von
Antje Margret Wengner
Lars Wortmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA40523A publication Critical patent/MA40523A/fr
Publication of MA40523B1 publication Critical patent/MA40523B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention porte sur des composés 2-(morpholin-4-yl)-l,7-naphtyridine substitués représentés par la formule générale (i) ou (ib), sur des procédés de préparation desdits composés, sur des composés intermédiaires utiles pour la préparation desdits composés, sur des combinaisons et des compositions pharmaceutiques comprenant lesdits composés et sur l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique utile pour le traitement ou la prophylaxie d'une maladie, en particulier d'une maladie hyperproliférative en tant qu'agent unique ou en combinaison avec d'autres principes actifs.
MA40523A 2014-08-04 2015-08-03 2-(morpholin-4-yl)-1,7-naphthyridines MA40523B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14179692 2014-08-04
EP15159342 2015-03-17
PCT/EP2015/067804 WO2016020320A1 (fr) 2014-08-04 2015-08-03 2- (morpholin -4-yl)-l,7-naphtyridines
EP15744596.6A EP3177619B1 (fr) 2014-08-04 2015-08-03 2-(morpholin-4-yl)-1,7-naphthyridines

Publications (2)

Publication Number Publication Date
MA40523A true MA40523A (fr) 2017-06-14
MA40523B1 MA40523B1 (fr) 2018-09-28

Family

ID=53762196

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40523A MA40523B1 (fr) 2014-08-04 2015-08-03 2-(morpholin-4-yl)-1,7-naphthyridines

Country Status (42)

Country Link
US (4) US9993484B2 (fr)
EP (2) EP3395818B1 (fr)
JP (2) JP6266839B2 (fr)
KR (2) KR102180006B1 (fr)
CN (3) CN106795156B (fr)
AP (1) AP2017009702A0 (fr)
AU (2) AU2015299173B2 (fr)
BR (1) BR112017002221B1 (fr)
CA (1) CA2956992C (fr)
CL (1) CL2017000287A1 (fr)
CO (1) CO2017001035A2 (fr)
CR (1) CR20170034A (fr)
CU (1) CU24419B1 (fr)
CY (2) CY1120673T1 (fr)
DK (2) DK3395818T3 (fr)
DO (1) DOP2017000038A (fr)
EA (2) EA031678B1 (fr)
EC (1) ECSP17007538A (fr)
ES (2) ES2679625T3 (fr)
HR (2) HRP20181143T1 (fr)
HU (2) HUE038533T2 (fr)
IL (2) IL250220B (fr)
JO (1) JO3447B1 (fr)
LT (2) LT3395818T (fr)
MA (1) MA40523B1 (fr)
MX (2) MX394442B (fr)
MY (1) MY192883A (fr)
NI (1) NI201700011A (fr)
PE (1) PE20170666A1 (fr)
PH (2) PH12017500204B1 (fr)
PL (2) PL3177619T3 (fr)
PT (1) PT3177619T (fr)
RS (2) RS62609B1 (fr)
SA (1) SA517380830B1 (fr)
SG (1) SG11201700750UA (fr)
SI (2) SI3395818T1 (fr)
TN (1) TN2017000027A1 (fr)
TW (2) TWI656121B (fr)
UA (2) UA123928C2 (fr)
UY (1) UY36254A (fr)
WO (1) WO2016020320A1 (fr)
ZA (1) ZA202101003B (fr)

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