MA46242A - Composés inhibiteurs de bêta-lactamase - Google Patents

Composés inhibiteurs de bêta-lactamase

Info

Publication number
MA46242A
MA46242A MA046242A MA46242A MA46242A MA 46242 A MA46242 A MA 46242A MA 046242 A MA046242 A MA 046242A MA 46242 A MA46242 A MA 46242A MA 46242 A MA46242 A MA 46242A
Authority
MA
Morocco
Prior art keywords
beta
inhibitor compounds
lactamase inhibitor
lactamase
compounds
Prior art date
Application number
MA046242A
Other languages
English (en)
Inventor
Gregory S Basarab
Janelle Comita-Prevoir
Thomas Francois Durand-Reville
Lise Gauthier
Bill Moss
John O'donnell
Jan Romero
Ruben Tommasi
Jeroen Cunera Verheijen
Frank Wu
Xiaoyun Wu
Jing Zhang
Original Assignee
Entasis Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entasis Therapeutics Ltd filed Critical Entasis Therapeutics Ltd
Publication of MA46242A publication Critical patent/MA46242A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00Formation or introduction of functional groups containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0834Compounds having one or more O-Si linkage
    • C07F7/0892Compounds with a Si-O-N linkage
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MA046242A 2016-09-16 2017-09-15 Composés inhibiteurs de bêta-lactamase MA46242A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662395464P 2016-09-16 2016-09-16
US201762456423P 2017-02-08 2017-02-08

Publications (1)

Publication Number Publication Date
MA46242A true MA46242A (fr) 2019-07-24

Family

ID=60083416

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046242A MA46242A (fr) 2016-09-16 2017-09-15 Composés inhibiteurs de bêta-lactamase

Country Status (24)

Country Link
US (1) US10800778B2 (fr)
EP (1) EP3512851B1 (fr)
JP (2) JP6997178B2 (fr)
KR (2) KR102667828B1 (fr)
CN (2) CN114591223B (fr)
AU (1) AU2017325863B2 (fr)
CA (1) CA3036557A1 (fr)
CY (1) CY1125826T1 (fr)
DK (1) DK3512851T3 (fr)
ES (1) ES2927986T3 (fr)
HR (1) HRP20221217T1 (fr)
HU (1) HUE060282T2 (fr)
IL (2) IL289686B2 (fr)
LT (1) LT3512851T (fr)
MA (1) MA46242A (fr)
MX (2) MX385507B (fr)
PH (1) PH12019500558B1 (fr)
PL (1) PL3512851T3 (fr)
PT (1) PT3512851T (fr)
SG (1) SG11201901658PA (fr)
SI (1) SI3512851T1 (fr)
SM (1) SMT202200397T1 (fr)
TW (1) TWI773687B (fr)
WO (1) WO2018053215A1 (fr)

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ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
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NZ758200A (en) 2017-05-08 2025-12-19 Entasis Therapeutics Inc Compounds and methods for treating bacterial infections
US12016868B2 (en) 2018-04-20 2024-06-25 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
SG11202101255UA (en) 2018-08-09 2021-03-30 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN112209928B (zh) * 2019-07-10 2023-02-17 华东理工大学 共价键标记丝氨酸类beta-内酰胺酶的试剂及制备和应用
CN110898999A (zh) * 2019-11-26 2020-03-24 中国矿业大学 一种煤焦油基煤泥浮选药剂及其制备方法
BR112022022367A2 (pt) 2020-05-05 2023-01-10 Qpex Biopharma Inc Derivados e síntese de ácido borônico, formas polimórficas e usos terapêuticos dos mesmos
CN111790439B (zh) * 2020-07-29 2022-12-27 成都能特科技发展有限公司 一种手性二级胺二苯基膦芳甲酰胺双功能催化剂及其制备方法与应用
EP4146650B1 (fr) 2020-09-01 2026-01-21 Ningxia Academy of Agriculture and Forestry Sciences Inhibiteurs de bêta-lactamase et leur préparation
EP4319760A4 (fr) * 2021-04-05 2025-01-08 Qpex Biopharma, Inc. Schémas posologiques de ceftibutène
US12410166B2 (en) 2021-05-07 2025-09-09 Ningxia Academy Of Agriculture And Forestry Sciences Sulfonylamidine substituted compounds and their use as beta-lactamase inhibitors
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation
WO2023206580A1 (fr) 2022-04-29 2023-11-02 Entasis Therapeutics Limited Formes cristallines de durlobactam
US20230398101A1 (en) * 2022-06-09 2023-12-14 Fleurir Abx Llc Co-agents as Therapy Against Anaerobic Pathogens
CN118271319B (zh) * 2022-12-30 2025-02-28 成都四面体药物研究有限公司 一种β-内酰胺酶抑制剂含脲双环化合物、其制备方法及其用途
CN118772145B (zh) * 2023-04-04 2025-10-10 上海医药工业研究院有限公司 一种二氮杂双环辛烯化合物的制备方法
CN116693531A (zh) * 2023-06-09 2023-09-05 河南师范大学 一种桥联多环内酰胺类化合物的合成方法
WO2025106662A1 (fr) * 2023-11-15 2025-05-22 Entasis Therapeutics, Inc. Préparation d'intermédiaires d'acide boronique utiles dans la préparation de composés pour le traitement d'infections bactériennes

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FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
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AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
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BR112015003592B1 (pt) 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
WO2014033561A1 (fr) 2012-09-03 2014-03-06 Wockhardt Limited Compositions anti-bactériennes
WO2014122468A1 (fr) 2013-02-06 2014-08-14 Astrazeneca Ab Polythérapie pour le traitement de la pneumonie nosocomiale
WO2014141132A1 (fr) 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. Nouveaux composés hétérocycliques et leur utilisation en tant qu'agents antibactériens et inhibiteurs de β-lactamase
KR102542392B1 (ko) 2014-11-17 2023-06-09 엔타시스 테라퓨틱스 리미티드 내성 박테리아 감염의 치료를 위한 배합물 치료제
BR112017020796A2 (pt) * 2015-03-31 2018-06-26 Mutabilis compostos, composição farmacêutica e kit
CN114591223B (zh) * 2016-09-16 2025-01-24 恩塔西斯治疗有限公司 β-内酰胺酶抑制剂化合物
KR20230007830A (ko) * 2021-07-06 2023-01-13 현대자동차주식회사 고강성 저선팽창 열가소성 수지 조성물 및 이를 포함하는 성형체

Also Published As

Publication number Publication date
JP6997178B2 (ja) 2022-02-03
EP3512851A1 (fr) 2019-07-24
IL265276B (en) 2022-02-01
KR102537340B1 (ko) 2023-05-26
TW201823207A (zh) 2018-07-01
SI3512851T1 (sl) 2022-11-30
JP2019532928A (ja) 2019-11-14
KR102667828B1 (ko) 2024-05-20
HRP20221217T1 (hr) 2022-12-23
IL289686B2 (en) 2023-03-01
JP2022046563A (ja) 2022-03-23
CN109715630A (zh) 2019-05-03
KR20230078830A (ko) 2023-06-02
MX385507B (es) 2025-03-18
NZ751016A (en) 2025-02-28
LT3512851T (lt) 2022-10-25
IL265276A (en) 2019-05-30
HUE060282T2 (hu) 2023-02-28
AU2017325863B2 (en) 2021-08-19
EP3512851B1 (fr) 2022-07-06
DK3512851T3 (en) 2022-10-17
AU2017325863A1 (en) 2019-03-14
PT3512851T (pt) 2022-10-11
CN114591223B (zh) 2025-01-24
CN114591223A (zh) 2022-06-07
CN109715630B (zh) 2022-02-22
WO2018053215A1 (fr) 2018-03-22
US20190202832A1 (en) 2019-07-04
MX2021010077A (es) 2022-05-23
BR112019005053A2 (pt) 2019-06-18
IL289686B (en) 2022-11-01
SMT202200397T1 (it) 2022-11-18
ES2927986T3 (es) 2022-11-14
MX392515B (es) 2025-03-24
PL3512851T3 (pl) 2022-11-14
PH12019500558A1 (en) 2019-07-29
PH12019500558B1 (en) 2023-09-08
IL289686A (en) 2022-03-01
US10800778B2 (en) 2020-10-13
MX2019003060A (es) 2019-07-08
CA3036557A1 (fr) 2018-03-22
KR20190043630A (ko) 2019-04-26
JP7281527B2 (ja) 2023-05-25
TWI773687B (zh) 2022-08-11
CY1125826T1 (el) 2026-02-25
SG11201901658PA (en) 2019-04-29

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