MA46743A - Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v - Google Patents

Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v

Info

Publication number
MA46743A
MA46743A MA046743A MA46743A MA46743A MA 46743 A MA46743 A MA 46743A MA 046743 A MA046743 A MA 046743A MA 46743 A MA46743 A MA 46743A MA 46743 A MA46743 A MA 46743A
Authority
MA
Morocco
Prior art keywords
inhibitors
integrin alpha
propionic acids
acids substituted
substituted
Prior art date
Application number
MA046743A
Other languages
English (en)
Inventor
Palanikumar Balasubramanian
Rita Civiello
Pratik Devasthale
Suresh Dhanusu
Leatte R Guernon
Xiaojun Han
Swanee E Jacutin-Porte
Michael F Parker
Kumaravel Selvakumar
Xiang-Yang Ye
Guohua Zhao
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA46743A publication Critical patent/MA46743A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA046743A 2016-11-08 2017-11-07 Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v MA46743A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662418848P 2016-11-08 2016-11-08

Publications (1)

Publication Number Publication Date
MA46743A true MA46743A (fr) 2019-09-18

Family

ID=60409432

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046743A MA46743A (fr) 2016-11-08 2017-11-07 Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v

Country Status (29)

Country Link
US (2) US10968219B2 (fr)
EP (1) EP3538525B1 (fr)
JP (1) JP7097358B2 (fr)
KR (1) KR102505629B1 (fr)
CN (1) CN110167935B (fr)
AR (1) AR110153A1 (fr)
AU (1) AU2017359023B2 (fr)
CL (1) CL2019001264A1 (fr)
CO (1) CO2019005824A2 (fr)
DK (1) DK3538525T3 (fr)
EA (1) EA038164B1 (fr)
ES (1) ES2925173T3 (fr)
HR (1) HRP20220990T1 (fr)
HU (1) HUE059708T2 (fr)
IL (1) IL266473B (fr)
LT (1) LT3538525T (fr)
MA (1) MA46743A (fr)
MX (1) MX380799B (fr)
MY (1) MY199931A (fr)
NZ (1) NZ754207A (fr)
PE (1) PE20191647A1 (fr)
PL (1) PL3538525T3 (fr)
PT (1) PT3538525T (fr)
RS (1) RS63483B1 (fr)
SI (1) SI3538525T1 (fr)
SM (1) SMT202200338T1 (fr)
TW (1) TWI763733B (fr)
WO (1) WO2018089353A1 (fr)
ZA (1) ZA201903665B (fr)

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WO2018089353A1 (fr) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v
CA3042710A1 (fr) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Composes mono et spirocycliques contenant du cyclobutane et de l'azetidine en tant qu'inhibiteurs de l'integrine .alpha.v
BR112019009245A2 (pt) * 2016-11-08 2019-07-16 Bristol-Myers Squibb Company azol amidas e aminas como inibidores de alfav integrina
KR20190100232A (ko) 2016-12-29 2019-08-28 세인트 루이스 유니버시티 인테그린 길항제
EP3760202A1 (fr) 2017-02-28 2021-01-06 Morphic Therapeutic, Inc. Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
IL316954A (en) 2017-02-28 2025-01-01 Morphic Therapeutic Inc (Alpha-V)(beta-6)integrin inhibitors
UY38353A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibición de integrina alfavbeta6
WO2020047208A1 (fr) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibiteurs de l'intégrine (alpha-v)(bêta-6)
UY38352A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
HUE070112T2 (hu) 2018-10-30 2025-05-28 Gilead Sciences Inc 3-(Kinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-dion-származékok mint alpha4beta7 integrin gátlók gyulladásos betegségek kezelésére
EP3873900B1 (fr) 2018-10-30 2025-01-08 Gilead Sciences, Inc. Dérivés de imidazo[1,2-a]pyridine en tant qu'inhibiteurs d'integrin alpha4beta7 pour le traitement de maladies inflammatoires
JP7189369B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４β７インテグリンの阻害のための化合物
CN112996786B (zh) 2018-10-30 2024-08-20 吉利德科学公司 用于抑制α4β7整合素的化合物
CN109824495B (zh) * 2019-02-02 2022-12-09 盐城师范学院 一种新型偶联反应在制备碳-碳键结构化合物中的应用
JP7491996B2 (ja) 2019-08-14 2024-05-28 ギリアード サイエンシーズ， インコーポレイテッド α４β７インテグリンの阻害のための化合物
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound
TW202513065A (zh) * 2023-09-21 2025-04-01 美商莫菲克醫療股份有限公司 抑制人類整合素α５β１

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CA2981371A1 (fr) * 2015-03-10 2016-09-15 The Regents Of The University Of California Inhibiteurs anti-integrine alphavbeta1 et methodes d'utilisation associees
WO2018089353A1 (fr) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Acides propioniques à substitution en position 3 en tant qu'inhibiteurs d'intégrine alpha v

Also Published As

Publication number Publication date
AR110153A1 (es) 2019-02-27
HUE059708T2 (hu) 2022-12-28
EP3538525A1 (fr) 2019-09-18
CN110167935A (zh) 2019-08-23
JP2019537594A (ja) 2019-12-26
LT3538525T (lt) 2022-09-26
CA3042707A1 (fr) 2018-05-17
HRP20220990T1 (hr) 2022-11-11
IL266473A (en) 2019-07-31
TW201823244A (zh) 2018-07-01
MX380799B (es) 2025-03-12
EA038164B1 (ru) 2021-07-16
PE20191647A1 (es) 2019-11-07
NZ754207A (en) 2025-09-26
ES2925173T3 (es) 2022-10-14
AU2017359023B2 (en) 2021-12-09
US11884661B2 (en) 2024-01-30
AU2017359023A1 (en) 2019-06-20
CL2019001264A1 (es) 2019-09-13
PT3538525T (pt) 2022-08-16
JP7097358B2 (ja) 2022-07-07
CN110167935B (zh) 2022-05-27
US20210188847A1 (en) 2021-06-24
SI3538525T1 (sl) 2022-09-30
KR102505629B1 (ko) 2023-03-02
US10968219B2 (en) 2021-04-06
WO2018089353A1 (fr) 2018-05-17
KR20190073554A (ko) 2019-06-26
MY199931A (en) 2023-11-29
TWI763733B (zh) 2022-05-11
RS63483B1 (sr) 2022-09-30
CO2019005824A2 (es) 2019-06-11
ZA201903665B (en) 2022-12-21
EP3538525B1 (fr) 2022-06-22
MX2019005244A (es) 2019-08-05
EA201991122A1 (ru) 2019-10-31
PL3538525T3 (pl) 2022-09-12
IL266473B (en) 2022-06-01
SMT202200338T1 (it) 2022-09-14
US20190263808A1 (en) 2019-08-29
DK3538525T3 (da) 2022-08-29

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