MA47079A - Composés amino-triazolopyidines et leur utilisation pour traiter le cancer - Google Patents
Composés amino-triazolopyidines et leur utilisation pour traiter le cancerInfo
- Publication number
- MA47079A MA47079A MA047079A MA47079A MA47079A MA 47079 A MA47079 A MA 47079A MA 047079 A MA047079 A MA 047079A MA 47079 A MA47079 A MA 47079A MA 47079 A MA47079 A MA 47079A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- salts
- triazolopyidine
- amino
- treat cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne d'une manière générale des composés de formule (i) et des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (i), r1 et r2 peuvent prendre une quelconque des significations définies dans la description. L'invention concerne également l'utilisation de ces composés et de leurs sels pour traiter ou prévenir une maladie induite par dna-pk, y compris le cancer. L'invention concerne en outre, des compositions pharmaceutiques et des kits comprenant lesdits composés et sels ; des procédés de fabrication desdits composés et sels ; des intermédiaires utiles dans la fabrication desdits composés et sels ; et des procédés de traitement de maladies induites par dna-pk, y compris le cancer, par l'utilisation desdits composés et sels.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436619P | 2016-12-20 | 2016-12-20 | |
| PCT/EP2017/083625 WO2018114999A1 (fr) | 2016-12-20 | 2017-12-19 | Composés amino-triazolopyridine et leur utilisation dans le traitement du cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA47079A true MA47079A (fr) | 2019-10-30 |
| MA47079B1 MA47079B1 (fr) | 2021-05-31 |
Family
ID=60937727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA47079A MA47079B1 (fr) | 2016-12-20 | 2017-12-19 | Composés amino-triazolopyidines et leur utilisation pour traiter le cancer |
Country Status (39)
| Country | Link |
|---|---|
| US (4) | US10407446B2 (fr) |
| EP (1) | EP3558997B1 (fr) |
| JP (1) | JP6883653B2 (fr) |
| KR (1) | KR102220971B1 (fr) |
| CN (1) | CN110177791B (fr) |
| AR (1) | AR110400A1 (fr) |
| AU (1) | AU2017384388B2 (fr) |
| BR (1) | BR112019012217B1 (fr) |
| CA (1) | CA3046339C (fr) |
| CL (1) | CL2019001714A1 (fr) |
| CO (1) | CO2019007810A2 (fr) |
| CR (1) | CR20190301A (fr) |
| CY (1) | CY1124239T1 (fr) |
| DK (1) | DK3558997T3 (fr) |
| DO (1) | DOP2019000168A (fr) |
| EA (1) | EA037745B1 (fr) |
| EC (1) | ECSP19044159A (fr) |
| ES (1) | ES2867274T3 (fr) |
| HR (1) | HRP20210548T1 (fr) |
| HU (1) | HUE054548T2 (fr) |
| IL (1) | IL267158B (fr) |
| JO (1) | JOP20190151B1 (fr) |
| LT (1) | LT3558997T (fr) |
| MA (1) | MA47079B1 (fr) |
| MX (1) | MX390535B (fr) |
| MY (1) | MY183036A (fr) |
| NI (1) | NI201900062A (fr) |
| NZ (1) | NZ755222A (fr) |
| PE (1) | PE20191474A1 (fr) |
| PH (1) | PH12019501350B1 (fr) |
| PL (1) | PL3558997T3 (fr) |
| PT (1) | PT3558997T (fr) |
| RS (1) | RS61701B1 (fr) |
| SI (1) | SI3558997T1 (fr) |
| SM (1) | SMT202100225T1 (fr) |
| TW (1) | TWI776835B (fr) |
| UA (1) | UA123032C2 (fr) |
| WO (1) | WO2018114999A1 (fr) |
| ZA (1) | ZA201904695B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20191474A1 (es) | 2016-12-20 | 2019-10-16 | Astrazeneca Ab | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cancer |
| TWI820146B (zh) * | 2018-06-15 | 2023-11-01 | 瑞典商阿斯特捷利康公司 | 嘌呤酮化合物及其在治療癌症中之用途 |
| WO2020186211A1 (fr) * | 2019-03-13 | 2020-09-17 | The Uab Research Foundation | Procédés et compositions pour le traitement d'une infection par le polyomavirus |
| TWI899080B (zh) * | 2019-05-27 | 2025-10-01 | 大陸商迪哲(江蘇)醫藥股份有限公司 | Dna依賴性蛋白激酶抑制劑 |
| US20230022146A1 (en) | 2019-06-17 | 2023-01-26 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| CA3159110A1 (fr) * | 2019-11-22 | 2021-05-27 | Kevin X Chen | Composes spiro pyrimidopyrrole et leurs derives en tant qu'inhibiteurs de la proteine dna-pk |
| CA3159290A1 (fr) * | 2019-11-25 | 2021-06-03 | Kevin X Chen | Composes de pyrimidoimidazole utilises en tant qu'inhibiteurs de la dna-pk |
| PE20221324A1 (es) * | 2019-11-26 | 2022-09-09 | Primmune Therapeutics Inc | Agonistas del tlr7 |
| EP4086258A4 (fr) * | 2019-12-31 | 2023-11-29 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Dérivé purine et son utilisation médicale |
| CN113121573A (zh) * | 2019-12-31 | 2021-07-16 | 成都百裕制药股份有限公司 | 嘌呤衍生物及其在医药上的应用 |
| WO2021136462A1 (fr) * | 2019-12-31 | 2021-07-08 | 成都百裕制药股份有限公司 | Dérivés furane et leur application en médecine |
| CN113493471B (zh) * | 2020-04-03 | 2024-06-11 | 山东轩竹医药科技有限公司 | 杂芳环类激酶抑制剂 |
| AU2021256235B2 (en) * | 2020-04-17 | 2024-05-09 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Imidazolidinone derivatives and medical use thereof |
| CN113549092B (zh) * | 2020-04-23 | 2022-10-18 | 山东轩竹医药科技有限公司 | 三并环类激酶抑制剂 |
| KR20230017783A (ko) | 2020-04-28 | 2023-02-06 | 인텔리아 테라퓨틱스, 인크. | 시험관내 세포 전달 방법 |
| WO2021260583A1 (fr) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur de la dna-pk |
| WO2022017368A1 (fr) * | 2020-07-20 | 2022-01-27 | 首药控股(北京)股份有限公司 | Inhibiteur sélectif de dna-pk, son procédé de préparation et son utilisation |
| US12280049B2 (en) * | 2020-08-04 | 2025-04-22 | Astrazeneca Ab | Methods of delaying pain progression and treating prostate cancer |
| CN114249753A (zh) * | 2020-09-22 | 2022-03-29 | 山东轩竹医药科技有限公司 | 三唑并吡啶类激酶抑制剂 |
| AU2021346954A1 (en) * | 2020-09-24 | 2023-05-25 | Auckland Uniservices Limited | Novel aminopyridines and their use in treating cancer |
| CN114573605A (zh) * | 2020-12-01 | 2022-06-03 | 武汉光谷亚太医药研究院有限公司 | Dna依赖蛋白激酶抑制剂及其应用 |
| CN114634522A (zh) * | 2020-12-15 | 2022-06-17 | 江苏恒瑞医药股份有限公司 | 嘌呤酮衍生物、其制备方法及其在医药上的应用 |
| CA3205138A1 (fr) | 2020-12-17 | 2022-06-23 | Vertex Pharmaceuticals Incorporated | Compositions et procedes pour l'edition de beta-globine pour le traitement d'hemoglobinopathies |
| TW202241901A (zh) * | 2020-12-21 | 2022-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 嘌呤酮衍生物、其製備方法及其在醫藥上的應用 |
| CN114656487B (zh) * | 2020-12-22 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 稠合嘧啶类化合物、其制备方法及其在医药上的应用 |
| WO2022135555A1 (fr) * | 2020-12-24 | 2022-06-30 | 江苏恒瑞医药股份有限公司 | Composé de purinone, son procédé de préparation et son application pharmaceutique |
| CN116917288B (zh) * | 2021-03-22 | 2026-04-14 | 成都赜灵生物医药科技股份有限公司 | 一种7,9-二氢嘌呤衍生物及其制药用途 |
| MX2023012236A (es) | 2021-04-17 | 2024-01-23 | Intellia Therapeutics Inc | Inhibidores de proteína cinasa dependente de acido desoxirribonucleico (and) y composiciones y usos de los mismos. |
| EP4342899A1 (fr) * | 2021-05-19 | 2024-03-27 | Zai Lab (Shanghai) Co., Ltd. | Forme saline et forme cristalline d'un dérivé de purinone substitué hétérocyclique |
| WO2023274310A1 (fr) * | 2021-06-29 | 2023-01-05 | 成都百裕制药股份有限公司 | Forme cristalline de dérivés de purine et leurs compositions pharmaceutiques |
| CN116023393B (zh) * | 2021-10-25 | 2025-08-12 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| CN116023394B (zh) * | 2021-10-25 | 2025-08-12 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| CN116023395B (zh) * | 2021-10-25 | 2025-07-15 | 山东轩竹医药科技有限公司 | 三环类激酶抑制剂的晶型 |
| US20250305004A1 (en) * | 2022-05-13 | 2025-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancing gene targeting efficiency in human cells with dna-pk inhibitor treatment |
| AU2023389547A1 (en) | 2022-12-06 | 2025-07-17 | Astrazeneca Ab | Polq inhibitors |
| CN121794270A (zh) * | 2023-07-21 | 2026-04-03 | 钟卫 | 取代的2-氨基-9-(3,3-二氟哌啶-4-基)-7,9-二氢-8h-嘌呤-8-酮化合物及其在癌症治疗中的用途 |
| WO2025049481A1 (fr) | 2023-08-28 | 2025-03-06 | Intellia Therapeutics, Inc. | Procédés d'édition in vitro d'un gène hla-a |
| WO2025181336A1 (fr) | 2024-03-01 | 2025-09-04 | Cellectis Sa | Compositions et procédés d'édition de hbb dans hspc |
| WO2025248119A1 (fr) | 2024-05-31 | 2025-12-04 | Astrazeneca Ab | Dérivés de 6-(cyclo)alcoxypurine utiles en tant qu'inhibiteurs de polq |
| WO2025248117A1 (fr) | 2024-05-31 | 2025-12-04 | Astrazeneca Ab | Dérivés de 6-aminopurine utiles en tant qu'inhibiteurs de polq |
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| BR112013026744B1 (pt) | 2011-04-21 | 2022-05-17 | Origenis Gmbh | Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica |
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-
2017
- 2017-12-19 PE PE2019001276A patent/PE20191474A1/es unknown
- 2017-12-19 KR KR1020197021026A patent/KR102220971B1/ko active Active
- 2017-12-19 BR BR112019012217-6A patent/BR112019012217B1/pt active IP Right Grant
- 2017-12-19 NZ NZ755222A patent/NZ755222A/en unknown
- 2017-12-19 PT PT178258299T patent/PT3558997T/pt unknown
- 2017-12-19 SM SM20210225T patent/SMT202100225T1/it unknown
- 2017-12-19 MY MYPI2019003492A patent/MY183036A/en unknown
- 2017-12-19 EA EA201991399A patent/EA037745B1/ru unknown
- 2017-12-19 JO JOP/2019/0151A patent/JOP20190151B1/ar active
- 2017-12-19 LT LTEP17825829.9T patent/LT3558997T/lt unknown
- 2017-12-19 HU HUE17825829A patent/HUE054548T2/hu unknown
- 2017-12-19 AU AU2017384388A patent/AU2017384388B2/en active Active
- 2017-12-19 SI SI201730707T patent/SI3558997T1/sl unknown
- 2017-12-19 AR ARP170103582A patent/AR110400A1/es active IP Right Grant
- 2017-12-19 UA UAA201907754A patent/UA123032C2/uk unknown
- 2017-12-19 ES ES17825829T patent/ES2867274T3/es active Active
- 2017-12-19 WO PCT/EP2017/083625 patent/WO2018114999A1/fr not_active Ceased
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2019
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2021
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2023
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