MA38391A1 - Dérivés de pyridinyl et triazolone pyridinyl de fusion - Google Patents

Dérivés de pyridinyl et triazolone pyridinyl de fusion

Info

Publication number
MA38391A1
MA38391A1 MA38391A MA38391A MA38391A1 MA 38391 A1 MA38391 A1 MA 38391A1 MA 38391 A MA38391 A MA 38391A MA 38391 A MA38391 A MA 38391A MA 38391 A1 MA38391 A1 MA 38391A1
Authority
MA
Morocco
Prior art keywords
pyridinyl
compounds
formula
triazolone
fusion
Prior art date
Application number
MA38391A
Other languages
English (en)
Other versions
MA38391B1 (fr
Inventor
John David Lawson
Mark Sabat
Nicholas Scorah
Christopher Smith
Phong H Vu
Haixia Wang
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of MA38391A1 publication Critical patent/MA38391A1/fr
Publication of MA38391B1 publication Critical patent/MA38391B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés de formule 1 ou des sels pharmaceutiquement acceptables de ceux-ci, dans la formule, r1, r2, r3, et r4 sont tels que définis dans la description. Cette invention concerne également des matières et des procédés permettant de préparer les composés de formule 1, des compositions pharmaceutiques contenant ces composés, ainsi que leur utilisation pour traiter des réactions d'hypersensibilité de type i, des maladies auto-immunes, des troubles inflammatoires, le cancer, des troubles proliférants bénins, et d'autres états associés à la tyrosine kinase de bruton (btk).
MA38391A 2013-03-11 2014-03-10 Dérivés de pyridinyl et triazolone pyridinyl de fusion MA38391B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776445P 2013-03-11 2013-03-11
PCT/US2014/022801 WO2014164558A1 (fr) 2013-03-11 2014-03-10 Dérivés de pyridinyl et triazolone pyridinyl de fusion

Publications (2)

Publication Number Publication Date
MA38391A1 true MA38391A1 (fr) 2018-01-31
MA38391B1 MA38391B1 (fr) 2018-09-28

Family

ID=50543655

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38391A MA38391B1 (fr) 2013-03-11 2014-03-10 Dérivés de pyridinyl et triazolone pyridinyl de fusion

Country Status (43)

Country Link
US (4) US9402841B2 (fr)
EP (2) EP2970202B1 (fr)
JP (2) JP6271700B2 (fr)
KR (1) KR102300612B1 (fr)
CN (1) CN105121427B (fr)
AP (1) AP2015008646A0 (fr)
AR (1) AR095198A1 (fr)
AU (1) AU2014249248B2 (fr)
BR (1) BR112015020264B1 (fr)
CA (1) CA2899948C (fr)
CL (1) CL2015002370A1 (fr)
CR (1) CR20150470A (fr)
CY (1) CY1119356T1 (fr)
DK (1) DK2970202T3 (fr)
DO (1) DOP2015000184A (fr)
EA (1) EA028584B1 (fr)
EC (1) ECSP15042779A (fr)
ES (2) ES2624439T3 (fr)
GE (1) GEP201706778B (fr)
HK (1) HK1245256B (fr)
HR (1) HRP20170622T1 (fr)
HU (1) HUE032720T2 (fr)
IL (1) IL240353B (fr)
JO (1) JO3377B1 (fr)
LT (1) LT2970202T (fr)
MA (1) MA38391B1 (fr)
ME (1) ME02693B (fr)
MX (1) MX364527B (fr)
MY (1) MY183927A (fr)
PE (1) PE20151889A1 (fr)
PH (1) PH12015502046B1 (fr)
PL (1) PL2970202T3 (fr)
PT (1) PT2970202T (fr)
RS (1) RS55879B1 (fr)
SG (1) SG11201506112QA (fr)
SI (1) SI2970202T1 (fr)
SM (1) SMT201700218T1 (fr)
TN (1) TN2015000342A1 (fr)
TW (1) TWI637950B (fr)
UA (1) UA114944C2 (fr)
UY (1) UY35376A (fr)
WO (1) WO2014164558A1 (fr)
ZA (1) ZA201505996B (fr)

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KR102391693B1 (ko) 2016-06-29 2022-04-29 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제
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KR102459858B1 (ko) * 2019-04-02 2022-10-27 연세대학교 산학협력단 신규 화합물 및 이를 유효성분으로 포함하는 호흡기 질환의 예방 또는 치료용 조성물
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TWI877239B (zh) 2019-10-14 2025-03-21 美商普林斯匹亞生物製藥公司 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法
EP4054579A1 (fr) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase
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JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج

Also Published As

Publication number Publication date
US20180015083A1 (en) 2018-01-18
PH12015502046A1 (en) 2016-01-18
KR20150126687A (ko) 2015-11-12
IL240353A0 (en) 2015-09-24
BR112015020264A2 (pt) 2017-07-18
MX364527B (es) 2019-04-30
EP3235814B1 (fr) 2018-12-12
SI2970202T1 (sl) 2017-07-31
EP3235814A1 (fr) 2017-10-25
ES2714166T3 (es) 2019-05-27
TWI637950B (zh) 2018-10-11
US10307414B2 (en) 2019-06-04
JP2018076357A (ja) 2018-05-17
UY35376A (es) 2014-10-31
ECSP15042779A (es) 2017-08-31
MA38391B1 (fr) 2018-09-28
US20160310483A1 (en) 2016-10-27
GEP201706778B (en) 2017-11-27
PH12015502046B1 (en) 2019-01-23
AP2015008646A0 (en) 2015-08-31
AU2014249248B2 (en) 2017-08-17
EP2970202A1 (fr) 2016-01-20
US20140256734A1 (en) 2014-09-11
ZA201505996B (en) 2016-11-30
HK1220183A1 (en) 2017-04-28
AU2014249248A1 (en) 2015-08-20
MX2015011533A (es) 2016-02-03
CN105121427A (zh) 2015-12-02
US9402841B2 (en) 2016-08-02
DOP2015000184A (es) 2015-11-30
TW201522328A (zh) 2015-06-16
CY1119356T1 (el) 2018-02-14
SMT201700218T1 (it) 2017-07-18
WO2014164558A1 (fr) 2014-10-09
UA114944C2 (uk) 2017-08-28
EA028584B1 (ru) 2017-12-29
ES2624439T3 (es) 2017-07-14
DK2970202T3 (en) 2017-05-08
HUE032720T2 (en) 2017-10-30
JP2016512515A (ja) 2016-04-28
SG11201506112QA (en) 2015-09-29
PT2970202T (pt) 2017-05-03
KR102300612B1 (ko) 2021-09-09
MY183927A (en) 2021-03-17
CR20150470A (es) 2016-01-11
RS55879B1 (sr) 2017-08-31
JP6271700B2 (ja) 2018-01-31
JP6462842B2 (ja) 2019-01-30
LT2970202T (lt) 2017-06-12
CA2899948A1 (fr) 2014-10-09
TN2015000342A1 (en) 2017-01-03
AR095198A1 (es) 2015-09-30
IL240353B (en) 2018-11-29
NZ710852A (en) 2020-12-18
EA201591686A1 (ru) 2015-12-30
US9801872B2 (en) 2017-10-31
EP2970202B1 (fr) 2017-02-01
ME02693B (fr) 2017-10-20
JO3377B1 (ar) 2019-03-13
PL2970202T3 (pl) 2017-08-31
CL2015002370A1 (es) 2016-03-11
HRP20170622T1 (hr) 2017-06-30
CN105121427B (zh) 2018-04-10
HK1245256B (en) 2019-09-27
PE20151889A1 (es) 2015-12-26
CA2899948C (fr) 2021-11-16
US20190224190A1 (en) 2019-07-25
BR112015020264B1 (pt) 2021-03-02

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