MA47380A - Composé de prolineamide substitué par un phényldifluorométhyle - Google Patents

Composé de prolineamide substitué par un phényldifluorométhyle

Info

Publication number
MA47380A
MA47380A MA047380A MA47380A MA47380A MA 47380 A MA47380 A MA 47380A MA 047380 A MA047380 A MA 047380A MA 47380 A MA47380 A MA 47380A MA 47380 A MA47380 A MA 47380A
Authority
MA
Morocco
Prior art keywords
phenyldifluoromethyl
substituted
prolineamide compound
compound
substituted prolineamide
Prior art date
Application number
MA047380A
Other languages
English (en)
Inventor
Yu Harayama
Sunao Imada
Shunichiro Matsumoto
Yutaka Nakajima
Kazuyuki Tsuchiya
Eriko Yamamoto
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MA47380A publication Critical patent/MA47380A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MA047380A 2017-01-24 2018-01-23 Composé de prolineamide substitué par un phényldifluorométhyle MA47380A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2017010321 2017-01-24

Publications (1)

Publication Number Publication Date
MA47380A true MA47380A (fr) 2021-03-17

Family

ID=62979051

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047380A MA47380A (fr) 2017-01-24 2018-01-23 Composé de prolineamide substitué par un phényldifluorométhyle

Country Status (31)

Country Link
US (2) US10322997B2 (fr)
EP (1) EP3575284B1 (fr)
JP (1) JP7001068B2 (fr)
KR (1) KR102553613B1 (fr)
CN (2) CN110248925B (fr)
AR (1) AR110767A1 (fr)
AU (1) AU2018211735B2 (fr)
BR (1) BR112019014788A2 (fr)
CA (1) CA3050224A1 (fr)
CO (1) CO2019009090A2 (fr)
CY (1) CY1124906T1 (fr)
DK (1) DK3575284T3 (fr)
ES (1) ES2892400T3 (fr)
HR (1) HRP20211613T1 (fr)
HU (1) HUE056920T2 (fr)
IL (1) IL268060B (fr)
JO (1) JOP20190181B1 (fr)
LT (1) LT3575284T (fr)
MA (1) MA47380A (fr)
MX (1) MX379651B (fr)
MY (1) MY195587A (fr)
PH (1) PH12019501645A1 (fr)
PL (1) PL3575284T3 (fr)
PT (1) PT3575284T (fr)
RS (1) RS62477B1 (fr)
SG (1) SG11201906777TA (fr)
SI (1) SI3575284T1 (fr)
TW (1) TWI764976B (fr)
UA (1) UA124036C2 (fr)
WO (1) WO2018139438A1 (fr)
ZA (1) ZA201904741B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4467565A3 (fr) 2016-12-21 2025-03-12 Amgen Inc. Formulations d'anticorps anti-tnf alpha

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20040800B1 (en) * 2002-03-05 2012-11-30 Merck Frosst Canada & Co Axys Cathepsin cysteine protease inhibitors
JP2010121918A (ja) 2008-11-17 2010-06-03 Hiroyoshi Asada 鍋等の取っ手部分の焼き焦げ防止具。
RU2535479C2 (ru) 2009-04-20 2014-12-10 Ф.Хоффманн-Ля Рош Аг Производные пролина в качестве ингибиторов катепсина
US7893099B2 (en) * 2009-06-11 2011-02-22 Hoffman-La Roche Inc. Cyclopentane derivatives
JP2012059507A (ja) 2010-09-08 2012-03-22 Panasonic Corp 基板間接続コネクタ構造
US8524710B2 (en) 2010-11-05 2013-09-03 Hoffmann-La Roche Inc. Pyrrolidine derivatives
DK2776392T3 (en) * 2011-11-11 2016-07-04 Hoffmann La Roche PROCESS FOR THE PREPARATION OF 1-acyl-4-PHENYLSULFONYLPROLINAMID DERIVATIVES AND NEW INTERMEDIATE
US8802665B2 (en) * 2012-02-17 2014-08-12 Genentech, Inc. Pyrrolidine derivatives
WO2014029722A1 (fr) 2012-08-21 2014-02-27 F. Hoffmann-La Roche Ag Nouveaux dérivés de pyridine
RU2692799C2 (ru) 2013-10-08 2019-06-27 Мерк Шарп И Доум Корп. Ингибиторы цистеинпротеаз катепсинов
WO2015051479A1 (fr) * 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine-protéases de type cathepsines
PT3419970T (pt) 2016-02-26 2020-02-28 H Hoffnabb La Roche Ag Novos derivados de pirrolidina

Also Published As

Publication number Publication date
TW201840531A (zh) 2018-11-16
CY1124906T1 (el) 2023-01-05
US10322997B2 (en) 2019-06-18
HUE056920T2 (hu) 2022-03-28
MX379651B (es) 2025-03-11
SG11201906777TA (en) 2019-08-27
LT3575284T (lt) 2021-10-25
EP3575284A1 (fr) 2019-12-04
BR112019014788A2 (pt) 2020-02-27
IL268060A (en) 2019-09-26
AR110767A1 (es) 2019-05-02
UA124036C2 (uk) 2021-07-07
PH12019501645A1 (en) 2020-03-09
RU2019122734A3 (fr) 2021-05-31
KR20190110549A (ko) 2019-09-30
TWI764976B (zh) 2022-05-21
HRP20211613T1 (hr) 2022-02-04
RS62477B1 (sr) 2021-11-30
AU2018211735B2 (en) 2021-08-12
CN111574422A (zh) 2020-08-25
EP3575284A4 (fr) 2020-08-12
MY195587A (en) 2023-02-02
SI3575284T1 (sl) 2021-11-30
KR102553613B1 (ko) 2023-07-07
ES2892400T3 (es) 2022-02-04
US20190248738A1 (en) 2019-08-15
JP7001068B2 (ja) 2022-01-19
EP3575284B1 (fr) 2021-08-25
JOP20190181B1 (ar) 2023-09-17
CN110248925B (zh) 2020-07-17
CN111574422B (zh) 2023-09-08
US20190071398A1 (en) 2019-03-07
DK3575284T3 (da) 2021-10-18
CA3050224A1 (fr) 2018-08-02
PL3575284T3 (pl) 2021-12-27
IL268060B (en) 2021-09-30
WO2018139438A1 (fr) 2018-08-02
CO2019009090A2 (es) 2019-08-30
ZA201904741B (en) 2020-12-23
PT3575284T (pt) 2021-10-01
RU2019122734A (ru) 2021-02-26
MX2019008756A (es) 2019-09-11
US10532979B2 (en) 2020-01-14
AU2018211735A1 (en) 2019-08-01
CN110248925A (zh) 2019-09-17
JOP20190181A1 (ar) 2019-07-22
JPWO2018139438A1 (ja) 2019-11-07

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