MA47775A - Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire - Google Patents

Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire

Info

Publication number
MA47775A
MA47775A MA047775A MA47775A MA47775A MA 47775 A MA47775 A MA 47775A MA 047775 A MA047775 A MA 047775A MA 47775 A MA47775 A MA 47775A MA 47775 A MA47775 A MA 47775A
Authority
MA
Morocco
Prior art keywords
control
cell culture
antibodies produced
afucosylated glycoforms
total afucosylated
Prior art date
Application number
MA047775A
Other languages
English (en)
Inventor
Prince Bhebe
Chung-Jr Huang
Madiha Khurshid
Li Zhang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA47775A publication Critical patent/MA47775A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
MA047775A 2017-03-14 2018-03-14 Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire MA47775A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471347P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
MA47775A true MA47775A (fr) 2020-01-22

Family

ID=61873969

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047775A MA47775A (fr) 2017-03-14 2018-03-14 Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire

Country Status (10)

Country Link
US (2) US12503700B2 (fr)
EP (1) EP3596225A1 (fr)
JP (3) JP7672196B2 (fr)
CN (1) CN110418846A (fr)
AU (2) AU2018235928B2 (fr)
CA (1) CA3056011A1 (fr)
IL (1) IL269197A (fr)
MA (1) MA47775A (fr)
SG (1) SG11201908328XA (fr)
WO (1) WO2018170099A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10961305B2 (en) 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
JP7471220B2 (ja) 2017-11-30 2024-04-19 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 哺乳動物細胞の培養方法
AU2020355251A1 (en) * 2019-09-26 2022-04-21 Amgen Inc. Methods of producing antibody compositions
US20230313259A1 (en) * 2020-08-14 2023-10-05 Bristol-Myers Squibb Company Manufacturing process for protein
AU2021360897A1 (en) 2020-10-15 2023-05-25 Amgen Inc. Relative unpaired glycans in antibody production methods
AR126089A1 (es) 2021-06-07 2023-09-13 Amgen Inc Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas
CN113584061B (zh) * 2021-07-30 2022-09-23 中国人民解放军空军军医大学 一种双途径拮抗pcsk9的重组基因、载体、外泌体及制备方法和应用
CN113684322B (zh) * 2021-09-09 2024-01-23 上海药明生物技术有限公司 一种降低抗体类蛋白高聚甘露糖型水平的方法
AU2024256160A1 (en) * 2023-04-20 2025-10-02 Amgen Inc. Methods of determining relative unpaired glycan content
WO2025141483A1 (fr) * 2023-12-29 2025-07-03 Intas Pharmaceuticals Ltd. Procédé de modulation du niveau de défucosylation du pertuzumab
WO2026090253A1 (fr) 2024-10-23 2026-04-30 Amgen Inc. Procédés de détermination de la teneur en appariement de glycanes

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (fr) 1988-10-31 1990-05-17 Immunex Corporation Recepteurs d'interleukine-4
US5714465A (en) 1989-05-19 1998-02-03 Amgen Inc. Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor
US7144731B2 (en) 1989-10-16 2006-12-05 Amgen Inc. SCF antibody compositions and methods of using the same
ATE255131T1 (de) * 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
US5574138A (en) 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US7211259B1 (en) 1993-05-07 2007-05-01 Immunex Corporation 4-1BB polypeptides and DNA encoding 4-1BB polypeptides
US7138500B1 (en) 1993-05-07 2006-11-21 Immunex Corporation Antibodies to human 4-1BB
US7045128B2 (en) 1993-05-24 2006-05-16 Immunex Corporation Antibodies against flt3-ligand
US6630143B1 (en) 1993-05-24 2003-10-07 Immunex Corporation Antibodies against flt3 ligand
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
US5919905A (en) 1994-10-05 1999-07-06 Immunex Corporation Cytokine designated LERK-6
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
AU720232B2 (en) 1996-07-19 2000-05-25 Amgen, Inc. Analogs of cationic proteins
PT951551E (pt) 1996-12-23 2008-10-28 Immunex Corp Ligando para receptor activador de nf-kb, ligando membro da superfamília de tnf
US5741772A (en) 1997-02-03 1998-04-21 Amgen Inc. Neurotrophic factor NNT-1
SI0975754T2 (sl) 1997-04-16 2016-04-29 Amgen Inc., Vezivni proteini in receptorji osteoprotegerina
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
DE69831754T2 (de) 1997-12-17 2006-06-29 Immunex Corp., Thousand Oaks Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden
WO1999032626A1 (fr) 1997-12-23 1999-07-01 Immunex Corporation Adn et polypeptides sigirr
US6562618B1 (en) 1997-12-25 2003-05-13 Japan Tobacco, Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
AU750767B2 (en) 1998-01-23 2002-07-25 Immunex Corporation ACPL DNA and polypeptides
DE69942861D1 (de) 1998-08-07 2010-11-25 Immunex Corp Ldcam genannte moleküle
EP1108042B1 (fr) 1998-08-07 2008-11-26 Immunex Corporation Molecules designees b7l-1
ES2288036T5 (es) 1998-11-13 2017-07-06 Immunex Corporation ADN de TSLP humano y polipéptidos
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
JP2001206899A (ja) 1999-11-18 2001-07-31 Japan Tobacco Inc ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
WO2001092340A2 (fr) 2000-05-26 2001-12-06 Immunex Corporation Utilisation d'antagonistes vis-a-vis de l'interleukine-4 (il-4) et compositions correspondantes
CA2421588C (fr) 2000-09-05 2010-01-26 Amgen Inc. Molecules analogues au recepteur du tnf et ses utilisations
PA8535501A1 (es) 2001-01-05 2003-07-28 Pfizer Anticuerpos contra el receptor del factor de crecimiento similar a insulina
US6887687B2 (en) 2001-07-30 2005-05-03 Immunex Corporation Nucleic acids encoding human ataxin-1-like polypeptide IMX97018
US7084257B2 (en) 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
EP2360169B1 (fr) 2001-10-23 2015-10-14 Psma Development Company, L.L.C. Anticorps contre le PSMA
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
CA2467597A1 (fr) 2001-12-03 2003-06-12 Abgenix, Inc. Anticorps anti-cd45rb s'utilisant dans le traitement de maladies auto-immunes et de rejet de greffon
EP1461082A4 (fr) 2001-12-03 2006-06-28 Abgenix Inc Anticorps contre l'antigene tumoral de l'anhydrase carbonique ix (ca ix)
EP1467757B1 (fr) 2001-12-28 2008-05-07 Amgen Fremont Inc. Utilisation d'anticorps diriges contre l'antigene muc18
WO2003057838A2 (fr) 2001-12-28 2003-07-17 Abgenix, Inc. Anticorps contre l'antigene muc18
JP2005516965A (ja) 2001-12-28 2005-06-09 アブジェニックス・インコーポレーテッド 抗ｍｕｃ１８抗体を使用する方法
US7135174B2 (en) 2002-01-07 2006-11-14 Amgen Fremont, Inc. Antibodies directed to PDGFD and uses thereof
ATE435239T1 (de) 2002-03-29 2009-07-15 Schering Corp Menschliche monoklonale antikörper gegen interleukin-5 sowie diese umfassende verfahren und zusammensetzungen
EP2314316A1 (fr) 2002-04-05 2011-04-27 Amgen, Inc Anticorps humain anti-OPGL neutralizant comme inhibiteurs selectifs de la voie de signalisaition par l'OPGL
HRP20050986A2 (en) 2002-08-19 2006-11-30 Abgenix Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof
CN104178491B (zh) 2002-09-06 2018-07-03 安姆根有限公司 治疗性人抗-il-1r1单克隆抗体
WO2004034988A2 (fr) 2002-10-16 2004-04-29 Amgen Inc. Anticorps humains neutralisants anti-ifn-$g(g) utilises comme inhibiteurs selectifs des voies de ifn-$g(g)
ATE472556T1 (de) 2002-12-02 2010-07-15 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
US7429491B2 (en) 2003-05-15 2008-09-30 Wyeth Restricted glucose feed for animal cell culture
US7736644B2 (en) 2003-06-27 2010-06-15 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
MEP31508A (hr) 2003-07-15 2010-10-10 Amgen Inc Humana anti-ngf neutrališuća antitijela kao selektivni ihibitori ngf signalne kaskade
ATE554108T1 (de) 2003-07-25 2012-05-15 Amgen Inc Verfahren bezüglich ldcam und crtam
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
US7318925B2 (en) 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
US7288253B2 (en) 2003-08-08 2007-10-30 Amgen Fremont, Inc. Antibodies directed to parathyroid hormone (PTH) and uses thereof
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
NZ547588A (en) 2003-11-07 2009-05-31 Immunex Corp Antibodies that bind interleukin-4 receptor
WO2005058961A2 (fr) 2003-12-12 2005-06-30 Amgen Inc. Anticorps anti-galanine et leurs utilisations
MX370489B (es) 2004-01-09 2019-12-16 Pfizer Anticuerpos contra madcam.
EP1751191A2 (fr) 2004-04-23 2007-02-14 Amgen Inc. Anticorps de l'angiogenèse inhibant des domaines de cd148
BRPI0510079A (pt) 2004-04-23 2007-10-16 Amgen Inc anticorpo isolado ou região de ligação de antìgeno do mesmo, célula de hibridoma, célula de transfectoma, anticorpo monoclonal ou região de ligação de antìgeno do mesmo, animal não humano transgênico, método para produzir um anticorpo ou região de ligação de antìgeno do mesmo, composição farmacêutica, uso do anticorpo ou região de ligação de antìgeno, polipeptìdeo isolado, imunoensaio, e, método para identificar um composto
CA2574881C (fr) 2004-08-04 2013-01-08 Amgen Inc. Anticorps contre dkk-1
US7423128B2 (en) 2004-11-03 2008-09-09 Amgen Fremont Inc. Anti-properdin antibodies, and methods for making and using same
JP2008520684A (ja) 2004-11-17 2008-06-19 アブジェニックス・インコーポレーテッド Ｉｌ−１３に対する完全ヒトモノクローナル抗体
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
CA2589860A1 (fr) 2005-01-24 2006-08-03 Amgen Inc. Anticorps anti-amyloide humanise
EP1851245B1 (fr) 2005-01-26 2012-10-10 Amgen Fremont Inc. Anticorps dirigés contre l'interleukine-1 beta
US8323645B2 (en) 2005-03-24 2012-12-04 Millennium Pharmaceuticals, Inc. Antibodies that bind OV064 and methods of use therefor
EP1877075A4 (fr) 2005-04-25 2008-07-30 Pfizer Anticorps diriges contre la myostatine
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
DK1915398T3 (en) 2005-07-18 2016-07-04 Amgen Inc Humane anti-B7RP1 neutraliserende antistoffer
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
KR101536506B1 (ko) 2005-09-07 2015-07-14 암젠 프레몬트 인코포레이티드 액티빈 수용체 유사 키나제-1에 대한 인간 모노클로날 항체
ATE552853T1 (de) 2005-12-13 2012-04-15 Medimmune Ltd Proteine die spezifisch insulin-ähnliche wachstumsfaktoren binden, und deren anwendungen
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
US7888482B2 (en) 2006-02-10 2011-02-15 Amgen Inc. Antibodies that bind PAR-2
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之ｃ-ｋｉｔ抗體
US7728110B2 (en) 2006-05-19 2010-06-01 Amgen, Inc. Antibodies to SARS coronavirus
WO2008008482A2 (fr) 2006-07-13 2008-01-17 Genentech, Inc. Polypeptides de liaison à br3 modifiés
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
CL2007002668A1 (es) 2006-09-20 2008-05-09 Amgen Inc Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2.
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
NZ576032A (en) 2006-10-12 2012-03-30 Genentech Inc Antibodies to lymphotoxin-alpha
CA2663536A1 (fr) 2006-10-24 2008-05-02 Trubion Pharmaceuticals, Inc. Module de dispositif electronique comprenant un copolymere de polyolefine
PA8775101A1 (es) 2007-04-02 2008-11-19 Pfizer Anticuerpos anti-ige
CL2008001887A1 (es) 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
RS56743B1 (sr) 2007-08-21 2018-03-30 Amgen Inc Humani c-fms antigen vezujući proteini
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
CA2709354C (fr) 2007-12-21 2014-06-17 Amgen Inc. Anticorps anti-amyloide et utilisations de ceux-ci
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
JP2011519279A (ja) 2008-05-01 2011-07-07 アムジエン・インコーポレーテツド 抗ヘプシジン抗体及び使用の方法
WO2010107752A2 (fr) 2009-03-20 2010-09-23 Amgen Inc. Anticorps antagoniste spécifique d'un hétérodimère alpha-4-bêta-7
WO2011019622A1 (fr) 2009-08-14 2011-02-17 Genentech, Inc. Procédés de culture cellulaire pour produire des anticorps avec une fonction de cytoxicité à médiation des cellules dépendante des anticorps
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
CA2794697A1 (fr) 2010-04-07 2011-10-13 Momenta Pharmaceuticals, Inc. Glycanes a haute teneur en mannose
WO2013114164A1 (fr) * 2012-01-30 2013-08-08 Dr. Reddy's Laboratories Limited Procédé d'obtention d'une composition glycoprotéique ayant une concentration accrue d'afucosylation
EP2809773B1 (fr) 2012-01-30 2020-09-02 Dr. Reddy's Laboratories Limited Procédé de modulation de man5 et/ou du taux d'afucosylation d'une composition de glycoprotéine
WO2013114167A1 (fr) * 2012-01-30 2013-08-08 Dr. Reddy's Laboratories Limited Procédé d'obtention d'une composition de glycoforme
WO2013114248A1 (fr) 2012-01-31 2013-08-08 Fundamo (Pty) Ltd Système de paiement de communication sonore proche
EP2765197A1 (fr) 2013-02-11 2014-08-13 ETH Zurich Capteur de pH de concepteur en tant que commande transgène universelle
US9677105B2 (en) 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
US9856502B2 (en) 2013-07-23 2018-01-02 Biocon Limited Methods for controlling fucosylation levels in proteins
BR112016017606A2 (pt) * 2014-01-29 2017-10-10 Amgen Inc superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes
WO2015128793A1 (fr) * 2014-02-25 2015-09-03 Dr. Reddy’S Laboratories Limited Procédé pour modifier une composition de glycoprotéine afin d'obtenir une forte teneur en mannose et une galactosylation réduite
WO2015128795A1 (fr) * 2014-02-25 2015-09-03 Dr. Reddy's Laboratories Limited Procédé de modification de la galactosylation et de la teneur en g0f d'une composition de glycoprotéine par un apport complémentaire en glutamine
WO2015128314A1 (fr) 2014-02-27 2015-09-03 F. Hoffmann-La Roche Ag Modulation de la croissance cellulaire et de la glycosylation dans la production de glycoprotéines de recombinaison
WO2015140700A1 (fr) 2014-03-19 2015-09-24 Dr. Reddy's Laboratories Limited Procédé de culture cellulaire
WO2015152219A1 (fr) 2014-03-31 2015-10-08 株式会社堀場製作所 Electrode, electrode composite et analyseur de liquide
PL3227454T3 (pl) * 2014-12-01 2020-07-27 Amgen Inc. Sposób manipulowania poziomem zawartości glikanów w glikoproteinie

Also Published As

Publication number Publication date
SG11201908328XA (en) 2019-10-30
JP7672196B2 (ja) 2025-05-07
JP2023055711A (ja) 2023-04-18
WO2018170099A1 (fr) 2018-09-20
AU2018235928A1 (en) 2019-09-26
EP3596225A1 (fr) 2020-01-22
US20260103716A1 (en) 2026-04-16
CN110418846A (zh) 2019-11-05
JP2020513813A (ja) 2020-05-21
AU2018235928B2 (en) 2023-09-21
JP2025098016A (ja) 2025-07-01
US12503700B2 (en) 2025-12-23
IL269197A (en) 2019-11-28
US20200131518A1 (en) 2020-04-30
AU2023285706A1 (en) 2024-01-18
CA3056011A1 (fr) 2018-09-20

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