MA47775A - Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire - Google Patents

Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire

Info

Publication number
MA47775A
MA47775A MA047775A MA47775A MA47775A MA 47775 A MA47775 A MA 47775A MA 047775 A MA047775 A MA 047775A MA 47775 A MA47775 A MA 47775A MA 47775 A MA47775 A MA 47775A
Authority
MA
Morocco
Prior art keywords
control
cell culture
antibodies produced
afucosylated glycoforms
total afucosylated
Prior art date
Application number
MA047775A
Other languages
English (en)
Inventor
Prince Bhebe
Chung-Jr Huang
Madiha Khurshid
Li Zhang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA47775A publication Critical patent/MA47775A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
MA047775A 2017-03-14 2018-03-14 Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire MA47775A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471347P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
MA47775A true MA47775A (fr) 2020-01-22

Family

ID=61873969

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047775A MA47775A (fr) 2017-03-14 2018-03-14 Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire

Country Status (10)

Country Link
US (2) US12503700B2 (fr)
EP (1) EP3596225A1 (fr)
JP (3) JP7672196B2 (fr)
CN (1) CN110418846A (fr)
AU (2) AU2018235928B2 (fr)
CA (1) CA3056011A1 (fr)
IL (1) IL269197A (fr)
MA (1) MA47775A (fr)
SG (1) SG11201908328XA (fr)
WO (1) WO2018170099A1 (fr)

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KR20230087539A (ko) 2020-10-15 2023-06-16 암젠 인크 항체 생산 방법에서의 상대적인 비결합 글리칸
EP4352094A1 (fr) 2021-06-07 2024-04-17 Amgen Inc. Utilisation de fucosidase pour contrôler le taux d'afucosylation de protéines glycosylées
CN113584061B (zh) * 2021-07-30 2022-09-23 中国人民解放军空军军医大学 一种双途径拮抗pcsk9的重组基因、载体、外泌体及制备方法和应用
CN113684322B (zh) * 2021-09-09 2024-01-23 上海药明生物技术有限公司 一种降低抗体类蛋白高聚甘露糖型水平的方法
AU2024256160A1 (en) 2023-04-20 2025-10-02 Amgen Inc. Methods of determining relative unpaired glycan content
WO2025141483A1 (fr) * 2023-12-29 2025-07-03 Intas Pharmaceuticals Ltd. Procédé de modulation du niveau de défucosylation du pertuzumab

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Also Published As

Publication number Publication date
JP2023055711A (ja) 2023-04-18
JP7672196B2 (ja) 2025-05-07
US20260103716A1 (en) 2026-04-16
IL269197A (en) 2019-11-28
JP2020513813A (ja) 2020-05-21
JP2025098016A (ja) 2025-07-01
WO2018170099A1 (fr) 2018-09-20
EP3596225A1 (fr) 2020-01-22
US20200131518A1 (en) 2020-04-30
SG11201908328XA (en) 2019-10-30
AU2018235928B2 (en) 2023-09-21
CN110418846A (zh) 2019-11-05
CA3056011A1 (fr) 2018-09-20
AU2018235928A1 (en) 2019-09-26
AU2023285706A1 (en) 2024-01-18
US12503700B2 (en) 2025-12-23

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